• 한국임상약학회지
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• 제6권2호
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• pp.7-13
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• 1996

The purposes of this study were to define the pharmacokinetic parameters of vancomycin in Korean neonates, to evaluate current neonatal vancomycin dosing guideline being used in a teaching hospital, and to develop the optimal vancomycin dosing guideline. The evaluation of 35 sets of peak and trough concentrations drawn on current dosing regimen showed that $29\%$ of peak concentrations and $46\%$ of though concentrations were within therapeutic range. Otherwise, pharmacokinetic parameters, based on 62 sets of peak and trough serum concentrations obtained from 39 neonates, showed that mean vancomycin clearance (CL), volume of distribution (Vd), and terminal elimination half-life were $0.13\pm0.08\;L/hr,\;0.94\pm0.48\;L,\;and\;5.6\pm2.13$ hours, respectively. Volume of distribution (Vd) normalized for body weight remained constant throughout PCA range, whereas the absolute CL (r=0.74) and normalized CL (r=0.36) showed high correlation with PCA. Also, the normalized CL showed a strong inverse correlation (r=-0.55) with serum creatinine concentrations (SrCr). Based on the high correlation among PCA serum creatinine concentration, CL, and the daily dosage requirements, the following dosing guideline for vancomycin in neonates was suggested: 10 mg/kg $12{\sim}18$ hourly for < 30 weeks PCA and < 0.6 mg/dl SrCr; 10 mg/kg 18 hourly for < 30 weeks PCA and $0.6{\sim}1.2$ mg/dl SrCr; 10 mg/kg 8 hourly for $30\sim44$ weeks PCA and < 0.6 mg/dl SrCr; 10 mg/kg 12 hourly for $30\sim44$ weeks PCA and $0.6{\sim}1.2$ mg/dl SrCr.

• 한국실내디자인학회논문집
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• 제22권1호
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• pp.3-10
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• 2013

This study, with a space of cafeteria for the object, selected adjective and space for space evaluation based on existing dissertations and experts' survey so as to analyze the perception features by adjective into perception types. At space evaluation, the purpose of visiting the cafeteria was setup for test. Analysis of what perceptual information on the space was acquired enables to set up any features at a space and the direction of designing. The approach through the evaluation of space perception assigning this kind of observing intentionality can be applied to emotion technique which connects a designer to customers. From this study, the following conclusion has been reached. Frist, the difference at perception type by gender is formality, which is higher with women than men. When it is considered that other types are identical, it can be seen that the formality is the perception type to decide the selection of gender and has the highest average value among all the three types. On the whole, men have the tendency for regarding spaciality as the most important, while women have that for looking upon formality as such. Second, to the question what element they would see first when visiting for conversation, men and women answered respectively that they would see partition (35.6%) and chairs (38.0%). Men had a very strong propensity for the element of area section(partition) supporting the activity of purpose and women regarded the element of behavior support(chair) carrying out the activity of purpose as important. Third, the analysis of deviance shown at the formality of perception type showed that men had dispersive selection at the process of selecting all adjectives and their features at the process of space perception were higher than spaciality and fancine.

• 한국의류학회지
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• 제34권5호
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• pp.844-855
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• 2010

An important issue for the improvement of product quality is to identify and understand the customer-required attributes of a product. This paper identifies and analyzes customer-required attributes of formal knitwear for middle age and elderly women through the use of the Kano model in order to develop competitive products. Various research methods were used in this study. Customer voices for formal knitwear were collected by means of brainstorming and in-depth interviews. The collected customer voices were transformed into customer-required attributes with the use of an affinity diagram. In addition, the data was collected by means of a questionnaire and was statistically analyzed to examine the dimensions of customer-required attributes on the basis of the Kano model. The results are as follows. Five categories of customer-required attributes were identified (symbolism, aesthetic, fitness, usefulness, and maintenance). The analysis based on the Kano model identifies a strong one-dimensional quality in all of the categories of customer-required attributes and the attractive quality that includes a one-dimensional quality in the categories of fitness and usefulness. The findings of this study demonstrate the applicability of the affinity diagram for apparel that educates formal knitwear developers of the customer-required attributes that they should strategically focus on in order to develop competitive products.

