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The Effect of Glasthma Syrup in Asthma: a study protocol for a triple-blind randomized controlled trial

  • Derakhshan, Ali Reza;Saeidinejat, Shahin;Khadem-Rezaiyan, Majid;Asnaashari, Amir-Mohammad-Hashem;Mirsadraee, Majid;Salari, Roshanak;Jabbari-Azad, Farahzad;Jalali, Shima;Jalali, Shabnam
    • Journal of Pharmacopuncture
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    • v.25 no.3
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    • pp.233-241
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    • 2022
  • Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.

A Study on the Decontamination of Cs-137 and Sr-90 Contained in the Liquid Radioactive Waste Discharged from the Spent Fuel Storage Tank Using Microalgae (미세조류를 이용한 사용후핵연료 저장조에서 배출되는 방사성 폐액에 함유된 Cs-137 및 Sr-90 제염에 관한 연구)

  • Kim, Tae Young;Park, Hye Min;Song, Yang Soo;Lee, Un Jang
    • Resources Recycling
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    • v.31 no.5
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    • pp.20-25
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    • 2022
  • In this study, the applicability of microalgae was evaluated for eco-friendly decontamination of cesium-137 (Cs-137) and strontium-90 (Sr-90), which are radioactive nuclides contained in radioactive waste. The monolithic radioactive solution used in the experiment was manufactured at a concentration of 1.5 Bq/mL Cs-137 and 1.0 Bq/mL Sr-90 by diluting a standard radioactive solution and distilled water. This experiment used two types of microalgae, Chlorella Vulgaris was used for Sr-90 decontamination and Hematococcus pluvialis for Cs-137 decontamination. The experimental method is to put the microalgae cultured for 2 weeks into a bottle with a semi-permeable membrane, and then put the bottle in which the microalgae was put into the manufactured radioactive solution, so that the microalgae and the radioactive solution react through the semi-permeable membrane for 48 hours. For the radioactivity concentration analysis of each sample, a gamma-ray nuclide analyzer was used for Cs-137, a γ-ray isotope, and a Liquid Scintillation Count(LSC) was used f or Sr-90, a β-ray isotope. As a result of the experiment, it was confirmed that about 88.0 % of Cs-137 and about 89.7 % of Sr-90 could be decontaminated, and about 98.6 % of Sr-90 was finally able to be decontaminated by the two-stage decontamination method.

Predicting Unsaturated Soil Water Content Using CIELAB Color System-based Soil Color (CIELAB 색 표시계 기반 토색을 활용한 불포화토 함수비 예측 연구)

  • Baek, Sung-Ha;Park, Ka-Hyun;Jeon, Jun-Seo;Kwak, Tae-Young
    • Journal of the Korean Geotechnical Society
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    • v.39 no.2
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    • pp.31-42
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    • 2023
  • A study was conducted to use soil color obtained from digital im ages as an indicator of soil water content. Digital images of Jumoonjin standard sand with five different water contents were captured under nine different lighting conditions. Through digital image processing, the soil color of the sample was obtained based on the CIELAB color system, and the effect of lighting conditions and water content on the soil color was analyzed. The results indicated that L* showed a high correlation with illuminance, whereas a* and b* showed a high correlation with color temperature. As the water content increased, L*, which represents the brightness of the soil color, decreased, and a* and b* increased. Therefore, the soil color changed from green and blue to red and yellow. Based on the regression analysis results of lighting conditions, water content, and soil color, a water content predicting method based on the soil color of silica-based sand photographed under irregular light conditions was proposed. The proposed method can predict the water content with a m axim um error of 0.29%.

The Estimation of the Population by Using the Estimated Appropriate Rate Based on Customized Classification of Agriculture, Livestock and Food Industry (농축산식품산업 특수분류 기반 추정적격률을 이용한 모집단 추정 )

  • Wee Seong Seung;Lee MinCheol;Kim Jin Min;Shin Yong Tae
    • KIPS Transactions on Software and Data Engineering
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    • v.12 no.3
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    • pp.117-124
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    • 2023
  • Through reorganization in 2008, The ministry of Agriculture, Food and Rural Affairs integrated management of the food industry by transferred functions which was scattered in the Ministry of Health and Welfare, and established comprehensive policies covering the primary, secondary, and tertiary industries. In the agricultural industry sector, new business concepts such as smart farm and food tech have recently emerged alongside the fourth industrial revolution. In order for the Ministry of Agriculture, Food, and Rural Affairs to develop appropriate policies for the fourth industrial revolution, it is necessary to accurately estimate the size of agricultural and livestock-related businesses. In 2017, the Ministry of Agriculture, Food, and Rural Affairs initiated research for the agriculture, livestock and food industry's special classification, which was approved by the National Statistical Office in 2020. The estimation of the agriculture, livestock and food industry's size based on special classification is crucial because it has a substantial impact on the formulation and significance of policies. In this paper, the appropriate rate was derived from samples extracted from the special classification and the Korean standard industrial classification. Proposed are a method for estimating the population of the agricultural and livestock food industry, as well as a method for calculating the appropriate rate that more accurately reflects the population than the method currently in use.

