• Journal of Ginseng Research
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• v.45 no.6
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• pp.695-705
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• 2021

Background: Ginsenosides have beneficial effects on several airway inflammatory disorders primarily through glucocorticosteroid-like anti-inflammatory activity. Among inflammatory cells, eosinophils play a major pathogenic role in conferring a risk of severe refractory diseases including chronic rhinosinusitis (CRS). However, the role of ginsenosides in reducing eosinophilic inflammation and CRS pathogenesis is unexplored. Methods: We investigated the therapeutic efficacy and underlying mechanism of ginsenoside F1 (G-F1) in comparison with those of dexamethasone, a representative glucocorticosteroid, in a murine model of CRS. The effects of G-F1 or dexamethasone on sinonasal abnormalities and infiltration of eosinophils and mast cells were evaluated by histological analyses. The changes in inflammatory cytokine levels in sinonasal tissues, macrophages, and NK cells were assessed by qPCR, ELISA, and immunohistochemistry. Results: We found that G-F1 significantly attenuated eosinophilic inflammation, mast cell infiltration, epithelial hyperplasia, and mucosal thickening in the sinonasal mucosa of CRS mice. Moreover, G-F1 reduced the expression of IL-4 and IL-13, as well as hematopoietic prostaglandin D synthase required for prostaglandin D2 production. This therapeutic efficacy was associated with increased NK cell function, without suppression of macrophage inflammatory responses. In comparison, dexamethasone potently suppressed macrophage activation. NK cell depletion nullified the therapeutic effects of G-F1, but not dexamethasone, in CRS mice, supporting a causal link between G-F1 and NK cell activity. Conclusion: Our results suggest that potentiating NK cell activity, for example with G-F1, is a promising strategy for resolving eosinophilic inflammation in CRS.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.3
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• pp.270-275
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• 2003

Histochemical characteristic and ultrastructure of the mantle of the granular ark, Tegillarca granosa are described using light and electron microscopy. The mantle of the clam is composed of outer epidermis, connective tissue and inner epidermis. The simple epidermis consists of supporting cells, ciliated cells of the two types and secretory cells of three types. Connective tissue is composed of matrix, collagen fibers, muscular fibers and hemolymph sinus. The columnar supporting cell is covered with microvilli on the free surface. Ciliated cells are distributed in the inner epidermis with numerous cilia, microvilli and tubular mitochondria. Secretory cells could be classified into three types (A, B and C) with morphological features of the secretory granules. Type A secretory cells contains secretory granules with fibrous materials of high electron density Type B secretory cells are more abundant than the other cells, and contains secretory granules of membrane-bounded and high electron density. Secretory granules of the type C cells are divided into fibrous core layer and homogeneous peripheral layer. Type B secretory cells are abundant in the both epidermis of marginal mantle, while large number of type A and C secretory cells are evident in the outer epidermis of the central and umbonal mantle. This result showed that the outer and the inner epidermis of the mantle are related with shell formation and cleaning of the mantle cavity, respectively.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.1A
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• pp.132-141
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• 2000

In this paper, we proposed the MAC protocol of APON supporting multi-class traffic such as CBBUVBR, ABR, UBR, to guarantee the required QoS of each service. For this, we analyze the performance of variousrequest mechanisms and employee the different request mechanism for each traffic classes. Upstream anddownstream frame structures to minimize transmission overhead are proposed based on our request mechanism.The proposed MAC protocol applies the different priority to permit distribution process. CBBWBR traffic, withthe stringent requirements on CDV or delay, is allocated prior to any other class. ABR traffic, which hasnon-strict CDV or delay criteria, uses flexibly the available bandwidth but ensures a minimum cell rate (MCR).UBR traffic is allocated with lowest priority for the remaining capacity. The performance of proposed protocol isevaluated in terms of transfer delay and 1-point CDV with various offered load. The result of simulation showsthat the proposed protocol guarantees the required QoS of the corresponding category, while making use of theavailable resources in both an efficient and dynamical way.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.12C
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• pp.1201-1207
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• 2006

In this paper, we say the adaptive shading correction system supporting multi-resolution for mobile camera. The shading effect is caused by non-uniform illumination, non-uniform camera sensitivity, or even dirt and dust on glass (lens) surfaces. In general this shading effect is undesirable [1-3]. Eliminating it is frequently necessary for subsequent processing and especially when quantitative microscopy is the fine goal. The proposed system is available on thirty nine kinds of image resolutions scanned by interlaced and progressive type. Moreover, the system is using forty kinds of continuous quadratic equations instead of using the piece-wise linear curve which is composed of multiple line segments. Finally, the system could correct the shading effect without discontinuity in any image resolution. The proposed system is implemented in VLSI with cell library based on Hynix $0.25{\mu}m$ CMOS technology.

• Journal of Electrochemical Science and Technology
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• v.8 no.3
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• pp.236-243
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• 2017

A fixed-bed zinc/nickel redox flow battery (RFB) is designed and developed. The proposed cell has been established in the form of a fixed bed RFB. The zinc electrode is immersed in an aqueous NaOH solution (anolyte solution) and the nickel electrode is immersed in the catholyte solution which is a mixture of potassium ferrocyanide, potassium ferricyanide and sodium hydroxide as the supporting electrolyte. In the present work, the electrode area has been maximized to $1500cm^2$ to enforce an increase in the energy efficiency up to 77.02% at a current density $0.06mA/cm^2$ using a flow rate $35cm^3/s$, a concentration of the anolyte solution is $1.5mol\;L^{-1}$ NaOH and the catholyte solution is $1.5mol\;L^{-1}$ NaOH as a supporting electrolyte mixed with $0.2mol\;L^{-1}$ equimolar of potassium ferrocyanide and potassium ferricyanide. The outlined results from this study are described on the basis of battery performance with respect to the current density, velocity in different electrolytes conditions, energy efficiency, voltage efficiency and power of the battery.

