• Mass Spectrometry Letters
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• 제15권2호
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• pp.69 -78
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• 2024

The advancement of high-throughput omics technologies and systems biology is essential for understanding complex biological mechanisms and diseases. The integration of proteomics and metabolomics provides comprehensive insights into cellular functions and disease pathology, driven by developments in mass spectrometry (MS) technologies, including electrospray ionization (ESI). These advancements are crucial for interpreting biological systems effectively. However, integrating these technologies poses challenges. Compared to genomic, proteomics and metabolomics have limitations in throughput, and data integration. This review examines developments in MS equipped electrospray ionization (ESI), and their importance in the effective interpretation of biological mechanisms. The review also discusses developments in sample preparation, such as Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX), analytical techniques, and data analysis, highlighting the application of these technologies in the study of cancer or Huntington's disease, underscoring the potential for personalized medicine and diagnostic accuracy. Efforts by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and integrative data analysis methods such as O2PLS and OnPLS extract statistical similarities between metabolomic and proteomic data. System modeling techniques that mathematically explain and predict system responses are also covered. This practical application also shows significant improvements in cancer research, diagnostic accuracy and therapeutic targeting for diseases like pancreatic ductal adenocarcinoma, non-small cell lung cancer, and Huntington's disease. These approaches enable researchers to develop standardized protocols, and interoperable software and databases, expanding multi-omics research application in clinical practice.

• 한국의류학회지
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• 제48권4호
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• pp.729-743
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• 2024

This research explores consumer preferences for materials in different clothing product categories, using web-crawling and text mining techniques. Specifically, the study focuses on the material-related terms found in consumer reviews across three distinct product categories: functional clothing, formal shirts, and knit sweaters. Top-selling products within each category were identified on the Naver Shopping website based on the volume of reviews, and the four most-reviewed products were selected. Six hundred reviews per product were analyzed using the Textom big-data analysis software to determine the frequency of material-related mentions and word associations. The analysis utilized two comparative metrics: product category and usage duration. Our findings reveal notable variations in the material preferences mentioned by consumers across different product categories. The study suggests a need to re-evaluate existing standardized review criteria to better reflect consumer interests specific to each product category. Additionally, an increase in material-related terms in reviews over one month indicates the potential importance of extending the duration of product reviews to enhance the accuracy of information that reflects longer-term consumer experiences with material quality.

• Nuclear Engineering and Technology
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• 제56권10호
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• pp.4127-4133
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• 2024

Noise reduction in low-dose positron emission tomography (PET) is a well-researched topic aimed at reducing patient radiation doses and improving diagnosis. Software-based noise reduction mainly improves the contrast between regions by reducing the variation of the acquired image. However, it should be performed under appropriate parameters to reduce discrimination. We propose a method that derives optimal noise-reduction parameters using the multi-scale structural similarity index measure and visual information fidelity, which are metrics for image quality assessment. Simulation and experimental studies demonstrated the viability of the proposed algorithm. The contrast-to-noise ratio value of the denoised reconstruction slice, which was used as the optimal parameter, increased approximately three times compared to that of the low-dose slice while preserving the resolution. The results indicate that the proposed method successfully predicted the parameters according to the noise-reduction algorithm and PET system conditions in the sinogram domain. The proposed algorithm should help prevent misdiagnosis and provide standardized medical images for clinical application by performing appropriate noise reduction.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제7권6호
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• pp.614-629
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• 2001

