• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.6863-6870
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• 2015

Background: Breast cancer accounted for almost 25% of all cancers in women globally in 2012. Although breast cancer is the most prevalent cancer in India, there is no organised national breast cancer screening programme. Local studies on the burden of breast cancer are essential to develop effective context-specific strategies for an early detection breast cancer programme, considering the cultural and ethnic heterogeneity in India. This study examined the knowledge, attitudes, and practices about breast cancer in rural women in Central India. Materials and Methods: This community-based cross sectional study was conducted in Wardha district, located in Maharashtra state in Central India in 2013. The sample included 1000 women (609 rural, 391 urban) aged 13-50 years, selected as representative from each of the eight development blocks in the district, using stratified cluster sampling. Trained social workers interviewed women and collected demographic and socio-economic data. The instrument also assessed respondents' knowledge about breast cancer and its symptoms, risks, methods of screening, diagnosis and treatment, as well as their attitudes towards breast cancer and selfreported practices of breast cancer screening. Chi-square and t-test were applied to assess differences in the levels of knowledge, attitude, and practice (the outcome variables) between urban and rural respondents. Multivariable linear regression was conducted to analyse the relationship between socio-demographic factors and the outcome variables. Results: While about two-thirds of rural and urban women were aware of breast cancer, less than 7% in rural and urban areas had heard about breast self-examination. Knowledge about breast cancer, its symptoms, risk factors, diagnostic modalities, and treatment was similarly poor in both rural and urban women. Urban women demonstrated more positive attitudes towards breast cancer screening practices than their rural counterparts. Better knowledge of breast cancer symptoms, risk factors, diagnosis, and treatment correlated significantly with older age, higher levels of education, and being office workers or in business. Conclusions: Women in rural Central India have poor knowledge about breast cancer, its symptoms and risk factors. Breast self-examination is hardly practiced, though the willingness to learn is high. Positive attitudes towards screening provide an opportunity to promote breast self-examination.

• 치위생과학회지
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• 제14권2호
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• pp.150-157
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• 2014

본 연구에서는 기존에 임상에서 염색제를 사용한 치면세균막검사와 periodental probe를 사용한 치은지수 평가방법대신 새로운 디지털 형광 장비인 QLF-D를 이용한 검사법의 활용 가능성을 확인하고자 하였다. 염색제를 이용하여 치면세균막지수를 산출하여 연구 대상자를 위험군별로 구분하여 일반적 특성을 확인하였고, 분석 소프트웨어를 이용하여 산출되는 QLF-D score와 전체 및 전치부 치면세균막지수, 치은지수의 상관성을 확인하였다. 정상치은과 치은염에 따른 QLF-D score를 비교하였고, 각 QLF-D score에 따른 치면세균막지수와 치은지수의 평균값을 비교하여 다음과 같은 결론을 내렸다. 연구대상자의 염색제를 이용한 평균 치면세균막지수는 $42.28{\pm}17.90$이었고, 6개의 선택치아의 치은지수는 $1.05{\pm}20.38$로 나타났으며, QLF-D score는 $1.26{\pm}1.50$이었다. 상하악전치부 QLF-D score와 치면세균막염색을 이용하여 평가한 전치부 치면세균막지수의 상관 분석 결과, 유의한 양의 상관관계를 확인하였다(r=0.638, p<0.001). 또한 상하악 전치부 QLF-D score와 periodontal probe를 이용한 치은지수와의 관계를 분석한 결과에서도 두 가지 평가 지표 간에 유의한 양의 상관관계를 보였다(r=0.562, p<0.001). 치면세균막지수와 치은지수에 따른 QLF-D score의 차이를 저위험군과 고위험군으로 분류하여 비교한 결과, 치면세균막지수(p<0.0001)와 치은지수(p=0.007) 모두 저위험군에 비해 고위험군 집단에서 QLF-D score가 통계적으로 유의하게 높았다. QLF-D score에 따른 치면세균막지수 및 치은지수 평균값을 비교한 결과, QLF-D score가 증가할수록 두 가지 지수 모두 통계적으로 유의하게 증가하는 양상을 보였다(p<0.0001). 이와 같은 결과를 통해, QLF-D로 치면세균막을 평가함으로써 치은상태를 모니터링 하는 것이 가능함을 확인하였다. 이를 통해 임상 현장에서 QLF-D를 활용한다면, 비교적 간편하게 구강 이미지를 획득하고 구강 상태를 점수화하여 제시함으로써 술자의 진단 절차가 간편해지고 환자와의 의사소통이 원활해질 수 있을 것으로 사료된다.

