• Journal of the Korean Magnetic Resonance Society
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• v.23 no.1
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• pp.26-32
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• 2019

${\alpha}B$-crystallin (${\alpha}BC$) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. ${\alpha}BC$ assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of ${\alpha}BC$ has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of ${\alpha}BC$ poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of ${\alpha}BCs$ and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of ${\alpha}BCs$, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various ${\alpha}BC$ oligomers, their quaternary dynamics, and structural heterogeneity.

• Structural Engineering and Mechanics
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• v.14 no.5
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• pp.543-563
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• 2002

The use of the epoxy pressure injection technique to rehabilitate reinforced concrete beam-column joints damaged by strong earthquakes is investigated experimentally and analytically. Two one-half-scale exterior beam-column joint specimens were exposed to reverse cyclic loading similar to that generated from strong earthquake ground motion, resulting in damage. Both specimens were typical of new structures and incorporated full seismic details in current building codes. Thus the first specimen was designed according to Eurocode 2 and Eurocode 8 and the second specimen was designed according to ACI-318 (1995) and ACI-ASCE Committee 352 (1985). The specimens were then repaired with an epoxy pressure injection technique. The repaired specimens were subjected to the same displacement history as that imposed on the original specimens. The results indicate that the epoxy pressure injection technique was effective in restoring the strength, stiffness and energy dissipation capacity of specimens representing a modem design.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2008.04a
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• pp.429-434
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• 2008

The objective of this paper is to introduce a project on developing Finish Drawing Automation System. The system aims to improve efficiency of the BIM-based estimation, which is realized by automatic derivation of three-dimensional geometry models of the finish details. First, overall workload differences between the drawing-based estimation methods and the BIM-based methods are analyzed. Second, an automated finish detail design method is proposed as a time-saving measure for the BIM-based estimation, as manual modeling accounts for the most time spent in the model-based estimation process. Finally, the proposed system is evaluated using a case of washboard design.

• Applied Microscopy
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• v.47 no.3
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• pp.160-164
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• 2017

Electron crystallography has been used as the one of powerful tool for studying the structure of biological macromolecules at high resolution which is sufficient to provide details of intramolecular and intermolecular interactions at near-atomic level. Previously it commonly uses two-dimensional crystals that are periodic arrangement of biological molecules, however recent studies reported a novel technical approach to electron crystallography of three-dimensional crystals, called micro electron-diffraction (MicroED) which involves placing the irregular and small sized protein crystals in a transmission electron microscope to determine the atomic structure. In here, we review the advances in electron crystallography techniques with several recent studies. Furthermore, we discuss the future direction of this structural approach.

• Proceedings of the KSR Conference
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• 2003.10b
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• pp.516-521
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• 2003

The presentation and development of LRT(light rail transit) is one of the effective solution to reduce the heavy traffic problems of urban area The metropolitan cities and operation companies of urban transit railway are driving to. construct the LRT system because of the advantage of construction cost and environmental serviceability. Up to now, the design criteria of structures for LRT is not established. Therefore, this paper presents the structural design criteria for LRT with rubber wheels. The proposed code provides a means of establishing minimum standards for acceptance of design and construction of LRT. In order to improve the proposed design criteria, some details will be tested and evaluated in test line.

• Journal of the Korean Society for Railway
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• v.10 no.2 s.39
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• pp.217-223
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• 2007

The purpose of this article is to depict the relationship between the frames of leadership and the dependent variables such as job satisfaction, respect from subordinates, promotion, and effective attainment of unit objectives. To attain this purpose, four types of multiple leadership frame, such as structural, human resources, political, and symbolic frames were surveyed through questionnaire and analyzed by SPSS. The major findings are : 1) In general, the symbolic frame is an important factor having a stronger influence on job satisfaction, respect from subordinates, promotion, and effective attainment of unit objectives. 2) In details, the human resources frame shows a positive effects on job satisfaction and respect; the structural frame on effective attainment of unit objectives; the political frame, to a certain degree, on promotion; and the symbolic frame, especially on respect from subordinates, promotion, and effective attainment of unit objectives.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1999.04a
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• pp.343-350
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• 1999

Orthotropic steel bridge decks are potentially liable to cause fatigue cracks due to weld defects, residual stresses, and in-plane or out-of-plane stresses. In particular, the cracks propagated through deckplate in longitudinal rib to deckplate joints occur at weld toe and weld root due to stress concentrations. Numerical parametric studies are performed to show the Influence of the parameters on the stress concentration at the connection between the longitudinal rib and the deckplate. The parameters include root gap, toe angle $\theta$, toe radius $\rho$, and weld penetration. This study provides a fundamental point for the improvement of fatigue resistance and the estimation of the fatigue crack propagation in wekded joint details.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.10a
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• pp.421-428
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• 2004

Various type of welded joints of the ship structure have been examined numerically and experimentally under bending and tensional cyclic constant-amplitude loading. Cyclic loading on structures can produce failures not readily predicted by conventional static analysis. The aim of a benchmark study is achieved with a generalization of the reference stress concept. Also different methods and procedures exist for the computation of the welded structure hot-spot stress a welded joints. These are either based on the extrapolation of stresses at certain reference points on the plate surface (or edge) close to the weld toe-as known from experimental investigations- or on the linearization of stresses in the through-thickness direction. In the present paper, the different methods are reviewed and applied to four different details in order to compare the methods with each other and to illustrate the differences.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05a
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• pp.106-109
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• 2006

It has been shown that many reinforced concrete(RC) structures designed without seismic details have experienced brittle shear failures in the beam-column joint area and may result in large permanent deformations and structural collapse. In this study, experimental investigations for RC beam-column joints strengthened with the carbon fiber-reinforced polymer(CFRP) under cyclic loadings were presented. The use of CFRP in the joint was varied to determine the effective way of improving the structural performances of RC joints. Ten RC beam-column joints were designed and tested with cyclic loadings. The experimental results showed that the use of CFRP in RC joints would be very effective solutions to improve the seismic performances of the non-seismic RC joints. All of the non-seismic design specimens strengthened with CFRP sheets showed the significant increase of strength and ductility.

• Structural Engineering and Mechanics
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• v.22 no.6
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• pp.685-700
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• 2006

The effective length factor is a familiar concept for practicing engineers and has long been an approach for column stability evaluations. Neglecting the effects of axial force in the restraining members, in the case of sway prevented frames, is one of the simplifying assumptions which the Alignment Charts, the conventional nomographs for K-Factor determination, are based on. A survey on the problem reveals that the K-Factor of the columns may be significantly affected when the differences in axial forces are taken into account. In this paper a new iterative approach, with high convergence rate, based on the general principles of structural mechanics is developed and the patterns for detection of the critical member are presented and discussed in details. Such facilities are not available in the previously presented methods. A constructive methodology is outlined and the usefulness of the proposed algorithm is illustrated by numerical examples.