• Title/Summary/Keyword: Structure-activity relation

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A Study on Evaluation Structure of luminous Environment in o residential space and office work space (주거.사무공간의 조명환경 평가구조에 관한 연구)

  • 이선영
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.17 no.2
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    • pp.1-9
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    • 2003
  • This paper is to find the difference of evaluation structure between a residential space and of ace work space and to examine a relation between mood item and behavior items on evaluation of the luminous environment. First 20 mood items md 15 behavior items were selected for evaluation item on the luminous environment. And then, subjective evaluation was experimented by the semantic differential method. The results are as follows: (1) In respect of evaluation un the mood both luminous environments that have each different character of space at evaluated by the three factors; activity, comfort and quality. (2) In respect of evaluation on the behavior, three factors, work, relaxation and entertainment are selected in the residential space and two factors, work and non-work are selected in the office work space. (3) In the residential space, activity is very important factor that affects on three behaviors, work, relaxation and entertainment. In the office work space, activity affects on work and quality affects on non-work.

Development of Work Breakdown Structure and Analysis of Precedence Relations by Activity in School Facilities Construction Work (학교시설 건설공사의 작업분류체계 구축 및 단위작업별 선후행 관계 분석)

  • Bang, Jong-Dae;Sohn, Jeong-Rak
    • Land and Housing Review
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    • v.8 no.3
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    • pp.189-200
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    • 2017
  • The work breakdown structure and the precedence relations by work activity are very important because they are the basic data for estimating the construction duration in the construction work. However, there is no standard to accurately estimate the construction duration since the size of the school facilities construction is smaller than the general construction work. Therefore, some schools are unable to open in March or September and the delay of the construction duration can cause damage to the students. To solve this problem, this study developed a work breakdown structure of school facilities construction work and analyzed the precedence relations by work activities. The work breakdown structure of the school facilities construction is composed of three steps. The operations corresponding to level 1 and level 2 are as follows. (1) 2 preparatory work categories; preparation period and temporary construction. (2) 17 architectural work categories; temporary construction, foundation & pile work, reinforced concrete work, steel roof work, brick work, plaster work, tile work, stone work, waterproof construction, wood work, interior construction, floor work, metal work, roof work, windows construction, glazing work and paint construction. (3) 7 mechanic and fire work categories; outside trunk line work, plumbing work, air-conditioning equipment work, machine room work, city gas plumbing work, sanitation facilities and inspection & test working. (4) 4 civil work categories; wastewater work, drainage work, pavement work and other work. (5) 1 landscaping work categories; planting work. The work breakdown structure was derived from interviews with experts based on the milestones and detailed statements of existing school facilities. The analysis of precedence relations by school facilities work activity utilized PDM(Precedence Diagramming Method)which does not need a dummy and the relations were applied using FS(Finish to Start), FF(Finish to Finish), SS(Start to Start), SF(Start to Finish). The analysis of this study shows that if one work activity is delayed, the entire construction duration may be delayed because the majority of the works are FS relations. Therefore, it is necessary to use the Lag at the appropriate time to estimate the standard construction duration of the school facility construction. Lag is a term used only in the PDM method and it is used to define the relationship between the predecessor and the successor in creating the network milestone. And it means the delay time applied to the two work activities. The results of this study can reasonably estimate the standard construction duration of school facilities and it will contribute to the quality of the school facilities construction.

