• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1460-1464
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• 2009

In spite of many studies on statistical model for pattern identifications (PIs), little attention has been paid to the complexity of pattern diagnosis processed by oriental physicians. The aim of this study is to develop a statistical diagnostic model which discriminates four PIs using multiple indicators in stroke. Clinical data were collected from 981 stroke patients and 516 data of which PIs were agreed by two independent physicians were included. Discriminant analysis was carried out using clinical indicators such as symptoms and signs which referred to pattern diagnosis, and applied to validation samples which contained all symptoms and signs manifested. Four Fischer's linear discriminant models were derived and their accuracy and prediction rates were 93.2% and 80.43%, respectively. It is important to consider the pattern diagnosis processed by oriental physicians in developing statistical model for PIs. The discriminant model developed in this study using multiple indicators is valid, and can be used in the clinical fields.

• Korean Circulation Journal
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• v.48 no.12
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• pp.1148-1156
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• 2018

Background and Objectives: It is controversial that decreased left ventricular function could predict poststroke outcomes. The purpose of this study is to elucidate whether left ventricular ejection fraction (LVEF) can predict cardiovascular events and mortality in acute ischemic stroke (AIS) without atrial fibrillation (AF) and coronary heart disease (CHD). Methods: Transthoracic echocardiography was conducted consecutively in patients with AIS or transient ischemic attack at Soonchunhyang University Hospital between January 2008 and July 2016. The clinical data and echocardiographic LVEF of 1,465 patients were reviewed after excluding AF and CHD. Poststroke disability, major adverse cardiac events (MACE; nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death) and all-cause mortality during 1 year after index stroke were prospectively captured. Cox proportional hazards regressions analysis were applied adjusting traditional risk factors and potential determinants. Results: The mean follow-up time was $259.9{\pm}148.8days$ with a total of 29 non-fatal strokes, 3 myocardial infarctions, 33 cardiovascular deaths, and 53 all-cause mortality. The cumulative incidence of MACE and all-cause mortality were significantly higher in the lowest LVEF (<55) group compared with the others (p=0.022 and 0.009). In prediction models, LVEF (per 10%) had hazards ratios of 0.54 (95% confidence interval [CI], 0.36-0.80, p=0.002) for MACE and 0.61 (95% CI, 0.39-0.97, p=0.037) for all-cause mortality. Conclusions: LVEF could be an independent predictor of cardiovascular events and mortality after AIS in the absence of AF and CHD.

• Journal of Korean Neurosurgical Society
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• v.64 no.1
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• pp.110-119
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• 2021

Objective : Preoperative prediction of the arachnoid membrane descent in pituitary surgery is useful for achieving gross total removal and avoiding cerebrospinal fluid leakage resulting from tearing of the arachnoid membrane in the chiasmatic cistern. In this study, we analyzed the patterns of arachnoid membrane descent during or after pituitary tumor surgery and identified the factors related to this descent. Methods : Analysis was restricted to pituitary macroadenomas not extending into the third ventricle or over the internal carotid artery. To minimize confounding factors, patients who underwent revision surgery, those who had a torn arachnoid during operation or small medial diaphragma sellae (DS) opening, and subtotal resections were excluded. We enrolled 41 consecutive patients in this retrospective analysis. The degree of arachnoid descent was categorized using intraoperative videos. Preoperative magnetic resonance findings, including tumor height, suprasellar extension, and variables including DS area and medial opening size, tumor composition, and displacement of the pituitary stalk and gland were evaluated to determine their correlations with arachnoid membrane descent. Results : Arachnoid membrane descent was significantly correlated with DS area and medial opening size. Based on T2-weighted images (T2WI) magnetic resonance (MR) images, tumor composition was significantly associated with arachnoid membrane descent. Other factors were not significantly correlated with arachnoid membrane descent. Conclusion : T2WI of tumor composition and preoperative MR imaging of DS area and medial opening provided valuable information regarding arachnoid membrane descent. These parameters may serve as fundamental measures to facilitate complete resection of pituitary macroadenomas.

• Journal of Advanced Navigation Technology
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• v.25 no.1
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• pp.96-101
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• 2021

This paper presents a machine learning model that predicts stroke risks in atrial fibrillation patients using public big data. As the training data, 68 independent variables including demographic, medical history, health examination were collected from the Korean National Health Insurance Service. To predict stroke incidence in patients with atrial fibrillation, we applied deep neural network. We firstly verify the performance of conventional statistical models (CHADS2, CHA2DS2-VASc). Then we compared proposed model with the statistical models for various hyperparameters. Accuracy and area under the receiver operating characteristic (AUROC) were mainly used as indicators for performance evaluation. As a result, the model using batch normalization showed the highest performance, which recorded better performance than the statistical model.

