• 동아시아경상학회지
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• 제1권1호
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• pp.8-16
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• 2013

Purpose: The objective of this paper is to identify and assess the contribution of budgetary, monetary and institutional shocks affecting the Tunisian economy over the period 1976-2003. The methodology used is vector autoregressive models and structural recent techniques for the analysis of time series related. The empirical results show a significant relationship between the supply shock and institutions on the one hand, and between institutional shocks and economic activity on the other hand. Research Design, Data and Methodology: As part of this section we will try to identify and assess the contribution of various shocks to macroeconomic variables' fluctuations for the Tunisian economy. The study period is: 1976-2003 and observations are annual. Results: The real business cycle theory argues that fluctuations in aggregate economic activity are the result of the interaction of the only real factors namely agents' preferences, technological opportunities, factor endowments and possibly certain institutional constraints. Conclusions: The lowest contribution to the variability of these rights is the monetary shock. As for "civil liberties", the largest share of their variability is the shock relating to the "political rights" during the first four periods .

• Biomolecules & Therapeutics
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• 제17권4호
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• pp.418-421
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• 2009

Structural alterations of wogonin were conducted to observe the role of each functional group at the A-ring of wogonin on the inhibitory activities against COX-2 catalyzed $PGE_2$ production from LPS-induced RAW 264.7 cells. Serial deletion of the functional groups at the A-ring of wogonin exhibited low to comparable bioactivity. The present study validated that all the functional groups at the A-ring of wogonin are important factors to exhibit the optimum inhibitory activities.

• 농업과학연구
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• 제35권1호
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• pp.33-40
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• 2008

The structural characteristics that influence on the fungicidal activities of N-phenylbenzenesulfonamide (1~24) and N-phenyltheinylsulfonamide (25~30) derivatives against Dampping-off (Pythium ultimum) were discussed quantitatively using the models of molecular holographic quantitative structure-activity relationships (HQSAR). From the based on these findings, the statistical results of the optimized HQSAR F-3 model showed better predictablity ($r^2_{cv.}$ or $q^2=0.581$) and correlation coefficient ($r^2_{ncv.}=0.963$). And, from the analytical results of the atomic contribution maps on the fungicidal activities, the most active compound is $R_1=2-fluoro-4-chloro$ substituent (4) and the most inactive one is $R_1=4-methoxy$ substituent (20). It was found that the 2-fluoro-4-chlorophenyl group as a $R_1$-group was an important structure and a characteristic factor not only for herbicidal activity but also for fungicidal activity.

• Bulletin of the Korean Chemical Society
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• 제30권11호
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• pp.2749-2753
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• 2009

Structural characteristics that influence on the insecticidal activity ($pI_{50}$) of 2-(n-octyl)isothiourea analogues (1-45) against the diamondback moth (Plutella xylostella, L.) based on three dimensional quantitative structure activity relationships (3D-QSARs) were discussed quantitatively using a comparative molecular field analysis (CoMFA) and a comparative molecular similarity indeces analysis (CoMSIA) methods. The statistical values of the CoMFA 2 model were better than those of the CoMSIA 1 model. The CoMFA 2 model was the optimized model with the correlativity (the training set: Ave. = 0.104 & PRESS = 0.613) and the predictability (the test set: Ave. = 0.086 & PRESS = 0.096). Insecticidal activities with the optimized CoMFA 2 model were dependent upon steric factors (79.4%) of $R_1-R_3$ substituents. From the analytical results of CoMFA contour maps, it is predicted that the R1 substituent of 1-45 which has a steric favor in a broad space, $R_2\;and\;R_3$ groups with a steric favor in a narrow space and a H-bond donor favor would have better the insecticidal activity.

