• Journal of Life Science
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• v.27 no.12
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• pp.1507-1514
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• 2017

The purpose of this study aimed at examining the antiproliferative effect of kimchi (kimchi B) adding mistletoe extract known as an anticancer function to improve the functions of kimchi. The study investigated the antiproliferative effect through hemocytometer counts and MTT assay, apoptosis induction through DAPI staining, and mRNA expression through RT-PCR using human lung carcinoma A549 cells. The standardized kimchi (Kimchi A) was used as a control group. As a result of hemocytometer counts and the MTT assay, it was found that kimchi samples inhibited the growth of A549 cells in a concentration-dependent manner. Kimchi B induced apoptosis in A549 cells through DAPI staining. The apoptosis induced by kimchi B was associated with the increase in the expression of pro-apoptotic Bax and with the decrease in the expression of anti-apoptotic Bcl-2 and Bcl-xL. Also, kimchi B influenced the increase in the expression of p21 mRNA, but did not have the effect on the expression of p53 mRNA. In conclusion, the antiproliferative effect of kimchi B was due to apoptosis induced by increasing Bax and decreasing Bcl-2, and increasing p21. The findings will be utilized to develop kimchi with the improved function for the patients having cancer.

• The Journal of Korean Medical History
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• v.30 no.1
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• pp.23-31
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• 2017

Euibangyoochui (醫方類聚), the largest medical book in Korea, has medical and historical significance in that it had classified almost all East Asian medical accomplishments before Joseon Dynasty (1392-1910). Focusing on these values, this research investigates Yi'an (醫案), an East Asian tradition of describing clinical encounters and the therapies employed, in Euibangyoochui. By this investigation, this study expected to not only establish how the genre of Yi'an is employed for what purpose in Euibangyoochui, but also to shed a light on the appearance of Yi'an before Joseon Dynasty. At first, this study extracted Yi'an from Euibangyoochui (醫方類聚), as Yi'an does not have a standardized format. In total, the number of extracted Yi'ans is 1,025 with handwork results. Extracted Yi'ans are analyzed statically, in order to find dispersion of Yi'ans for each chapter and its references. Overall, there are 73 chapters of Euibangyoochui, which has a total of 93 chapters, containing Yi'an, while the chapter on gynecology contains the highest number of Yi'ans, 86. Judged from these result, the genre of Yi'an was used diversely and frequently, indicating various messages in Euibangyoochui. To categorize the usage and purpose of writing of Yi'ans in Euibangyoochui, this study considers some examples of Yi'ans and concludes that 3 types of Yi'ans are employed in Euibangyoochui in order to deliver the adequate medical message. One is result-centered Yi'an delivering a broader medical lesson, such as a taboo in treatment or a doctrine in medicine. The second is the concise-styled Yi'an presenting a short effective medical method. The third is multiple-information Yi'an that describes complex information of patients and medical theories, transmitting diverse lessons. Yi'ans in Euibangyoochui refer to 58 medical books. Books written by JangJaHwa (張子和; 1156-1228) are the most cited books, offering almost a quarter of total amount of Yi'ans in Euibangyoochui. This study is meaningful in that it provides basic information, such as numbers, applications, purpose of writing and references of Yi'an in Euibangyoochui. Moreover considering the historic values of Euibangyoochui, this information reflects, on the other hands, overall figures of Yi'an written before publication of Euibangyoochui.

• Quality Improvement in Health Care
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• v.5 no.1
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• pp.42-57
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• 1998

Background : It is increasing the concern for patient satisfaction as a customer information. This study was planned to investigate the activities related to patient satisfaction survey at the Korean hospitals. Methods : We performed the nationwide survey on 235 general hospitals by using the self-administrated checklist from Sep. 9 to Oct. 9, 1996. The response rate were 50.2%. We analyzed the descriptive statistics and chi-square test by SAS software on 118 hospitals. Results : First of all, 62.7% of study hospitals showed to conduct the patient satisfaction survey, and most of hospitals which did not conduct it had a plan to do it within 5 years. The reason that hospitals did not conduct satisfaction survey was due to a lack of administrator's interest or adequate questionnaire form. Second, the bigger, public and being more located in the big city or opened more than 10 years, the more hospitals conducted the patient satisfaction survey. Also, patient satisfaction survey was mainly handled by planning dept. or administrative team. Third, most hospitals had their own way of making questionnaires without proving reliability and validity. The results of the survey were applied to hospital management timely, and were mostly reported to top manager level. Most CEO concerned about the results of satisfaction survey. Fourth, the staffs in charge of survey had problems such as skill related to data analysis and development of questionnaire and they suggested that this problems could be solved through inducing the implementation of the survey results on hospital management, support for the development of standardized questionnaires and increasing the top manager's interests. Fifth, most questionnaires composed of lots of questioning items on hospital equipments and environment, and kindness of hospital employee to patients. Conclusions : Although this study had some limitations in generalization due to low response rate in big hospitals, it is meaningful to find the present state and the problems related to patient satisfaction survey of the general hospitals. We can conclude that there are increasing the concern for patient satisfaction survey among the hospitals nationwide, and it can be needed for technical support related to development of survey tool or method.