• Journal of Yeungnam Medical Science
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• v.33 no.1
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• pp.8-12
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• 2016

Background: The decision to administer oral anticoagulation therapy depends on accurate assessment of stroke risk in patients with atrial fibrillation (AF). Various stroke risk stratification schemes have been developed to help inform clinical decision making. The CHADS2 and CHA2DS2-VASc scores have been used in estimating the risk of stroke in patients with AF. Recently R2CHA2DS2-VASc score was developed. The objective of the current study is to validate the usefulness of the R2CHA2DS2-VASc score and to compare the accuracy of the CHADS2, CHA2DS2-VASc, and R2CHA2DS2-VASc scores in predicting a patient's risk of stroke. Methods: Based on medical records, we conducted a retrospective study of patients hospitalized with AF from March 2011 to July 2013. A total of 448 AF patients were included in this study. The receiver operating characteristic (ROC) curve analysis in MedCalc was used for comparison with respective diagnostic values. Results: The patient characteristics showed male predominance (60.9%). Among the 448 AF patients, 131 (29.2%) patients had strokes during the study. A R2CHA2DS2-VASc score of more than 5 is the optimal cut-off value for prediction of stroke. A risk score of three, the area under the ROC curve (AUC) of R2CHA2DS2-VASc score (AUC 0.631; 95% confidence interval, 0.585-0.679) was the highest. A significant difference was observed between AUC for R2CHA2DS2-VASc, CHADS2, and CHA2DS2-VASc scores, but no meaningful difference between CHADS2 and CHA2DS2-VASc scores. Conclusion: We determined the usefulness of the R2CHA2DS2-VASc score, which showed better association with stroke than the CHADS2 and CHA2DS2-VASc scores.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1999.03b
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• pp.203-206
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• 1999

The shift of flow behavior due to dynamic recrystallization during hot forming process is investigated, A series of load relaxation and compression tests has been conducted at various temperatures Constitutive relations and recrystallization behaviors were formulated from the mechanical test results, The consideration of dynamic recrystallization during a specific forming process was implemented to commercial FEM package by conditioned remeshing and remapping of state variables. Improvement of Load-Stroke prediction was validated by comparison with experimental results.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 1996.06a
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• pp.87-95
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• 1996

The stamping process consists of two stages : First, the blank is held by the blank holder and then it is further formed into the die cavity by punch stroke. In actual stamping process, the accurate prediction of binder wrap is an indispensable step in sheet metal forming analysis because the initial plastic buckling induced by improper die design is directly related with fatal defect at the final stage. In the present work, an approach including the gravity effect of blank material and proper consideration of contact and friction is proposed. Computations are carried out for some actual auto-body parts using 3D FEM code to investigate the validity of the proposed methodology. Comparisons with experimental results show that the suggested scheme can be effectively applied to the precise prediction of binder wrap for arbitrarily curved die faces in which gravity and contact effect must be taken into account.

• Transactions of Materials Processing
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• v.26 no.4
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• pp.205-209
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• 2017

In this paper, finite element prediction of deformation of material due to springback after material removal by an axisymmetric forging fabrication at room temperature is conducted. An elastoplastic finite element method is employed considering die plastic deformation. The predictions of a springback analysis conducted after the final stroke of an axisymmetric cold forging process containing residual stresses are utilized to be mapped onto the final material after the material removal. It is assumed that material removal occurs at an instant, i.e., all the material to be removed disappears at once. The predictions are compared with experiments, revealing strong qualitative agreement.

• Transactions of Materials Processing
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• v.9 no.1
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• pp.59-65
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• 2000

Most studies of failure analysis in ductile metals have been based on the classical plasticity theory using the local constitutive relations. These frequently yields a physically unrealistic solution, in which a numerical prediction of the onset of a deformation localization shows an inherent mesh-size sensitivity. A one way to remedy the spurious mesh sensitivity resulted in the unreasonable results is to incorporate the non-local plasticity into the simulation model, which introduce an internal (material) length-scale parameter into the classical constitutive relations. In this paper, a non-local version of the modified Gurson constitutive relation has been introduced into the finite element formulation of the simulation for plane strain compression of the visco elastic-plastic void material. By introducing the non-local constitutive relations we could successfully removed the inherent mesh-size sensitivity for the prediction of the deformation localization. The effects of non-local constitutive relation are discussed in terms of the load-stroke curve and the strain distributions accross the shear band.

• Korean Circulation Journal
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• v.53 no.3
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• pp.170-184
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• 2023

Background and Objectives: Several cases involving severe right ventricular (RV) failure in advanced cancer patients have been found to be pulmonary tumor thrombotic microangiopathies (PTTMs). This study aimed to discover the nature of rapid RV failure syndrome with a suspected diagnosis of PTTM for better diagnosis, treatment, and prognosis prediction in clinical practice. Methods: From 2011 to 2021, all patients with clinically suspected PTTM were derived from the one tertiary cancer hospital with more than 2000 in-hospital bed. Results: A total of 28 cases of clinically suspected PTTM with one biopsy confirmed case were included. The most common cancer types were breast (9/28, 32%) and the most common tissue type was adenocarcinoma (22/26, 85%). The time interval from dyspnea New York Heart Association (NYHA) Grade 2, 3, 4 to death, thrombocytopenia to death, desaturation to death, admission to death, RV failure to death, cardiogenic shock to death were 33.5 days, 14.5 days, 7.4 days, 6.4 days, 6.1 days, 6.0 days, 3.8 days and 1.2 days, respectively. The NYHA Grade 4 to death time was 7 days longer in those who received chemotherapy (7.1 days vs. 13.8 days, p value=0.030). However, anticoagulation, vasopressors or intensive care could not change clinical course. Conclusions: Rapid RV failure syndrome with a suspected diagnosis of PTTM showed a rapid progressive course from symptom onset to death. Although chemotherapy was effective, increased life survival was negligible, and treatments other than chemotherapy did not help to improve the patient's prognosis.