21세기 지식기반 사회로의 정착화와 글로벌 인터넷화 추진으로 소프트웨어는 대형화 및 복잡화 되어가고 있으며, 그 수요는 폭주하는 실정이다. 이에, 표준화된 컴포넌트의 개발 및 유통을 통한 재사용의 활성화가 최근 산업계와 학계에서 중요한 이슈로 부각되는 실정이다. 현재, 컴포넌트의 재사용을 위하여 해외 컴포넌트 판매 마켓에서는 자사별 판매하는 제품의 특성에 따라 정보를 제공하고 있으나, 상이하게 정보를 정의하고 있으며, 그 정보의 수준이 미약하며, 표준화되지 않은 메타정보를 제공하고 있다. 즉, 국제표준 ISO 11179에 기반한 컴포넌트 데이타 레지스트리의 구축이 이루어지고 있지 않다. 국내에서는 2001년도에 공용 컴포넌트의 출시를 추진하고 있다. 따라서, 개발된 컴포넌트의 정보 공유와 유통을 위한 지원도구로서 표준화된 컴포넌트의 메타정보를 서비스 해주는 시스템이 필요하다. 본 논문은 컴포넌트 재사용 활성화의 일환으로 체계적인 정보공유와 정보유통을 위하여, 제품화된 공용 컴포넌트에 대한 표준화된 메타정보의 등록 및 관리를 제공해주는 ISO 11179 표준에 근거한 컴포넌트 유통환경의 도구로서, 컴포넌트 메타데이타 레지스트리(C_MDR) 시스템을 제시한다. 이를 위해, 컴포넌트에 대한 메타정보의 명세 플랫폼을 제시하고, 이 플랫폼에 따라 메타정보를 정의하고, 또한 타 시스템과의 정보의 호환성 증진을 위해 XML을 이용해 표현한다. 그리고 시스템 디자인을 위해 3계층 아키텍쳐 표현방식을 적용하여 단순하고 이해성 있는 시각화 모델링을 제공한다. 시스템 구현은 웹 상의 인터넷을 통해 컴포넌트 메타정보를 서비스를 할 수 있도록 시스템을 구축하며, ASP 개발언어와 PC용 RDMS 오라클을 사용한다. 이로서, 제품화된 컴포넌트j에 대한 유통 메타정보의 표준화를 기할 수 있고, 재사용을 위한 유통지원도구로서 지원이 가능할 것이다.

• 한국환경보건학회지
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• 제43권3호
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• pp.223-232
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• 2017

Objectives: In response to increased interest in the safety of children's products, a risk management system is being prepared through exposure assessment of hazardous chemicals. To estimate exposure levels, risk assessors are using deterministic and probabilistic approaches to statistical methodology and a commercialized Monte Carlo simulation based on tools (MCTool) to efficiently support calculation of the probability density functions. This study was conducted to analyze and discuss the usage patterns and problems associated with the results of these two approaches and MCTools used in the case of probabilistic approaches by reviewing research reports related to exposure assessment for children's products. Methods: We collected six research reports on exposure and risk assessment of children's products and summarized the deterministic results and corresponding underlying distributions for exposure dose and concentration results estimated through deterministic and probabilistic approaches. We focused on mechanisms and differences in the MCTools used for decision making with probabilistic distributions to validate the simulation adequacy in detail. Results: The estimation results of exposure dose and concentration from the deterministic approaches were 0.19-3.98 times higher than the results from the probabilistic approach. For the probabilistic approach, the use of lognormal, Student's T, and Weibull distributions had the highest frequency as underlying distributions of the input parameters. However, we could not examine the reasons for the selection of each distribution because of the absence of test-statistics. In addition, there were some cases estimating the discrete probability distribution model as the underlying distribution for continuous variables, such as weight. To find the cause of abnormal simulations, we applied two MCTools used for all reports and described the improper usage routes of MCTools. Conclusions: For transparent and realistic exposure assessment, it is necessary to 1) establish standardized guidelines for the proper use of the two statistical approaches, including notes by MCTool and 2) consider the development of a new software tool with proper configurations and features specialized for risk assessment. Such guidelines and software will make exposure assessment more user-friendly, consistent, and rapid in the future.

• 정보처리학회논문지D
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• 제10D권1호
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• pp.85-100
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• 2003

