• Macromolecular Research
• /
• v.13 no.3
• /
• pp.167-175
• /
• 2005

This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of l-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The SOC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.

• Polymer(Korea)
• /
• v.24 no.6
• /
• pp.737-743
• /
• 2000

Polyquinonediimines (PQDI) which have stable structure on heat and contains mono-azobenzene in the side chain were synthesized by means of condensation polymerization under TiCl$_4$. The synthesized monomers and polymers were identified by FT-IR, $^1$H-NMR, and elementary analysis. Especially, PQDI was comfirmed by the double-bonding peak of >C=N appeared near 1625 $cm^{-1}$ / by means of FT-IR spectrum. PQDI containing mono-azobenzene group in both side chains wat not soluble in non-polar solvents at all but partially soluble in the polar solvents having small dielectric constant, and dissolved in the strong acid such as sulfuric acid and $CH_3$SO$_3$H. Molecular weight distribution of PQDI measured by GPC showed 1.74. It was confirmed through X-ray diffraction analysis that the polymer was partially crystalline at the low angle region, but amorphous after heat treatment at 1$25^{\circ}C$. The glass transition temperature (T$_{g}$ ) of synthesized polymer was measured as 1$25^{\circ}C$ by differential scanning calorimetry. The SHG value for $\chi$$^{(2)}$ after poling at 1$25^{\circ}C$ was 8.6 pm/V (λ=1.542 ${\mu}{\textrm}{m}$). The SHG value slowly decreased with time from the start but appeared temporal stability after 100 hours.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.8
• /
• pp.456-464
• /
• 2016

Increasing the strength of structural materials allows their self-weight to be reduced and this, in turn, enables the structures to satisfy esthetic requirements. The yield strength of high-performance steel is almost 480 MPa, which is approximately 50% higher than that of general structural steel. The use of high strength materials, however, makes the sections more slender, which can potentially result in significant local stability problems. The strength of slender element sections might be governed by their elastic buckling behavior, and the elastic buckling strength is very sensitive to the boundary conditions. Because the web provides the boundary conditions of the compressive thin-flange, the stiffness of the web can affect the elastic buckling strength of the flange. In this study, therefore, the effects of the flange and web slenderness ratios on the elastic flange local buckling of I-girders subjected to a pure bending moment were evaluated by finite element analysis (FEA). The analysis results show that the elastic local buckling strength and buckling modes were affected not only by the web support conditions, but also by the flange and web slenderness ratios.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.11
• /
• pp.5879-5884
• /
• 2013

With the rapid industrialization and economical development, the electricity demands of the industrial facilities and densely populated large cities are continuing to increase in Korea. The increase in the power consumption requires the extension of power facilities, but it is difficult to secure spaces for equipment installation in the limited space of urban areas. In addition, the 154 kV or 345 kV transmission systems in Korea has a short transmission distance, and are connected to one another in network structures that ensure the high reliability and stability of power supply. This structure reduces the impedance during the fault in power system, and increases the magnitude of in the short circuit fault current. The superconducting fault current limiter (SFCL) was devised to effectively address these existing problems. The SFCL is a new-concept eco-friendly protective device that ensures fast operation and recovery time for the fault current and does not need additional fault detection devices. Therefore, many studies are being conducted around the world. In this paper, based on the wiring method the initial fault current characteristics, current limiting characteristics, according to the incident angle and the change in inductance current limiting characteristics were analyzed in a multifaceted methods.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.12
• /
• pp.247-253
• /
• 2019

3D printing technology has attracted considerable attention because of its potential to fabricate the intricate design of ceramic products. In this study, ceramic 3D nozzle printing was introduced to manufacture complex alumina products with a ceramic pigment. The alumina paste was formulated by incorporating an elastomer to impart viscoelastic properties. Viscoelastic pastes play an essential role in ceramic 3D nozzle printing. The effects of the viscoelastic properties of the ceramic pastes on their printability were assessed using comprehensive rheological analysis, and various shapes were printed. As a result, the paste with a high yield stress showed better printability. In addition, a ceramic pigment was added to the developed pastes to increase the aesthetics of the printed ceramic structure. The printed ceramic parts were sintered in air at 1300 ℃. The stability of the ceramic pigment was confirmed even after high-temperature sintering.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.9
• /
• pp.333-340
• /
• 2018

Recently, free-form buildings have been designed with complex shapes due to digitization of the construction industry. Exterior and interior components of free-form buildings have free cross sections and curved shapes. Therefore, structural members with curvature are frequently seen. In the modeling and stability evaluation of these structures, commercial programs using classical finite element analysis are not able to perform rapid shape modeling, resulting in a decrease in productivity. Therefore, in this study, pre- and post-processing modules were developed using a prior study to rapidly model the surface of a free-form building and to automatically generate frame structures that make up the cladding. The developed modules use a subdivision algorithm with spline curves. This algorithm is used to automatically generate analytical elements from the configuration information of NURBS curves. In addition, the deformation after analysis can be viewed more realistically. The modules can quickly construct complex curved surfaces. An analysis model of the frame structure was also automatically generated. Therefore, the modules could contribute to the productivity improvement of free-form building design.