Antineoplastic Natural Products and the Analogues(IX). A Review of the Series

  • Ahn, Byung-Zun;Kim, Shin-Il;Ryu, Sung-Ho;Kang, Kyu-Sang;Lee, You-Hui
    • Korean Journal of Pharmacognosy
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    • v.17 no.2
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    • pp.168-177
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    • 1986
  • Bioassay-directed isolation has yielded some cytotoxic substances against L1210 cell from the Korean traditional medicine. These include 5,2'-dihydroxy-6,7,8,6'-teramethoxyflavone $(IV,\;scutellaria\;root,\;ED_{50}\;=\;1.7\;{mu}g/ml)$, 7-geranyloxycoumarin $(XXXII,\;poncirus\;fruit,\;10.2\;{mu}g/ml) $and panaxydol $(I,\;white\;ginseng,\;0.03\;{mu}g/ml)$. IV, XXXII and their derivatives were synthesized in the purpose of in vivo tests and for observation of structure-activity relations. Among the flavone derivatives, 5,2',6'-trihydroxy-6,7,8-trimethoxy flavone (XVIII), 5-hydroxy-6,7,8-trimethoxy-6'-benzyloxyflavone (XVII) and 5,8-dihydroxy-6,7-dimethoxyflavone (X) showed the cytotoxicity which has no correlation to the flavone structures. Of the coumarins synthesized, 7,8-dihydroxycoumarin (XXVI), 6-7-dihydroxycoumarin (XXIX) and 6-hydroxy-5,7-dimethoxycoumarin (XXXI) showed considerable activities. Acetylated XXXI has moderate activity $(ED_{50}=17.2\;{mu}g/ml)$. Monobydroxycoumarins or their methyl and allyl ether were inactive. IV inhibits the growth of the solid form of S-180 by 70% at 40 mg/kg and shows T/C of 166% on the ascitic S-180 at 40 mg/kg. It strongly inhibits the activity of the membrane bounded ATPase from L1210 cell. The most cytotoxic fraction of the antitumor materials studied is the one from the trichosanthes root showing $ED_{50}=0. 0003\;{mu}g/ml$ against L1210 cell. This fraction, obtained from ethyl acetate extract, showed T/C of 130 and 135%, on ICR mice bearing S-180 and $BDF_1$ mice bearing L1210 at 10 mg/kg and 7.5 mg/kg, respectively.

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Effects of PCB Congeners in Rodent Neuronal Cells in Culture : Effects of Chitosan (PCB 이성질체가 설치류 신경세포에 미치는 영향: 키토산의 효과)

  • Kim, Sun-Young;Lee, Hyun-Gyo
    • Environmental Analysis Health and Toxicology
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    • v.22 no.3
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    • pp.279-285
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    • 2007
  • The present study attempted to analyze the mechanism of PCB-induced neurotoxicity with respect to the PKC signaling. Since the developing neuron is particularly sensitive to PCB-induced neurotoxicity, we isolated cerebellar granule cells derived from 7-day old SD rats and grew cells in culture for additional 7 days to mimic PND-14 conditions. Only non-coplanar PCBs at a high dose showed a significant increase of total PKC activity at $[^3H]PDBu$ binding assay, indicating that non-coplanar PCBs are more neuroactive than coplanar PCBs in neuronal cells. PKC isoforms were immunoblotted with respective monoclonal antibodies. PKC-alpha and-epsilon were activated with non-coplanar PCB exposure. The result suggests that coplanar PCBs have a PKC pathway different from non-coplanar PCBs. Activation of PKC with exposure was dampened with treatment of high molecular weight of chitosan. Chilean (M.W. > 1,000 kDa) inhibited the total activity of PKC induced by the non-coplanar PCBs. Translocation of PKC isoforms was also inhibited by the high molecular weight of chitosan. The study demonstrated that non-coplanar PCBs are more potent neurotoxic congeners than coplanar PCBs and the alteration of PKC activities by PCB exposure can be blocked with the treatment of chitosan. The results suggest a potential use of chitosan as a means of nutritional intervention to prevent the harmful effects of pollutant-derived diseases.

AgI/AgCl/H2WO4 Double Heterojunctions Composites: Preparation and Visible-Light Photocatalytic Performance

  • Liu, Chunping;Lin, Haili;Gao, Shanmin;Yin, Ping;Guo, Lei;Huang, Baibiao;Dai, Ying
    • Bulletin of the Korean Chemical Society
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    • v.35 no.2
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    • pp.441-447
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    • 2014
  • $AgI/AgCl/H_2WO_4$ double heterojunctions photocatalyst was prepared via deposition-precipitation followed by ion exchange method. The structure, crystallinity, morphology, chemical content and other physical-chemical properties of the samples are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray spectra (EDX), UV-vis diffuse reflectance spectroscopy (DRS), and photoluminescence (PL). The photocatalytic activity of the $AgI/AgCl/H_2WO_4$ was evaluated by degrading methyl orange (MO) under visible light irradiation (${\lambda}$ > 400 nm). The double heterojunctions photocatalyst displayed more efficient photocatalytic activity than pure AgI, AgCl, $H_2WO_4$ and AgCl/$H_2WO_4$. Based on the reactive species and energy band structure, the enhanced photocatalytic activity mechanism of $AgI/AgCl/H_2WO_4$ was discussed in detail. The improved photocatalytic performance of $AgI/AgCl/H_2WO_4$ double heterojunctions could be ascribed to the enhanced interfacial charge transfer and the inhibited recombination of electron-hole pairs, which was in close relation with the $AgI/AgCl/H_2WO_4$ heterojunctions formed between AgI, AgCl and $H_2WO_4$.

