• 생물정신의학
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• 제28권1호
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• pp.1-6
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• 2021

Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.

• Earthquakes and Structures
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• 제17권6호
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• pp.557-566
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• 2019

The evaluation of the seismic hazard for a given site is to estimate the seismic ground motion at the surface. This is the result of the combination of the action of the seismic source, which generates seismic waves, the propagation of these waves between the source and the site, and site local conditions. The aim of this work is to evaluate the sensitivity of dynamic response of extended structures to spatial variable ground motions (SVGM). All factors of spatial variability of ground motion are considered, especially local site effect. In this paper, a method is presented to simulate spatially varying earthquake ground motions. The scheme for generating spatially varying ground motions is established for spatial locations on the ground surface with varying site conditions. In this proposed method, two steps are necessary. Firstly, the base rock motions are assumed to have the same intensity and are modelled with a filtered Tajimi-Kanai power spectral density function. An empirical coherency loss model is used to define spatial variable seismic ground motions at the base rock. In the second step, power spectral density function of ground motion on surface is derived by considering site amplification effect based on the one dimensional seismic wave propagation theory. Several dynamics analysis of a curved viaduct to various cases of spatially varying seismic ground motions are performed. For comparison, responses to uniform ground motion, to spatial ground motions without considering local site effect, to spatial ground motions with considering coherency loss, phase delay and local site effects are also calculated. The results showed that the generated seismic signals are strongly conditioned by the local site effect. In the same sense, the dynamic response of the viaduct is very sensitive of the variation of local geological conditions of the site. The effect of neglecting local site effect in dynamic analysis gives rise to a significant underestimation of the seismic demand of the structure.

• 한국방재안전학회논문집
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• 제15권2호
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• pp.45-56
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• 2022

가뭄 및 갈수시에 용수부족 현상이 발생하나 회귀수량을 고려한 대응이나 대책 마련이 진행되지 않고 있다. 이에 본 연구에서 자료기반의 기계학습 모형(LSTM)을 통해 회귀수량 중 하수종말처리장의 방류량을 예측하였다. 입력자료로 방류량, 유입량, 강수량, 수위를 사용하였고 예측 결과의 정확도를 개선하기 위하여 추가적으로 입력변수의 변동성 분포를 고려하였다. 방류량 자료의 변동성을 확인하기 위해서 관측값과 분포 사이의 잔차를 복합삼각함수 형태로 가정하여 이론적인 확률분포와 함께 방류량 최적의 분포 형태로 나타내었다. 변동성 분포를 고려한 입력자료를 이용한 결과와 그렇지 않는 결과를 비교한 결과, 오차정도가 감소함을 보였으며 이는 변동성 분포가 계절성을 상대적으로 잘 재현하였기 때문이라 판단된다. 따라서 본 연구에서 구축한 하수종말장처리장의 방류량 예측 모형을 활용할 경우 보다 정확한 회귀수량 예측이 가능하여 효율적인 하천수 관리 체계를 수립하는데 기초자료로 활용될 수 있을 것으로 기대된다.

• Archives of Plastic Surgery
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• 제44권3호
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• pp.223-227
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• 2017

Background Carpal tunnel release is one of the most common surgical procedures performed by hand surgeons. The authors created a surgical simulation of open carpal tunnel release utilizing a mobile and rehearsal platform app. This study was performed in order to validate the simulator as an effective training platform for carpal tunnel release. Methods The simulator was evaluated using a number of metrics: construct validity (the ability to identify variability in skill levels), face validity (the perceived ability of the simulator to teach the intended material), content validity (that the simulator was an accurate representation of the intended operation), and acceptability validity (willingness of the desired user group to adopt this method of training). Novices and experts were recruited. Each group was tested, and all participants were assigned an objective score, which served as construct validation. A Likert-scale questionnaire was administered to gauge face, content, and acceptability validity. Results Twenty novices and 10 experts were recruited for this study. The objective performance scores from the expert group were significantly higher than those of the novice group, with surgeons scoring a median of 74% and medical students scoring a median of 45%. The questionnaire responses indicated face, content, and acceptability validation. Conclusions This mobile-based surgical simulation platform provides step-by-step instruction for a variety of surgical procedures. The findings of this study help to demonstrate its utility as a learning tool, as we confirmed construct, face, content, and acceptability validity for carpal tunnel release. This easy-to-use educational tool may help bring surgical education to a new- and highly mobile-level.

