• 제목/요약/키워드: Structured P2P system

검색결과 85건 처리시간 0.194초

Folate-Targeted Nanostructured Lipid Carriers (NLCs) Enhance (Letrozol) Efficacy in MCF-7 Breast Cancer Cells

  • Sabzichi, Mehdi;Mohammadian, Jamal;Khosroushahi, Ahmad Yari;Bazzaz, Roya;Hamishehkar, Hamed
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권12호
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    • pp.5185-5188
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    • 2016
  • Objective: Targeted-drug-delivery based lipid nanoparticles has emerged as a new and effective approach in cancer chemotherapy. Here, we investigated the ability of folate-modified nanostructured lipid carriers (NLCs) to enhance letrozol (LTZ) efficacy in MCF-7 breast cancer cells. Methods: New formulations were evaluated regarding to particle size and scanning electron microscope (SEM) features. Anti-proliferative effects of LTZ loaded nanoparticles were examined by MTT assay. To understand molecular mechanisms of apoptosis and cell cycle progression, flow cytometric assays were applied. Results: Optimum size of nanoparticles was obtained in mean average of $98{\pm}7nm$ with a poly dispersity index (PDI) of 0.165. The IC50 value was achieved for LTZ was $2.2{\pm}0.2{\mu}M$. Folate-NLC-LTZ increased the percentage of apoptotic cells from 24.6% to 42.2% compared LTZ alone (p<0.05). Furthermore, LTZ loaded folate targeted NLCs caused marked accumulation of cells in the subG1 phase. Conclusion: Taken together, our results concluded that folate targeted LTZ can be considered as potential delivery system which may overcome limitations of clinical application of LTZ and improve drug efficacy in tumor tissue.

A Study on the Development of Core Competency Diagnostic Tools for Professors at A' University

  • Soo-Min PARK;Tae-Chang RYU
    • 융합경영연구
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    • 제11권4호
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    • pp.31-39
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    • 2023
  • Purpose: This study attempted to systematize a support system that can enhance teaching core competencies by establishing a scale for diagnosing teaching core competencies at University A. Research design, data and methodology : To this end, the first Delphi was conducted With six experts related to university core competency modeling research by extracting factors and designing structured questionnaires through a literature review process that collects and analyzes prior research related to domestic and foreign university teaching competency. The derived questions were diagnosed on 27 professors, and independent sample t-verification and ANOVA were conducted using SPSS 24.0 for analysis by key teaching competency factors. Result: What is the standard suitability of KMO. It was shown as 929 (KMO standard conformity value is close to 1), and Barlett's sphericity verification showed χ2=5773.295, df=1081, p<.It appeared as 001 and confirmed that it was suitable for conducting factor analysis. Conclusions: The core competencies of A University teachers were set based on the educational goals of A University, such as basic teaching competency, creative teaching competency, practical teaching competency, and communication teaching competency. This means that the concept and factors of the core competency of professors are likely to change, and in the end, continuous efforts to upgrade and apply research on core competency of professors are essential to quickly and organically respond to changes in competency required to increase the competitiveness of universities.

도서지역 주민의 건강상태에 관한 연구 (A Study on The Health Status of Island Community People in Island)

  • 신경림
    • 성인간호학회지
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    • 제12권2호
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    • pp.296-310
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    • 2000
  • During the past 10 years, concern for community people's health has increased together with the changes. Public health policies and studies for community people's health, however, have influenced those in childmaternal health care to want more general coverage and studies of health and wellness. Particularly, the study of community people's health in the extent an island area is almost rare as that personal and the material benefits in this area are lacking of community people's work is large, and the basic elements of living, such as diet and elimination, are irregular due to the schedule of the tide. Thus, there are many potential health problems. In this regard, the study attempted to understand the health problems of island community people and to provide a basis for developing health promotion and health education programs. In collecting data for the study, face to face interviews were made through a structured questionnaire from October 1 to December 30, 1996. Collected data were analyzed with the SAS statistics program, descriptive statistics, t-test and ANOVA. Subjects' health status was examined by classifying into such categories as their health perception, complaints of health problem, related lifestyle, psychosocial health staus, the result of examination is as follows; 1. For subjects' health perception, 26.9% of the subject answered not sick, but not so healthy'; 30.9% thought they were healthy, while 22.9% answered that they were not healthy. 2. For the health problem complaints many complained of pains in their muscles and skeletal system, especially knee joint pain. Women's health problems related with breast and the reproductive system included 52.3% of cases doing breast self examination, while 56.55% received the cervical cancer screening test. In men's health problems, 44.2% of subjects answered that they have moderate to severe BPH(Benign Prostatic Hypertrophy) symptom. 3. There were statistically a significant difference in the degree of physical health according to marital status(p=0.0028), occupation(p=0.0442), income(p=0.0357). 4. For stress status, 17.2% was to need the intervention, 50.2% was to need observation. 5. The mean score of self-esteem was 27.7 showing a relatively high score. 6. For the rate of smoking, 37.7% used to smoke, while 28% used to take alcohol. 7. The rate of substance abuse was 45.9% of subjects. 8. Most of subjects' health behaviors included most of the acupuncture (52%). 9. The rate of subjects receiving comprehensive medical testing was 34.36% while 34.78% did after care managing behavior. 10. For the obesity grade, 53% is normal weight, low-weight 32.8%, obesity 33%. 11. For nutrition status, 78.7% illy balanced to need intervention of nutritional education. 12. For 78.7% of subjects, muscle strength and 40.7% of stretching were not good enough to need health education on physical exercises. Therefore, based on the results, appropriate health education programs need to be developed to promote health of community people on an island.