Theoretical Calculation of Activity Coefficients of Liquid Mixtures (액체혼합물의 활동도계수의 이론적 계산)

  • Moon Dae-Won;Jhon Mu Shik;Lee Taikyue
    • Journal of the Korean Chemical Society
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    • v.21 no.6
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    • pp.395-403
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    • 1977
  • Significant structure theory was applied to some liquid mixture systems ranging from simple monatomic molecule systems to polyatomic molecule systems, and the activity coefficients ${\gamma}$ of the liquid mixture systems were calculated over whole mole fractions using the following thermodynamic relation $RTln_{{\gamma}i} = (\frac{{\partial A}^E}{{\partial N}_i})_{T,V,N_i} $ where $A^E$ represents the excess Helmholtz free energy, and $N_i$ is the number of molecules of component i. The activity coefficients of the solutions such as monatomic molecule systems (Ar-Kr, Kr-Xe) and diatomic molecule systems $(Ar-O_2,\;N_2-CO)$ and $CH_4-Kr$ systems whose components have similar shapes for intermolecular potential curves were calculated successfully only with the ${\delta}E_s$, correction parameter for energy $E_s$, for mixture systems. For other systems such as $Ar-N_2,\;O_2-N_2\;and\;CH_4-C_3H_8$ whose components have dissimilar intermolecular potential curve shapes an additional correction parameters ${\delta}$V and even one more parameter ${\delta}$n were necessary [see Eqs.(10)∼(12)].

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Synthesis of CdS with Graphene by CBD(Chemical Bath Deposition) Method and Its Photocatalytic Activity

  • Pawar, R.C.;Lee, Jin-Yong;Kim, Eun-Jeong;Kim, Hyungsub;Lee, Caroline Sunyong
    • Korean Journal of Materials Research
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    • v.22 no.10
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    • pp.504-507
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    • 2012
  • Synthesis of RGO (reduced graphene oxide)-CdS composite material was performed through CBD (chemical bath deposition) method in which graphene oxide served as the support and Cadmium Sulfate Hydrate as the starting material. Graphene-based semiconductor photocatalysts have attracted extensive attention due to their usefulness for environmental and energy applications. The band gap (2.4 eV) of CdS corresponds well with the spectrum of sunlight because the crystalline phase, size, morphology, specic surface area and defects, etc., of CdS can affect its photocatalytic activity. The specific surface structure (morphology) of the photocatalyst can be effective for the suppression of recombination between photogenerated electrons and holes. Graphene (GN) has unique properties such as a high value of Young's modulus, large theoretical specific surface area, excellent thermal conductivity, high mobility of charge carriers, and good optical transmittance. These excellent properties make GN an ideal building block in nanocomposites. It can act as an excellent electron-acceptor/transport material. Therefore, the morphology, structural characterization and crystal structure were observed using various analytical tools, such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy. From this analysis, it is shown that CdS particles were well dispersed uniformly in the RGO sheet. Furthermore, the photocatalytic property of the resulting RGO-CdS composite is also discussed in relation to environmental applications such as the photocatalytic degradation of pollutants. It was found that the prepared RGO-CdS nanocomposites exhibited enhanced photocatalytic activity as compared with that of CdS nanoparticles. Therefore, better efficiency of photodegradation was found for water purification applications using RGO-CdS composite.

Effect of Balance Training on Ankle Muscle Activity and Static Balance in Stroke Patients (균형훈련이 뇌졸중환자의 발목 근육 활성도와 정적균형에 미치는 영향)

