• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.5031-5035
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• 2016

Docetaxel, recognized as a stabilizing microtubule agent, is frequently administrated as a first line treatment for prostate cancers. Due to high side effects of monotherapy, however, combinations with novel adjuvants have emerged as an alternative strategy in cancer therapy protocols. Here, we investigated the combined effects of stattic and docetaxel on the DU145 prostate cancer cell line. Cytotoxicity was evaluated by MTT assay. To understand molecular mechanisms of stattic action, apoptotic related genes including Bcl-2, Mcl-1, Survivin and Bax were evaluated by real-time RT-PCR. Alteration in the expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 genes and Bax/Bcl-2 ratio were investigated via the $2^{{\Delta}{\Delta}CT}$ method. The $IC_{50}$ values for docetaxel and stattic were $3.7{\pm}0.9nM$ and $4.6{\pm}0.8{\mu}M$, respectively. Evaluation of key gene expression levels revealed a noticeable decrease in antiapoptotic Bcl-2 and Mcl-1 along with an increase in pro-apoptotic Bax mRNA levels (p<0.05). Our results suggest that combination of a STAT3 inhibitor with doctaxel can be considered as a potent strategy for induction of apoptosis via increasing Bax mRNA expression.

• Journal of the Korean Geotechnical Society
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• v.16 no.1
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• pp.227-234
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• 2000

Soilcrete has been a traditional material for pavement and soft ground improvement techniques. However, since the durability is not excellent and the quality is not consistent, it has not been used for various purposes up to date. However, with the increase of naturally oriented needs for light traffic roads such as pedestrian roads of garden, golf courses and sidewalks, the cases of the high strength soilcrete paving have been increased lately. This study aims at making a reference table of mix design in accordance with the required design specifications fur the high strength soilcrete admixtured with the pozzolanic cement by using a statistical experimental method. The treated soil is the clay which is widely found in Korea. As the results of this study, we could derive an effective reference mix design table for the clay treated with the pozzolanic cement stabilizer in accordance with the compressive strength of $50~150kg/cm^2$ soilcrete.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.10 no.3
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• pp.226-232
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• 2000

Corrosion mechanisms by molten steel and slag were investigated in the zirconia/graphite composite as a material of submerged entry nozzle (SEN) using for producing high quality steel. Most of corrosions were started by the dissolution of zirconia particles into molten steel and oxidation of graphite, but subsequently three modes of corrosion were observed. Firstly, the penetration of slag into zirconia matrix was induced to the diffusion of stabilizing agent outward cubic zirconia grains, and the destabilization of cubic to fine monoclinic zirconia particles, which is enhanced to the decomposition and dissolution of them into slag. Secondly, molten slag penetrates into large cubic zirconia particles along grain boundary and decomposed them to fine cubic grains, which is also enhanced to the dissolution of zirconia grains into slag. Lastly, reaction between carbon and cubic zirconia was formed porous ZrC and enhanced the dissolution of it into slag.

• Korean Journal of Biological Psychiatry
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• v.5 no.2
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• pp.227-234
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• 1998

Objective : Many evidences suggest that patients with bipolar disorder have functional abnormalities in their postreceptor signal transduction pathways, and mood stabilizing effect of lithium is exerted by modulating this dysfunctioning system. Carbamazepine, an antiepileptic agent, is also known to be effective in the treatment and prevention of bipolar disorder. But the precise mechanism of action of the drug is still poorly understood. This study was performed to elucidate the possible therapeutic mechanism of carbamazepine. Method : The effects of chronic carbamazepine administration on protein kinase A and protein kinase C activities in frontal cortex of rat brain after 2 weeks of drug administration were measured and compared with those of control subjects. Results : Mean(${\pm}SE$) value of activity(phosphate transfer ${\mu}mol/mg$ of $protein{\cdot}min$) of protein kinase A in control and test group was $0.249563{\pm}0.036$ and $0.539853{\pm}0.078$, and that of protein kinase C was $0.654817{\pm}0.053$ and $1.146205{\pm}0.052$ respectively, being increased in test group. And differences between the two groups were statistically significant for both enzymes(protein kinase A ; p<0.01, protein kinase C ; p<0.001). Conclusion : These results show that chronic carbamazepine administration increases protein kinase A and C activities, and concerning the possible mode of therapeutic action in bipolar disorder it is suggested that enhanced enzymes phosphorylate receptor-G-protein-effector complexes to dampen hyperfunctioning neuronal activity and thus stabilize the system.