• International Journal of Safety
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• 제1권1호
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• pp.36-42
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• 2002

This paper is aimed at predicting the life of rubber insulating gloves under normal operating stresses from relatively rapid test performed at higher stresses. Specimens of rubber insulating gloves are subject to multiple stress conditions, i.e. combined electrical and thermal stresses. Two modes of electrical stress, step voltage stress and constant voltage stress are used in specimen aging. There are two types of test for electrical stress in this experiment: the one is Breakdown Voltage (BDV) test under step voltage stress and thermal stress and the other is lifetime test under constant voltage stress and temperature stress. The ac breakdown voltage defined as the break-down point of insulation that leakage current excesses a limit value, l0mA in this experiment, is determined. Because the very high variability of aging data requires the application of statistical model, Weibull distribution is used to represent the failure times as the straight line on Weibull probability paper. Weibull parameters are deter-mined by three statistical methods i.e. maximum likelihood method, graphical method and least squares method, which employ SAS package, Weibull probability paper and FORTRAN, respectively. Two chosen models for predicting the life under simultaneous electrical and thermal stresses are inverse power model and exponential model. And the constants of life equation for multistress aging are calculated using numerical method, such as Gauss Jordan method etc.. The completion of life equation enables to estimate the life at normal stress based on the data collected from accelerated aging test. Also the comparison of the calculated lifetimes between the inverse power model and the exponential model is carried out. And the lifetimes calculated by three statistical methods with lower voltage than test voltage are compared. The results obtained from the suggested experimental method are presented and discussed.

• 한국콘텐츠학회논문지
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• 제10권6호
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• pp.27-34
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• 2010

본 논문은 가중 퍼지소속함수 기반 신경망(neural network with weighted fuzzy membership functions, NEWFM)과 웨이블릿 기반의 특징 추출기법을 사용하여 왼쪽 또는 오른쪽의 운동 형상을 분류하는 방안을 제안하고 있다. 초기 특징을 추출하기 위해서 첫 번째 단계에서 웨이블릿 변환(wavelet transforms)을 이용하여 뇌파(electroencephalogram, EEG) 신호로부터 웨이블릿 계수들을 추출하였다. 두 번째 단계에서는 첫 번째 단계에서 추출한 웨이블릿 계수들을 통계적인 방법인 주파수 분포와 주파수 변동량을 이용하여 60개의 초기 특징을 추출하였다. 이들 60개의 초기 특징은 NEWFM에서 제공하는 비중복면적 분산 측정법에 의해 중요도가 가장 낮은 특징을 하나씩 제거되면서 정확도가 가장 높은 6개의 최소 특징을 선택되었다. 이들 6개의 최소 특징을 NEWFM의 입력으로 사용하여 86.43%의 정확도를 구하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제9권2호
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• pp.149-153
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• 1996

In the first step, birth weights and weights at 9 and 12 months were analysed and their variability were studied. Birth weight of kids had large within breed variation ranging from 0.50 to 1.60 kg. There were more than 100 kids with birth weights ranging from 1.2 to 1.6 kg. The birth weight of kids increased with the increase of kidding weight of dams. The weights of kids at 9 and 12 months also showed large within variation ranging from 5.0 to 18.0 kg and 16.0 to 19.0 kg respectively. In the second step, these existing large within breed variations were exploited selecting best animals for further mating. The birth weight of selected group($1.13{\pm}0.2kg$) was significantly(p<0.01) higher than the random group($0.93{\pm}0.05kg$). The weights in selected group for 3 and 6 months were $4.94{\pm}0.04$ and $8.40{\pm}0.05kg$ and that of random group was $3.99 {\pm}0.08$ and $7.07{\pm}0.11kg$ respectively and differences wee significant. Significantly higher average daily gains were noticed for selected group ($42.7{\pm}0.43g/day$) as against random group($33.3{\pm}0.81g/day$). From the results it may be concluded that selection and mating of best performing animals have some effect on the improvement of growth performance of kids which may be exploited for future planning and development in the field of goat production.

