• Clinical Endoscopy
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• 제57권3호
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• pp.283-292
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• 2024

We developed three e-learning systems for endoscopists to acquire the necessary skills to improve the diagnosis of early gastric cancer (EGC) and demonstrated their usefulness using randomized controlled trials. The subjects of the three e-learning systems were "detection", "characterization", and "preoperative assessment". The contents of each e-learning system included "technique", "knowledge", and "obtaining experience". All e-learning systems proved useful for endoscopists to learn how to diagnose EGC. Lecture videos describing "the technique" and "the knowledge" can be beneficial. In addition, repeating 100 self-study cases allows learners to gain "experience" and improve their diagnostic skills further. Web-based e-learning systems have more advantages than other teaching methods because the number of participants is unlimited. Histopathological diagnosis is the gold standard for the diagnosis of gastric cancer. Therefore, we developed a comprehensive diagnostic algorithm to standardize the histopathological diagnosis of gastric cancer. Once we have successfully shown that this algorithm is helpful for the accurate histopathological diagnosis of cancer, we will complete a series of e-learning systems designed to assess EGC accurately.

• Clinical Endoscopy
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• 제57권5호
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• pp.571-580
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• 2024

Malignant gastric outlet obstruction (GOO) is a condition characterized by blockage or narrowing where the stomach empties its contents into the small intestine due to primary malignant tumors or metastatic diseases. This condition leads to various symptoms such as nausea, vomiting, abdominal pain, and weight loss. To manage malignant GOO, different treatment options have been employed, including surgical gastrojejunostomy (SGJ), gastroduodenal stenting (GDS) using self-expandable metallic stent (SEMS), and endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ). This review focuses on comparing the clinical outcomes of endoscopic stenting (GDS and EUS-GJ) with SGJ for malignant GOO. Studies have shown that GDS with SEMS provides comparable clinical outcomes and safety for the palliation of obstructive symptoms. The choice between covered and uncovered SEMS remains controversial, as different studies have reported varying results. EUS-GJ, performed via endoscopic ultrasound guidance, has shown promising efficacy and safety in managing malignant GOO, but further studies are needed to establish it as the primary treatment option. Comparative analyses suggest that GDS has higher recurrence and reintervention rates compared to EUS-GJ and SGJ, with similar overall procedural complications. However, bleeding rates were lower with GDS than with SGJ. Randomized controlled trials are required to determine the optimal treatment approach for malignant GOO.

• Archives of Pharmacal Research
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• 제26권4호
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• pp.264-269
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• 2003

5-Aminosalicylic acid (5-ASA) is an active ingredient of therapeutic agents used for Crohn s disease and ulcerative colitis. Because it is absorbed rapidly and extensively in the upper intestine, delivery of the agent specifically to the colon is necessary. We selected taurine as a colon-specific promoiety and designed 5-aminosalicyltaurine (5-ASA-Tau) as a new colon-specific prodrug of 5-aminosalicylic acid (5-ASA). It was expected that introduction of taurine would restrict the absorption of the prodrug and show additive effect to the anti-inflammatory action of 5-ASA after hydrolysis. 5-ASA-Tau was prepared in good yield by a simple synthetic route. The apparent partition coefficient of 5-ASA-Tau in 1-octanol/pH 6.8 phosphate buffer or $CHCl_3$/pH 6.8 phosphate buffer was 0.10 or 0.18, respectively, at $37^{\circ}C$. To determine the chemical and biochemical stability in the upper intestinal environment, 5-ASA-Tau was incubated in pH 1.2 and 6.8 buffer solutions, and with the homogenates of tissue and contents of stomach or small intestine of rats at $37^{\circ}C$. 5-ASA was not detected from any of the incubation medium with no change in the concentration of 5-ASA-Tau. On incubation of 5-ASA-Tau with the cecal and colonic contents of rats, the fraction of the dose released as 5-ASA was 45% and 20%, respectively, in 8 h. Considering low partition coefficient and stability in the upper intestine, 5-ASA-Tau might be nonabsorbable and stable in the upper intestine. After oral administration, it would be delivered to the colon in intact form and release 5-ASA and taurine. These results suggested 5-ASA-Tau as a promising colon-specific prodrug of 5-ASA.

