• Journal of Pharmaceutical Investigation
• /
• v.34 no.1
• /
• pp.1-14
• /
• 2004

A promising approach to the development of a new single-step vaccine, which would eliminate the requirement for multiple injections, involves the encapsulation of antigens into microspheres. Biodegradable poly(lactide-co-glycolide) (PLGA) microspheres gave us a bright insight for controling antigen release in a pulsatile fashion, thereby mimicking two or tree boosting injections. However, in spite of the above merits, the level of immunization induced by a single-shot vaccination is often lower tan two doses of alum-adsorbed antigen. Therefore, optima modification of the microsphere is essential for the development of single-step vaccines. In the review, we discuss the stability of antigen in microsphere, safety and non-toxic in human and encapsulation technology. Also, we attempted to outline relevant physicochemical properties on the immunogenicity of microsphere vaccine and attainment of pulsatile release pater by combination of different microsphere, as well as to analyze immunological data associated with antigen delivery by microsphere. Although a lot of variables are related to the optimized microsphere formulation, we could conclude that judicious choice of proper polymer type, adjustment of particles size, and appropriate immunization protocol along with a suitable adjuvant might be a crucial factor for the generation of long-lasting immune response from a single-step vaccine formulation employing PLGA microsphere.

• Korean Chemical Engineering Research
• /
• v.46 no.5
• /
• pp.949-957
• /
• 2008

Estimating the first order plus time delay model on the basis of the step responses has been widely used in industry for the tuning of PID controllers. Even though various model identification methods from simple graphical approaches to complicated approaches based on least squares method have been proposed, simple approaches to incorporate noisy step responses are rarely available. In this research, we will compare and analyze recent approaches using the integrals of the step responses and develop an improved identification method to incorporate real situations more effectively.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
• /
• 2007.11a
• /
• pp.199-201
• /
• 2007

This paper presents the installation of measuring system for the transient behaviors of grounding system impedances using portable impulse current generator. The measuring system is controller, with controller, power supply, impulse current generator and data aquisition system. In the evaluation of the impulse response in a ground electrode, the step response is calculated based on the ratio of the voltage and current observed.

• Journal of Institute of Control, Robotics and Systems
• /
• v.15 no.11
• /
• pp.1071-1075
• /
• 2009

This article describes a robust control method by using peak control of a sensitivity function in the state-feedback control systems. This method apparently reduces the peak, and as a result makes closed loop systems more stable. The designed closed loop systems also make the response to an external step disturbance more fast with a lower undershoot. At the conclusion, it is verified that the proposed method enhances robust stability and robust performance to parametric uncertainties through $\mu$-plot.

• Proceedings of the KIEE Conference
• /
• 1993.11a
• /
• pp.73-75
• /
• 1993

In this paper, the transient shielding characteristics of slitted electrothermal shield of superconducting alternator is studied. The field current and the armature currents variations during three phase short circuit fault are calculated and compared to those of the conventional one. And the response of the armature current due to step-up of the excitation voltage showes the feasibility of the quick response excitation system available for improving the transient stability.

• 제어로봇시스템학회:학술대회논문집
• /
• 2002.10a
• /
• pp.59.5-59
• /
• 2002

In this paper, we present a robust controller design method that can not only deal with the constant time delay plant but also an uncertain time delay one. For a constant time delay plant. The proposed DTC can independently adjust the set response and the disturbance response without any stability constraint. And in the uncertain time delay case, one can process the control design step with uncertainty norm bound. To verify real effectiveness, theoretical analysis and simulation results are given.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2002.10a
• /
• pp.725-728
• /
• 2002

In this Paper, a mathematical model describing the dynamics of pilot operated pressure control valve was derived. A attempt to analyze the Parameters(seat diameter, cone angle, spring stiffness, control volume) which relate to the performance of the object valve was carried out. Simulation using AMESim as a simulation tool was operated, and verified the validity of our simulation by means of comparison our simulation results with an experimental results of the pilot operated pressure control valve.

• Journal of the Korean Data and Information Science Society
• /
• v.17 no.1
• /
• pp.187-193
• /
• 2006

This paper shows how to use continuation-ratio logits for the analysis of structured polytomous data. Here, response categories are considered to have a nested binary structure. Thus, conditionally nested binary random variables can be defined in each step. Two types of factors are considered as independent variables affecting response probabilities. For the purpose of analyzing categorical data with binary nested strutures a continuation-ratio mixed model is suggested. Estimation procedure for the unknown parameters in a suggested model is also discussed in detail by an example.

• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2003.03a
• /
• pp.69-76
• /
• 2003

Near-field ground motions exhibit special characteristics that are different from ordinary far-field ground motions. This paper first briefly examines the characteristics of near-field ground motions associated with fault directivity and fling-step effects. Then evaluation of near-field ground motions by inelatstic response spectrum analysis is performed and analyzed. As a result, ductility demand in near-field ground motions is larger in hanging wall than in foot wall in long period regions. Also in long period regions ductility demand in soil site is larger than that in rock site.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.23 no.4
• /
• pp.571-577
• /
• 1986

In this paper, we have investigated pole-zero shifting due to variable stopband frequency Ws and passband ripple Ap of elliptic function filters. Also we have studied the phase, group-delay, unit step response and impulse response of elliptic filters. We show that in the passband the phase linearity improves as Ws increases, and eventually it approaches that of a chebyshev function filter.