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만경 동진강 하구계의 동물플랑크톤의 분포와 염분 (Salinity and Distribution of Zooplankton in the Estuarine System of Mankyong River and Dongjin River)

  • 서해립;서호영
    • 한국해양학회지
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    • 제26권3호
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    • pp.181-192
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    • 1991
  • 만경 동진강 하구계의 표층에 분포하는 동물플랑크톤을 1989년 10월과 1990년 3 월, 5월 그리고 7월에 표준 네트로 수평 채집하였다. 우점하였던 주요 분류군은 10월 과 3월은 요각류, 5월과 7월은 야광충이었다. 동물플랑크톤의 출현량은 개체수가 $12~9,256ind./m^3$, 습증량이 $2.8~1,889.8{\;}mg/m^3$ 범위로 상당한 시공간적인 연동을 보 였다. 요각류의 우점종은 10월에 Pseudodiaptomus inopinus와 Paracalanus indicus, 3 월에 Acartia hudsonica와 P. indicus, 5월에 A. hudsonica와 Centropages abdominalis 그리고 7월에 A. pacifica P. indicus와 Tortanus spinicaudatus로 변하 였다. 7월에는 강물의 유입량 증가로 정점간 염분변화가 심하게 나타났으며 ($0.7~28.9\textperthousand$), 이것은 요각류의 군집구조를 변화시켰다. 중염기수역($5.0~28.0\textperthousand$)에서는 Acartia pacifica, A. hudsonica, Centropages tenuilemis, C. abdominalis, Labidocera euchaeta, Tortanus spinicaudatus, Corycaeus affunis 그리고 Paracalanus indicus 8종이 분포 하였다. 저염분에 강한 요각류가 빈염기수역($0.5~5.0\textperthousand$)에 분포하였으며, 이들은 Thermocyclops hydlinus, Pseudodiaptomus inopinus 그리고 Sinocalanus tenellus 의 3종이었다. 고염기수역($>28.0\textperthousand$)에서는 Labidocera bipinnata, Oithona similis, Calanus sinicus, Acartia omorii 그리고 Tortanus forcipatus가 나타났다.

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치과기공사의 직무환경이 건강상태에 미치는 영향 (The Influence of the Job Environment and Health Condition of Dental Technicians)

  • 권은자;한민수
    • 대한치과기공학회지
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    • 제33권4호
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    • pp.467-478
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    • 2011
  • Purpose: The purpose of this study was to analyze dental technician's job environment and health condition level and to examine its correlation. Methods: 250 dental technicians in Seoul, Incheon, and Jeonbuk area were selected. Survey was carried out from October 11, 2010 to November 25, 2010 by using self-administered questionnaire. As for the tools for this study, the structured questionnaire was used with its proven reliability and feasibility, and the questionnaire consisted of total 49 questions which included general attribute of subjects(14 questions), job Environment(13 questions) and health condition(22 questions). The data analysis was processed by computerized system with SPSS Win 17.0. Statistical analysis techniques included frequency, percentage, T-test, One-way ANOVA analysis and regression analysis. Results: As a result of analyzing the research subjects' job environment level, there was significant difference in the item of gender, working hours a day(Hour), healthy condition, job satisfaction level with dental technician, plan for task continuity in dental technician(P<0.05). The average in the job environment was indicated to be high with 2.85. As a result of analyzing the research subjects' health condition level, there was significant difference in the item of gender, task field, working hours a day(Hour), healthy condition, job satisfaction level, plan for task continuity(P<0.05). The average in the self health recognition was indicated to be high with 2.83. Conclusion: Correlation between job environment and health condition, all of variables were indicated to have reverse correlation, thereby having been shown that the worse job environment leads to the more physical subjective symptoms.