오늘날의 컴퓨팅 시스템은 인터넷을 사용하여 비즈니스 거래와 분산 업무 처리로 확대되어가고 있으며 정보 기술은 점차적으로 재사용성과 독립성 그리고 이식성을 가진 컴포넌트를 기반으로 한 응용 개발이 확산되고 있다. 컴포넌트 개발 형태는 코드의 재사용이나 클래스 라이브러리보다 좀 더 발전된 형태의 부품개발 형태로서, CBD(Component Based Development)를 기초로 한다. 그러나, CBD를 이용하여 새로운 컴포넌트를 구축하는 비용의 증가와 함께 비즈니스 요구사항에 맞는 컴포넌트 개발을 위한 노력이 필요하며, 빠르게 정확한 컴포넌트 정보를 웹 상에서 지원할 수 있도록 시스템 측면에서 정규화 형태의 컴포넌트 모델이 요구되고 있다. 본 논문에서는 사용자의 요구사항에 접근하고 웹 상에서 빠르고 신속하게 애플리케이션이 개발되는데 목적을 두고 있으며, 네트워크 상에서 비즈니스 도메인을 기반한 가장 소규모 단위의 분산 컴포넌트를 대상으로 인터페이스 명세를 제공하고자 한다. 분산 컴포넌트 내부와 외부 관계를 담고 있는 명세는 사용자 중심의 컴포넌트를 제공하기 위해서 웹 상에서 요구사항을 작성하고 결국 이들은 조합되어 e-비즈니스 컴포넌트 명세 제공이 요구된다. 따라서 본 논문에서는 사용자가 분산 컴포넌트를 등록하고, 이에 대한 컴포넌트 정보를 검색말 수 있는 e-BCOS(e-Busines Component System)을 설계 구현한다. e-BCOS는 컴포넌트 등록. 검색을 위한 에이전트 시스템으로, 비즈니스 도메인에서의 분산 컴포넌트의 e-비즈니스 컴포넌트 개발을 통해 재사용성을 증대시키고, 웹 상에서 애플리케이션 구축을 빠르고 신속하게 처리될 수 있도록 하며, 사용자가 쉽게 컴포넌트에 관한 정보를 얻고 이해할 수 있도록 해준다. 또한 명세의 공유와 유통을 원활히 하기 위해서 XML(extensible Markup Language)로 명세를 표현하여 사용자의 다양한 욕구를 충족시키도록 한다. 따라서, e-BCOS는 에이전트에 의해서 효율성 증대와 시간 절약 및 신뢰성과 유지보수성을 증대할 수 있는 잇점을 가진다.

• 한국산학기술학회논문지
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• 제16권4호
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• pp.2749-2756
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• 2015

최근 데이터의 질이 높아짐에 따라 영상을 처리하는데 많은 시간이 소모되는 문제가 제기되어 영상 처리 알고리즘의 가속화가 필요하게 됨으로써, 기존의 CPU와 CUDA(Compute Unified Device Architecture) 기반의 인식 시스템에서 연산속도와 성능이득 비교를 위해 OpenMP를 가지고 측정할 수 있는 문자 인식시스템으로 학습된 문자데이터가 입력되면 매칭이 가장 잘 되는 영상의 영역을 인식하는 환경으로 구현하여 각 영문 알파벳의 글씨체가 일정하고 크기가 규격화 되어 있으므로 문자를 학습하고 문자 정합도를 계산하기 위한 영상 매칭 방법을 구현하게 되었다. GPGPU(General Purpose GPU)프로그래밍 플랫폼 기술인 CUDA연산 기법을 이용하여 알고리즘을 빠르고 효율적으로 처리하는 OpenMP에서 인텔 i5 2500의 네 개의 코어를 사용하여 인식 할 때, 기존 CPU의 성능보다 4배의 속도가 나오지 않고 데이터의 분할과 병합 연산의 지연으로 인해 약 3.2배의 속도로 향상되는 가속화 방법을 제안하고 그래픽카드에서 처리하는 병렬처리 결과, 순차적 연산을 수행하였던 CPU 기반의 처리에 비해 성능이득이 약 21X(배)로 향상됨을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.33-37
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• 2016