• 한국동물생명공학회지
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• 제36권1호
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• pp.35-44
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• 2021

A pregnancy diagnosis is an important standard for control of livestock's reproduction in paricular dairy cattle. High reproductive performance in dairy animals is a essential condition to realize of high life-time production. Pregnancy diagnosis is crucial to shortening the calving interval by enabling the farmer to identify open animals so as to treat or re-breed them at the earliest opportunity. MicroRNAs are short RNA molecules which are critically involved in regulating gene expression during both health and disease. This study is sought to establish the feasible of circulating miRNAs as biomarkers of early pregnancy in cattle. We applied Illumina small-RNA sequencing to profile miRNAs in plasma samples collected from 12 non-pregnant cows ("open" cows: samples were collected before insemination (non-pregnant state) and after pregnancy check at the indicated time points) on weeks 0, 4, 8, 12 and 16. Using small RNA sequencing we identified a total of 115 miRNAs that were differentially expressed weeks 16 relative to non-pregnancy ("open" cows). Weeks 8, 12 and 16 of pregnancy commonly showed a distinct increase in circulating levels of miR-221 and miR-320a. Through genome-wide analyses we have successfully profiled plasma miRNA populations associated with pregnancy in cattle. Their application in the field of reproductive biology has opened up opportunities for research communities to look for pregnancy biomarker molecules in dairy cattle.

• 항공우주기술
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• 제13권1호
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• pp.37-43
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• 2014

저궤도 위성을 운영하는 지상국에서는 10분 내외의 교신 시간 동안 위성의 건강 상태를 확인한 후 영상 촬영을 위한 임무 명령을 전송하거나 촬영한 영상을 수신한다. 제한된 교신 시간동안 매일의 임무를 위한 일련의 절차를 완료하기 위해 위성 및 지상국 시스템에서는 적절한 수준의 자율성이 적용되어 있다. 예를 들어 위성의 자세 및 궤도를 유지하기 위한 제어 로직은 운영자의 개입 없이도 오랜 시간동안 자동으로 수행되어야 하므로 높은 자율성을 갖는 부분이다. 이와는 대조적으로 위성의 고장 관리 로직의 경우 고장 상황 인지 및 안전 조치는 위성에서 자동으로 수행되지만 대체적으로 고장의 원인 판단 및 복구 절차는 지상에서 수행하도록 설계하므로 상대적으로 낮은 자율성을 갖는 부분이라 할 수 있다. 위성의 자율성 수준은 지상국 운영에도 영향을 준다. 지상국에서는 촬영 임무를 위한 일련의 명령 세트 등을 생성한다. 위성이 좀 더 높은 수준의 자율성을 갖는다면, 지상국에서 수행하는 동작의 일부를 위성에서 수행할 수 있을 것이며 지상국의 절차를 간소화할 수 있을 것이다. 이 논문에서는 위성의 자율성 수준에 대해 논의하고 적절한 자율성 수준을 위한 설계 개념을 제안한다.

• 환경위생공학
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• 제6권1호
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• pp.7-25
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• 1991

Until now, pure drinking water grnerally menas the water without taste, odor, general bacteria, coliform, and other exotic substance. Such a definition has been changing recently due to the finding of numerous other inorganic and organic substances unknown to us. 10 years ago, major causes of death were infectious agents and parasites contained in water, but recently, it has become apparent that some substances contained in drinking water cause cancer and heart diseases. We must drink about 2L of water everyday in order to maintain healthy condition. Waters used for drinking include tap water, well water, spring water, filtered water, etc., but the quality of drinking water has more polluted due to the industrial development and population increase. For example, industrial waste waters from industrial plants pollute the water supply sources ; toxic substances contained in the waste waters pollute the ground water sources by penetrating the geological strata, and municipal, livestock, public building waste waters also pollute the water supply sources. Sometimes, the polluted surface waters were announced to be polluted by various kinds of orgainc substance, and it is reported that the pollution of ground water by orga nic substances has few in number but high in its concectration comparing with those of surface water. As the water quality pollution level increases, so the amount of disinfectant also increase. For example, chlorine solution, one of widely used disinfectants, creates trihalomethane(THM), a carcinogen, and halogen compounds. According to Oliver, through chlorine disinfection process, humine substance and chlorine create bolatile organic halide and nonvolatile organic halide by chemical reaction. There are tens or hundreds filtering devices, but filtering principles and maintenance metjhods are different, so their efficiency tests are needed. According to Smith, the effeciency tests aginst over 30 Ameican filtering devices show that 10 devices can remove 85% of volatile organics and further studies on filtered waters are underway. In consideration of important impacts of polluted drinking water on national health, authors studied the state of water quality pollution against tap water used as drinking water, filtration device passed water, ground water, and conserved drinking water ; tested the efficiency of filtration devices for tap water ; tried to sep up the detection method by using ion chromatography based on negative ion and positive ion by using single column, and attemped the simple filtration method for general households.