• 생약학회지
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• 제42권2호
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• pp.144-148
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• 2011

Rhubarb (Rhei Rhizoma) has been used for the various clinical purposes such as purgative, stomach protective and pain relief for a long time. However, rhubarb in current market has a problem of quality control under which many of rhubarb fail to meet the standard specified in Korean Pharmacopoeia. This study was carried out to validate the method for the evaluation of the quality of five rhubarbs and Rumex species; Rheum palmatum, R. officinale, R. tanguticum, R. franzenbachii, R. undulatum, and Rumex species. The content of sennoside A with five anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) in five rhubarbs and one Rumex has been performed by using HPLC quantitation analysis. In results, only four samples in Palmata sect. were qualified with sennoside A and those samples were R. officinale and R. tanguticum. Samples of R. palmatum did not meet the standard contents of sennoside A. The contents of anthraquinones in Palmata sect. were two times larger than those in Rhapontica sect. Moreover the content variations of anthraquinones were smaller than those of sennoside A. Thus, anthraquinones can be the key characterizing molecules to control quality of rhubarb.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.419-426
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• 2013

본 연구에서는 간암 치료시 Body fix를 이용하여 4DRT를 실시할 경우 종양의 체적, 위치의 변화정도, 종양 및 정상조직의 선량흡수정도를 파악하여 Body fix의 유용성을 평가하였다. 사전 연구에 동의한 23명의 환자를 대상으로 Body fix의 착용 유무에 따라 각기 다른 4차원 모의치료영상을 획득하여 영상을 바탕으로 종양조직 및 정상조직을 설정하고 분석하였다. 종양의 용적을 분석해본 결과 Body fix의 사용이 GTV는 0.17%, CTV와 PTV는 3.2% 정도 체적을 줄일 수 있었으며, 종양의 운동성은 AP방향에서 29.8%, UL방향에서 5.31%의 움직임을 감소시킬 수 있었다. 종양의 흡수선량 값은 Body fix를 사용한 경우가 다소(1.3%) 높았으며 정상조직(정상간, 위, 우측신장, 척수)의 흡수선량은 5% 정도 줄일 수 있었다. 따라서 간암의 4DRT시 Body fix는 유용하게 사용할 수 있을 것으로 생각된다.

• 한국동물학회지
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• 제33권1호
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• pp.22-27
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• 1990

본 연구는 옴개구리의 위저부 점막을 전자현미경으로 관찰한 결과, 내분비세포의 분비 과립의 크기, 형태, 전자밀도 및 세포의 형태에 따라서 다음과 같이 3종류의 세포를 분류하였다. 제 I 형 : 전자밀도가 높고 원형 또는 난원혀으이 과립을 가지며, 과립내용물과 한계막 사이의 편제하거나 공포상으로 출현하였다. 과립의 크기는 직경이 300-500nm였다. 제 II 형 : 구형 또는 난원형의 과립을 가지며, 전자밀도는 낮거나 높게 나타나며, 한계막과 과립내용물 사이에는 좁은 halo를 나타내었다. 과립의 크리는 직경이 110-230nm였다. 제 III 형 : 신장된 난원형 또는 다형태성의 과립을 가지며, 전자밀도는 낮거나 중등도이며 과림가 내용물 사이에는 명확한 halo를 형성하고 세포질내에는 미세섬유들이 풍부하게 출현하였다. 과립의 크기는 직경이 50-200nm였다.

• 한국축산식품학회지
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• 제34권3호
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• pp.297-306
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• 2014

Basic information regarding the yield and nutritional composition of edible pork by-products, namely heart, liver, lung, stomach, spleen, uterus, pancreas, and small and large intestines, was studied. Our results revealed that the yields varied widely among the pork by-products examined; in particular, liver had the highest yield (1.35%); whereas, spleen had the lowest yield (0.16%). The approximate composition range (minimum to maximum) of these by-products was found to be: moisture 71.59-82.48%; fat 0.28-19.54%; ash 0.155-1.34%, and protein 8.45-22.05%. The highest protein, vitamin A, B2, B6, and total essential amino acid (EAA) contents were found in liver. Large intestine had the highest fat content and lowest EAA content. Heart had the highest vitamin B1 content, whereas pancreas had the highest niacin and vitamin B3 contents. The concentrations of Fe and Zn were highest in liver and pancreas. Total saturated fatty acids (SFA) levels and polyunsaturated fatty acids (PUFA) levels between the by-products ranged from 43.15-50.48%, and 14.92-30.16%, respectively. Furthermore, with the exception of large intestine, all the by-products showed favorable PUFA/SFA ratios. The study indicated that almost all of the pork by-products examined were good sources of important nutrients, and that these data will be of great importance in the promotion of the consumption of edible pork by-products, as well as their utilization in meat processing.

