• The Korean journal of internal medicine
• /
• v.39 no.2
• /
• pp.261-271
• /
• 2024

Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper and lower GI tract in concomitant aspirin and acid suppressant users using the nationwide database of national claims data from the Korean National Health Insurance Service (NHIS). Methods: An aspirin cohort was constructed using the NHIS claims data from 2013 to 2020. Patients who manifested with hematemesis, melena, or hematochezia were considered to have GI bleeding. A Cox proportional hazards regression model was used to determine the risk factors for GI bleeding associated with the concomitant use of GI drugs and other covariates among aspirin users. Results: Overall, a total of 432,208 aspirin users were included. The concurrent use of an acid suppressant and eupatilin (hazard ratio [HR] = 0.85, p = 0.016, vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Moreover, a more than 3-month duration (HR = 0.88, p = 0.030) of acid suppressant and eupatilin prescription (vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Conclusions: Eupatilin administration for ≥ 3 months showed additional preventive effect on GI bleeding in concomitant aspirin and acid suppressant users. Thus, cotreatment with eupatilin with a duration of 3 months or longer is recommended for reducing GI bleeding among aspirin plus acid suppressant users.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.17 no.5
• /
• pp.10-17
• /
• 2013

This paper describes a study on after-burning suppressant in a solid propellant to reduce the plume formed outside of rocket nozzles, which could expose the launch site and the flight track. The minimum smoke propellant to enhance the stealth ability was formulated in terms of the kinds and the effects of after-burning suppressant on the ballistic performance and the amount of primary smoke. A after-burning suppressant, $K_2SO_4$ of about 1.1% weight content was found to show profound reduction of the rocket plume, giving negligibly slight increase in pressure exponent of burning rate. Also minimum smoke propellant with less than 1.1% of $K_2SO_4$ corresponds to A-class satisfaction in primary smoke by AGARD standard.

• Archives of Pharmacal Research
• /
• v.29 no.11
• /
• pp.990-997
• /
• 2006

Sarcococca saligna is a shrub that is traditionally used for its medicinal properties in Pakistan. In this study we report the cardio-suppressant, vasodilator and tracheal relaxant activities of the aqueous-methanolic extract (Ss.Cr) of the plant. Ss.Cr, that tested positive for the presence of saponins, flavonoids, tannins, phenols, and alkaloids, exhibited a dose-dependent (0.3-5 mg/mL) negative inotropic and chronotropic effect on the isolated guinea-pig atrium which was resistant to atropine ($1\;{\mu}M$) and aminophylline ($10\;{\mu}M$) pretreatment. In rabbit thoracic aorta, Ss.Cr dose-dependently (0.1-3 mg/mL) relaxed the high $K^{+}$ (80 mM) and phenylephrine ($PE,\;1\;{\mu}M$)-induced contractions, indicating a possible $Ca^{++}$ channel blocking (CCB) effect. When tested against PE ($1\;{\mu}M$) control peaks in normal $Ca^{++}\;and\;Ca^{++}$-free Kreb's solution, Ss.Cr exhibited dose-dependent (0.1-3 mg/mL) inhibition, being more potent in relaxing the PE responses in $Ca^{++}$-free Kreb's solution, thus indicating specific blockade of $Ca^{++}$ release from the intracellular stores. Ss.Cr also relaxed the agonist-induced contractions in: a) rat aorta irrespective of the presence of endothelium or nitric oxide synthase inhibitor L-NAME and b) rabbit and guinea-pig tracheal strips. The data shows that Ss.Cr possesses possible $Ca^{++}$ channel blocking activity which might be responsible for its observed cardio-suppressant, vasodilator and tracheal relaxant effects though more tests are required to confirm this $Ca^{++}$ channel blocking effect.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.7 no.5
• /
• pp.172-177
• /
• 1999

In this paper, the physical and electrical properties of the synthetic fluids No. 2 class Ⅶ used the insulating oils for automobile ignition coil are studied. Also, benzotriazole(BTA) as the streaming electrification suppressant additive is added to the oil, and the change of physical and electrical properties due to different BTA concentration is investigated. To investigate the electrical characteristics, the breakdown strength of each specimen by an experiment for AC breakdown and the changes of conductivity by measuring volume resistivity are analyzed. It is considered that the effective content of BTA as charge suppressant additive is about 10[ppm] from the results of AC breakdown and volume resistivity test.