• International Journal of Highway Engineering
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• v.20 no.4
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• pp.21-26
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• 2018

PURPOSES : The objective of this study is to evaluate the application of soil stabilization method for soft shoulder construction in the iRoad Project of Sri Lanka. METHODS : Firstly, the quantitative analysis of soil strength improvement due to soil stabilization was done for soil samples collected from iRoad construction sites. Two types of soils were selected from iRoad Project sites and prepared for soil stabilization testing by the Road Development Authority. Secondly, the appropriate stabilizer was selected at given soil type based on test results. Two different stabilizers, ST-1 and ST-2, produced in Korea were used for estimating soil strength improvements. Finally, the optimum stabilizer content was determined for improving shoulder performance. The uniaxial compressive strength (UCS) test was conducted to evaluate the strength of stabilized soil samples in accordance with ASTM D 1633. The use of bottom ash as a stabilizer produced from power plant in Sri Lanka was also reviewed in this task. RESULTS : It is found from the UCS testing that a 3% use of soil stabilizer can improve the strength up to 2~5 times in stabilized soft shoulder soils with respect to unstabilized soils. It is also observed from UCS testing that the ST-1 shows high strength improvement in 3% of stabilizer content but the strength improvement rate with increase of stabilizer content is relatively low compared with ST-2. The ST-2 shows a low UCS value at 3% of content but the UCS values increase significantly with increase of stabilizer content. When using the ST-2 as stabilizing agent, the 5% is recommended as minimum content based on UCS testing results. Based on the testing results for bottom ash replacement, the stabilized sample with bottom ash shows the low strength value. CONCLUSIONS : This paper is intended to check the feasibility for use the soil stabilization technique for shoulder construction in Sri Lanka. The use of soil stabilizer enables to improve the durability and strength in soft shoulder materials. When applying the bottom ash as a soil stabilizer, various testings should be conducted to satisfy the specification criteria.

• Biomolecules & Therapeutics
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• v.24 no.1
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• pp.99-107
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• 2016

Triclosan is an antimicrobial or sanitizing agent used in personal care and household products such as toothpaste, soaps, mouthwashes and kitchen utensils. There are increasing evidence of the potentially harmful effects of triclosan in many systemic and cellular processes of the body. In this study, we investigated the effects of triclosan in the survivability of cultured rat neural stem cells (NSCs). Cortical cells from embryonic day 14 rat embryos were isolated and cultured in vitro. After stabilizing the culture, triclosan was introduced to the cells with concentrations ranging from $1{\mu}M$ to $50{\mu}M$ and in varied time periods. Thereafter, cell viability parameters were measured using MTT assay and PI staining. TCS decreased the cell viability of treated NSC in a concentration-dependent manner along with increased expressions of apoptotic markers, cleaved caspase-3 and Bax, while reduced expression of Bcl2. To explore the mechanisms underlying the effects of TCS in NSC, we measured the activation of MAPKs and intracellular ROS. TCS at $50{\mu}M$ induced the activations of both p38 and JNK, which may adversely affect cell survival. In contrast, the activities of ERK, Akt and PI3K, which are positively correlated with cell survival, were inhibited. Moreover, TCS at this concentration augmented the ROS generation in treated NSC and depleted the glutathione activity. Taken together, these results suggest that TCS can induce neurodegenerative effects in developing rat brains through mechanisms involving ROS activation and apoptosis initiation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.29 no.2 s.43
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• pp.131-147
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• 2003

