• Journal of the Korean Society for Aviation and Aeronautics
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• v.20 no.1
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• pp.13-18
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• 2012

'Navigable airspace' means an airspace at and above the minimum safe flight level, including airspace or flight procedures needed for safe takeoff and landing. Airspace may be established as needed and may be abolished, and in some cases may be limited to airspace management. These are absolutely based on risk assessment. Safety is the state in which the risk of harm to persons or of property damage is reduced to, and maintained at or below, an acceptable level through a continuing process of hazard identification and risk management. 'Risk' is the assessed potential for adverse consequences resulting from a hazard and 'Risk assessment' involves consideration of both the frequency and the severity of any adverse consequence. This paper proposed 'risk assessment procedure' for the structural changes of Navigable Airspaces through literature reviews relevant to manuals on airspace management and risk management.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1995.10a
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• pp.87-94
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• 1995

In highway bridges robust damage detection exercises are mandatory to secure the safety of the structures from hostile environmental conditions such as fatigue earthquake, wind, and corrosion. This paper presents a damage detection practice in a full-scale highway bridge by utilizing modal response parameters of as-built and damaged states of the structure. first the test structure is described and modal testing procedures are outlined. Next, a damage detection model which yields information on the location of damage directly from changes in mode shapes is outlined. Finally, the damage detection model is implemented to predict the location of damage in the ten structure. From the results, it was found that the damage detection model accurately locates damage in the test structures for which modal parameters of only a single mode are available for pre-damage (as-built) and post-damage stages.

• Bulletin of the Korean Chemical Society
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• v.18 no.9
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• pp.981-985
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• 1997

13C, 15N, and 29Si NMR chemical shifts have been computed for selected X-substituted silatranes (X=Cl, F, H, CH3) using Gauge-Including Atomic Orbitals (GIAO) at the Hartree-Fock level of theory. The isotropic 13C chemical shifts are largely insensitive to substituent-induced structural changes. In this study, the isotropic 13C chemical shifts between 1-methyl- and 1-hydrogensilatranes by GIAO-SCF calculation at the HF/6-31G level are very similar. But the results of 1-chloro- and 1-fluorosilatranes are about 4 ppm different from the experimental values. In contrast, the isotropic 15N and 29Si chemical shifts and the chemical shielding tensors are quite sensitive to substituent-induced structural changes. These trends are consistent with those of the experiment. The isotropic 15N chemical shift demonstrates a very clear correlation with Si-N distance. But in case of 29Si the correlations are not as clean as for the 15N chemical shift; the calculated variation in the 29Si chemical shift is much larger.

• Journal of architectural history
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• v.28 no.2
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• pp.31-40
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• 2019

Considering the situation in the early 20th century when the existing urban system centered on urban areas began to change, the biggest factors causing urban structural changes in urban areas are construction of railroad and urban dismantling. The change process of Eupseong, in the microscopic viewpoint, can be understood as a process of change in the course of dismantlement of town's demarcation, improvement of accessibility and urban expansion due to the construction of railroads, process of urban expansion following the crumbling boundaries and structural changes. This study aimed to look at the transformation process of the Eupseong in the early 20th century, focusing on the demolition of the castle and the railway construction from a microscopic point of view of city.

• Applied Chemistry for Engineering
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• v.33 no.4
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• pp.425-430
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• 2022

L-alanine (LA, as an amino acid residue) pentamer model was used to investigate changes in the dihedral angle, intramolecular hydrogen bonding and formation energies during structural optimization. LA pentamers having four conformation types [𝛽: 𝜑/𝜓=t-/t+, 𝛼: 𝜑/𝜓=g-/g-, PP_II: 𝜑/𝜓=g-/t+ and P-like: 𝜑/𝜓= g-/g+] were carried out by quantum chemical calculations (QCC) [B3LYP/6-31G(d,p)]. In LA, 𝛽, 𝛼, and P-like types did not change by optimization, having an intra-molecular hydrogen bond: NH⋯OC (H-bond), and PP_II types in the absence of H-bond were transformed into P-like at the designated 𝜓 of 140°, and to 𝛽 at that of 160° or 175°. P-like and 𝛼 were about 0.5 kcal/mol/mu more stable than 𝛽. In order to understand the processes of the transformations, the changes of 𝜑/𝜓, distances of NH-OC (d_NH/CO) and formation energies (𝜟E, kcal/mol/mu) were examined.