• Proceedings of the KIEE Conference
• /
• 1997.07d
• /
• pp.1414-1416
• /
• 1997

The electrical breakdown characteristics of the synthetic fluids No.2 of KS class VII used for insulating and cooling the materials for the ignition coil are studied. Also, Benzotriazole(BTA) as the streaming electrification suppressant additive is added to the oil, and the change of electrical properties due to different BTA concentration is investigated. To investigate the electrical characteristics, the breakdown strength of each specimen by an experiment for AC breakdown are analyzed. The breakdown strength of specimen by adding BTA is higher than virgin specimen in low e region, but lower than that in high region because of melting BTA. It is considered that the effective content of BTA as charge suppressant additive is about 10[ppm] from the results of AC breakdown.

• Journal of Aerospace System Engineering
• /
• v.7 no.4
• /
• pp.42-48
• /
• 2013

In this paper, a study of solid rocket propellant formulation is performed to suppress plume and reduce IR(infrared) signature which occurs in propellant combustion. The solid propellant to enhance the stealthy ability was formulated in terms of the kinds and the effects of afterburning suppressant on the ballistic performance and the amount of primary smoke. In addition, substantial decrease in plume and IR signature is confirmed by static firing test by a 4 inch standard motor.

• Fire Science and Engineering
• /
• v.22 no.5
• /
• pp.48-54
• /
• 2008

Forest fires occur the world over, with large-scale fires constantly breaking out. A suppressant a type of forest fire chemical is widely used to respond to fires rapidly and effectively. In general, suppressants used for fires have been divided into dry powder, liquid, foam, and gel type, according to physical form and use. This study has conducted toxicity tests relating to phytotoxicity(Pinus densiflora seed germination rate and mortality of containerized seedling), and soil organism toxicity(earthworm acute toxicity tests), of these suppressants, with the loaded stream suppressant for direct forest fire extinguishing a Loaded Stream and foam concentrates generally being used in Korea. From the results of the tests, the loaded stream and the foam concentrate had an effect on the toxicity levels. In the case of the loaded stream type, it was observed that toxicity indicating a 100% lethality rate was found among all toxicity test methods. Therefore, it is determined that forest ecology environmental toxicity impact assessments related to the suppressant used to extinguish forest fires are necessary in the near future.

• Journal of Soil and Groundwater Environment
• /
• v.23 no.6
• /
• pp.82-89
• /
• 2018

The objective of this study is to evaluate efficiencies of chemical suppressants for control of fugitive dust in ash pond of thermal power plant. In this study, $MgCl_2$, PAM (polyacrylamide), and PVA (poly vinyl alcohol) that are generally applied to suppression of fugitive dust generated from unpaved road, coal mining, storage piles and etc, were employed as chemical dust suppressants. The coal ash (coal combustion residuals) were sampled from the ash pond of Yeongheung power division in Incheon, South Korea. The characterization of the sample including particle size distribution, pH, $pH_{PZC}$ and pore volume as well as XRF analysis were carried out. The suppressant treated-samples were investigated with the wind tunnel experiments to estimate and compare the effect of suppressants on stabilization of the surface of coal ash samples. According to the results, the stability of suppressant-treated samples were significantly improved compared to water-treated samples. Among the three kinds of suppressants, PAM and PVA showed higher efficiencies and cost saving than $MgCl_2$.

• Parasites, Hosts and Diseases
• /
• v.41 no.2
• /
• pp.81-87
• /
• 2003

The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine (a histamine receptor H$_1$ blocker), cimetidine (a H$_2$ blocker), cyclosporin-A (a helper T-cell suppressant), and prednisolone (a T- and B-cell suppressant). Infected, but untreated controls, and uninfected controls, were prepared. Worm recovery rate and intestinal mastocytosis were measured on weeks 1, 2, 3, 5, and 7 post-infection. Compared with the infected controls, worm expulsion was significantly (P < 0.05) delayed in hydroxyzine- and cimetidine-treated rats, despite mastocytosis being equally marked in the duodenum of all three groups. In the cyclosporin-A- and prednisolone-treated groups, mastocytosis was suppressed, but worm expulsion was only slightly delayed, without statistical significance. Our results suggest that binding of histamine to its receptors on intestinal smooth muscles is more important in terms of the expulsion of N. seoulense from rats than the levels of histamine alone, or mastocytosis.

• Journal of The Korean Society of Clinical Toxicology
• /
• v.12 no.1
• /
• pp.35-38
• /
• 2014

Phentermine has been widely used as an appetite suppressant since 2004 in Korea. The authors experienced two cases of acute phentermine overdose and report with the literature review. A 36-year-old man and a 24-year-old woman presented together to the emergency department with taking 13 tablets (390 mg) of phentermine 16 hours ago. They had tachycardia, hypertension and complained visual symptoms, nausea, insomnia and anxiety. These symptoms were resolved by conservative management.