• 대한지역사회영양학회지
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• 제7권1호
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• pp.102-110
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• 2002

Cigarette smoking has long been recognized as a major risk factor in the development of coronary heart disease. Several investigators have reported the strong association between smoking and high serum cholesterol, triglyceride concentration, SFA and low HDL cholesterol, PUFA and $\omega$6 concentrations. Therefore, this study was done to investigate the effect of smoking on the serum lipid profile and fatty acid composition of college women. Sixty-one non-smokers and twenty-seven smokers were selected from college women students in the Seoul area. Their lipid intake, serum lipid concentration and fatty acid composition were examined. There were no differences in the general characteristics and anthropometric indices between the smokers and non-smokers. However, alcohol consumption was significantly higher in smokers than non-smokers (p<0.001). The daily caloric intake of smokers and non-smokers were 1875.84 kcal and 1915.53 kacl, respectively. On the other hand, the mean daily intake of lipids and cholesterol were significantly lower in smokers (p<0.05). In smokers, the mean concentrations of serum total cholesterol, LDL-cholesterol and the LDL-C/HDL-C ratio were higher, and the compositions of EPA and DHA were lowe than in non-smokers. There was a negative correlation between the serum triglyceride and PUFA levels in the two groups. Also, serum HDL-C correlated negatively with MUFA in smokers and non-smokers (p<0.01). These results suggest that smoking cause inadequate changes in serum lipid profile and serum fatty acid composition, thereby increasing the tendency for coronary heart disease.

• 근관절건강학회지
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• 제14권2호
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• pp.181-187
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• 2007

Purpose: The purpose of the study was to identify the relationship between obesity and bone mineral density in middle aged women. Methods: A cross-sectional survey design was utilized with a check list and physiological measurements. A total of 827 convenient samples were recruited from women who lived in the community. Bone mineral density was measured by T-score using the pixi method of Lumar on the left heel. Descriptive statistics and pearson correlation coefficient were utilized for data analysis. Results: Most were assessed as having normal weight(37.9%) or obese (57.4%) by BMI. Only 32% was assessed as having normal bone mineral density, while 40.3% had osteopenia, and 27.7% as osteoporosis. The BMI scores were significantly related to age, and episodes of fractures. Those with lower bone mineral density reported significantly more episodes of fractures and chronic disease. The T scores of Bone mineral density were significantly correlated with the scores of BMI (r= .126, p< .001). Conclusion: There is a strong need to develop intervention programs for this age group to manage bone mineral density loss to prevent occurrences of osteoporosis, and episodes of fracture.

• Nutrition Research and Practice
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• 제11권4호
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• pp.300-306
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• 2017

BACKGROUND/OBJECTIVES: The doubly labeled water (DLW) method is considered the gold standard for the measurement of total energy expenditure (TEE), which serves to estimate energy requirements. This study evaluated the accuracy of predictive dietary reference intake (DRI) equations for determining the estimated energy requirements (EER) of Korean adults by using the DLW as a reference method. SUBJECTS/METHODS: Seventy-one participants (35 men and 36 women) aged between 20 and 49 years were included in the study. The subjects' EER, calculated by using the DRI equation ($EER_{DRI}$), was compared with their TEE measured by the DLW method ($TEE_{DLW}$). RESULTS: The DRI equations for EER underestimated TEE by -36.3 kcal/day (-1.3%) in men and -104.5 kcal/day (-4.9%) in women. The percentages of accurate predictions among subjects were 77.1% in men and 62.9% in women. There was a strong linear correlation between $EER_{DRI}$ and $TEE_{DLW}$ (r = 0.783, P < 0.001 in men and r = 0.810, P < 0.001 in women). CONCLUSIONS: The present study supports the use of DRI prediction equations to determine EER in Korean adults. More studies are needed to confirm our results and to assess the validity of these equations in other population groups, including children, adolescents, and older adults.

• 기본간호학회지
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• 제13권2호
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• pp.242-248
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• 2006

Purpose: The purpose of this study was to identify the effects of a BeHaS exercise program on pain, health status, body weight in middle-aged women who have osteoarthritis in their knees. Method: The participants in this study were eighteen women whose mean age was 56.22years and who had osteoarthritis in the knees. The BeHaS exercise program consists of approximately one and half hour of exercise, two days per week, for twelve weeks. Data were gathered from September 2005 to December 2005 using a questionnaire and measuring VAS for pain, KWOMAC for health status, body weight for scale. Data were analyzed with the SPSS Win 11.0 using frequency and paired t-test for differences between pre-exercise and post-exercise. Results: The results of this study are as follows: Scores for pain on post test were statistically lower than pre test(t=4.202, p=0.001), health status was statistically improved after exercise program (t=3.479, p=0.002). But body weight did not change(t=-.774, p=0.222). Conclusion: From these results, it is concluded that the BeHaS exercise program can be effective in decreasing pain and increasing health status in middle-aged women with knee osteoarthritis.

