• 한국직업건강간호학회지
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• 제22권1호
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• pp.47-56
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• 2013

Purpose: This study is to identify the factors that affect middle-aged workers' health promoting behaviors. Methods: 214 middle-aged workers participated in surveys, and the data were collected from August to September 2012 and analyzed by using descriptive statistics, Pearson's correlation coefficient, and multiple regression analysis with PASW 18.0 program. Results: It was found that among the factors, the degree of job stress (t=7.69, p<.001) and depression (t=6.23, p<.001) were significantly high for type D individuals, while non type D showed meaningful degree of self-related health status (t=-3.66, p<.001) and health promoting behaviors (t=-4.71, p<.001). The notable variable that affected the health promoting behaviors of the middle-aged workers was depression for both type D (${\beta}$=-.357, p= .029) and non type D (${\beta}$=-.325, p<.001) individuals, and this variable accounted for 24.1% and 18.2% respectively. Conclusion: The study revealed that the middle-aged workers showed high degree of job stress and depression that influenced on their health promoting behaviors. Thus, they are recommended to receive health management programs that offer treatment through consulting considering their individual personalities.

• 한국보건간호학회지
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• 제26권3호
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• pp.453-464
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• 2012

Purpose: The purpose of this study was to provide the basic data for university students to develop program for achieving successful developmental task. Method: The subjects involved this study were 462 1-4th grade university students located at Kangwon-Do & Chungchung-Do. Data were measured using Global assessment of recent stress scale, CES-D and Self-esteem scale. Data were analyzed using SPSS WIN 17.0 program that included mean, standard deviation, ANOVA, Sheffe test and Pearson correlation coefficients. Results: 1) The mean score of the degree of perceived stress was 4.17(${\pm}1.43$), depression was .92(${\pm}.47$), and self esteem was 2.89(${\pm}.48$). 2) There were significant differences in the degree of stress according to gender(t=2.03, p=.043), level of living(F=3.55, p=.029). Likewise, there were significant differences in the degree of depression according to gender(t=3.35, p=.001), age(t=2.15, p=.032), level of living(F=3.38, p=.035) and in the degree of self-esteem there were significant difference according to gender(t=3.64, p<.001), age(t=2.81, p=.005), participation of regular meeting or not(t=3.14, p=.002), frequency of alcohol drinking(F=5.59, p=.004), onset age of alcohol drinking(t=2.43, p=.016). 4) There was a significant relationship between stress and depression(r=.556, p<.001), self-esteem (r=-.423, p<.001). Also, there was a significant relationship between depression and self esteem(r=-.667, p<.001). Conclusions: Nursing interventions and educational programs which can help the students to accomplish the developmental tasks required.

• 대한한의학방제학회지
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• 제26권4호
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• pp.329-340
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• 2018

Objectives : In Traditional Korean medicine, Daucus carota L. has been used for treating dyspepsia, diarrhea, dysentery and cough. Recent pharmacognosic evidence showed D. carota has anti-oxidant, anti-cancer, anti-fungal, and hypotensive effects. Present study investigated hepato-protective effect of D. carota ethanol extract (DCE) against oxidative stress in HepG2 cells. Methods : After HepG2 cells were pretreated with different concentrations of DCE, the cells were exposed to tert-butyl hydroperoxide (tBHP) for inducing oxidative stress. Cell viability, hydrogen peroxide production, glutathione concentration, and mitochondrial membrane potentials were measured to explore hepato-protective effect of DCE. Phosphorylation of AMP-activated protein kinase (AMPK) and effect of compound C on cell viability were determined to investigate the role of AMPK on DCE-mediated cytoprotection. Results : DCE significantly decreased the tBHP-mediated cytotoxicity in a concentration dependent manner and reduced the changes on apoptosis-related proteins by tBHP in HepG2 cells. In addition, DCE significantly prevented hydrogen peroxide production, glutathione depletion, and mitochondrial membrane impairment induced by tBHP. Treatment with DCE increased phosphorylation of AMPK, and the DCE-mediated cytoprotection was abolished by pretreatment with compound C. Conclusions : These results demonstrate that DCE can protect hepatocytes from oxidative stress through activation of AMPK.