• 한국전산구조공학회논문집
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• 제22권1호
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• pp.89-103
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• 2009

이 연구에서는 얇은 판형구조물의 손상탐지에 널리 사용되어오는 램파에 시간반전(time reversal)개념의 적용성을 이론적으로 규명한다. 고전적 시간반전 음향학에 의하면, 센서에서의 출력신호를 시간영역에서 반전 후 재입사시켜 원래의 가진점으로 돌려보내면, 그 가진점에서 원래 입력신호가 복원된다. 그러나 램파에 시간반전과정을 적용하게 되면 램파 고유의 분산성과 판 경계에서의 파 반사로 인해 시간반전성이 복잡한 양상을 띠게 된다. 이러한 램파의 시간반전성을 보다 잘 이해하기 위해 이 연구에서는 램파의 시간반전과정을 이론적으로 규명한다. 특히, 램파의 내부모드분산, 다중모드분산, 그리고 판 경계면에서의 램파의 반사가 시간반전성에 미치는 영향을 정식화하였다 간단한 수치예제를 통해 이 연구에서 제시된 이론적 발견들의 타당성을 검증한다.

• 한국항공우주학회지
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• 제30권1호
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• pp.105-113
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• 2002

본 연구에서는 터보프롭 엔진의 정상상태 성능해석 프로그램을 개발하고 비 장창 및 장착조건에서 성능이 해석되었다. 개발프로그램의 검증을 위해 GASTURB 8.0프로그램의 해석결과와 엔진 제작사의 주어진 성능자료를 비교하였다. 개발 프로그램은 GASTURB 8.0과의 비교 결과 5%내의 오차를 나타내어 프로그램의 신뢰성을 확인할 수 있었다. 성능진단을 위해 선형 및 비선형 GPA프로그램을 개발하였으며, 최적계측변수의 선정을 위한 연구를 수행하였다. 계측변수의 종류의 수가 진단의 정확성에 미치는 영향을 알아보기 위하여 선형 및 비선형 GPA프로그램은 다양한 변수를 이용하여 해석 되었다. 그 결고 적절하게 선택된 계측변수는 보다 적은 계측장비로도 신뢰성있고 경제적인 손상 탐지가 가능함을 확인하였다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.239-240
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• 2012

With advancements in semiconductor device technologies, manufacturing processes are getting more complex and it became more difficult to maintain tighter process control. As the number of processing step increased for fabricating complex chip structure, potential fault inducing factors are prevail and their allowable margins are continuously reduced. Therefore, one of the key to success in semiconductor manufacturing is highly accurate and fast fault detection and classification at each stage to reduce any undesired variation and identify the cause of the fault. Sensors in the equipment are used to monitor the state of the process. The idea is that whenever there is a fault in the process, it appears as some variation in the output from any of the sensors monitoring the process. These sensors may refer to information about pressure, RF power or gas flow and etc. in the equipment. By relating the data from these sensors to the process condition, any abnormality in the process can be identified, but it still holds some degree of certainty. Our hypothesis in this research is to capture the features of equipment condition data from healthy process library. We can use the health data as a reference for upcoming processes and this is made possible by mathematically modeling of the acquired data. In this work we demonstrate the use of recurrent neural network (RNN) has been used. RNN is a dynamic neural network that makes the output as a function of previous inputs. In our case we have etch equipment tool set data, consisting of 22 parameters and 9 runs. This data was first synchronized using the Dynamic Time Warping (DTW) algorithm. The synchronized data from the sensors in the form of time series is then provided to RNN which trains and restructures itself according to the input and then predicts a value, one step ahead in time, which depends on the past values of data. Eight runs of process data were used to train the network, while in order to check the performance of the network, one run was used as a test input. Next, a mean squared error based probability generating function was used to assign probability of fault in each parameter by comparing the predicted and actual values of the data. In the future we will make use of the Bayesian Networks to classify the detected faults. Bayesian Networks use directed acyclic graphs that relate different parameters through their conditional dependencies in order to find inference among them. The relationships between parameters from the data will be used to generate the structure of Bayesian Network and then posterior probability of different faults will be calculated using inference algorithms.

