• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.3
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• pp.671-676
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• 2005

In this study, we investigated the antioxidant effect of extract from Monascus pillosus, on the human wild-type p53 and p21 expressing A549 lung epithelial cell line and MCF-7 mammary adenocarcinoma cell line stimulated by NO. $P21^{waf/cip1}$ was identified as a gene induced in senescent cells. It is a cyclin-dependent kinase inhibitor and has been shown to cause cell cycle arrest and apoptosis. While p53-regulated stimulation of p21 appears to be central for the permanent growth-arrest, the role of p21 in p53-triggered cell death is unclear. Low dose of sodium nitroprusside (SNP) induced the development of senescence associated with increased expression of p53 and p21 in A549 cells. Inhibition of p21 transactivating activity requires high level correlates with the amount of p53 necessary to cause cell death. Association of p21 and p53 results in inhibition of p21-stimulated transcription. This requires a higher p53 level than is necessary for transcriptional activation of endogenous p53-responsive gene but correlates well with the level of p53 necessary to cause cell death. Exposure to W-1 inhibited oxidative stresses-induced senescence-like arrest, resulting in a significant reduction in p53 and p21 steady state levels. These results suggest that p53 and p21 play a central role in the onset of senescence. Thus, it is important to emphasize control of oxidative balance in tumor prevention and aging.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.4
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• pp.114-120
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• 2018

Recently, the plate girder bridge is offen designed a temporary bridge for underground roadway construction have not interrupt railroad operation. The integral support plate girder bridge which have longitudinal girder and cross-girder is improved workability and reduction cost and of construction time. The cross beam of the integral support plate girder bridge has a normal box shape to distribute load on the main girde to end both side girder. In this study, On the change to the web distance of the cross box shows characteristics of related to the stresses and displacements on the flange and web plate. Afterward, the various analysis contributed to the safety improvement of crossbeam of the integral support crossbeam plate girder bridge.

• The Journal of the Korea Contents Association
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• v.12 no.7
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• pp.306-313
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• 2012

We have published a paper which is on stress and dietary life for college students considering weight, height, BMI by the sex of them. It was on obesity index, stress durability and stress strength, meal intake by stress, stress reduction and stress relief for the sample students. In this paper, we monitored taste changing of their favorite food under stresses, feeling after food intake for stress relief, score of stress with life style, strength of stress correlated with characteristic and BMI. The students preferred hot and sweet taste on their stress. However there is no difference feeling their stress after taking food for stress relief by ages, major area and monthly expenses. The stress is more severe for them according to do not sleeping and health status. The stress is not affected by exercising, smoking, drinking alcohols, healthcare mind in their life. The impetuous students get more stress easily but the stress is not affected on BMI. As a result, we need to provide them a nutrition education program that guide the students to improve their dietary life style and practice of their life attitude.

• Journal of the Korean GEO-environmental Society
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• v.10 no.6
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• pp.35-48
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• 2009

An excessive ground displacement occurs with excavating tunnel in a fault zone because the fault has properties of soft ground in generally. It may have had a bad influence to adjacent structure. So, rapid reduction of ground strength by groundwater inflow should be prevented. It must be established for an impervious and reinforcing effect of ground to ensure a tunnel stability. The ground settlement and reinforcing effects were estimated by numerical analyses on tunnel through 570 m sector in Yangsan fault zone of Keongbu high-speed railway. Settlements evaluated by numerical analysis is similar to those calculated by using equation of Loganathan & Poulo. It was shown that reliable estimate of ground settlement by applying a prediction equation is possible. Applicability of adopted tunnel reinforcement method in fault zone was investigated by results of pilot construction and numerical analysis. Results from this study indicate that the adopted reinforcement method make tunnel displacements and member stresses restrain in design criteria.

