• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.12 no.1
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• pp.62-69
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• 2016

Current guidance considers that uniaxially loaded specimen with a deep crack is used for the determination of the ductile-to-brittle transition temperature. However, reactor pressure vessel is under biaxial loading in real and the existence of deep crack is not probable through periodic in-service-inspection. The elastic stress intensity factor and the elastic-plastic J-integral which were used for crack-tip stress field and fracture mechanics assessment parameters. The difference of the loading condition and crack geometry can significantly influence on these parameters. Thus, a constraint effect caused by differences between standard specimens and a real structure can over/underestimate the fracture toughness, and it affects the results of the structural integrity assessment, consequentially. The present paper investigates the constraint effects by evaluating the master curve $T_0$ reference temperature of PCVN (Pre-cracked Charpy V-Notch) and small scale cruciform specimens which was designed to simulate biaxial loading condition with shallow crack through the fracture toughness tests and 3-dimensional elastic-plastic finite element analyses. Based on the finite element analysis results, the fracture toughness values of a small scale cruciform specimen were estimated, and the geometry-dependent factors of the cruciform specimen considered in the present study were determined. Finally, the transferability of the test results of these specimens was discussed.

• Microbiology and Biotechnology Letters
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• v.35 no.4
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• pp.292-297
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• 2007

The unicellular green alga, Haematococcus pluvialis used as a biological production system for astaxanthin. It accumulates large amounts of the red ketocarotenoid astaxanthin when exposed to various environmental stress such as active oxygen species and high light intensities. To induce astaxanthin biosynthesis of H. pluvialis, cells were incubated in either nitrate free at $25^{\circ}C$ under continuous high light intensity ($1,000\;{\mu}mol$ photons $m^{-2}s^{-1}$) for 2 days or high light stress only. Expressions of astaxanthin biosynthetic genes such as carotenoid hydroxylase, IPP isomerase and ${\beta}$-carotene ketolase were monitored under different culture conditions by using real time RT-PCR. All the subjected genes increased their expression under highlight and N-deprivation condition where a large amount of astaxanthin was accumulated.

• IMMUNE NETWORK
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• v.5 no.4
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• pp.232-236
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• 2005

Background: A physically active lifestyle and regular exercise training incurs many health benefits. One recently recognized benefit of regular moderate exercise is stress reduction and immune enhancement. Thus, a physical stress such as exercise may act at any number of points in the complex sequence of events collectively termed the immune response. Although exercise causes many propound changes in parameters of immune function, the nature and magnitude of such changes rely on several factors including the immune parameters of interest; type, intensity, and duration of exercise; fitness level or exercise history of the subject; environmental factors such as ambient temperature and humidity. Methods: This study was undertaken to investigate the effect of different type of exercise on superoxide dismutase (SOD), neutrophils, and T lymphocytes of Sprague-Dawley rats. Sprague-Dawley rats were randomly divided into three groups; a non-Trained group (NTG, n=6), a swim-Trained group (STG), and a treadmill-Trained group (TTG). The exercise regimen was designed in a treadmill (5 times/5 days/week) during 8-weeks for TTG, and swim training (5 times/5 days/week) during 8-weeks for STG, and the volume of exercise training was the same in both groups. Results: 8 weeks of regular swim and treadmill training significantly increased liver SOD concentration however, muscle SOD concentration was not statistically significant. In the level of neutrophils, TTG and STG showed significant difference, compared to NTG. TTG was the highest level of neutrophils. In the level of immune cell counts, there was significant difference among TTG, STG, and NTG both in the spleen and thymus. Conculsion: In conclusion, it can be stated that eight weeks swim and treadmill exercise training has beneficial effect in improving immune response and antioxidant defence capacity by augmenting immune cells and SOD activities of SD rats.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.13 no.1
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• pp.92-99
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• 2014

An aspherical lens, which resolves several problems with a spherical lens,typically serves asa key part of an optical system. Generally, an aspherical lens is fabricated using a diamond turning machine or by mean of injection molding. However, residual stress and/or tool marks can arise when using a commercial fabricating method such as DTM or injection molding. A polishing process, thus, is commonly used to obtain a high-precision aspherical lens. In this study, a polishing method using MR fluid was applied to minimize several problems, in this case residual stress and the creation of tool marks, during the cutting process. The MR polishing system was developed to polish aspherical lenses. A series of experiments were performed to obtain a very fine surface roughness. PMMA (the lens material for molding) was used as a workpiece, and the gap size, magnetic field intensity, wheel speed and feed rate were selected as the parameters in this study. Finally, a very fine surface roughness of Ra=2.12nm was obtained after MR polishing.