• 대한교통학회지
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• 제21권4호
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• pp.145-154
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• 2003

본 연구에서는 활동기반모형의 방법론중, 최근 많이 이루어지고 있는 구조방정식(SEM:Structural Equation Model)과 다수준 모형(Multi-Level Model)을 동시에 구축하여 개인의 활동참여와 통행행태의 가구 구성원간 영향력을 설명하였다. 모형의 실효성을 검증하기 위하여 미국 Puget Sound 지역에서 1989년부터 수행된 928 가구의 1,621명의 교통통행조사자료를 분석에 사용하였다. 분석 결과, 개인의 활동참여와 통행행태의 가구간 유사성이 0.13에서 0.33의 값으로 예측되어 가구 구성원간에 강한 상호작용을 하는 것으로 나타났다. 또한, 유사성의 범위는 0에서 1의 범위를 가지나 0.05와 0.20의 값을 가져도 다수준 모형을 이용한 분석이 타당하다고 판단하기 때문에 본 연구에서 제시한 다수준 다변량 구조방정식을 이용한 개인의 활동참여와 통행행태 설명이 타당한 것으로 분석되었다.

• Food Science and Biotechnology
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• 제17권3호
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• pp.501-507
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• 2008

The quantitative structure-activity relationships (QSAR) study of antioxidative anthocyanidins and their glycosides were evaluated using 4 different assays of Trolox equivalent antioxidant capacity (TEAC), superoxide radical ($O_2^{{\cdot}-}$), hydrogen peroxide ($H_2O_2$), and peroxynitrite radical ($ONOO^-$) scavenging with TSAR software. Four models were developed with significant predictive values ($r^2$ and p value), which indicated that the antioxidant activities were mainly governed by the 3-dimensional structural energy (torsional energy), constitutional properties (the number of hydroxyl and methyl groups), and electrostatic properties (heat of formation, and dipole, quadrupole, and octupole components). This QSAR approach could contribute to a better understanding of structural properties of anthocyanidins and their glycosides that are responsible for their antioxidant activities. It might also be useful in predicting the antioxidant activities of other anthocyanins.

• BMB Reports
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• 제33권1호
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• pp.82-88
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• 2000

A homologous gene to alanine racemase was cloned from a hyperthermophilic bacterium, Aquifex pyrophilus. The cloned gene encodes a protein of 341 amino acids, which has a significant homology to alanine racemase of Bacillus stearothermophilus, Lactobacillus brevis, and E. coli. When the gene was expressed in Escherichia coli, it produced a 40 kDa protein. The purified protein contains one mole pyridoxal 5-phosphate per one mole of protein, which is essential for catalytic activity of alanine racemase. The purified protein catalyzed racemization of L-alanine to D-alanine, or vice versa, indicating that the cloned gene encoded alanine racemase. It also showed significant racemization activity against L-serine and ${\alpha}-aminobutylic$ acid. The A. pyrophilus alanine racemase showed strong thermostability, and it maintained catalytic activity in the presence of organic solvents.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.233.1-233.1
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• 2003

Interleukin (IL)-5 appears to be one of the main proinflammatory mediators among a growing number of cytokines and chemokines that induce eosinophilic inflammation. Sophoricoside and their analogs isolated from Sophora japonica show relatively potent inhibitory activity of interleukin (IL)-5 as a small molecule. Initial attempt to identify the structural requirement of this isoflavonone led to find new chalcones to exhibit the inhibitory activity of IL -5. (omitted)

• 한국자기공명학회논문지
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• 제23권1호
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• pp.26-32
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• 2019

${\alpha}B$-crystallin (${\alpha}BC$) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. ${\alpha}BC$ assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of ${\alpha}BC$ has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of ${\alpha}BC$ poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of ${\alpha}BCs$ and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of ${\alpha}BCs$, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various ${\alpha}BC$ oligomers, their quaternary dynamics, and structural heterogeneity.

• 한국항만경제학회지
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• 제19권2호
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• pp.55-67
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• 2003

The purpose of this study is to estimate and forecast the marine trading volumes based on the structural model. We employ GPH cointegration test since the structural model must be stationary to get the accurate predicted values. The empirical results show that our model is stationary. This paper also applies variance decompositions and impulse-response functions to the structural model composed of exchange rate, domestic industrial activity, and world business. The results indicate that while both loading and unloading volumes respond positively to the shocks in income and then decay very slowly, their responses are different to the shocks in exchange tate.