• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.1-14
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• 2004

A promising approach to the development of a new single-step vaccine, which would eliminate the requirement for multiple injections, involves the encapsulation of antigens into microspheres. Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres gave us a bright insight for controling antigen release in a pulsatile fashion, thereby mimicking two or tree boosting injections. However, in spite of the above merits, the level of immunization induced by a single-shot vaccination is often lower tan two doses of alum-adsorbed antigen. Therefore, optima modification of the microsphere is essential for the development of single-step vaccines. In the review, we discuss the stability of antigen in microsphere, safety and non-toxic in human and encapsulation technology. Also, we attempted to outline relevant physicochemical properties on the immunogenicity of microsphere vaccine and attainment of pulsatile release pater by combination of different microsphere, as well as to analyze immunological data associated with antigen delivery by microsphere. Although a lot of variables are related to the optimized microsphere formulation, we could conclude that judicious choice of proper polymer type, adjustment of particles size, and appropriate immunization protocol along with a suitable adjuvant might be a crucial factor for the generation of long-lasting immune response from a single-step vaccine formulation employing PLGA microsphere.

• Korean Chemical Engineering Research
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• 제46권5호
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• pp.949-957
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• 2008

공정의 계단응답으로부터 일차시간지연모델을 구하고, 이로부터 PID(Proportional-Integral-Derivative) 제어기를 설계하는 방법은 공정제어 분야에서 널리 사용되는 오랜 것이다. 이를 위한 간단한 그래프에 근거한 방법에서 복잡한 수치적 최소자승법에 근거한 방법까지 다양한 방법들이 제안되어 있는데, 노이즈가 섞여 있는 계단응답에 대응하는 간단한 방법들은 의외로 잘 알려져 있지 못하다. 최근 계단응답 신호의 적분을 이용하는 방법들이 제안되어 있는데 이들을 비교 검토하여 실용적인 방법을 찾고자 한다. 계단응답의 적분 신호는 현 제어 계기에서 쉽게 얻어진다.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2007년도 추계학술대회 논문집
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• pp.199-201
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• 2007

This paper presents the installation of measuring system for the transient behaviors of grounding system impedances using portable impulse current generator. The measuring system is controller, with controller, power supply, impulse current generator and data aquisition system. In the evaluation of the impulse response in a ground electrode, the step response is calculated based on the ratio of the voltage and current observed.

• 제어로봇시스템학회논문지
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• 제15권11호
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• pp.1071-1075
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• 2009

This article describes a robust control method by using peak control of a sensitivity function in the state-feedback control systems. This method apparently reduces the peak, and as a result makes closed loop systems more stable. The designed closed loop systems also make the response to an external step disturbance more fast with a lower undershoot. At the conclusion, it is verified that the proposed method enhances robust stability and robust performance to parametric uncertainties through $\mu$-plot.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1993년도 정기총회 및 추계학술대회 논문집 학회본부
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• pp.73-75
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• 1993

In this paper, the transient shielding characteristics of slitted electrothermal shield of superconducting alternator is studied. The field current and the armature currents variations during three phase short circuit fault are calculated and compared to those of the conventional one. And the response of the armature current due to step-up of the excitation voltage showes the feasibility of the quick response excitation system available for improving the transient stability.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2002년도 ICCAS
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• pp.59.5-59
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• 2002

In this paper, we present a robust controller design method that can not only deal with the constant time delay plant but also an uncertain time delay one. For a constant time delay plant. The proposed DTC can independently adjust the set response and the disturbance response without any stability constraint. And in the uncertain time delay case, one can process the control design step with uncertainty norm bound. To verify real effectiveness, theoretical analysis and simulation results are given.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.725-728
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• 2002

In this Paper, a mathematical model describing the dynamics of pilot operated pressure control valve was derived. A attempt to analyze the Parameters(seat diameter, cone angle, spring stiffness, control volume) which relate to the performance of the object valve was carried out. Simulation using AMESim as a simulation tool was operated, and verified the validity of our simulation by means of comparison our simulation results with an experimental results of the pilot operated pressure control valve.

• Journal of the Korean Data and Information Science Society
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• 제17권1호
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• pp.187-193
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• 2006

This paper shows how to use continuation-ratio logits for the analysis of structured polytomous data. Here, response categories are considered to have a nested binary structure. Thus, conditionally nested binary random variables can be defined in each step. Two types of factors are considered as independent variables affecting response probabilities. For the purpose of analyzing categorical data with binary nested strutures a continuation-ratio mixed model is suggested. Estimation procedure for the unknown parameters in a suggested model is also discussed in detail by an example.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 2003년도 춘계 학술발표회논문집
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• pp.69-76
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• 2003

Near-field ground motions exhibit special characteristics that are different from ordinary far-field ground motions. This paper first briefly examines the characteristics of near-field ground motions associated with fault directivity and fling-step effects. Then evaluation of near-field ground motions by inelatstic response spectrum analysis is performed and analyzed. As a result, ductility demand in near-field ground motions is larger in hanging wall than in foot wall in long period regions. Also in long period regions ductility demand in soil site is larger than that in rock site.

• 대한전자공학회논문지
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• 제23권4호
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• pp.571-577
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• 1986

In this paper, we have investigated pole-zero shifting due to variable stopband frequency Ws and passband ripple Ap of elliptic function filters. Also we have studied the phase, group-delay, unit step response and impulse response of elliptic filters. We show that in the passband the phase linearity improves as Ws increases, and eventually it approaches that of a chebyshev function filter.