• Journal of health informatics and statistics
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• 제43권4호
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• pp.336-343
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• 2018

Objectives: The purpose of this study was to test and validate a model to predict antenatal depression. Methods: Data were collected from a self-administered questionnaire of 251 pregnant women in D metropolitan city. Exogenous variables were self-esteem, social support, and high risk pregnancy. Endogenous variables consisted of pregnancy stress, pregnancy coping, and antenatal depression. Data were analyzed by SPSS 23.0 and AMOS 21.0. Results: Model fit indices for the hypotheoretical model fitted to the recommended levels. Out of 12 paths, 6 were statistically significant. Variables accounted for 72.6% of antenatal depression. Predictors of antenatal depression were pregnancy stress (t = 7.64), self-esteem (t = -2.03), and social support (t = -2.06). Conclusions: Results indicate that an intervention program which increases self-esteem would be useful for pregnant women to decrease antenatal depression level. Antenatal program are needed to be applied to spouse and family members as well. To decrease pregnancy stress in pregnant women contributes to antenatal depression.

• Journal of Korean Biological Nursing Science
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• 제25권1호
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• pp.73-85
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• 2023

Purpose: This study focused on identifying the interaction effects of genetic and lifestyle-environmental factors on the development of type 2 diabetes mellitus (T2D). Methods: Study subjects were selected from the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2014. Data on genetic variations, anthropometric measurements, biochemical data, and seven lifestyle factors (diet, physical activity, alcohol drinking, smoking, sleep, depression, and stress) were obtained from 4,836 Koreans aged between 40 and 59 years, including those with T2D at baseline (n = 1,209), newly developed T2D (n= 1,298) and verified controls (n = 3,538). The genetic risk score (GRS) was calculated by using 11 single-nucleotide polymorphisms (SNPs) related to T2D development and the second quartile was used as the reference category. A Cox proportional hazards regression model was used to evaluate the associations of GRS and lifestyle factors with T2D risk, controlling for covariates. Results: Multivariate regression analysis revealed that GRS was the strongest risk factor for T2D, and body mass index (BMI), smoking, drinking, and spicy food preference also increased the risk. Lifestyle/environmental factors that showed significant interactions with GRS were BMI, current smoking, current drinking, fatty food preference, and spicy food preference. Conclusions: Interactions between genetic factors and lifestyle/environmental factors were associated with an increased risk of T2D. The results will be useful to provide a new perspective on genetic profiling for the earlier detection of T2D risk and clues for personalized interventions, which might be more effective prevention strategies or therapies in individuals with a genetic predisposition to T2D.

• 한국직업건강간호학회지
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• 제21권2호
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• pp.154-163
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• 2012

Purpose: The purpose of study was to identify the relationships among attitude on job rotation, job stress and organizational commitment of hospital nurses. Methods: The data were collected from the self-reported questionnaire responses of 430 nurses from Sep. 1 to Sep. 30, 2010 at a university hospital in D city and analyzed by descriptive statistics, t-test, ANOVA, Scheff$\acute{e}$ test and Pearson correlation coefficients. Results: Nurses who experienced job rotation showed negative attitude on job rotation (t=-4.84, p<.001), high level of job stress (t=3.81, p<.001) and low level of organizational commitment (t=-1.99, p= .047). There was a significantly negative correlation between nurses' attitude on job rotation and job stress (r=-.13, p<.01). Also, there was a significantly positive correlation between nurses' attitude on job rotation and organizational commitment (r=.32, p<.001). Conclusion: These results suggest that job rotation in nurses needs to be planned based on the individual attitude, opinion, specialty and capability in nurse for reducing their job stress and enhancing organizational commitment of hospital nurses.

• 한국자기학회지
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• 제13권2호
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• pp.76-81
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• 2003

매설된 송유관이나 가스관의 외부면과 내부면에 생성된 원형 결함(double circular pit) 부근에서 누설되는 자속 신호에 미치는 결함깊이와 인장응력(tensile stress)의 영향을 3차원 유한요소법을 이용하여 계산하였다. 배관의 축 및 방사상 방향의 누설자속 (Magnetic Flux Leakage: MFL) 신호는 배관 외$.$내부 면의 이중 결함깊이와 인장응력에 의해 영향을 받으며, 결함의 깊이가 깊어질수록 인장응력이 커질수록 MFL 신호는 증가하였다. 그러나 원주 방향의 MFL 신호는 결함깊이와 인장응력에 거의 영향을 받지 않았다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권11호
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• pp.1462-1468
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• 2010

