• The Korean Journal of Physiology and Pharmacology
• /
• 제6권1호
• /
• pp.1-7
• /
• 2002

Congenital Long QT syndrome (LQTs) is a relatively rare pathologic disorder but results frequently in sudden cardiac death. Of the six LQTs that have been clinically described, five have been worked out for their genetic and biophysical profile. Most are generated by mutations which cause a loss of function in two delayed $K^+$ currents, $i_{Ks}\;and\;i_{Kr}.$ One syndrome is generated by mutations in the $Na^+$ channel which causes essentially a gain of function in the channel. Clinically the syndromes are characterized by slowed repolarization of the cardiac ventricular action potential and the occurrence of typical arrhythmias with undulating peaks in the electrocardiogram, called Torsade de Pointes. Arrhythmias are initiated by early or delayed afterdepolarizations and continue as reentry. Triggers for cardiac events are exercise (swimming; LQT1), emotion (arousal; LQT2) and rest/sleep (LQT3). ${\beta}-blockers$ have a high efficacy in the treatment of LQT1 and LQT2. In LQT3 their use is questionable. The study of congenital LQTsyndromes is a remarkable example of how basic and clinical science converge and take profit of each other's contribution.

• 한국화재소방학회논문지
• /
• 제30권2호
• /
• pp.87-91
• /
• 2016

최근 우리나라의 인구구조가 표주박형태의 고령화 사회로 변화함에 따라 급사의 원인이 되는 심장질환의 발생이 고령이 될수록 증가하고 있다. 심정지나 호흡이 정지된 환자에게 사용되는 인공호흡기중 전 세계적으로 보급되고 있는 공급되는 산소의 압력만으로 자동으로 작동되는 휴대용 인공호흡기의 필요성이 증가하고 있다. 이러한 휴대용 인공호흡기의 구성품 및 인공호흡기에 중요시되는 성능요구사항에 따른 시험방법을 제시하고 그에 따른 인공호흡기 내부감압셋팅 변화조건에 따른 최적 성능요구조건에 적합한 내부 감압조건을 찾고자 한다.

• Journal of Chest Surgery
• /
• 제3권1호
• /
• pp.3-12
• /
• 1970

During the last 10 years of period, one hundred patients with various pulmonary diseases were pneumonectomized upon at the Department of Chest Surgery of Pusan University Hospital. This paper is concerned with the clnical results of these patients along with the serious postoperative complications such as postoperative intrapleural infection and hemorrhage. The results were obtained as follows. 1.Left pneumonectomy was done in sixty-six of 100 patients [66 %] and the right one was done in the rest thirty-four[34 %]. The ratio between left and right was nearly 2:1. 2.Of all oostoperative complications, the intrapleural infection was most common, and these were 53 % in empyema thoracis and 12.7 % in pulmonary tuberculosis respectively. 3.More postoperative complications could be seen after right pneumonectomy than the left one. 4.It was thought that the postoperative intrapleural infection was closely correlated with the methods of pleural dissection at pneumonectomy,postoperatlve tube drainage, time of operation, massive hemorrhage during operation, prolongation of bleeding time, and dysfunction of the liver. 5.The repeated thoracenteses with infusion of neomycin into the infected thoracic cavity and intravenous administrations of the high units of penicillin were effective in treatment of the postoperative intrapleural infection, however, the refractory cases have to be cured by thoracoplasty with open window. 6.Immediate secondary open thoracotomy appears to be the method of choice in life saving who developed massive intrathoracic hemorrhage after pneumonectomy. 7.The mortality rate was 10 % in our cases and the main causes of death were postoperative respiratory insufficiency, pulmonary edema, hemorrhage and sudden cardiac arrest.

• Journal of Chest Surgery
• /
• 제38권9호
• /
• pp.644-647
• /
• 2005

좌심방의 자유 부유 구혈전은 매우 드물며, 치명적인 전신성 색전증이나 혹은 좌심실 유입구의 폐쇄로 드물게 급사를 초래한다. 저자들은 7년 전에 기계판막으로 승모판대치술을 시행 받은 환자에서 크고, 자유 부유하는 좌심방의 구혈전을 경험하였기에 보고하는 바이다.

• 대한기계학회논문집
• /
• 제18권12호
• /
• pp.3149-3158
• /
• 1994

In this paper, using the formulation of dynamic equivalent load considering the effects of moment load and the equation to estimate the cage rotational speed, the new life equation of deep groove ball bearing under radial and moment loads was proposed. Fatigue life test apparatus with the measuring equipment of shaft and cage speed was designed and developed to be capable of subjecting combined radial and moment load. Fatigue life tests were executed by sudden death test method and the reliability of fatigue lives was evaluated by Weibull distribution analysis. From the results of fatigue tests and analysis, the relationships between film parameters and life adjustment factors were acquired. And it was turned out that so as to estimate the effect of moment load on fatigue life, the life adjustment factor as well as the dynamic equivalent load must be taken into account.

