• The Korean Journal of Physiology
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• v.7 no.1
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• pp.13-21
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• 1973

An attempt was made to study circulatory and respiratory responses to the passive tilt. Anesthetized dogs were tilted from horizontal to upright $(+90^{\circ})$ and head down $(-90^{\circ})$ position. The arterial blood pressure was decreased in the upright position and was decreased slightly in the head down position comparing to that in the horizontal position. Cardiac index also decreased in the both upright and head down positions. The total systemic vascular resistance was slightly increased in the upright position and was markedly increased in the head down position. The mean pulmonary arterial pressure was significantly decreased in the both upright and head down positions. The total pulmonary vascular resistance was decreased in the both upright and head down positions. Oxygen consumption was slightly decreased in the upright position, whereas it was slightly increased in the head down position. The A-V $O_2$ difference (vol. %) was slightly increased in the upright position and increased in the head down position. From the above results, process of the circulatory compensation to the gravity in the Passive tilting test was discussed. Neuronal cardiovascular regulation to the gravity and tile adaptation of capacitance vessles to hydrostatic stress and oxygen consumption concerning anoxic endurance of the brain were also discussed.

• Journal of Microbiology and Biotechnology
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• v.21 no.3
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• pp.243-251
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• 2011

The gene bolA was discovered in the 80's, but unraveling its function in the cell has proven to be a complex task. The BolA protein has pleiotropic effects over cell physiology, altering growth and morphology, inducing biofilm formation, and regulating the balance of several membrane proteins. Recently, BolA was shown to be a transcription factor by repressing the expression of the mreB gene. The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6 and thereby demonstrating the versatility of BolA as a cellular regulator. In this work, we also demonstrate that reduction of cell growth and survival can be connected to the overexpression of the bolA gene in different E. coli backgrounds, particularly in the exponential growth phase. The most interesting finding is that overproduction of BolA affects bacterial growth differently depending on whether the cells were inoculated directly from a plate culture or from an overnight batch culture. This strengthens the idea that BolA can be engaged in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions.

• Journal of the Korean Home Economics Association
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• v.33 no.3
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• pp.85-99
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• 1995

The major purpose of this research was to investigate the causal relationships among working wives' work-family conflict, socialization of housework, and home management satisfaction. the double ABCX model of family stress and adaptation provided the theoretical framework for this study. the data were recruited from working wives who had more than one pre-school child. The respondents were asked to complete the self-administered questionnaires, and the responses of 536 working wives were used for the final analysis. basically Cronbach's α to the reliability of major variables, frequencies, percentages, means, standard deviation, pearson's correlation coefficients, and LISREL 7 program were performed to test the research model. The results of this study can be summarized as follows : 1. The frequency of work-family conflict was affected by the flexibility of work time and wives' income. 2. The severity of wok-family conflict was directly influenced by the frequency of the conflict, the flexibility of work-time, and wives' education level. 3. The variables influencing the degree of socialization of housework were found to be the frequency and the severity of work-family conflict, wives' education, and the degree of husband's participation in housework. 4. The higher degree of home management satisfaction was associated with the higher level of family member's health status, the greater degree of the flexibility of work-time, and the greater degree of husband's participation in household labor.

• Korean Journal of Occupational Health Nursing
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• v.16 no.2
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• pp.119-129
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• 2007

Purpose: The purposes of this study were to understand the coping experience that family caregivers undergo during the process of care, to grasp coping behaviors used to solve problems and, finally, to develop a substantive theory by analyzing the coping process. Method: The methodology of collecting and analyzing data used in this study followed the ground theory. Data were collected through in-depth interviews with open-ended and descriptive questions about the subjects' coping experiences. The survey was conducted between May 2006 and August. The subjects of this study were 10 women. Result: The result of the study is as follows. Core category of This Study was "Self-Sacrifice". And The coping process of family caregivers while taking care of the industrial disaster victim was found to have five stages: shocked stage; undertaking stage of new role; skilled stage; exhausted stage; and desiderating stage. Seven coping behaviors were found to reduce the stress of role and anguish resulting from care. Conclusion: The result of this study is helpful for developing effective industrial nursing strategies suitable for each coping stage. It is necessary to practice nursing mediation and to analyze the change about nursing effect and family caregivers' adaptation.

• Nuclear Engineering and Technology
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• v.49 no.6
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• pp.1318-1325
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• 2017

Direct Numerical Simulation (DNS) serves as an irreplaceable tool to probe the complexities of multiphase flow and identify turbulent mechanisms that elude conventional experimental measurement techniques. The insights unlocked via its careful analysis can be used to guide the formulation and development of turbulence models used in multiphase computational fluid dynamics simulations of nuclear reactor applications. Here, we perform statistical analyses of DNS bubbly flow data generated by Bolotnov ($Re_{\tau}=400$) and LueTryggvason ($Re_{\tau}=150$), examining single-point statistics of mean and turbulent liquid properties, turbulent kinetic energy budgets, and two-point correlations in space and time. Deformability of the bubble interface is shown to have a dramatic impact on the liquid turbulent stresses and energy budgets. A reduction in temporal and spatial correlations for the streamwise turbulent stress (uu) is also observed at wall-normal distances of $y^+=15$, $y/{\delta}=0.5$, and $y/{\delta}=1.0$. These observations motivate the need for adaptation of length and time scales for bubble-induced turbulence models and serve as guidelines for future analyses of DNS bubbly flow data.