• Journal of Applied Biological Chemistry
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• 제65권4호
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• pp.299-306
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• 2022

In this study, derivatives of trimethoxybenzene were investigated as inhibitors of melanogenesis. We examined the effects of methyl 3,4,5-trimethoxybenzoate (MTB), ethyl 3,4,5-trimethoxybenzoate (ETB), methyl 3,4,5-trimethoxycinnamate (MTC), and ethyl 3,4,5-trimethoxycinnamate (ETC). First, the inhibitory effects of these agents on melanin production were evaluated using α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. We found that all derivatives decreased α-MSH-induced melanin production in B16F10 melanoma cells; ETC showed a strong inhibitory effect at half of the concentration of the other derivatives. As tyrosinase is considered a key enzyme of melanogenesis, we also examined whether the derivatives inhibited tyrosinase activity. MTC and ETC reduced mushroom tyrosinase activity and expression levels of α-MSH-induced B16F10 cellular tyrosinase protein. Inhibitory effects of all derivatives on α-MSH-induced B16F10 cellular tyrosinase activity were shown in a dose-dependent manner. Additionally, the derivatives were exposed to diphenylpicrylhydrazyl free radical to examine their antioxidant characteristics. All derivatives showed considerable antioxidant activity, which was 2-fold higher than that of arbutin. In conclusion, the trimethoxybenzene derivatives, including MTB, ETB, MTC, and ETC exerted anti-melanogenic and antioxidant effects on α-MSH-stimulated melanogenesis, demonstrating their potential for use as novel hypopigmenting agents and antioxidants.

• 페미니즘연구
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• 제9권1호
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• pp.79-111
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• 2009

이글은 서울대 여성연구소가 학력, 연령, 지역을 고려하여 선정한 38명에 대하여 '모성'을 주제로 시행한 구술생애사 면접조사 자료에서, 모성에 관한 이야기 틈틈이 발견된 아버지에 대한 기억들을 정리한 것이다. 38명의 구술은 아버지의 역할과 관련하여, 첫째, 아버지에 대해 전혀 말하지 않은 사람(5명), 둘째, 아버지에 대해서 간단한 부정적인 언급을 한 경우(5명), 셋째, 아버지가 경제적으로 무능력했지만 훈육과 따뜻한 보살핌을 준 경우(6명), 넷째, 다양한 역할을 수행한 아버지(11명), 그리고 다섯째, 아버지와 매우 친밀하고 아버지 역할이 중요하게 구술된 경우(12명, 그중 1명은 경제적 무능으로 세 번째 범주에도 속하여 겹침)로 유형화된다. 이 연구결과는 보편적 부성의 존재와 함께, 부성없는 부모됨이나 전통적 부성-새로운 부성의 이분법, 그리고 사회변화와 함께 등장한 새로운 부성의 명제가 적어도 한국사회에서는 부정된다는 것을 말해준다. 그것은 양육적 부성의 다층성과도 연관된다. 또한 대체로 따듯하고 양성평등의 가치관을 가진 아버지가 딸의 임파워먼트에 중요한 역할을 한 것을 볼 수 있다.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4671-4677
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• 2023

For the first time Pb, Ni, and Cu nanocomposites were synthesized by versatile solution combustion synthesis using Aloevera extract as a reducing agent, to study the potential applications in X-ray/gamma, neutron, and Bremsstrahlung shielding. The synthesized Lead-Nickel-Copper (LNC) nanocomposites were characterized by PXRD, SEM, UV-VIS, and FTIR for the confirmation of successful synthesis. PXRD analysis confirmed the formation of multiphase LNC NCs and the Scherrer equation and the W-H plot gave the average crystal sizes of 19 nm and 17 nm. Surface morphology using SEM and EDX confirmed the presence of LNC NCs. Strong absorption peaks were analyzed by UV visible spectroscopy and the direct energy gap is found to be 3.083 eV. Functional groups present in the LNC NCs were analyzed by FTIR spectroscopy. X-ray/gamma radiation shielding properties were measured using NaI(Tl) detector coupled with MCA. It is found to be very close to Pb. Neutron shielding parameters were compared with traditional shielding materials and found LNC NCs are better than lead and concrete. Secondary radiation shielding known as Bremsstrahlung shielding characteristics also studied and found that LNC NCs are best in secondary radiation shielding. Hence LNC NCs find shielding applications in ionizing radiation such as X-ray/gamma and neutron radiation.