• Molecules and Cells
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• v.42 no.6
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• pp.441-447
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• 2019

RAS gene mutations are frequently found in one third of human cancers. Affecting approximately 1 in 1,000 newborns, germline and somatic gain-of-function mutations in the components of RAS/mitogen-activated protein kinase (RAS/MAPK) pathway has been shown to cause developmental disorders, known as RASopathies. Since RAS-MAPK pathway plays essential roles in proliferation, differentiation and migration involving developmental processes, individuals with RASopathies show abnormalities in various organ systems including central nervous system. The frequently seen neurological defects are developmental delay, macrocephaly, seizures, neurocognitive deficits, and structural malformations. Some of the defects stemmed from dysregulation of molecular and cellular processes affecting early neurodevelopmental processes. In this review, we will discuss the implications of RAS-MAPK pathway components in neurodevelopmental processes and pathogenesis of RASopathies.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2023.11a
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• pp.97-98
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• 2023

Recently, the use of digital technology in architectural technology is gradually increasing with the development of various industrial technologies. There are artificial intelligence and drones in the field of architecture, and among them, deep learning technology has been introduced to conduct research in areas such as precise inspection of buildings, and it is expressed in a highly reliable way. When a building is deteriorated, various defects such as cracks in the surface and subsidence of the structure may occur. Since these cracks can represent serious structural damage in the future, the detection of cracks was conducted using artificial intelligence that can detect and identify surface defects by detecting cracks and aging of buildings.

• Composites Research
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• v.28 no.4
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• pp.148-154
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• 2015

In order to detect damage in early stages and properly maintaining structures, the structural health monitoring technology is employed. In most cases, active-sensing SHM needs many piezoelectric (PZT) sensors and actuators. Thus, if there is a defect on PZT used for active-sensing SHM, the structural status could be misclassified. This study, for reliable SHM performance, investigated to detect defects of sensors by using the admittance-based sensor diagnostics. This study also introduced an algorithm that can diagnose sensor defects based only on data measured from the sensors in case that information about the changes in adhesive and environmental investigation, this study confirms that the proposed algorithm could be efficiently applied to real-world structures in which a significant temperature variation could take place.

• The Journal of the Acoustical Society of Korea
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• v.28 no.4
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• pp.308-317
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• 2009

In the present work, a sensor system composed of an oscillator sensor and a Lamb wave sensor is proposed for the purpose of structural health monitoring. The oscillator sensing system detecting the shift of a structural resonant frequency in proportion to the amount of defects in the structure is a pretty sensitive and simple device, but its detectable range is limited to its local zone. The Lamb wave sensor system, however, is applicable to global detection of the defects. This study is aimed at investigating the feasible combination of the two systems to exploits their merits simultaneously. The scheme to use PZT patches as the oscillator sensor as well as the Lamb wave sensor was proposed to identify the position, length and number of cracks by means of TOF and amplitude of signals, and its validity was confirmed through experiments.

• Journal of Welding and Joining
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• v.35 no.1
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• pp.55-60
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• 2017

There are many Industry Code and Standard (ICS) for Structural Integrity Assessment (SIA) on welded structure with defect. The general ICSs, such as R6, BS 7910 and API 579-1/ASME FFS-1, provide equations to determine the upper bound residual stress profiles based on collections from many literatures. However, these residual stress profiles used in the SIA cause the conservative design for welded structures. In this study, the structural integrity assessment for girth weld in pipeline has been conducted based on fracture mechanics. In addition, thermo-elastic plastic FE analysis was performed for evaluating the residual stress of girth weld in pipeline. The weight function solution is used to determine the stress intensity factor using the residual stress profile obtained by the FE analysis. This approach can account for redistribution and relaxation of residual stress as the defects grow. In order to the evaluate quantitative comparison between BS 7910 and weight function solution, structural integrity assessment determining allowable crack size on cracked pipe was performed with failure assessment diagram.

• Structural Engineering and Mechanics
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• v.31 no.4
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• pp.439-451
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• 2009

The paper deals with the problem related to the modelling of riveted assemblies for crashworthiness analysis of full-scale complete aircraft structures. Comparisons between experiments and standard FE computations on high-energy accidental situations onto aluminium riveted panels show that macroscopic plastic strains are not sufficiently localised in the FE shells connected to rivet elements. The main reason is related to the structural embrittlement caused by holes, which are currently not modelled. Consequently, standard displacement FE models do not succeed in initialising and propagating the rupture in sheet metal plates and along rivet rows as observed in the experiments. However, the literature survey show that it is possible to formulate super-elements featuring defects that both give accurate singular strain fields and are compatible with standard displacement finite elements. These super-elements can be related to the displacement model of the hybrid-Trefftz principle of the finite element method, which is a kind of domain decomposition method. A feature of hybrid-Trefftz finite elements is that they are mainly used for elastic computations. It is thus proposed to investigate the possibility of formulating a hybrid displacement finite element, including the effects of a hole, dedicated to crashworthiness analysis of full-scale aeronautic structures.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.2
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• pp.45-50
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• 2021