• 한국통신학회논문지
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• 제31권8C호
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• pp.763-770
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• 2006

본 논문에서는 소실 복호 기능을 갖는 가변형 Reed-Solomon(RS) 복호기가 수정 유클리드 알고리즘(modified Euclid's algorithm; MEA)을 기반으로 설계되었다. 복호기의 가변성은 원시 RS(255, 239, 8) 부호와는 다른 RS(124, 108, 8) 부호를 기반으로 단축과 펑처링을 통해 구현된다. 이렇게 하므로써 복호 시간을 단축시켰다. 복호기는 4단계 파이프라인 구조를 갖으며, 파이프라인의 각 단계는 서로 다른 클럭으로 동작할 수 있도록 설계하였다. 따라서 MEA 블록에 고속 클럭을 사용하므로써 복호기의 복잡도 및 복호 지연을 단축할 수 있으며, 버스트 및 연속 모드의 복호를 모두 지원한다. 설계된 복호기는 VHDL로 구현하고 FPGA에 합성하였으며, 3,717개의 로직 셀과 2,048 비트의 메모리가 사용되었다. 설계된 복호기는 최고 33MByte/sec의 데이터를 복호 할 수 있다.

• 대한기계학회논문집A
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• 제26권10호
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• pp.2073-2081
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• 2002

In product design and manufacturing, axiomatic design provides a systematic approach for the decision-making process. Two axioms have been defined such as the Independence Axiom and the Information Axiom. The Information Axiom states that the best design among those that satisfy the independence axiom is the one with the least information content. In other words, the best design is the one that has the highest probability of success. On the other hand, the Taguchi robust design is used in the two-step process; one is "reduce variability," and the other is "adjust the mean on the target." The two-step can be interpreted as a problem that has two FRs (functional requirements). Therefore, the Taguchi method should be used based on the satisfaction of the Independence Axiom. Common aspects exist between the Taguchi method and Axiomatic Design in that a robust design is induced. However, different characteristics are found as well. The Taguchi method does not have the design range, and the probability of success may not be enough to express robustness. Our purpose is to find the one that has the highest probability of success and the smallest variation. A new index is proposed to satisfy these conditions. The index is defined by multiplication of the robustness weight function and the probability density function. The robustness weight function has the maximum at the target value and zero at the boundary of the design range. The validity of the index is proved through various examples.gh various examples.

• 한국정보전자통신기술학회논문지
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• 제14권3호
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• pp.215-222
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• 2021

인간과 컴퓨터의 상호 작용 (Human Computer Interface) 기술의 중요성이 더욱 커지고 있으며 HCI에 대한 연구가 진행됨에 따라 사용자의 직접적인 입력에 의한 컴퓨터 반응이 아닌 감정 추론 혹은 사용자 의도에 따른 컴퓨터 반응에 대한 연구가 증가되고 있다. 스트레스는 현대 인간 문명사회에서의 피할 수 없는 결과이며 복잡한 현상을 나타내며 통제 유무에 따라 인간의 활동능력은 심각한 변화를 받을 수 있다. 본 논문에서는 인간과 컴퓨터의 상호 작용의 일환으로 스트레스를 통해 증가된 심박변이도 (HRV)와 가속도 맥파(APG)를 측정한 후 스트레스를 완화시키기 위한 방안으로 음악을 이용한 지능형 감성 추천시스템을 제안하고자 한다. 사용자의 생체정보 즉, 스트레스 지수를 획득 및 인식하여 신뢰성 있는 데이터를 추출하고자 차분진화 알고리즘을 사용하였으며 이렇게 획득된 스트레스 지수를 단계별에 따라 시멘틱 웹 (Semantic Web)을 통해 감성추론을 하였다. 또한 스트레스 지수와 감성의 변화에 매칭 되는 음악 리스트를 검색 및 추천함으로써 사용자의 생체정보에 맞는 감성 추천시스템을 애플리케이션으로 구현하였다.