• Journal of the Korean Society of Visualization
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• v.17 no.3
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• pp.12-18
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• 2019

Direct numerical simulation of a fully developed turbulent plane Couette-Poiseuille flow with a two-dimensional (2-D) rod-roughened wall is performed to investigate the impacts of the surface roughness. It is shown that the logarithmic region in the mean velocity profile over the rough wall Couette-Poiseuille flow is significantly shortened by the surface roughness compared to that over a turbulent Couette-Poiseuille flow with smooth wall. The Reynolds shear stress over the rough wall Couette-Poiseuille flow is decreased compared to that for a smooth case in the outer layer. These results are attributed to weakened turbulence activity or roll-cell mode over the rough wall Couette-Poiseuille flow near the channel centerline due to suppressed development of u'-structure on the top wall, as documented through spanwise energy spectra of the streamwise velocity fluctuations. Inspection of congregation motion near the bottom wall and time evolution of u'-structure reveal weakened co-supporting cycle for the rough wall case.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.1B
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• pp.18-26
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• 2003

Earlier efforts on optical access concentrated on the design of PONs for the collection and distribution portion of the access network PON architecture is very simple but it requires MAC protocol for control of upstream traffic This paper proposes a Request-Counter MAC protocol for a broadband access network using an ATM Passive Optical Network supporting CBR/rtVBR, nrtVBR, UBR and ABR traffic For the proposed MAC scheme, we present Grant Field format, Minislot format, and bandwidth allocation algorithm From the simulation result, we have confirmed that our proposed scheme can reduce the average cell delay in comparison to that of conventional MAC schemes.

• Applied Microscopy
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• v.31 no.4
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• pp.325-331
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• 2001

Integumentary structures of the stone flounder, Karefus bicoloratus were examined by means of the light and transmission electron microscopy. Stratified epidermal layer consists of supporting cells, unicellular glands and granular cells. The epidermal layer could be classified into superficial, intermediated and basal layer by morphology and structure of the supporting cells . The cytoplasm of supporting cells is divided into cortex and medullar part. In the cortex microfilaments are well developed. Mucous cells of unicellular gland were observed in the superficial and intermediated layer of the epidermis. The mucous materials were identified as glycoprotein of neutral and carboxylated mucosubstance by histochemical methods. Club cell has well developed smooth endoplasmic reticula and Golgi complex in the cytoplasm. Granular cells were observed in the intermediated and basal layer, and the cytoplasm is occupied with membrane-bounded granules of electron dense. Three types of pigment cells could be distinguished with electron density of cytoplasmic inclusions. Nerve myelins were observed near the pigment cells.

• Convergence Security Journal
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• v.7 no.1
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• pp.77-82
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• 2007

Supporting Quality of Service (QoS) for multimedia services in heterogeneous mobile networks is a part of key issue for Beyond Three Generation (B3G) development. In particular, if QoS degradation are occurred because cell overload and error late patterns of wireless links during the transmission of multimedia data, the efficient QoS management is necessary to maintain the same QoS of transmitted multimedia data because the QoS may be defected by some delay and information loss. This paper deals with QoS Degradation reason Intra-System Handover (D-ISHO) for handling QoS of multimedia services over heterogeneous mobile networks. For this aim, the function modules for supporting QoS of D-ISHO are proposed. The sequence diagram showing interaction between the modules is described and then a scenario for D-ISHO is considered. Simulation is focused on the average delay and packet loss rate. The proposed heterogeneous mobile system using the QoS-Guaranteed Resource Management (QGRM) provides a better performance than each different access system.

• Journal of the korean society of oceanography
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• v.31 no.4
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• pp.196-206
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• 1996

Vertical profiles of the chlorophyll ${\alpha}$, phytoplankton abundance, nutrients and sigma-t were compared with the vertical distribution of phytoplankton species in conjunction with $^{14}$C primary production in the Southern Waters of the East Sea, Korea. In the upper mixed layer the water column was only weakly stratified and ambient nitrogenic nutrient concentrations were markedly depleted. Dissolved silicate seemed to be another limiting nutrient in the surface layer. The occupation of different water depths by several dominant diatom species was well explained by the degree of silicification of each cell and the silicate concentration of ambient seawater. Subsurface chlorophyll maxima were continuously observed in the lower parts of the euphotic layer and the depth coincided with nutricline, supporting our view that chlorophyll maximum was sustained partially by enhancement of in situ growth of phytoplankton and partially by increase of cellular chlorophyll content. The persistence of chlorophyll maximum layer was attributed to the physiological adaptation of the phytoplankters to low light intensities and to the utilization of regenerated nutrients. Integrated water column production of organic matter by photosynthesis appeared to be better related to phytoplankton cell division than to the cell growth in terms of biosynthesis of pigments and other intracellular components.