• 제목/요약/키워드: Substituted

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Synthesis and In Vitro Antibacterial Activity of C-3' Pyridinium Cephalosporin Derivatives

  • Chung, In-Hwa;Kim, Choong-Sup;Seo, Jae-Hong;Chung, Bong-Young
    • Archives of Pharmacal Research
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    • 제22권4호
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    • pp.391-397
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    • 1999
  • The quaternary ammonium cephalosporin derivatives were prepared with various pyridines substituted at the 3 or/and 4 position. Their in vitro antibacterial activities were determined and substituent effect on pyridine nucleus was studied. Preparation of substituted pyridines are also described.

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Synthesis and biological activity of 4,5-polymethylenepyrazole-derived HMG-CoA reductase inhibitors

  • Kim, Jin-Il;Choi, Young-Hee;Yurngdong Jahng
    • Archives of Pharmacal Research
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    • 제20권2호
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    • pp.158-170
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    • 1997
  • New HMG-CoA reductase inhibitors, in which 3-substituted 4, 5-polymethylenepyrazoles are employed as a hydrophobic anchor connected to tetrahydro-4-hydroxy-2H-pyran-2-one by a two-carbon bridge, were designed and synthesized to exhibit significant inhibitory activity comparable to mevinolin. The most potent enzyme inhibitor $(11cc, IC_{50}=0.01{\mu}M)$ is 4-fold more potent than lovastatin.

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Regiospecific Ring-Opening of Unsymmetrical Epoxides to the Corresponding Less Substituted Alcohols by Newly-Devised Meerwein-Ponndorf-Verley Type Reagents

  • Cha, Jin Soon
    • 통합자연과학논문집
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    • 제5권2호
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    • pp.91-99
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    • 2012
  • A newly-devised Meerwein-Ponndorf-Verley (MPV) reagents, such as diisobutylacetoxyalanes and diisobutylmethanesulfonylalanes, achieved a clean conversion of unsymmetrical epoxides to the corresponding less substituted alcohols. This review covers the recent developments for such a regiospecific ring-opening reaction of epoxides.

New Efficient Synthesis of 3-Carboxylquinolines

  • Kirankumar, S.;Rambabu, D.;Sekhar, N. Chandra;Prasad, A.S.G.;Rao, M.V. Basaveswara
    • 대한화학회지
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    • 제56권3호
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    • pp.322-327
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    • 2012
  • Rapid and efficient synthesis of substituted 3-carboxylquinoline derivatives from 4-chloro-3-formylcoumarin and substituted anilines using 30% $H_2SO_4$ in methanol at room temperature within the duration of 5-30 min., through domino condensation-cyclization-ring opening reaction.

마이크로웨이브 반응조건에서 염화 테트라부틸암모늄을 촉매로 이용한 치환된 Benzimidazole화합물들의 합성 (Tetra Butyl Ammonium Chloride Catalyzed Synthesis of Substituted Benzimidazoles under Microwave Conditions)

  • Karuvalam, Ranjith. P.;Siji, M.;Divia., N.;Haridas, Karickal. R.
    • 대한화학회지
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    • 제54권5호
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    • pp.589-593
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    • 2010
  • TBACl (10 mol %) 를 촉매로 사용하여 치환된benzimidazoles을 합성하는 간단하고 효율적인 합성방을 개발하였다.