• Earthquakes and Structures
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• v.11 no.1
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• pp.83-107
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• 2016

In this study, the response and behavior of machine foundations resting on dry and saturated sand was investigated experimentally. A physical model was manufactured to simulate steady state harmonic load applied on a footing resting on sandy soil at different operating frequencies. Total of (84) physical models were performed. The parameters that were taken into consideration include loading frequency, size of footing and different soil conditions. The footing parameters are related to the size of the rectangular footing and depth of embedment. Two sizes of rectangular steel model footing were used. The footings were tested by changing all parameters at the surface and at 50 mm depth below model surface. Meanwhile, the investigated parameters of the soil condition include dry and saturated sand for two relative densities; 30 % and 80 %. The dynamic loading was applied at different operating frequencies. The response of the footing was elaborated by measuring the amplitude of displacement using the vibration meter. The response of the soil to dynamic loading includes measuring the stresses inside soil media by using piezoelectric sensors. It was concluded that the final settlement (St) of the foundation increases with increasing the amplitude of dynamic force, operating frequency and degree of saturation. Meanwhile, it decreases with increasing the relative density of sand, modulus of elasticity and embedding inside soils. The maximum displacement amplitude exhibits its maximum value at the resonance frequency, which is found to be about 33.34 to 41.67 Hz. In general, embedment of footing in sandy soils leads to a beneficial reduction in dynamic response (displacement and excess pore water pressure) for all soil types in different percentages accompanied by an increase in soil strength.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.40 no.4
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• pp.230-236
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• 2017

The recent domestic construction market is in a difficult situation due to reduction of the government's SOC budget and new orders from public-sector, and the deterioration of housing supply situation in the private sector etc. In addition, the number of disasters in the construction industry has increased in recent years with 26,570 people (up 5.7% from the previous year) in 2016, unlike other industries that are in a declining trend. As such, the construction industry has unique characteristics and problems such as high industrial accidents rate, abnormal subcontracting structure, excessive working hours and work intensity. As a result, the construction workers have a lot of job stresses. Job stress has been recognized as one of the major causes of industrial accidents and many researches have been conducted on that. However, most of the researches were about the factors that induce job stress and how these factors affect disaster occurrence, job satisfaction, job performance, turnover intentions, and job exhaustion. The purpose of this study is to investigate the effect of positive psychological capital on job stress, which is emerging as a new human resources development paradigm useful in corporate management in order to find ways to reduce job stress. To do this, 347 data collected from construction workers in Daejeon, Sejong, and Chungcheong provinces were analyzed using statistical package(IBM SPSS 22) for basic statistical analysis, reliability analysis, and regression analysis. As a result, positive psychological capital has shown an alleviate effect on job stress. In particular, the higher the optimism, hope, and resiliency of positive psychological capital, the lower the job stress. However, the higher the self - efficacy, the higher the job stress.

• Structural Engineering and Mechanics
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• v.66 no.1
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• pp.85-96
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• 2018

This study investigates the response of functionally graded (FG) gas pipe under unsteady internal pressure and temperature. The pipe is proposed to be manufactured from FGMs rather than custom carbon steel, to reduce the erosion, corrosion, pressure surge and temperature variation effects caused by conveying of gases. The distribution of material graduations are obeying power and sigmoidal functions varying with the pipe thickness. The sigmoidal distribution is proposed for the 1st time in analysis of FG pipe structure. A Two-dimensional (2D) plane strain problem is proposed to model the pipe cross-section. The Fourier law is applied to describe the heat flux and temperature variation through the pipe thickness. The time variation of internal pressure is described by using exponential-harmonic function. The proposed problem is solved numerically by a two-dimensional (2D) plane strain finite element ABAQUS software. Nine-node isoparametric element is selected. The proposed model is verified with published results. The effects of material graduation, material function, temperature and internal pressures on the response of FG gas pipe are investigated. The coupled temperature and displacement FEM solution is used to find a solution for the stress displacement and temperature fields simultaneously because the thermal and mechanical solutions affected greatly by each other. The obtained results present the applicability of alternative FGM materials rather than classical A106Gr.B steel. According to proposed model and numerical results, the FGM pipe is more effective in natural gas application, especially in eliminating the corrosion, erosion and reduction of stresses.