• Plant Biotechnology Reports
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• v.5 no.4
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• pp.309-315
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• 2011

Rice grown in anaerobic waterlogged soil accumulates ammonium as a major source of nitrogen (N). We have compared the physiological symptoms of rice seedlings subjected to N-starvation stress with those receiving sufficient N, based on measurements of shoot/root length and weight and an analysis of protein expression patterns. N starvation marginally increased root growth but notably decreased shoot biomass. N uptake was reduced by >50% in the roots and shoots of N-starved seedlings. To better understand the mechanism of N starvation in rice, we performed a comparative proteome analysis of proteins isolated from rice leaves. Twenty-five differentially expressed proteins were analyzed by matrixassisted laser desorption/ionization time-of-flight (TOF) mass spectrometry and electron spray ionization quadrupole TOF. Functional analysis of the N-starvation response proteins suggested their involvement in protein synthesis and fate, metabolism, and defense. These results indicate that these proteins may play important roles in regulating the plant's complex adaptation responses for N use during N starvation. The proteins may be useful for further characterization of protein function in plant N nutrition.

• Molecules and Cells
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• v.27 no.4
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• pp.493-496
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• 2009

Hypoxia-inducible factor $1{\alpha}$ ($HIF1{\alpha}$) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation (ODD) domain of $HIF1{\alpha}$ responsible for the negative regulation of $HIF1{\alpha}$ in normoxia is intrinsically unfolded. Here, we carried out the backbone $^1H$, $^{15}N$, and $^{13}C$ resonance assignment of a proteolysis-resistant fragment (residues 404-477) in the $HIF1{\alpha}$ ODD domain using NMR spectroscopy. About 98% (344/352) of all the $^1HN$, $^{15}N$, $^{13}C{\alpha}$, $^{13}C{\beta}$, and $^{13}CO$ resonances were unambiguously assigned. The results will be useful for further investigation of the structural and dynamic states of the $HIF1{\alpha}$ ODD domain and its interaction with binding partners.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.25 no.3
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• pp.185-196
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• 2018

Purpose: The purpose of this study was to investigate the alopecia experience in adults and to explain the process of their experiences. Methods: Using a grounded theory methodology, 18 interviews were performed with fourteen men and four women, 34~57 years of age, suffering from alopecia. Data were analyzed using the constant comparative analysis method. Results: The core category emerged as "inescapable fetters". adults with alopecia engaged in three stages: embarrassment, seeking solution, and acceptance phase. Causal conditions were a vicious cycle of stress, biological factors and poor life style. Contextual conditions were recognition of irreversibleness, negative social awareness, and marriage. The central phenomenon of the adaptation process among the adults with alopecia was withdrawn life due to negative body image. Action/Interaction strategies included rely on medical treatment, efforts to take good care of hair, research for information treatment, efforts to cover up hair loss, and mind control. Intervening conditions were time cost, economic cost, support of surrounding people. Consequences was burden of unfinished lifetime homework. Conclusion: When caring for these adults, it is important to identify needs, allow patients to express what they want at that moment and support them in maintaining a daily life.

• Journal of Korean Public Health Nursing
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• v.33 no.2
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• pp.242-257
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• 2019

Purpose: This study examined the life experiences of the wives of men who were born with normal vision but gradually developed a visual impairment, with particular focus on their way of facing and coping with their life crisis. Method: A narrative approach was used to not only understand women's experiences within sociocultural contexts, but also reveal the subjective meaning of their personal life stories through their own voices. A purposive sample of three participants having husbands unexpectedly diagnosed with visual impairment during their marriage was recruited. The data were analyzed using the narrative analysis methods suggested by Clandinin and Connelly. Results: The wives took the crisis of their husbands' visual impairment as an economic crisis of the family. They faced a variety of difficulties, including extreme despair, role changes, and economic burdens. On the other hand, they tried to keep the family secure through a range of coping strategies that were motivated by compassion toward the husbands, maternal affection for the children, and a sense of responsibility for their families. Conclusion: This study revealed the need for financial support for temporarily disadvantaged families. In addition, various nursing and counseling programs for the family members will also be needed to help recover the family functions.

• BMB Reports
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• v.52 no.3
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• pp.163-164
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• 2019

The ribosomal synthesis of proteins in the eukaryotic cytosol has always been thought to start from the unformylated N-terminal (Nt) methionine (Met). In contrast, in virtually all nascent proteins in bacteria and eukaryotic organelles, such as mitochondria and chloroplasts, Nt-formyl-methionine (fMet) is the first building block of ribosomal synthesis. Through extensive approaches, including mass spectrometric analyses of the N-termini of proteins and molecular genetic techniques with an affinity-purified antibody for Nt-formylation, we investigated whether Nt-formylated proteins could also be produced and have their own metabolic fate in the cytosol of a eukaryote, such as yeast Saccharomyces cerevisiae. We discovered that Nt-formylated proteins could be generated in the cytosol by yeast mitochondrial formyltransferase (Fmt1). These Nt-formylated proteins were massively upregulated in the stationary phase or upon starvation for specific amino acids and were crucial for the adaptation to specific stresses. The stress-activated kinase Gcn2 was strictly required for the upregulation of Nt-formylated proteins by regulating the activity of Fmt1 and its retention in the cytosol. We also found that the Nt-fMet residues of Nt-formylated proteins could be distinct N-terminal degradation signals, termed fMet/N-degrons, and that Psh1 E3 ubiquitin ligase mediated the selective destruction of Nt-formylated proteins as the recognition component of a novel eukaryotic fMet/N-end rule pathway, termed fMet/N-recognin.