  • Lee, Young-Min;Kim, Sang-Chul;Yoon, Sung-Kyeung
    • PNF and Movement
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    • v.12 no.4
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    • pp.209-215
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    • 2014
  • Purpose: This study aims to understand the effect of balance training on ankle muscle activity and static balance in stroke patients. Methods: The subjects were composed of 12 patients who were admitted with chronic stroke in H, K, and R hospitals located in Gangwon-do from August to October 2014. This study conducted balance training on the subjects for 20 min a session, twice a day, five times a week for six weeks. This study measured the surface electromyogram (EMG) of the paretic side's tibialis anterior and medial gastrocnemius for muscle activity. Static balance was measured as a TETRAX stability index. The measurements were conducted before the experiment and six weeks after. The result was statistically analyzed using paired t-test at the significance level of 0.05. Result: Muscle activity of the paretic side's tibialis anterior and medial gastrocnemius did not show a significant difference in the comparison between pre- and post-balancing training. However, the stability index showed a significant difference (p<0.05) between standing with eyes open (NO) and standing on a sponge with eyes open (PO). Conclusion: Although balance training did not affect the muscle activity of chronic stroke patients, it had an effective influence on the stability index. That is, balance training was effective at the functional level, but it did not change the structure level in terms of the ICF evaluation standard. Balance training becomes more effective when it is applied in relation to task.

Herbicidal activity and molecular design of benzotriazole derivatives (Benzotriazole계 유도체의 제초활성과 분자 설계)

  • Sung, Nack-Do;Park, Hyeon-Joo;Park, Seung-Heui;Pyon, Jong-Yeong
    • Applied Biological Chemistry
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    • v.34 no.3
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    • pp.287-294
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    • 1991
  • The relationships between the quantitative structure of benzotriazoles and their post-emergence growth inhibiting activity$(pI_{50})$ against Oryzae sativa L. and Echinochloa crus-galli were investigated using a generalized quantitative structure activity relationships (QSAR). According to the QSAR analysis, the free radical parameter $(E_R)$ is a very important factor and the growth inhibiting activity values showed parabolic relation to $E_R$ parameter of para-substituents(X). The activity of (3) was superior to those of (4) and (3b) is selected as the most highly effective compound. The optimal values of $E_R$ parameter of the growth inhibiting activity aganist E.crus-galli are $E_R(3)=0.52\;and\;E_R(4)=0.15$, respectively. From the result of molecular design, the substituents(X) of electron withdrawing properties and $E_R$ parameter of optimal value(0.52) were most desirable for high activity of the benzotriazoles. And in view of this, benzotriazoles may also be effective in blocking the photosynthetic electron transfer.

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The structure of consciousness of board system collegian who attended in fisheries and maritime college (수, 해운 승선계열 대학생의 의식 구조)

  • Lee, Kil-Rae;Bae, Seok-Je;Hong, Sung-Kun
    • Journal of Fisheries and Marine Sciences Education
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    • v.6 no.2
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    • pp.143-160
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    • 1994
  • I have investigated questionaire concerning to the view of worth and construction of consciousness as to boarding system collegian who will employed in fisheries and maritime industries. The results were as follows; It appeared 38.9% that most collegian had a firm subjectivity about enrolled motive, selection of department, they had selected department according to the neighborhood recommendation, own squired score rather than the adaption and prospection, also it was appeared 55% that they had not satisfied with attending to their college, accordingly, the effectiveness of education were demolished in such aspects. It was appeared 74.3% that the education of fisheries and maritime college were divided into theory and practice pertinently also, 77.1% that modulate both technical education and human like education but as a general rule, the education of ocean going liscensed officer was appeared 7.1% only so that, the reformation of the curriculum and contents of education would be needed. As to the relation between professors and collegian, it was appeared 38.4% that well understanding professor, 18.1% that well teaching professor, 13.3% that they having humanlish relation with professor, 30.6% that they will benefit to vocational selection. consequently, the professor have to brings up the harmony on dint of education and industries. The things which collegian think to be worth were 43.6%, intercourse of friend 30.3%, circle activity. 6.6% listening lecture, also, the leisure activity after school were 74.7% with friends. 16.4% alone. consequently, the professor has to guide of leisure activity after lesson. most collegian has a good relationship with their parent(91.6%) but the respond with bad relationship was 8.4%. The most serious agony which collegian think about is vocational problems (48.9%), the other sex problem(22.5%). The objects consult with agony was aquaintance(54.9%). The parent(5.1%), professors(2.3%), the collegian who did not consult with agony was 20.9%. The parents and the professor is not object consult with their agony. so that, the professors has to strengthen the education according to the human nature. As to job after graduation of such college, collegian who wish to be taken job on the fisheries and maritime industry were 50.5%, on the contrary, the collegian who wish to be taken a job no relation with his major subjects was 29.1% especially, the collegian who want to be embarked was 26.3% (fisheries 23.3%, maritime 30.5%). so that, we must adopt the counter plan for the globalization and effective investment on the fisheries and maritime college.

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