Skin cancer is one of the most common cancers worldwide, including in Iran. Variations in its incidence rate among geographical areas are due to various contributing factors. Since there has been a lack of studies on this topic in our country, the present spatial analysis of skin cancer incidence in Iran in 2009 was conducted using data from the cancer registry system for the country. The reported incidences of the disease were standardized on the basis of the World Health Organization population and the direct method. Then the data were inserted into the GIS software, and finally, using the analysis of hot spots (Getis-Ord Gi), high-risk areas were drawn. Provinces that were 1.9 SD higher or lower than the national average were considered hot spots or cold spots, with significance at the level of 0.05. In 2009, a total of 9,964 cases of skin cancer occurred, 3,696 in women and 6,268 in men (standardized incidence rates of 15.8 and 22.6, respectively). The results of the study showed that in men and women, the disease demonstrated high incidence in the central provinces and desert regions. In women, Yazd Province and in men, Qom Province had significant hot spots (p <0.05). While Isfahan, Markazi, Tehran and Kurdistan provinces were expected to be hot spots, the differences from the national average were not significant at the 0.05 level. As well, the provinces of Sistan Va Baluchistan, Kerman, and Hormozgan were identified as cold or low-risk disease regions (p <0.05). The central provinces of the country due to hot weather conditions, more solar radiation, and closer vicinity to the central desert of Iran demonstrated higher incidence rates for skin cancer, so further epidemiological studies into the etiology and early detection are essential in these areas.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.53-57
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• 2016

Colorectal cancer is one of the most common cancers. Due to demographic changes, it is predicted that the incidence of this cancer will increase. Variations of its incidence rate among geographical areas are due to various contributing factors. Since there have been a lack of studies on this topic in our country, the present assessment of spatial patterns of colorectal cancer incidence in Iran was performed. In this ecological study, the new cases of colon cancer were extracted from Cancer Registry Center report of the Health Deputy of Iran in 2009. The reported incidences of the disease were standardized on the basis of the World Health Organization population and the direct method. Then the data were inserted into the GIS software, and finally, using the analysis of hot spots (Getis-Ord Gi) high-risk areas were drawn. Provinces that are higher or lower than the national average (1.9 SD) were considered hot spots or cold spots, significant at the level of 0.05. A total of 6,210 cases of colorectal cancer were registered in Iran in 2009, of which 3,727 were in men and 2,783 in women (age-standardized rates of 11.3 and 10.9 per 100,000 population, respectively). The results showed that in central and northern Iran including Isfahan, Qom, Tehran, Qazvin and Mazandaran significant hot spots in men were present (p <0.05). In women also we have high incidence in northern and central states: Mazandaran province (p<0.01) and the province of Tehran (p<0.05) had higher incidences than the national average and were apparent as significant hot spots. Analysis of the spatial distribution of colorectal cancer showed significant differences between different areas pointing to the necessity for further epidemiological studies into the etiology and early detection.

• 한국산업보건학회지
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• 제32권3호
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• pp.242-252
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• 2022

Objectives: Firefighters and police officers are exposed to various occupational hazards. No studies in Korea have investigated the occurrence of cancer by type of cancer for the two occupations. This study aims to investigate the risk of occurrences associated with types of cancers in firefighters and police officers. Methods: Utilizing National Health Insurance(NHI) Claims data from 2006-2015, the study included 8,871,468 general workers, 25,001 firefighters, and 102,274 police officers. Using general workers as a control group, we calculated the standardized incidence ratios(SIR) by types of cancer for firefighters and police officers. After calculating the SIR for all subjects, the SIR was calculated by stratifying according to gender. Results: SIR of colon cancer 1.38(95% CI, 1.11-1.69), cancer of the liver and intrahepatic bile ducts 1.27(95% CI, 1.04-1.54), and 1.88(95% CI, 1.28-2.65) bladder cancer were higher firefighters than general workers. SIR of Lip, oral cavity, and pharynx 1.26(95% CI, 1.07-1.47), Stomach 1.14(95% CI, 1.06-1.23), colon 1.33(95% CI, 1.21-1.46), liver and intrahepatic bile ducts 1.21(95% CI, 1.10-1.32), pancreas 1.24(95% CI, 1.02-1.49), other skin 1.60(95% CI, 1.26-2.00), bladder 1.27(95% CI, 1.04-1.54), other urinary tract 1.46(95% CI, 1.27-1.68), other parts of central nervous system 1.68(95% CI, 1.10-2.46) were higher police officers than general workers. Conclusions: Both firefighters and police officers are exposed to various cancer occurrence risks, necessitating the development of occupational medical protection measures to reduce risk exposure factors.