• Journal of Korean Society of Forest Science
• /
• v.80 no.3
• /
• pp.265-278
• /
• 1991

The purpose of this study is to suggest objective basic data for the design and management of the national park roadside slopes through the quantitative analysis of the visual quality included in the physical environment of the Chi-ri national park, for this, visual volumes of physical elements have been evaluated by using the mesh analysis, spatial images structure of physical elements have been analyzed by factor analysis algorithm, and degree of visual quality have been measured mainly by questionnaires. Result of this thesis can be summarized as fallows. Visual volumes of the naked, rock, ground cover of seed spray, and artificial planting are found to be the main factor determining the visual quality. Factors covering the spatial image of the national park roadside slopes landscape have been found to be the overall synthetic evaluation, spatial, appeal, physical, openness and dignity factors such as the overall the spatial, physical and openness yield high factor scores. As for the factors determining the degree of visual quality of the roadside slopes, variables such as the summit, the constructions management, harmony of landscape, visual stability of roadside slopes, suitable artificial planting and suitable constructions.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.27 no.5
• /
• pp.315-323
• /
• 2015

Damage level of coastal structures has been scaled up according to increase of wave height and duration of the storm due to the abnormal global climate change. So, the design criteria for new breakwaters is being intensified and structural strengthening is also conducted for the existing breakwaters. Recently, interlocking concept has been much attention to enhance the structural stability of the conventional caisson structure designed individually to resist waves. The interlocking caisson breakwater may be survival even if unusual high wave occurs because the maximum wave force may be reduced by phase lags among the wave forces acting on each caisson. In this study, the dispersion characteristics of wave forces using interlocking system that connect the upper part of caisson with cable in the normal direction of breakwater was investigated. A simplified linear model was developed for computational efficiency, in which the foundation and connection cables were modelled as linear springs, and caisson structures were assumed to be rigid. From numerical experiments, it can be found that the higher wave forces are transmitted through the cable as the angle of incident wave is larger, and the larger the stiffness of the interlocking cable makes larger wave dispersion effect.

• Journal of Korean Society of Environmental Engineers
• /
• v.38 no.4
• /
• pp.177-183
• /
• 2016

Sewage treatment using microorganisms is affected by multiple factors such as microbial properties, characteristics of sewage and operating conditions, and nanoparticles inflow may cause negative effects on sewage treatment system especially on the system stability and efficiency. It was studied to assess the toxic effects of nanoparticles on microorganism growth. The activated sludge in the sewage treatment plant of university was cultured in the optimized medium for each strain. Bacillus (gram-positive), Pseudomonas and E.coli (gram-negative) in the activated sludge were selected as target microorganisms, and ZnO and $TiO_2$ were chosen as nanoparticles. For same concentration of nanoparticles, average growth inhibition rate of Bacillus was 60% or more, while that of Pseudomonas was less than 10%. The toxicity of nanoparticles was shown to be higher for gram-positive bacteria than gram-negative bacteria because of their differences on structure of cell wall, components of cell wall protein, physiology of cells and metabolism. ZnO affected 3 times more negative on the growth of microorganisms as compared to $TiO_2$. It was assumed that, therefore, toxicity of ZnO was found to be greater than $TiO_2$.

• Journal of Animal Science and Technology
• /
• v.58 no.4
• /
• pp.14.1-14.9
• /
• 2016

Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candidate genes in a mixed sample panel composed of several cattle breeds with different meat quality, validate single nucleotide polymorphisms (SNPs) in a local crossbred population (Angus - Hereford - Limousin) and evaluate their effects on meat quality traits (backfat thickness, intramuscular fat content and fatty acid composition), supporting the association tests with bioinformatic predictive studies. Results: Globally, nine SNPs were detected in the PPARG and CEBPA genes within our mixed panel, including a novel SNP in the latter. Three of these nine, along with seven other SNPs selected from the Single Nucleotide Polymorphism database (SNPdb), including SNPs in the RXRA gene, were validated in the crossbred population (N = 260). After validation, five of these SNPs were evaluated for genotype effects on fatty acid content and composition. Significant effects were observed on backfat thickness and different fatty acid contents (P < 0.05). Some of these SNPs caused slight differences in mRNA structure stability and/or putative binding sites for proteins. Conclusions: PPARG and CEBPA showed low to moderate variability in our sample panel. Variations in these genes, along with RXRA, may explain part of the genetic variation in fat content and composition. Our results may contribute to knowledge about genetic variation in meat quality traits in cattle and should be evaluated in larger independent populations.