• 한국약용작물학회지
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• 제18권3호
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• pp.135-142
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• 2010

Low quality fresh ginseng was fermented by Pheliuus linteus mycelium at $22^{\circ}C$ for 30 days, then extracted by water solvent at $100^{\circ}C$ for 180 min. On human normal cell lines (HEK293), cytotoxicity was about 10% lower in adding extracts of the fermentation ginseng than that from low quality ginseng. The fermented extracts also inhibited the growth of several human cancer cells. Among them, respectively, digestive organs related cancer cells, such as human stomach adenocarcnioma and human epithelial adenocarcinoma were most effectively inhibited up to 85% and 90%, respectively. Then, selectivities were in the ranges of 3 to 5, compared to 2 to 3 from low quality fresh ginseng. Generally, fermented ginseng extract showed higher anticancer activities as well as higher DPPH radical sacavening activity, possibly due to high contents of total phenolic components as 6.96 mg/g. It was very interesting that the fermented ginseng contained very higher contents of ginsenoside-Rc+$Rb_2$, compared to others in low quality fresh ginseng because of partition digestion of mycelium growth. The results can tell that low quality fresh ginseng can be utilized by the fermentation with Pheliuus linteus mycelium.

• 대한한의학원전학회지
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• 제21권1호
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• pp.183-203
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• 2008

"Uihakdokseogi(醫學讀書記)" is a casual work which mentions Ujaekyeong(尤在涇)'s thoughts on various problems found through extensive studying or in practice. The book does not focus on a single topic, thus the spectrum of the work is broad and is filled with problems which would interest most medical professionals. The major contents of the first volume of "Uihakdokseogi(醫學讀書記)" include differences of view on health preservation, the Five Circuit Phases[五運] and Six Atmospheric Influences[六氣], diseases, and the "Naegyeong(內經)", mentions on errors in transcription , and the gap between certain contents in "Yeongchu(靈樞)" and "Somun(素問)". U[尤在涇] asserts that Eum and Yang(陰陽) in a human should be in harmony as is the Gi(氣) of the sky and earth[天地] is, and that one should live according to the Gi(氣) of the four seasons to live a healthy life. He does not vary largely from the context of other writers on the matter of the Five Circuit Phases [五運] and Six Atmospheric Influences[六氣], and focuses on the concepts of predominant Gi[主氣], guest Gi[客氣], corresponding years[天符] , correlating years[歲會], and Taeeul corresponding years[太乙天符]. He mentions causes, symptoms, and treatments of various diseases such as cough due to asthenia of the viscera, stagnation of Yang(陽), stagnation of Eum(陰), abscess of the stomach, hard abscess of the intestines, upper emaciation, edema of the limbs, inability to raise the limbs, broken thigh, turbid fluid, inversion of Gi(氣) flow, sudden onset of fainting with cold extremities, diarrhea due to disorder of Gi(氣), and malaria. U[尤在涇] also points out faults of "Classic of Acupuncture and Moxibustion[甲乙經]" in the understanding of "Naegyeong(內經)".

• 한국약용작물학회지
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• 제18권2호
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• pp.113-117
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• 2010

The antioxidant and anticancer activities of Phellinus linteus, Inonotus obliquus, and Pleurotus ostreatus according to extraction methods were measured. The contents of polyphenolic compounds were higher in fermented extracts than those in water extracts. The contents were 192.4mg/100 $m{\ell}$ for Inonotus obliquus vinegar, 186.9 mg/100 $m{\ell}$ for Phellinus linteus vinegar, and 156.5 mg/100 $m{\ell}$ for Pleurotus ostreatus vinegar, respectively. EDA(electron donating ability) in Phellinus linteus that was highest among mushrooms was 83.9% in the water extract and 96.8% in the fermented extract. The growth of stomach cancer cells, SNU-719 was inhibited 62.4%, 65.5%, and 53.0% by Phellinus linteus vinegar, Inonotus obliquus vinegar, and Pleurotus ostreatus vinegar, respectively and also the growth of liver cancer cells, Hep3B was inhibited 67.1%, 68.3%, and 57.6% by Phellinus linteus vinegar, Inonotus obliquus vinegar, and Pleurotus ostreatus vinegar, while the growth of normal cell, DC2.4 was not affected. Even though Phellinus linteus and Inonotus obliquus showed higher inhibition in cancer cell growth, Pleurotus ostreatus can be efficiently used for antioxidant and anticancer activities due to their cheap price in the market.