• Title/Summary/Keyword: Sulfoxide

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Effects of Cryoprotectants and Diluents on Cryopreservation of the Red Seabream, Pagrus major Sperm (참돔, Pagrus major 정자의 동결보존에 미치는 희석제와 동해방지제의 효과)

  • Kho, Kang Hee
    • Korean Journal of Ichthyology
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    • v.19 no.2
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    • pp.173-177
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    • 2007
  • A series of experiments were conducted to compare the effects of various diluents and cryoprotectants on the motility and survival rate in cryopreservation of the red seabream, Pagrus major sperm. Sperm was efficiently cryopreserved using 300 mM glucose as a diluent. Two cryoprotectant, dimethyl sulfoxide (DMSO) and glycerol, were added to 300 mM glucose to formulate the extenders at concentrations between 5% and 30% by volume for freezing. The highest post-thawed sperm motility and survival rate were obtained with 10% DMSO.

Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives

  • Shim, Young Sun;Hwang, Hyun Sook;Nam, Ghilsoo;Choi, Kyung Il
    • Bulletin of the Korean Chemical Society
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    • v.34 no.8
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    • pp.2317-2320
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    • 2013
  • Thiourea and vinyl sulfoxide derivatives were designed based on the structures of sulforaphane and gallic acid, prepared and tested for HO-1 inducing activity as a measure of Nrf2 activation, and inhibitory effect on NO production as a measure of anti-inflammatory activity. Both series of compounds showed moderate activity on HO-1 induction, and no inhibitory effect on NO production. Interestingly the thiourea compound 6d showed better HO-1 induction (71% SFN) than the corresponding isothiocyanate compound 6a (55% SFN). Overall, it seemed that more efficient electrophile is needed to get more effective Nrf2 activator.

Filter- Photometry of Chemiluminescence from Firefly Luciferin Intermediate M420 in Deoxygenated Dimethyl Sulfoxide

  • Shibata, Rikuo;Yoshida, Yasuhiko;Wada, Naohisa
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.290-292
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    • 2002
  • The intermediate M420 formed in a solution of firefly luciferin in deoxygenated dimethyl-sulfoxide added potassium f-butoxide was observed to emit yellow-green and red light by filter-photometry. By H-NMR, M420 was found to be deprotonated at the site where luciferin reacts with oxygen.

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Effects of Dimethyl Sulfoxide on the Differentiation of Myocardial and Endothelial Cells (심근세포 및 내피새포의 분화에 미치는 Dimethyl Sulfoxide의 영향)

  • Lee, Dong-Hyup;Park, Yee-Tae;Han, Sung-Sae;Lee, Yung-Chang
    • Journal of Yeungnam Medical Science
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    • v.5 no.2
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    • pp.111-119
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    • 1988
  • To elucidate the effects of dimethyl sulfoxide on myocardial and endothelial cells in culture, the cells were exposed to 10% dimethyl sulfoxide in culture medium for 1 hour at 48 hours after cell isolation. The general morphology and the cytochemical reaction of marker enzymes for mitochondria and Golgi complexes were investigated. The results were summarized as follows. : 1. DMSO induced elongation and narrowing of the cells and increase of mitochondrial reaction in myocardial cells. 2. DMSO induced destruction and disruption of myofibrils in myocardial cells resulting in increase of contractile activities. 3. In the endothelial cells, DMSO suppressed proliferative activities but thiamine pyrophosphatase reactions were enhanced indicating increase of Goigi complex activity. 4. DMSO seemed to hamper with the adhesiveness and motility of the endothelial cells causing the decrease of the number of cells in vitro.

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An Increased Intracellular Calcium Ion Concentration in Response to Dimethyl Sulfoxide Correlates with Enhanced Expression of Recombinant Human Cyclooxygenase 1 in Stably Transfected Drosophila melanogaster S2 Cells (Dimethyl sulfoxide에 의한 세포내 칼슘이온 농도 증가가 안정적으로 형질 전환된 초파리 S2 세포에서 재조합 사람 cyclooxygenase 1의 발현에 미치는 영향)

  • Chang, Kyung Hwa;Park, Jong-Hwa;Kim, Do Hyung;Chung, Ha Young;HwangBo, Jeon;Lee, Hyun Ho;Lee, Hee-Young;Shon, Dong-Hwa;Kim, Wonyong;Chung, In Sik
    • KSBB Journal
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    • v.27 no.5
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    • pp.313-318
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    • 2012
  • Dimethyl sulfoxide (DMSO) increased the intracellular calcium ion concentration in stably transfected Drosophila melanogaster S2 cells expressing recombinant cyclooxygenase 1 (COX-1). DMSO did not increase the Drosophila NOS (dNOS) transcript level in calcium chelator-treated cells. Expression of recombinant COX-1 due to DMSO was diminished in cells treated with calcium chelators or channel blockers. Our results indicate that an increased intracellular calcium ion concentration due to DMSO is associated with up-regulation of the dNOS gene, leading to enhanced expression of COX-1.

Partial Molal Volume and Viscosity of Tetraethylammonium Chloride in Dimethyl Sulfoxide-Water Mixtures (Dimethyl Sulfoxide-물 混合溶媒中에서 Tetraethylammonium Chloride의 分몰容積 및 粘度에 관한 硏究)

  • Cho Byung Rin;Lee Yong Ja;Lee Ikchoon
    • Journal of the Korean Chemical Society
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    • v.19 no.1
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    • pp.3-10
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    • 1975
  • The partial molal volumes and relative viscosities of tetraethylammonium chloride in a series of dimethyl sulfoxide (DMSO)-water mixtures were measured at $30^{\circ}C$. A maximum structuredness of solvent, that leads to a minimum viscosity A-coefficient and a maximum viscosity B-coefficient of the Jones-Dole equation(${\eta}_r=1+AC^{1/2}$ + BC), was found at 0.2${\sim}$0.3 mole fraction of DMSO. The solvent structure, that leads to a minimum partial molal volume due to the maximum electrostrictive effect of chloride ion and to a minimum viscosity B-coefficient, was found at 0.4${\sim}$0.5 mole fraction of DMSO. An approximate relationship between the limiting effective flowing volume, $V_e^{\circ}$, and the B-coefficient was found to be B = 2.5 $V_e^{\circ}$ in the Einstein equation.

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A Synthesis of 1,4-Thiazine Carboxanilide: Neighboring Group Participation in Pummerer Reaction (1,4-Thiazine Carboxanilide의 합성: Pummerer 반응에서의 인접기 참여효과)

  • Han, Ho-Gyu;Nam, Gi-Dal;Ma, Hye-Deok
    • Journal of the Korean Chemical Society
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    • v.46 no.4
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    • pp.330-336
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    • 2002
  • For the purpose of development of new agrochemical fungicide of ${\alpha},{\beta}-unsaturated$ carboxanilide series a synthesis of 4-acetyl-3-methyl-N-phenyl-1,4-thiazine-2-carboxamide (6) is described. Pummerer reaction of sulfoxide 7 obtained by sulfoxidation of dihydro-1,4-thiazine methyl ester 11 gave ${\alpha}-acetoxy$ dihydro-1,4-thiazine 10a. Under the same reaction conditions, dihydro-1,4-thiazine carboxanilide sulfoxide 14 was converted to acetoxymethyl dihydro-1,4-thiazine 18 through vinylogous Pummerer reaction involving carboxanilide of sulfonium ion through intermediate 15.1,4-Thiazine carboxanilide 6 was synthesized from the treatment of ${\alpha}-acetoxy$ dihydro-1,4-thiazine 10a with acid cat-alyst followed by hydrolysis and then the reaction with aniline.