• Pediatric Infection and Vaccine
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• v.25 no.1
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• pp.17-25
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• 2018

Purpose: Blood culture is an essential diagnostic tool and requires clear indications, proper techniques, and quality control. We aimed to investigate whether blood cultures in children are appropriate for indications, are performed correctly, and receive proper quality control. Methods: We conducted an online survey targeting pediatric infectious diseases (ID) specialists working in general hospitals and neonatologists (Neo) working at hospitals operating a neonatal intensive care unit in Korea. Results: Approximately 81.1% (30/37) of pediatric ID specialists and 72.2% (52/72) of Neo responded to the survey. Some of the respondents (33.3% of ID and 59.6% of Neo) performed blood culture as a regular test irrespective of the indication. Approximately 40% of ID and 65.4% of Neo ordered only one set of blood culture in patients suspected with bacteremia. The most commonly used disinfectant for skin preparation was povidone-iodine, while the skin preparation method varied by institution. Approximately two-thirds of the institutions were monitoring the blood culture contamination rate, whereas relatively few provided staff with feedback on that rate. In addition, less than half of the institutions were providing regular staff training on blood culture (40% of ID and 28.8% of Neo). Conclusions: The indication and methods of blood culture for children varied according to institution, and few hospitals exert effort in improving the quality of blood culture. Institutions have to strive constantly toward improvement of blood culture quality and evidence-based recommendations for pediatric blood cultures should be standardized.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.11
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• pp.4951-4958
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• 2011

The purpose of this study was availability for the classical test method. The test were called CLSI(Clinical and Laboratory Standards Institute) that was disk diffusion method, the newly designed E-test(made use disk diffusion method) can estimate the MIC and modified broth microdilution method that was standardized. Those tests were observed by MicroScan MicroSTREP plus panel. Target strains were 53 strains of S.pneumoniae and 51 strains of ${\alpha}$-hemolytic streptococci which were separated from the inpatient in university hospital for 6 months from February to August, 2009. The 9 antimicrobial agent of target evaluation were cefotaxime, chloramphenicol, clindamycin, erythromycin, levofloxacin, penicillin, tetracycline, trimethoprim/sulfamethoxazole, and vancomycin. researched comparative analysis both S.pneumoniae and ${\alpha}$-hemolytic streptococci. The result of the high concordance rates in ${\alpha}$-hemolytic streptococci was recognized formally in clinical microbiology laboratory.

• Therapeutic Science for Rehabilitation
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• v.8 no.1
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• pp.73-84
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• 2019

Objective: The purpose of this study is to compare the effect of Lee Silverman Voice Treatment-BIG(LSVT-BIG) intervention which consisted of standardized exercise programs and occupation-based activities for people with Parkinson Disease(PD) on motor functions and quality of life Methods: This study applied a one group pretest-posttest design. The experiment was divided into two parts: pre intervention and post intervention period. Before and after LSVT-BIG intervention, Unified Parkinson's Disease Rating Scale(UPDRS), Time up and go(TUG), Parkinson's Disease Questionnaire-39(PDQ-39) were used to measure the participants' motor functions and quality of life. Based on the LSVT-BIG protocol, three participants received 16 one-hour sessions over 4 weeks by a certified occupational therapist. The results were analyzed by using SPSS. Results: There were improvements in UPDRS and TUG. Additionally, PDQ-39 scores decreased in all participants, which means that their quality of life was improved. Conclusions: The study demonstrated positive effects of LSVT-BIG intervention on motor functions and quality of life of patients with PD.