Is the t-test insensitive than the bootstrap method in the P300-based concealed information test? (P300 숨긴정보검사에서 t 검증이 부트스트랩 방법보다 덜 민감한가?)

  • Eom, Jin-sup;Sohn, Jin-Hun;Park, Mi-Sook
    • Korean Journal of Forensic Psychology
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    • v.11 no.1
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    • pp.21-36
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    • 2020
  • In P300-based concealed information test (P300 CIT), it evaluates whether the P300 amplitude for the probe is significantly greater than that of the irrelevant to determine if the suspect is telling a lie. An independent sample t-test or a bootstrap method can be used as a statistical test to make that decision. Rosenfeld et al. (2004) used the bootstrap method, claiming that "t tests on single sweeps are too insensitive to use to compare mean probe and irrelevant P300s within individuals" and their method has been accepted to date. The purpose of the study is to evaluate whether the power of t-test is lower than that of the bootstrap method in the P300 CIT. The Monte Carlo study was conducted by using EEG collected from 39 participants. The results showed that the type I error rates of the t-test and the percentile bootstrap method were similar and the power of the percentile bootstrap method was slightly higher than that of the t-test. The type I error rates of the t-test and the percentile bootstrap method were slightly lower than the significance level and the powers of the two tests were also slightly lower than that of the theoretical t-test. On the other hand, the type I error rate and power of the standard error Bootstrap method were the same as those of the theoretical t-test and its power was .012 ~ .081 higher than that of t-test depending on experimental conditions.

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An Experimental Study on the Load-settlement Behavior and Settlement-reducing Effect of the Disconnected Piled Raft Foundation (말뚝보강기초의 하중-침하량 거동 및 침하감소효과에 대한 실험적 연구)

  • Lee Yeong-Saeng;Hong Seung-Hyeun
    • Journal of the Korean Geotechnical Society
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    • v.22 no.4
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    • pp.95-104
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    • 2006
  • For the interests in the economical and safe design of foundation system, the concern on the piled raft or disconnected piled raft foundation system is increasing now. In this study, the behavior and the effects of the disconnected piled raft foundation not studied actively in this country were examined using the triaxial compression tests in place of laboratory model tests. The triaxial test samples were prepared with Jumunjin standard sand and the carbon rods, which simulate the ground soil and piles respectively. After the sample in which carbon rods were arranged was laid inside the triaxial chamber, the confining pressure was applied and then loading test was conducted. To analyze the reinforcing effects of the disconnected piled raft foundation, a few number of tests were carried out by changing the number, the diameter and the length of the model piles. As a result of this study, in the disconnected piled raft foundation system, even though the number of pile is few and the diameter of pile is small, the settlement of the foundation system decreased greatly.

A simple method to determine lycopene in solid supplementary food preparations using saponification and liquid chromatography (비누화 및 액체크로마토그래프를 활용한 고상 건강기능식품 중 라이코펜 분석법 개발)

  • Young Min Kim;Ye Bin Shin;Min Kyeong Kwon;Jin Hwan Kim;Ji Seong Kim;Dong-Kyu Lee;Myung Joo Kang;Yong Seok Choi
    • Analytical Science and Technology
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    • v.36 no.3
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    • pp.105-112
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    • 2023
  • Lycopene, a carotenoid hydrocarbon is known to have effects on reducing cardiovascular risk factors, blood lipids, and blood pressure. Thus, a lot of supplementary foods with lycopene in several dosage forms like soft capsule filled with liquid and hard capsule filled with powder are available in a market. Recently, however, our research group found that the lycopene assay in Supplementary Food Code of South Korea is only valid for oily lycopene preparation. Thus, here, we developed a simple method to determine lycopene in solid preparations for Supplementary Food Code of South Korea using saponification and liquid chromatography with an absorbance detector. The method was validated following Ministry of Food and Drug Safety guidelines. All validation parameters observed in this study were within acceptable criteria of the guidelines (selectivity, linearity of r2 ≥ 0.991, lower limit of quantification of 0.0149 mg/mL, accuracy as recovery (R) between 92.70 and 97.18 %, repeatability as relative standard deviation (RSD) values of R between 0.85 and 1.59 %, and reproducibility as the RSD value of interlaboratory R of 3.70 %). Additionally, the practical sample applicability of the validated method was confirmed by accuracy between 98.81 and 101.59 % observed from its lycopene certified reference material (CRM) analyses. Therefore, the present method could contribute to fortify the supplementary food safety management system in South Korea.

