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http://dx.doi.org/10.4062/biomolther.2009.17.4.418

Structural Alterations of Wogonin Significantly Reduce the Inhibitory Activity against COX-2 Catalyzed PGE2 Production from LPS-Induced RAW 264.7 Cells  

Gurung, Santosh Kumar (College of Pharmacy, Kangwon National University)
Lim, Hyun (College of Pharmacy, Kangwon National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Park, Hae-Il (College of Pharmacy, Kangwon National University)
Publication Information
Biomolecules & Therapeutics / v.17, no.4, 2009 , pp. 418-421 More about this Journal
Abstract
Structural alterations of wogonin were conducted to observe the role of each functional group at the A-ring of wogonin on the inhibitory activities against COX-2 catalyzed $PGE_2$ production from LPS-induced RAW 264.7 cells. Serial deletion of the functional groups at the A-ring of wogonin exhibited low to comparable bioactivity. The present study validated that all the functional groups at the A-ring of wogonin are important factors to exhibit the optimum inhibitory activities.
Keywords
Structural alterations; Wogonin; $PGE_2$ production; COX-2; Anti-inflammatory activity;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 2
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