• The Journal of Korean Medicine
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• v.39 no.1
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• pp.35-43
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• 2018

Objectives: In the brain, glutamate is the most important excitable neurotransmitter in physiological and pathological conditions. However, the high level of glutamate induces neuronal cell death due to exitotoxicity and oxidative stress. The present study investigated to evaluate a possible neuroprotective effect of furosin isolated from Euphorbia helioscopia against glutamate-induced HT22 cell death. Methods: Furosin was isolated from methanol extract of Euphorbia helioscopia and examined whether it protects glutamate-induced neuronal cell death. The cell viability was determined using Ez-Cytox assay. Anti-oxidative effect of furosin was determined by DPPH scavenging activities, and the levels of intracellular reactive oxygen species (ROS) were determined by the fluorescent intensity after staining the cells with $H_2DCFDA$. To evaluate apoptotic cell death, we performed nuclear staining and image-based cytometeric analysis. Results: The cell viability was significantly increased by treatement with furosin compared with the treatment with glutamate. Furosin showed a strong DPPH radical scavenging activity ($EC50=1.83{\mu}M$) and prevented the accumulation of intra cellular ROS. Finally, the presence of 50 and $100{\mu}M$ furosin significantly the percentage of apoptotic cells compared with glutamate treatment. Conclusion: The present study found that furosin is a potent neuroprotectant against glutamate-induced oxidative stress through inhibition of apoptotic cell death induced by glutamate. Therefore, the present study suggests that furosin as a bioactive compound of E. helioscopia can be a useful source to develop a drug for the treatment of neurodegenerative diseases and acute brain injuries.

• Journal of Mechanical Science and Technology
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• v.19 no.2
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• pp.634-648
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• 2005

Performed here is a comparative assessment study for the probabilistic fracture mechanics approach of the pressurized thermal shock of the reactor pressure vessel. A round robin consisting of one prerequisite deterministic study and five cases for probabilistic approaches is proposed, and all organizations interested are invited. The problems are solved by the participants and their results are compared to issue some recommendation of best practices and to assure an understanding of the key parameters in this type of approach, like transient description and frequency, material properties, defect type and distribution, fracture mechanics methodology etc., which will be useful in the justification through a probabilistic approach for the case of a plant over-passing the screening criteria. Six participants from 3 organizations responded to the problem and their results are compiled and analyzed in this study.

• Journal of Fisheries and Marine Sciences Education
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• v.9 no.2
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• pp.198-208
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• 1997

Recently, with rapid increase of gas demand, there occurs much interest their security of safety in the gas storage tanks and pressure vessels etc. In order to solve the problems, the occurrence of corrosion fatigue crack and the propagation behavior must be investigated. Especially the occurrence of corrosion fatigue crack and the propagation behavior in the part which has concentrated stress or defects, must be studied more carefully. In this paper, the high-tensile steel of SPV 50 which is much used for building the LPG storage tanks was tested by the use of a plane bending corrosion fatigue tester under the various marine environment and in the air. These experiments were carried out to investigate the surface crack propagation behavior, the value of experimental constant for Paris' rule(da/dN=$C(K)^m$), the crack depth propagation rate and the accelerative factor of the surface crack propagation rate. The main results obtained are as follows ; 1) As the specific resistances of marine environment decreases, the exponential value of slope m of Paris' rule(da/dN=$C(K)^m$) decreases and the value of intercept C increases. 2) The surface crack propagation rate and the crack depth propagation rate are delayed, as the specific resistances of marine environment is increased. 3) The accelerative factor of the surface crack propagation rate by corrosion fatigue is higher, according as the stress intensity factor range ${\Delta}K_A$ is small.

• Economic and Environmental Geology
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• v.13 no.1
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• pp.1-19
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• 1980

The local earthquake data, observed by Wiechert seismograph in Korea during Feb. 1926-May 1943, was provided and investigated. Using S-P monogram of JMA, mainly Tsuboi's formula and additional intensity data, the earthquake parameters are obtained as much as possible within a reasonable discrepancy. The seismic characteristics as to the epicenter distribution was discussed under the viewpoint of its relation to the adjacent geologic structure. Some statistical results are analyzed comparing with Kyushu region which provide a reasonable interpretation on the seismicity of Korea. By superposing the available information of the individual events, the general trend of stress field was found to be east-west compression, which mostly agree with that of the southwestern Japan.

• Korean Journal of Environmental Biology
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• v.22 no.1
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• pp.233-241
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• 2004

Chlorophyll fluorescence and antioxidative enzyme activity were investigated from leaves of Crinum asiaticum var. japonicum under the natural condition in winter, in order to monitor plant response and physiological states such as vitality, productivity and so on. In the O-J-I-P transients, the fluorescence intensity of J, I, P-step decreased remarkably depending on temperature drop in winter. The photochemical efficiencies of PSII, Fv/Fm, were significantly low in late winter with decrease of Fm. These results indicate that Crinum plants were affected by seasonal drop of temperature. The catalase activity significantly decreased depending on temperature drop in winter. However, the activity of superoxide dismutase ascorbate peroxidase and peroxidase slightly increased in winter while some isoenzymes appeared in winter. These results, with the remarkable decrease of Ev/Fm in winter, represent that Crinum plants were exposed to oxidative stress and subsequently damaged leading to cell death.

• Journal of the Korean Geotechnical Society
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• v.29 no.1
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• pp.13-22
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• 2013

This paper presents the results of a numerical investigation into the behavior of retaining wall subject to cycles of wetting and drying due to rainfall. The stress-pore pressure coupled finite element modeling strategy was first established for stimulating the wall behavior. A series of finite element analyses were then performed on a range of conditions including different rainfall and backfill conditions. The results indicated that the rainfall intensity was the primary influencing factor for the wall behavior. Also revealed was that the pre-rainfall condition determines the magnitudes and the distribution of matric suction which in fact has a significant impact on the behavior of wall during a major rainfall. This result demonstrates the importance of incorporating the pre-rainfall condition for numerical modeling of walls during heavy rainfall. Practical implications of the findings from this study are discussed in great detail.