• Journal of Korean Tunnelling and Underground Space Association
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• v.13 no.2
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• pp.115-131
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• 2011

Recently, considering the aspects of disaster prevention and environmental damage, the construction of a twin tunnel is increasing. When constructing a twin tunnel, the stresses are concentrated at the pillar so that stability of the tunnel is decreased. Since the previous studies on the behavior of a twin tunnel pillar are mainly restricted to the estimation of the tunnel behavior and the analysis of surface settlement, there is a limit to a quantitative stability estimation of the pillar. Therefore, it was quantitatively investigated how the pillar width of a twin tunnel affects its stability. To ensure this end, global tunnel safety factors obtained numerically using shear strength reduction technique, local safety factors of a pillar using the equation that Matsuda et al. suggested, and strength/stress ratios of the pillar were estimated and their results were analyzed for two sections with different rock covers. For a reasonable design of a twin tunnel pillar, it was turned out that strength/stress ratio, the local pillar safety factor, and global tunnel safety factor should be used interrelatedly rather than independently.

• Smart Structures and Systems
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• v.26 no.3
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• pp.319-329
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• 2020

Structural damage to an arch dam is often of major concern and must be evaluated for probable rehabilitation to ensure safe, regular, normal operation. This evaluation is crucial to prevent any catastrophic or failure consequences for the life time of the dam. If specific major damage such as a large crack occurs to the dam body, the assessments will be necessary to determine the current level of safety and predict the resistance of the structure to various future loading such as earthquakes, etc. This study investigates the behavior of an arch dam cracked due to water pressure. Safety factors (SFs), of shear and compressive tractions were calculated at the surfaces of the contraction joints and the cracks. The results indicated that for cracking with an extension depth of half the thickness of the dam body, for both cases of penetration and non-penetration of water load into the cracks, SFs only slightly reduces. However, in case of increasing the depth of crack extension into the entire thickness of the dam body, the friction angle of the cracked surface is crucial; however, if it reduces, the normal loading SFs of stresses and joints tractions reduce significantly.

• Archives of Pharmacal Research
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• v.19 no.3
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• pp.178-182
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• 1996

Using superoxide dismutase (SOD)-deficient mutants of Saccharomyces cerevisiae, the oxidative stresses induced by 0.1 mM of copper ion $(Cu^{++})$ was studied. In aerobic culture condition, yeasts lacking MnSOD (mitochondrial SOD) showed more significant growth retardation than CuZnSOD (cytoplasmic SOD)-deficient yeasts. However, not so big differences in growth pattern of those mutants compared withwild type were observed under anaerobic condition. It was found that, under aerobic condition, the supplementation of 0.1 mM copper ioh:(Cu") into culture medium caused the remarkable increase of CuZnSOD but not so significant change in MnSOD. It was also observed that catalase activities appeared to be relatively high in the presence of copper ion in spite of the remarkable reduction of glutathion peroxidase in CuZnSOD-deficient yeasts, but the slight increments of catalase and glutathion peroxidase were detected in MnSOD-deficient strains. It implies that the lack of cytoplasmic SOD could be compensated mainly by catalase. However, these phenomena resulted in the significantincrease of cellular lipid peroxides content in CuZnSOD-deficient yeasts and the slight increment of lipid peroxides in MNSOD-deficient cells. In anaerobic cultivation supplementing copper ion, the cellular enzyme activities of catalase and glutathion peroxidase in SOD-deficient yeasts were slightly increased without any significant changes of lipid peroxides in cell membrane. It suggests that a little amount of free radicals generated by copper ion under anaerobic condition could be sufficiently overcome by catalase as well as glutathion peroxidase.dase.