• Journal of Chest Surgery
• /
• 제28권5호
• /
• pp.491-494
• /
• 1995

A fibroma arising in the right ventricle outflow tract of a 14 month-old infant was successfully removed. The patient was first seen because of shortness of breath and tachycardia. Pertinent clinical and laboratory findings included a grade II/VI systolic murmur, blood pressure of 120/60 mmHg, slight cardiomegaly on chest X-ray, a mass obstructing the outflow tract of the right ventricle on echocardiography and magnetic resonance imaging. On october 30,1992, under cardiopulmonary bypass, a 4cm x 3cm x 3cm tumor was resected from the right ventricular outflow tract, together with a portion of the ventricular wall. Histologically, it was diagnosis as a fibroma. The patient was sent home on the 6th postoperative day following an uneventful recovery form the operation. Although cardiac fibroma is the second most common cardiac tumor in infancy and childhood, it is usually found in the left ventricle and one arising in the right ventricle is considered rare. Although it is a benign tumor, it could produce a severe cardiac dysfunction and even sudden death, depending on its size and location. With the advance in diagnostic techniques and operative management, there is a renewed interest in the early detection and operative removal of these tumors. The case herein presented is the first such case successfully managed and reported in the Korean literature.

• 한국의류학회지
• /
• 제44권3호
• /
• pp.427-440
• /
• 2020

This study developed a vest prototype capable of monitoring body temperature using textile electrodes to prevent the sudden death of babies as well as to determine the quality of developed products by evaluating usability with commercial products. Based on the results of the 7th Size Korea Project, a basic pattern for a vest prototype was drafted by applying the average size of two-year-old Korean babies. Two prototypes were the detachable (VEST I) and integrated textile electrodes vest type (VEST II), which followed the same design. The materials were 100% cotton single jersey (SJ) and double jersey (DJ). Six experts evaluated the usability of the developed vests (VEST I & VEST II) and commercial product (VEST M). The single-layer woven textile electrode appeared to have a slightly higher conductivity than the double-layer one. There was no statistical difference in the body temperature sensing function between VEST I and VEST II. Finally, the superiority of the VEST I was verified through a comparison with commercial products (VEST M). The usability test suggested that a wearable smart clothing system of the integrated conductive textile could be further commercialized for bio-monitor applications in Ubiquitous-health care.

• 한국동물위생학회지
• /
• 제27권3호
• /
• pp.239-247
• /
• 2004

Classical swine fever (CSF) was confirmed in 19 herds in Jeunbuk provence (Iksan, Gimje, Wanju, Buan, and Jangsu) in Korea between March and May, 2003 and 10,263 pigs were slaughtered. Pigs contacted with CSF virus in primary outbreak farm show fever, reduced appetite, arched back and chill in company with sever respirative sign and then most infected farms also were observed to fever, reduced appetite, sudden death, and leukopenia (101 pigs). In order to detecting infectious pig with CSF virus, A total of 555 pigs were inspected in 65 herds and blood samples were collected and serological test (ELISA), antigen ELISA, and reverse transcription-polymerase chain reaction (RT-PCR) had been done. Positive rate were $74\%$ (410 pigs) in antibody ELISA, $2\%$ (11 pigs) in antigen ELISA and $33\%$ (182 pigs) in RT-PCR, respectively. As shown that the RT-PCR was useful than the ELISA for determining CSF virus in blood, meat, and other organs.

• 대한수의학회지
• /
• 제48권3호
• /
• pp.323-326
• /
• 2008

A two-year-old mixed breed sow was requested to the Veterinary Pathology Laboratory of Cheju National University with a clinical signs of severe abdominal pain and sudden death. Grossly, there was severe hemorrhage in abdominal cavity. Most of internal parenchymas and subcutaneous muscle showed severe pale discoloration. Both ovaries were enlarged with oval to round protruding multilobular masses and dark red in color. And they were firm and contained multiple small cysts in their cut surface. Histopathologically, numerous neoplastic granulosa cells had spherical-to-oval, hyperchromatic nuclei and scant eosinophilic cytoplasms were distributed with follicular pattern in ovarian masses. And the typical Call-Exner bodies, distinctive microcavityies, were observed in the center of small neoplastic follicles. Based on the gross and histopathologic findings, this case was diagnosed as granulosa cell tumor. In our best knowledge, this is believed to be the first report of granulosa cell tumor in a sow in Korea.

• Journal of Chest Surgery
• /
• 제31권12호
• /
• pp.1238-1242
• /
• 1998

심근교각을 해부학적인 정의을 하면 심외막의 관상동맥 주행중 국한된 부분의 관상동맥이 심근섬유에 의해 둘러싸여 있는 것을 말한다. 이질환은 주로 관상동맥 조영술에서 심근수축시 관상동맥이 좁아지거나 또는 압박효과을 나타내기 때문에 알게된다. 관상동맥중 좌전하행지의 중간부위에 가장 많이 발생 한다. 심근교각은 허혈 효과을 가지고 있어서 건강한 사람에서 협심증, 심근경색, 혹은 사망의 원인이 되기도 한다. 저자들은 좌전하행지 중간부분의 압박으로 협심증을 호소한 2례의 환자을 치험하고 보고 하고자 한다. 수술은 심폐 우회술하에 좌전하행지 동맥상부을 덮은 심근에 근절개술을 시행하였다. 수술후 협심증과 압박효과는 호전되었다.