In the recent fourth industrial revolution, the demand for additive processes has emerged rapidly in many mechanical industries, including the aircraft and automobile industries. Additive processes, in contrast to subtractive processes, can be used to produce complex-shaped products, such as three-dimensional cooling systems and aircraft parts that are difficult to produce using conventional production technologies. However, the limitations of additive processes include nonuniform surface quality, which necessitates the use of post-processing techniques such as subtractive methods and grinding. This has led to the need for hybrid machines that combine additive and subtractive processes. A hybrid machine uses additional additive and subtractive modules, so product deformation, for instance, deflection, is likely to occur. Therefore, structural analysis and design optimization of hybrid machines are essential because these defects cause multiple problems, such as reduced workpiece precision during processing. In this study, structural analysis was conducted before the development of an additive/subtractive hybrid processing machine. In addition, structural optimization was performed to improve the stability of the hybrid machine.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.652-662
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• 2010

The purpose of this experiment was to study the effects of demineralized bone matrix (DBM), calcium sulfate (CS), and calcium metaphosphate (CMP) on osteogenesis of unicortical 5-mm-diameter defects in canine femurs. Seventy-two femoral unicortical defects of nine adult beagles (eighteen femurs, four unicortical femoral defects were made in each femur) were made. Three bone graft substitutive materials such as CS, DBM, and CMP and the empty controls were compared each other. The postimplanted specimens were harvested at week 4, 8, and 24 for radiographic, biochemical and histomorphologic evaluation. In radiograph, CS group appeared to be absorbed rapidly and made new cortical bone. Defects of cortical bone was gradually filled with new bone around bone graft materials in DBM group. Bone graft substitutes weren't absorbed rapidly but, remained performing structural roles in cortical bone after 24 weeks in CMP group. Radiographic intensity of control group showed significantly (p < 0.05) lower compared to that of experimental group. Defects treated with either CS, DBM or CMP had more bone formation than the untreated defects (p < 0.05). The results of analysis in the cortical bone region were deduced the conclusions as follows. Three bone graft materials seemed to accelerate the formation of new bone compared with controls for 24 weeks. CMP group having more or less large particle space was more adequate than DBM group, as well as more compact CS group was more pertinent than CMP group as the glues for bones.

• Korean Journal of Environment and Ecology
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• v.36 no.5
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• pp.535-549
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• 2022

Damage to forests, such as broken or falling trees, has increased due to the increased intensity and frequency of abnormal climate events, such as strong winds and heavy rains. However, it is difficult to respond to them in advance based on prediction since structural defects such as cavities and bumps inside trees are difficult to identify with a visual inspection. Non-invasive sonic tomography (SoT) is a method of estimating internal defects while minimizing physical damage to trees. Although SoT is effective in diagnosing internal defects, its accuracy varies depending on the species. Therefore, it is necessary to analyze the reliability of its measurement results before applying it in the field. In this study, we measured internal defects in wood by cross-applying destructive resistance micro drilling on old Pinus densifloraSiebold & Zucc. and Ginkgo bilobaL., which are representative tree species in Korea, to verify the reliability of SoT and compared the evaluation results. The t-test for the mean values of the defect measurement between the two groups showed no statistically significant difference in pine trees and some difference in ginkgo trees. Linear regression analysis results showed a positive correlation with an increase in defects in SoT images when the defects in the drill resistance graph increased in both species.

• Journal of Welding and Joining
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• v.13 no.2
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• pp.42-52
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• 1995

In the evaluation of aging degradation on the structural materials based on the fracture mechanics, the detection and size prediction of defect are very important. Aiming at nondestructive detection and size prediction ol defect with high accuracy and resolution, therefore, an lnduced Current Focusing Potential Drop(ICFPD) technique has been developed. The principle of this technique is to induce a focusing current at an exploratory region by an induction wire flowing an alternating current(AC) that is a constant ampere and frequency. Defects are assessed with the potential drops that are measured the induced current on the surface of metallic material by the potential pick-up pins. In this study, the lCFPD technique was applied for evaluating the location and size of the surface crack and blind crack made in plate specimens, and also for detecting the defects existing in valve, a field component, that were developed by SCC etc. during the service. The results of this present study show that surface crack and blind crack are able to defect with potential drop. these cracks are distinguished with the distribution of potential drop, and the crack depths can be estimated with each normalized potential drop that are parameters estimating the depth of each type crack. In the field component, the defects estimated by experiment result correspond with those in the cutting face of the measuring point within a higher sensitivity.