• Journal of The Korean Society of Clinical Toxicology
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• v.19 no.1
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• pp.1-7
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• 2021

Purpose: The purpose of this study was to conduct a systematic review to investigate the socio-economic benefits of the poison control center (PCC) and to assess whether telephone counseling at the poison control center affects the frequency of emergency room visits, hospitalization, and length of stay of patients with acute poisoning. Methods: The authors conducted a medical literature search of the PubMed, EMBASE, and Cochrane Library databases. Two reviewers evaluated the abstracts for eligibility, extracted the data, and assessed the study quality using a standardized tool. Key results such as the cost-benefit ratio, hospital stay days, unnecessary emergency room visits or hospitalizations, and reduced hospital charges were extracted from the studies. When meta-analysis was possible, it was performed using RevMan software (RevMan version 5.4). Results: Among 299 non-duplicated studies, 19 were relevant to the study questions. The cost-benefit ratios of PCC showed a wide range from 0.76 to 36 (average 6.8) according to the level of the medical expense of each country and whether the study included intentional poisoning. PCC reduced unnecessary visits to healthcare facilities. PCC consultation shortened the length of hospital stay by 1.82 (95% CI, 1.07-2.57) days. Conclusion: The systematic review and meta-analysis support the hypothesis that the PCC operation is cost-beneficial. However, when implementing the PCC concept in Korea in the future, it is necessary to prepare an institutional framework to ensure a costeffective model.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.399-408
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• 2021

The purpose of this study was to determine the effects of simulation-based practice and clinical practice on nursing students' critical thinking disposition and nursing process confidence. This study is a quasi-experimental design using the non-equivalent control group pretest-posttest only design, targeting 103, 4th grade(51=control group, 52=experimental group) in the Department of Nursing at D University. The collected data were analyzed using the SPSS/WIN 23.0 program, and the main research results are as follows. Students who experienced simulation-based practice showed significant improvement in critical thinking tendencies(t=-3.28, p=.001) compared to those who experienced clinical practice. There was no significant difference in nursing process confidence (t=-1.78, p=.079), but it was significantly higher in actual application, collaborative contsistency, and nursing contsistency. As a result, There were no significant difference in some, but it was contfirmed that simulation-based practice improved the critical thinking disposition and nursing process confidence in of nursing students. In addition to clinical practice, it is considered necessary to study simulation-based practice using repetitive practice and standardized patients in a free simulation practice environment.

• Journal of Internet of Things and Convergence
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• v.7 no.4
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• pp.51-58
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• 2021

This study is a quasi-experimental study designed to examine the effects of color therapy on job stress and depression by applying color therapy to intensive care unit nurses. The subjects of this study were S hospital located in S city, a secondary medical institution with 500 beds, P hospital located in B city, and nurses in the intensive care unit of two general hospitals. The data collection period was 8 weeks from November 2, 2020 to December 25, 2020, with 29 patients in the experimental group and 29 in the control group. The data were analyzed by chi-square test, independent t-test and paired t-test using the SPSS WIN 22.0 program. The experimental group applied color therapy twice a day (before and after work) using a standardized canvas frame painted in yellow, red, blue, and three colors, and a total of 20 times for 10 days, and the control group lived and woked as usual without appiled color therapy. As a result of study, the experimental group showed a significant decrease in job stress score by 0.43 points and depression score by 0.26 points compared to the control group

• Archives of Plastic Surgery
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• v.49 no.2
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• pp.266-274
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• 2022

Background Many authors have researched ways to optimize fat grafting by looking for a technique that offers safe and long-term fat survival rate. To date, there is no standardized protocol. We designed a "hydraulic system technique" optimizing the relationship among the quantity of injected fat, operative time, and material cost to establish fat volume cutoffs for a single procedure. Methods Thirty-six patients underwent fat grafting surgery and were organized into three groups according to material used: standard, "1-track," and "2-tracks" systems. The amount of harvested and grafted fat as well as material used for each procedure was collected. Operating times were recorded and statistical analysis was performed to establish the relationship with the amount of treated fat. Results In 15 cases the standard system was used (mean treated fat 72 [30-100] mL, mean cost 4.23 ± 0.27 euros), in 11 cases the "1-track" system (mean treated fat 183.3 [120-280] mL, mean cost 7.63 ± 0.6 euros), and in 10 cases the "2-tracks" one (mean treated fat 311[220-550] mL, mean cost 12.47 ± 1 euros). The mean time difference between the standard system and the "1-track" system is statistically significant starting from three fat syringes (90 mL) in 17.66 versus 6.87 minutes. The difference between the "1-track" system and "2-tracks" system becomes statistically significant from 240 mL of fat in 15 minutes ("1-track") versus 9.3 minutes for the "2-tracks" system. Conclusion Data analysis would indicate the use of the standard system, "1-track," and "2-tracks" to treat an amount of fat < 90 mL of fat, 90 ÷ 240 mL of fat, and ≥ 240 mL of fat, respectively.