The Relationship between Foreign Ownership, Executive Compensation and Firm Performance in the Korean Export Manufacturing SMEs (한국 수출제조 중소기업의 외국인지분율 및 경영자보상과 기업성과 간의 관계)

  • Kim, Dong-Soon;Lim, Seo-Ha
    • Korea Trade Review
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    • v.41 no.1
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    • pp.67-90
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    • 2016
  • This study examines whether there is any significant relation between executive compensation and future firm performance for the Korean export manufacturing small and medium-sized firms. We sorted the whole sample firms into the sub-groups of 10 deciles by firm size and the KSIC standard. We found the following empirical results. First, Korean export manufacturing small and medium-sized firms typically showed lower or even negative profitability in terms of return on equity and operating profit ratio to sales. Foreign equity ownership is very low with an average of 3.77%. Second, for the firms with higher ratio of excess executive compensation to asset had lower future firm performance. It implies that the typical owner-manager in Korean export manufacturing SMEs earns excess pay, but do not contribute much to firm performance. Third, as for future cumulative abnormal returns for future one- and three-year periods, firms with higher owner-executive pay had lower returns compared with firms with lower pay. So the stock market investors set a lower value on them. Fourth, there is a positive relation between excess executive pay and executive overconfidence, and it implies that owner-CEOs with higher pay may become overconfident, thereby lowering future firm performance somehow.

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Design Improvement Based on the Analysis of Informational Materials for University Hospital Inpatient Hospitalization (대학병원 입원생활 안내문의 현황 분석과 디자인 개선 제안)

  • Kim, Ye Ji;Paik, Jin Kyung
    • Design Convergence Study
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    • v.14 no.5
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    • pp.1-14
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    • 2015
  • The purpose of this research is to analyze the current status of hospital life guides in Korean and overseas hospitals, draw problems, and propose a design improvement. in order to improve the visual convenience and efficiency of information delivery of hospital life guidelines. As a result of examining and analyzing the current status of the notice on hospital life in 16 hospitals at home and abroad, problems such as information selection without certain standard, increase of items due to unnecessary items, and forms that do not consider the convenience for notice use were discovered. In order to solve them, this study suggested a survey questionnaire for finding detailed improvements, and it divided the participants into two groups of 50 patients/nurses and 50 nurses in each. The study carried out a user awareness investigation and survey on the efficiency and understanding of information, number and importance of items, and color and form, and then made another sample notice to conduct a detailed survey on color and form. As a result, the study could identify that important items for each users were different. It is considered that a new design with improved visual convenience of users and efficiency of information delivery, by applying layout and graphic elements as well as selecting information that meets consumer demand, will be proposed based on this.

Determination of the presence of benzene in vitamin drinks using headspace - solid phase microextraction and gas chromatography - mass spectrometry (Headspace Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry를 이용한 비타민드링크 제품 중 Benzene의 미량분석)

  • Kim, Jong-Hun;Lee, Kyung-Min
    • Analytical Science and Technology
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    • v.20 no.3
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    • pp.237-245
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    • 2007
  • The presence of benzene in 31 products of vitamin drinks purchased from 20 retail outlets was determined using headspace solid phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS). The sample (25 ml) was stirred at 1200 rpm for 4 min using a magnetic bar with a $100{\mu}m$ SPME fiber as an adsorbent for benzene which was then desorbed from the fiber for 1 min in the GC injector. Quantitation was achieved using the standard addition method. The limit of detection was determined as 0.56 ng/ml and over a concentration range 0-40 ng/ml the coefficient of correlation was greater than 0.999. The concentration of benzene in the drinks examined was in the range not detectable to 47.35 ng/ml. Benzene was detected in 15 of the drinks with concentration in 5 of them greater than 10 ng/ml which is the limit set for the presence of benzene in the Drinking Water Regulations. The concentrations of benzene in the 5 drinks which exceeded the limit of 10 ng/ml were 16.99, 35.14, 16.03, 47.35 and 14.28 ng/ml respectively.