양호교사(養護敎師) 업무(業務)에 대(對)한 인지(認知) 및 기대(期待) 조사연구(調査硏究) (A Study on Recognition and Expectation on School Nurse's Work at the Primary, Secondary School Students and Their Teachers in Suwon)

  • 박영남
    • 한국학교보건학회지
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    • 제4권1호
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    • pp.100-115
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    • 1991
  • The purpose of this study is to provide the necessary data for the effective performance of school nurse's work by comparing with the recognition and expectation on school nurse's work by the students and their teachers in school settings. The sample of this study was consisted of the 441 students and 535 teachers in Suwon. The data were collected by means of a structured questionnaire from 24th, Sept, to 29th, Sept. 1990. The collected data were analyzed utilizing SAS/PC program for percentage, frequency, mean, standard deviation and chisquare test. The major findings of this study were as follows: 1. The result of analysis in recognition on school nurse's work. There is no statistically significant difference 'depending on teachers' school level, sex, age and career with school nurse(P>0.05). The students show significant difference on their school level and sex(P>0.05). Also, in the areas of school nurse's work, school clinic management has the highest recognition and school environment management has the lowest recognition. 2. The result of analysis in expectation on school nurse's work. There is statistically significant difference depending on teachers' and students' school level: the order of expectation is elementary, middle, and high school(P<0.05). In the result of comparison with students' and teachers' expectation in the same school level, there is significant difference only in elementary school(P<0.05). However, there is no statistically significant difference depending on teachers' sex, age, career with school nurse and students' sex(P>0.05). Also, in the areas of school nurse's work, school clinic management has the highest expectation and school environment management has the lowest expectation. Synthesizing the result of the study, we can have the conclusion like following. First, students' recognition on school nurse's work is lower than teachers' because most of school nurse's work is performed through their homeroom teachers or other teachers. That can be the limitation for students to recognize school nurse's work. So, there must be a chance of regular meeting between school nurse and students to perform school nurse's work effectively. For this. we must change our educational system and make school nurse charge regular lesson. Second, in each area of school nurse's work, both students' and teachers' recognition and expectation about the area of school environment management has much lower score than the other areas. This indirectly shows the school nurse don't do the work of the area actively. So, school nurses must make an effort to do the work of the area actively. And we must enforce the education of this area in education for new school nurses or re-education for school nurses.

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치과병·의원 환기방법에 따른 실내공기질 자각증상 수준 및 근무환경 만족요인 (A Subjective Symptom Level and Satisfaction Factor by Indoor Air Quality According to Ventilation System in Dental Clinic)

  • 최미숙;지동하;최재호
    • 치위생과학회지
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    • 제11권4호
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    • pp.353-359
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    • 2011
  • 본 연구는 치과위생사가 근무하는 병원의 미세먼지(PM-10), 포름알데히드(HCHO), 이산화탄소($CO_2$), 일산화탄소(CO), 휘발성유기화합물(VOCs) 등에 의해 오염된 실내공기가 치과위생사의 건강 및 작업능률에도 많은 영향을 끼친다는 사실을 인식하여 치과위생사를 대상으로 근무하는 병원의 냉 반방 방식 및 창문개폐를 통한 환기 횟수에 따른 실내공기질에 대한 신체자각증상 정도를 비교하고, 근무하는 병원의 실내공기질과 관련된 환경 만족에 미치는 요인을 분석하므로써 치과위생사의 건강관리를 위한 효율적인 근무환경개선방안을 제시하기 위하여 시도되었다. 조사대상자는 전국 치과병 의원에 근무하는 치과위생사로 하였으며 2010년 10월 1일 부터 2011년 1월 21일까지 자기기입식 설문조사 방식으로 582부의 설문지를 수집하여 SPSS 12.0 프로그램을 이용하여 분석하였다. 1. 냉 난방 방식별 창문 개폐를 통한 하루 환기 횟수를 비교한 결과 창문개폐를 통한 환기가 편리한 개별 냉 난방 방식에서 높은 것으로 나타났다. 2. 치과위생사는 실내공기질과 관련된 자각증상으로 인하여 불편함을 가장 많이 느끼는 시간은 오후 2시 전 후이며 불편함을 느끼기 시작한 지 1시간 경과 후인 3시 전 후에 불편함의 정도가 가장 심한 것으로 조사되었다. 3. 치과위생사의 자각증상에 따른 불편함 수준을 냉 난방 방식 및 하루 창문개폐를 통한 환기 횟수와 비교하여 분석한 결과 창문 개폐를 이용하여 자연환기가 유리한 개별 냉 난방 방식의 사무실에 근무하는 치과위생사의 수준이 낮은 것으로 나타났다. 4. 근무하는 병원의 만족에 미치는 요인을 실내공기 조건과 관련된 항목을 독립변수로 하여 중회귀 분석을 실시한 결과 "병원 공기의 냄새가 기분 좋게한다", "병원 실내 온도조건은 근무하기에 편하다", "병원의 조명은 일하기에 적당한 편이다", "병원의 환기가 잘 된다", "병원 시끄러움", "병원공기가 신선하다고 느낀다", "병원 더움" 순으로 유의하게 나타났으며 설명력은 42.9%인 것으로 나타났다.