In the 21st century, the development of cosmetics is led to pursue the high functionality of cosmetics with excellent effectiveness and safety. As Cosmetic Act took effect in 2000, functional cosmetics is provided in the law. As a result, the research and development of functional cosmetics has continually increased, and the number of patent applications in functional cosmetics has also rapidly increased as a plan for preoccupying in the functional cosmetics age. Now, the cosmetic industry has a great interest in developing anti-wrinkle cosmetics among functional cosmetics, because women's desire for having young resilient skin has increased since Korea entered an aging society thanks to the advanced medical technology. The patent application trends of anti-wrinkle cosmetics at home since 2000 particularly show the rapid increase in the applications in natural plant extracts. It may be because Korean consumers preference of vegetable cosmetics has resulted in the development of raw materials based on the traditional medicine. As for the existing preparation such as Retinoid or Ascorbic acid, the patent application itself will be an essential technical element in the future because patent applications are filed in the field of a preparation of cosmetics for stabilizing ingredients, reducing skin irritability or promoting absorbance, and in the field of cosmetic formulation technology. As there are many studies on the causes of skin wrinkles, it is expected that new raw materials of cosmetics can be developed due to new mechanisms, and that the number of patent applications in new technologies will increase due to a change in the thought of cosmetics accompanied by the integration of cosmetics with biotechnology using Genetic Engineering, including the practical application of the medicine previously used far treating skin diseases to an anti-wrinkle agent and the mass production of active ingredients of cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.2
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• pp.153-158
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• 2004

In cosmetics, the saturated lecithin, one of the main surfactants to prepare liposome has been used for its stability but it has been substituting with unsaturated lecithin which has excellent skin affinity and penetration property. So we studied to prepare nano-liposome that size of particles were below than 50nm by unsaturated lecithin. It was important that many factors including solvent such as propylene glycol, pH balance, homogenizing pressure, various cosurfactants and stabilizers to make stable nano-liposome. In our experimental conditions, cosurfactants with stearate class as lipophilic part were more suitable than others for our purpose. But in liposome by saturated lecithin, cosurfactants had negative effect and appropriate amount of oil should be used to be stable. These results indicated that unsaturated lecithin were more suitable than saturated lecithin to prepare nano-liposome.

• The Journal of Information Systems
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• v.19 no.2
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• pp.37-71
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• 2010

This article identifies factors affecting successful ERP systems by focusing on the stages after stabilizing ERP systems and overcoming temporary performance dip by introduction of ERP systems, and suggests change management tactics to control those identified factors. We can not expect that every users are familiar with the usage of an ERP system even after they are informed about the expected advantage of the newly implemented ERP system and trained intensively for changed business process and system usage while implementing a new ERP system. Moreover, even after more than six months usage of the system, the users may still have some trouble due to the reason why they have insufficient information about the expected advantage of the system (recognition gap) and insufficient knowledge about the changed usage of the system (knowledge gap). Hence, this article diagnoses by conducting a case study that those recognition and knowledge gap would have a severe bad influence upon the users' trust and satisfaction on ERP systems. This article suggests an appropriate change management tactics to overcome those recognition and knowledge gap by considering the relationship with the efforts for change management before, during, and after the introduction of ERP systems and performing an in-depth analysis on the users' dissatisfaction and request for update during the stages after the stabilization of the ERP systems. This article also shows a corroborative evidence that these efforts of change management consequently contributes to the solution of users' distrust and dissatisfaction. In sum, this article identifies the factors influencing badly on the magnitude and seriousness of knowledge and recognition gap, and suggests a conceptual research model which says that the satisfaction of ERP users could be uplifted by the solution of their knowledge and recognition gap if we keep making efforts on appropriate change management considering those identified factors during the stages after the stabilization of an ERP system.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.6
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• pp.244-257
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• 2017

Traffic congestion occurs from drivers' human factors such as driver reaction time, reckless lane change, and inexperienced driving. When Automated Vehicles are introduced, human factors are excluded, resulting in increased average vehicle speed, stabilizing traffic flow, and increasing road capacity. This study analyzed traffic flow changes through traffic volume-speed-density plots, and increased road capacity due to Automated Vehicles. As a result of the analysis, when rate of automated vehicles gests higher, the traffic flow became stable. Additionally, it was analyzed that when all vehicles were automated, the road capacity increased by about 120 %. It is expected that there will be a positive expectation in terms of traffic congestion and traffic demand management due to the introduction of Automated Vehicles.