The effects of vitamin C and vitamin E with selenium on acid-base balance and some stress hormones were evaluated during heat stress in goats. Goats, 1.5 years of age, were divided into control, heat stress and antioxidant treatment groups 1, 2 and 3. Except for the control, all groups were exposed to a temperature of $40{\pm}2^{\circ}C$ with a relative humidity of 30% for 5 h/d for 21 days in a psychrometric chamber. Rectal temperature and respiratory rates were recorded daily post exposure. Blood samples were collected on every 3rd day for estimation of plasma vitamins C and E, total antioxidant activity and hormones, and separate blood samples were taken to estimate acid-base status. The rectal temperature and respiratory rates were increased (p<0.05) in the heat stress group only. Except for pH and $pO_2$, which were increased significantly (p<0.05) other parameters of acid-base balance such as $pCO_2$, $HCO_3^-$, $TCO_2$, BEb, BEcef, PCV and Hb were significantly decreased (p<0.05) in the heat stress group. An improvement in acid-base status was noted in the antioxidant supplemented groups. Prolactin and cortisol levels were significantly (p<0.05) higher and free T3 and T4 levels were significantly (p<0.05) lower in the heat stress group. Levels of prolactin and cortisol were decreased and free T3 and T4 were increased in antioxidant treatment groups. Different levels of antioxidant supplementation resulted in similar protection against heat stress.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3213-3222
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• 2015

Background: Cancer metastasis depends on cell motility which is driven by cycles of actin polymerization and depolymerization. Reactive oxygen species (ROS) and metabolic oxidative stress have long been associated with cancer. ROS play a vital role in regulating actin dynamics that are sensitive to oxidative modification. The current work aimed at studying the effects of sub-lethal metabolic oxidative stress on actin cytoskeleton, focal adhesion and cell migration. Materials and Methods: T47D human breast cancer cells were treated with 2-deoxy-D-glucose (2DG), L-buthionine sulfoximine (BSO), or doxorubicin (DOX), individually or in combination, and changes in intracellular total glutathione and malondialdehyde (MDA) levels were measured. The expression of three major antioxidant enzymes was studied by immunoblotting, and cells were stained with fluorescent-phalloidin to evaluate changes in F-actin organization. In addition, cell adhesion and degradation ability were measured. Cell migration was studied using wound healing and transwell migration assays. Results: Our results show that treating T47D human breast cancer cells with drug combinations (2DG/BSO, 2DG/DOX, or BSO/DOX) decreased intracellular total glutathione and increased oxidized glutathione, lipid peroxidation, and cytotoxicity. In addition, the drug combinations caused a reduction in cell area and mitotic index, prophase arrest and a decreased ability to form invadopodia. The formation of F-actin aggregates was increased in treated T47D cells. Moreover, combination therapy reduced cell adhesion and the rate of cell migration. Conclusions: Our results suggest that exposure of T47D breast cancer cells to combination therapy reduces cell migration via effects on metabolic oxidative stress.

• Steel and Composite Structures
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• 제2권1호
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• pp.35-50
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• 2002

A series of tests on simple-welded plate specimens (SWPS) and T-stub tension specimens simulating some of the joint details in moment frame connections were conducted in this investigation. The effects of weld strength mismatch and weld metal toughness on structural behavior of these specimens were considered under both static and dynamic loading conditions. Finite element analyses were performed by taking into account typical weld residual stress distributions and weld metal strength mismatch conditions to facilitate the interpretation of the test results. The major findings are as follows: (a) Sufficient specimen size requirements are essential in simulating both load transfer and constraint conditions that are relevant to moment frame connections, (b) Weld residual stresses can significantly elevate stress triaxiality in addition to structural constraint effects, both of which can significantly reduce the plastic deformation capacity in moment frame connections, (c) Based on the test results, dynamic loading within a loading rate of 0.02 in/in/sec, as used in this study, premature brittle fractures were not seen, although a significant elevation of the yield strength can be clearly observed. However, brittle fracture features can be clearly identified in T-stub specimens in which severe constraint effects (stress triaxiality) are considered as the primary cause, (d) Based on both the test and FEA results, T-stub specimens provide a reasonable representation of the joint conditions in moment frame connections in simulating both complex load transfer mode and constraint conditions.