일 상급종합병원 의료서비스 불만족 내용의 의료 융합적 분석 (Medical Convergence Analysis of Complaint about Medical Service in an Affiliated Hospital)

  • 김정숙;엄애현;유문숙
    • 한국융합학회논문지
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    • 제7권5호
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    • pp.117-125
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    • 2016
  • 의료서비스를 이용하는 고객의견 대한 구현은 효과적이고 효율적인 관리가 중요하다. 이에 본 연구는 고객의 불만족 사항에 대한 내용의 의료융합적 분석을 확인하여 전략을 수립하고자하는 후향적 조사연구이다. 2014년 3월부터 2015년 2월까지 일 상급종합병원의 민원 319건을 대상으로 분석하였다. 본 연구에서는 초진보다 재진이, 입원환자보다는 외래환자의 불만족이 높았으며 불만족 분류 시 행정서비스의 업무절차, 진료 및 간호영역의 의사소통 및 설명부분에서 불만족이 높았다. 질병 분류에서는 소화기계와 암 진단관련 대상자들의 불만족이 높았다(p<0.05). 본 연구를 바탕으로 의료서비스의 질을 향상시키고 불만족의 재발을 막는 고객 지향적 의료융합 경영전략을 수립하기 위해 각 환자의 질환별 불만족 요인의 내용을 융합분석하고 지속적인 융합연구를 통해 질환별 구체적인 의료서비스 전략에 대해 유형을 구조화 할 필요가 있다.

치과기공소의 작업환경이 이직의도에 미치는 영향 (Effect of Dental Laboratory's Working Environment on the Turnover Intention)

  • 권은자;한민수;오선미
    • 대한치과기공학회지
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    • 제32권3호
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    • pp.211-220
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    • 2010
  • Purpose: The purpose of this study was to analyze dental laboratory's working environment and turnover intention level and to examine its correlation. Methods: 180 dental technicians in Seoul, Incheon, and Chungnam area were selected. Survey was carried out from April 6, 2009 to May 20, 2009 by using self-administered questionnaire. As for the tools for this study, the structured questionnaire was used with its proven reliability and feasibility, and the contents of questionnaire consisted of 43 questions on the basis of related references. The questionnaire consisted of total 32 questions which included general attribute of subjects(14 questions), working Environment(20 questions) and turnover intention(9 questions). The data analysis was processed by computerized system with SPSS 12.0. Statistical analysis techniques included frequency, percentage, T-test, F-test analysis and regression analysis. Results: As a result of analyzing the research subjects' working environment level, there was significant difference in the item of health(P<0.05). The average in the working environment was indicated to be high with 1.53. As a result of analyzing the research subjects' turnover intention level, there was difference in the item of working hours a day(Hour), job satisfaction level, plan for task continuity, most difficulty given task(P<0.05). The average of turnover intention was indicated to be high with 2.85. Conclusion: Correlation between working environment and turnover intention, most of variables were indicated to have reverse correlation, thereby having been shown that the worse working environment leads to the more turnover intention.

급속 응고 된 Bi2Te3-PbTe계 열전소재의 미세구조와 열전 특성 (Microstructures and Thermal Properties of Water Quenched Thermoelectric Material in Bi2Te3-PbTe System)

  • 임주혁;정규호;유현우;김광천;김진상
    • 한국전기전자재료학회논문지
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    • 제23권6호
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    • pp.502-507
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    • 2010
  • In order to design nano structured materials with enhanced thermoelectric properties, the alloys in the pseudo-binary $Bi_2Te_3$-PbTe system are investigated for their micro structure properties. For this synthesis, the liquid alloys are cooled by the water quenching method. Micro structure images are obtained by using an electron probe micro analyzer(EPMA). Dendritic and lamellar structures are clearly observed with the variation in the composition ratio between $Bi_2Te_3$ and PbTe. The increase in the $Bi_2Te_3$ composition ratio causes to change of the structure from dendritic to lamellar. The Seebeck coefficient of sample 5, in which the mixture rate of $Bi_2Te_3$ is 83%, is measured as the highest value. In contrast, the others decrease with the increase of the $Bi_2Te_3$ composition ratio. Meanwhile, p-type characteristics are observed in sample 6, at 91%-$Bi_2Te_3$ mixture rate. The power factors of the all samples are calculated with the Seebeck coefficient and resistivity.