• Molecules and Cells
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• v.45 no.1
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• pp.16-25
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• 2022

Mechanical forces play pivotal roles in regulating cell shape, function, and fate. Key players that govern the mechanobiological interplay are the mechanosensitive proteins found on cell membranes and in cytoskeleton. Their unique nanomechanics can be interrogated using single-molecule tweezers, which can apply controlled forces to the proteins and simultaneously measure the ensuing structural changes. Breakthroughs in high-resolution tweezers have enabled the routine monitoring of nanometer-scale, millisecond dynamics as a function of force. Undoubtedly, the advancement of structural biology will be further fueled by integrating static atomic-resolution structures and their dynamic changes and interactions observed with the force application techniques. In this minireview, we will introduce the general principles of single-molecule tweezers and their recent applications to the studies of force-bearing proteins, including the synaptic proteins that need to be categorized as mechanosensitive in a broad sense. We anticipate that the impact of nano-precision approaches in mechanobiology research will continue to grow in the future.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.2
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• pp.69-75
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• 2022

Chronic pain is induced by tissue or nerve damage and is accompanied by pain hypersensitivity (i.e., allodynia and hyperalgesia). Previous studies using in vivo two-photon microscopy have shown functional and structural changes in the primary somatosensory (S1) cortex at the cellular and synaptic levels in inflammatory and neuropathic chronic pain. Furthermore, alterations in local cortical circuits were revealed during the development of chronic pain. In this review, we summarize recent findings regarding functional and structural plastic changes of the S1 cortex and alteration of the S1 inhibitory network in chronic pain. Finally, we discuss potential neuromodulators driving modified cortical circuits and suggest further studies to understand the cortical mechanisms that induce pain hypersensitivity.

• Journal of the Korean Magnetic Resonance Society
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• v.28 no.3
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• pp.10-14
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• 2024

Caveolin3, mainly expressed in muscle tissue types, is a structural scaffolding protein of caveolae which are microdomains of plasma membrane. To elucidate the relationship between structure and function, several studies on the structure of caveolins using NMR have been reported. Because the ionic strength can affect the electrostatic-driven association of proteins with ligand and protein structure, the effect of salt in the structural studies has to be considered. In this work, we observed that the chemical shifts of Cav3 in the LPPG detergent change depending on salt concentration. The R2 values also show salt concentration-dependent changes. Specifically, in the N-terminal region where conformational changes and various interactions occur, the R2 values decrease. Interestingly, the R2 values of residues expected to be located in the LPPG detergent are also influenced by the salt concentration. This work suggests that the concentration of NaCl can affect interpretation of NMR data from membrane proteins.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.3
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• pp.218-224
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• 2011

A modal method is presented for the investigation of the effects of measurement errors in damage detection for dynamic structural systems. The structural modifications to the baseline system result in the response changes of the perturbed structure, which are measured to determine a unique system in the inverse problem of damage detection. If the numerical modal data are exact, mathematical programming techniques can be applied to obtain the accurate structural changes. In practice, however, the associated measurement errors are unavoidable, to some extent, and cause significant deviations from the correct perturbed system because of the intrinsic instability of eigenvalue problem. Hence, a self-equilibrating inverse system is allowed to drift in the close neighborhood of the measured data. A numerical example shows that iterative procedures can be used to search for the damaged structural elements. A small set of selected degrees of freedom is employed for practical applicability and computational efficiency.

• Structural Engineering and Mechanics
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• v.39 no.1
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• pp.1-20
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• 2011

This study investigates the feasibility of detecting structural damage using the HHT method. A damage detection index, the ratio of bandwidth (RB) is proposed. This index is highly correlated or approximately equal to the change of equivalent damping ratio for an intact structure incurring damage from strong ground motions. Based on an analysis of shaking table test data from benchmark models subjected to adjusted Kobe and El Centro earthquakes, the damage detection index is evaluated using the Hilbert-Huang Transform (HHT) and the Fast Fourier Transform (FFT) methods, respectively. Results indicate that, when the response of the structure is in the elastic region, the RB value only slightly changes in both the HHT and the FFT spectra. Additionally, RB values estimated from the HHT spectra vs. the PGA values change incrementally when the structure response is nonlinear i.e., member yielding occurs, but not in the RB curve from the FFT spectra. Moreover, the RB value of the top floor changes more than those from the other floors. Furthermore, structural damage is detected only when using the acceleration response data from the top floor. Therefore, the ratio of bandwidth RB estimated from the smoothed HHT spectra is an effective and sensitive damage index for detecting structural damage. Results of this study also demonstrate that the HHT is a powerful method in analyzing the nonlinear responses of steel structures to strong ground motions.