• 한국항해항만학회지
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• 제46권4호
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• pp.367-374
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• 2022

본 연구는 자율운항 선박의 연료 계통 펌프와 청정기를 대상으로 고장을 진단 사례를 제시하였다. 계측된 신호의 시간종속성을 반영한 심층학습(Deep learning) 알고리즘 적용 절차를 구성하고, 장비의 정상 운전상태와 고장 상태에서 계측한 진동 신호를 고장 패턴 학습에 사용하였다. 특히, 진동 신호에 내포된 열화의 시간 종속성을 반영할 수 있는 방법을 찾고자 하였으며, 슬라이딩 윈도우 연산 과정을 가진 Conv1D를 이용하여고장의 시간 종속성을 반영하였다. 또한 계측된 신호의 차수를 2차원에서 3차원으로 확장하여 시간 영역의 특징을 반영할 수 있는 데이터 전처리과정을 고안하였다. Conv1D 알고리즘의 적층과 변수를 결정하는 과정에서 그리드 탐색 기법을 사용하여 초매개변수의 최적 값을 결정하였다. 마지막으로 제안한 데이터 전처리 방법과 시계열 데이터의 시간 종속성을 반영한 Conv1D 모델이 이상 감지 및 고장 진단에 타당성이 있음을 확인하였다.

• Journal of Preventive Medicine and Public Health
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• 제21권1호
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• pp.89-98
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• 1988

While there have been not a few reports on the seroepidemiological characteristics of hepatitis B virus (HBV) infection in Korea, most of them, however, have had several limitations; operational definition of HBV infection, validity of detection methods of HBV serologic markers, size of the study population, and confirmation of the vaccination history against HBV, etc. In order to avoid such limitations, authors randomly selected 1,495 healthy adults among the 217,511 insured (target population) of Korean Medical Insurance Corporation, living in seoul, and tested HBV serologic markers by RIA method and conducted direct interview to them. Although HBV serologic markers (HBsAg, anti-HBs and anti-HBc) of all the subjects were tested, 392(26.2%) of interview failure cases and 361 vaccinee were excluded from the actual population. Finally, the serologic markers tested of 742 nonvaccinee (study population) only were analysed for the seroepidemiologic observation of the natural infection of HBV. The seroepidemiological characteristics of HBV infection in Korea were as follows ; 1. Point prevalence of HBs antigenemia was 11.7(9.1{\sim}14.3)% in male, which was slightly higher than that of female, 9.5($3.7{\sim}15.3$)%. This level was one of the highest among those of Asian-Pacific countries. Decreasing tendency of HBsAg prevalence alter the age of 50 was observed, which seems to be due to selective attrition of HBV chronic carriers among the healthy adults and/or to the limited-lasting duration of the HBs antigenemia, in part. 2. Point prevalence of anti-HBc(78.8% in male,50.9% in female) was higher than that of anti-HBs(65.2% in male,46.6% in female), respectively. And both of them were higher in male than in female. Increasing tendency of the prevalence of both antibodies was observed by age, which seems to be largely due to recurrent infection in adults and to some cumulative effect, in part, of their relatively longer-lasting duration. 3. The level of HBV infection defined by positive for at least one of the 3 serologic markers of HBV by RIA method was 84.7($81.8{\sim}87.6$)% in male and 61.2($51.9{\sim}70.5$)% in female, which was also one of the highest among those of Asian-Pacific countries. The proportion of susceptible population to HBV infection among healthy adults was 15.3% in male and 38.8% in female. 4. The relative frequency of current or past infection and chronic carrier among HBV infected person was estimated. The currently or past infected was estimated 75.7% in male and 71.8% in female, and chronic carrier state, 13.8% in male and 14.1% in female. The analysis of the geometric mean of the antibody titer in anti-HBs positive sera indicated also to be compatible with the above findings, suggesting that active, even though inapparent, infection of HBV occur so frequently among healthy adults in Korea.