• Journal of the Korean Data and Information Science Society
• /
• v.25 no.2
• /
• pp.327-336
• /
• 2014

Recurrent event data occurs when a subject experiences same type of event repeatedly and is found in various areas such as the social sciences, Economics, medicine and public health. To analyze recurrent event data either a total time or a gap time is adopted according to research interest. In this paper, we analyze recurrent event data with incomplete observation gap using a gap time scale. That is, some subjects leave temporarily from a study and return after a while. But it is not available when the observation gaps terminate. We adopt an interval censoring mechanism for estimating the termination time. Furthermore, to model the association among gap times of a subject, a frailty effect is incorporated into a model. Programs included in Survival package of R program are implemented to estimate the covariate effect as well as the variance of frailty effect. YTOP (Young Traffic Offenders Program) data is analyzed with both proportional hazard model and a weibull regression model.

• Proceedings of the IEEK Conference
• /
• 2002.06e
• /
• pp.293-296
• /
• 2002

In this study, the object is a development on uroflowmetry system to detect a voiding symptom conveniently in home or hospital. The hardware was composed of mechanism and system circuit part, the software was divided into firmware and PC program part. The following experiment was performed to evaluate an ability of classification and fitness. First, the following parameters was calculated in each flow curve pattern. The parameters are MFR, AFR, VOL, VT, FT, and TMF. A significant difference among parameters was examined through a statistical analysis for extracted parameters between normal and abnormal group. In the next work, the following experimentation was performed to classify the voiding symptom. Analysis of congregate rate was examined to find out classification possibility about each symptom of BPH, voiding difficulty, detrusor failure and hyperreflexia, unstable bladder. The uroflow data with the above symptom was divided into normal and abnormal group using fuzzy classifier. and that was performed appending the other group again. Fuzzy classification result using MFR and AFR was superior by 89.6 % more than grouping evaluation including VOL.

• Anxiety and mood
• /
• v.4 no.2
• /
• pp.148-156
• /
• 2008

Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

• The Journal of Korean Medicine
• /
• v.15 no.2 s.28
• /
• pp.241-252
• /
• 1994

It is known that the pattern of combustion temperature can be classified into preheating, heating. retaining and cooling periods. In this experiment. the authors have studied the heating mechanism by the density of moxa material during the heating and retaining periods. The starting point. the point at which it begins to reach the maximum gradient temperature. the ending point of the heating period. and the ending point of the retaining period were measured in order to get effective stmulation by repetition of moxa-combustion. For the experiment. samples of 300mg. 400mg, and 500mg of moxa material were molded into conical molds with each 10mm in diameter and height resulting in the volume of $0.26cm^3$. The following results were obtained: The $300mg/0.26cm^3$ denstiy sample reached al1 points tested faster than the samples of $400mg/0.26cm^3$ and $500mg/0.26cm^3$ It dose not reveal any statistical differences between $400mg/0.26cm^3$ and $500mg/0.26cm^3$ in the ending point. the point at which it begins to reach the maximum gradient temperature of the heating period or the ending point of the reataining period The only difference shown was in the starting point of the heating period. According to the above results. it is concluded that the lower density moxa material reached each point of the the respective period faster than the high density moxa material.

• Interdisciplinary Bio Central
• /
• v.5 no.2
• /
• pp.3.1-3.7
• /
• 2013

Recently, the productivity of drug discovery has gradually decreased as the limitations of single-target-based drugs for various and complex diseases become exposed. To overcome these limitations, drug combinations have been proposed, and great efforts have been made to predict efficacious drug combinations by statistical methods using drug databases. However, previous methods which did not take into account biological networks are insufficient for elaborate predictions. Also, increased evidences to support the fact that drug effects are closely related to metabolic enzymes suggested the possibility for a new approach to the study drug combinations. Therefore, in this paper we suggest a novel approach for analyzing drug combinations using a metabolic network in a systematic manner. The influence of a drug on the metabolic network is described using the distance between the drug target and an enzyme. Target-enzyme distances are converted into influence scores, and from these scores we calculated the correlations between drugs. The result shows that the influence score derived from the targetenzyme distance reflects the mechanism of drug action onto the metabolic network properly. In an analysis of the correlation score distribution, efficacious drug combinations tended to have low correlation scores, and this tendency corresponded to the known properties of the drug combinations. These facts suggest that our approach is useful for prediction drug combinations with an advanced understanding of drug mechanisms.

• Journal of Trauma and Injury
• /
• v.22 no.2
• /
• pp.212-217
• /
• 2009

Purpose: To analyze delayed diagnosis, we collected date on pediatric and adolescent patients who had been admitted to the Emergency Department with injuries due to minor trauma Methods: We retrospectively analyzed the age distribution, trauma mechanism, time interval for each affected body region at delayed diagnosis, hospital stay, and outcome for 161 pediatric and adolescent patients who had been admitted to the Emergent Department of Gachon University Gil Hospital from January 2006 to September 2008. Results: The incidence of delayed diagnosis in pediatric and adolescent trauma was 11.8% in our retrospective review of 161 pediatric and adolescent patients. Lengths of hospitalization were longer in patients with delayed diagnosis (p<0.05). Patients with delayed diagnosis were more often transferred to other hospitals than patients with non-delayed diagnosis (p<0.05). The time intervals for each different affected body regions at delayed diagnosis were significantly different, but the hospital stays were not. There were no statistical significance to age on affected body region. Conclusion: From this study, we found that admission result and hospital stay were statistically significant differences between the delayed-diagnosis patient group and the non-delayed-diagnosis patient group. Finally, we must follow up pediatric and adolescent patients with minor trauma, closely considering missed injuries.

• Journal of the Korean Society of Physical Medicine
• /
• v.5 no.1
• /
• pp.15-24
• /
• 2010

Purpose : The purpose of this study was to investigate the effect of loading position on plantar center of pressure(COP) displacement when carrying a schoolbag during walking. Methods : Forty-four normal subjects were randomly assigned to five groups according to the method of carrying a schoolbag. The carrying a schoolbag methods were classified into five conditions: no bag (condition 1), a backpack (condition 2), a shoulder bag (condition 3), a cross bag (condition 4), a one-hand bag (condition 5). COP displacement such as anteroposterior distance and mediolateral distance of COP were measured with F-scan system. The repeated one-way analysis of variance (ANOVA) and independent t-test were used to confirm the statistical significance. Results : In the comparison of parameters of COP displacement between conditions, anteroposterior distance and mediolateral distance in the left foot and mediolateral distance in the right foot were not significantly different(p>.05), but anteroposterior diatance in the right foot was significantly different(p>.05). Between left and right foot, at condition 1 and 5 the mediolateral distance of COP was significantly different(p<.05) but anteroposterior distance at condition 1 and 5, anteroposterior distance and mediolateral distance of COP at condition 2, 3 and 4 were not significantly different(p>.05). Conclusion : These findings showed that the various loading position by five types of carrying a schoolbag didn't have influence significantly on COP displacement on during walking because of mechanism of postural adaption.

• Journal of the Korean Society of School Health
• /
• v.22 no.2
• /
• pp.157-167
• /
• 2009

Purpose : The purpose of this study is to explore the students injuries by analyzing the data which has been inputted by the emergency center of the cooperated hospitals and the 119 rescue party through the injury surveillance system in Cheonan city. Method : Students were divided into the elementary, middle, high school students with the 776 cases of children and teenagers(7-19years old) of injury surveillance system in Cheonan area from january to june in 2009. Frequency analysis and $x^2$-test was done to recognize the features of students injuries among the groups. The program to be used for the statistical analysis is SPSS 17.0. Result : Out of the injury incidence rate, the elementary school students(52.1%) are first, the high school students (24.9%) are second, the middle school students appear to be 23.1%. Male is about two times higher than female by 66.6% in the injury incidence. In terms of the injury mechanism, the injury(22.2%) by hit is the first, the traffic accident(21.5%) is the second, the slippery(16.8%) is followed. The injuries were occurred most largely at 16:00-20:00(33.4%), and the 33.6% of injury by daily leisure activity occurs at 16:00-20:00 chiefly. Conclusion : Analysis using the data of the injury surveillance system has some advantages compared to the previous research such as reliability and specification. To prevent the students injuries, not the individual problem but the social dimension should be acknowledged so that we can secure and promote the safety from the risk. Therefore, we must organize the role assignment and the cooperative network in the school, home and community.

• Health Policy and Management
• /
• v.18 no.3
• /
• pp.110-127
• /
• 2008

Expenditures on pharmaceuticals of different concepts were estimated and their functional, financing and providers' breakdowns were examined in line with the OECD's System of Health Accounts (SHA) manual. This study also shows the way such estimates are made. The results are then analyzed particularly from the international perspective. Data from both Household Survey by the National Statistical Office and the National Health and Nutritional Survey by the Ministry of Health and Welfare of Korea were used to estimate pharmaceutical expenditures that. are financed by out-of-pocket payments of the household, while national health insurance data etc. were used for estimation of pharmaceutical expenditures that are financed by public funding sources. The 'per capita expenditure on pharmaceutical/medical non-durables' in Korea stood at 380 US$ PPPs, less than the OECD average of 443 US$ PPPs in 2006, but its share of the per capita health expenditure of 25.9% noticeably outnumbered the OECD average of 17.1%, due partly to low per capita health expenditure as a denominator of the ratio. This indicates that Koreans tend to spend less on health care than an OECD average, while tending to spend more on pharmaceuticals than on other health care services, much like the pattern found in relatively low income countries. An international pharmaceuticals pricing mechanism is most likely responsible for such a tendency. In addition, it is to be noted that the percentage comes down to 21.0%, when expenditures on both medical non-durables and herbal medicine, which is locally quite popular among the elderly, have been excluded.

• Journal of KIISE:Computing Practices and Letters
• /
• v.9 no.6
• /
• pp.610-622
• /
• 2003

Metadata Registry was developed to dynamically manage metadata and to increase interoperability between various and heterogeneous metadata. The built metadata registry can be used as a standard guideline for creation of new databases and it provides a radical data integration mechanism. However, in the situation that an enormous databases must be integrated progressively, there is a limit to the existing metadata-based approach. In case that each database has no statistical information for its use rate and the restricted cost is given to us for a unit time, existing metadata-based approaches do not provide how to select some databases to be preferentially integrated and to build a metadata registry progressively, In this paper, we propose a methodology that can create progressively metadata registries in the case. The proposed methodology is based on data visibility and hierarchical metadata registry. We also describe the system that have been developed for applying the methodology to a real domain, and then described its results.