• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.97-100
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• 2004

Steel encased composite columns are widely used due to their excellent structural performance in terms of stiffness, strength, and ductility. However, experimental studies were usually for the columns having higher steel ratio $(3-4\%)$. There are two different design concepts for SRC columns. ACI-318 specifies the design strength of the column using the same concept of reinforced concrete columns. AISC-LRFD specifies the P-M diagram using the concept of steel column. In this paper, SRC columns have the steel ratio of $0.53\%\;and\;1.06\%$. From the test results, ACI-318 specifications showed better evaluation of SRC columns having low steel ratio. H beam and steel tube partially filled with concrete were embedded in concrete. Flexural tests showed considerably high ductility.

• Journal of Digestive Cancer Research
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• v.6 no.2
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• pp.55-58
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• 2018

Gastric signet ring cell carcinoma (SRC) is a poorly differentiated or undifferentiated cancer of the stomach. However, early gastric SRC showed lower LN metastasis in many studies, thus some endoscopists now regard early gastric SRC as a candidate for endoscopic treatment. But there are unsolved problems of the validity of endoscopic resection in early gastric SRC. In this review, we will comprehensively review the previous clinical studies and discuss the limitation of current studies and the possibility of endoscopic resection of early gastric SRC.

• Steel and Composite Structures
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• v.21 no.1
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• pp.157-175
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• 2016

It was found that the lateral stiffness changes obvious at the transfer position of the section configuration from SRC to RC. This particular behavior leads to that the transfer columns become as the important elements in SRC-RC hybrid structures. A comprehensive study was conducted to investigate the seismic behavior of SRC-RC transfer columns based on a low cyclic loading test of 16 transfer columns compared with 1 RC column. Test results shows three failure modes for transfer columns, which are shear failure, bond failure and bend failure. Its seismic behavior was completely analyzed about the failure mode, hysteretic and skeleton curves, bearing capacity deformation ability, stiffness degradation and energy dissipation. It is further determined that displacement ductility coefficient of transfer columns changes from 1.97 to 5.99. The stiffness of transfer columns are at the interval of SRC and RC, and hence transfer columns can play the role of transition from SRC to RC. All specimens show similar discipline of stiffness degradation and the process can be divided into three parts. Some specimens of transfer column lose bearing capacity swiftly after shear cracking and showed weak energy dissipation ability, but the others show better ability of energy dissipation than RC column.

• BMB Reports
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• v.43 no.2
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• pp.91-96
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• 2010

The function of macrophage inhibitory cytokine-1 (MIC-1) in cancer remains controversial, and its signaling pathways remain poorly understood. In this study, we demonstrate that MIC-1 induces the transactivation of EGFR, ErbB2, and ErbB3 through the activation of c-Src in SK-BR-3 breast cells. MIC-1 induced significant phosphorylation of EGFR at Tyr845, ErbB2 at Tyr877, and ErbB3 at Tyr1289 as well as Akt and p38, Erk1/2, and JNK mitogen-activated protein kinases (MAPKs). Treatment of SK-BR-3 cells with MIC-1 increased the phosphorylation level of Src at Tyr416, and induced invasiveness of those cells. Inhibition of c-Src activity resulted in the complete abolition of MIC-1-induced phosphorylation of the EGFR, ErbB2, and ErbB3, as well as invasiveness and matrix metalloproteinase (MMP)-9 expression in SK-BR-3 cells. Collectively, these results show that MIC-1 may participate in the malignant progression of certain cancer cells through the activation of c-Src, which in turn may transactivate ErbB-family receptors.

• Composites Research
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• v.17 no.5
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• pp.25-38
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• 2004

In this study, the stiffness of spatially reinforced composites (SRC) are predicted by using superposition of a rod and matrix stiffnesses in an arbitrary direction. To confirm the predicted values, the material properties of SRC are measured. The predicted values from the volume average of stiffness matrix are consistent with the tested values in a rod direction, but are inconsistent in an off-rod direction while reverse is true fur the volume average of compliance matrix. Therefore, the harmony function from superposition of stiffness and compliance matrix is introduced. The predicted values from the harmony function are consistent with the tested values in both the rod and the off-rod directions.

• Journal of Sensor Science and Technology
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• v.18 no.2
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• pp.122-127
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• 2009

We have developed and reported several micro-spikes for minimally invasive biopsy. In this paper, a micro-tissue collecting tool for tissue diagnosis extracted by micro-spike is presented. Using proposed polydimethy-siloxane (PDMS) micro-tissue collecting tool, which has a negative micro-spike structure in a porous chamber, the extracted tissue in a micro-spike is effectively detached. The gastro-intestinal tissue of a pig is extracted in an in vivo environment, and then it is detached from a micro-spike using the PDMS micro-tissue collecting tool. A fine clinical picture of the detached tissue is acquired.

• Biomolecules & Therapeutics
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• v.23 no.5
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• pp.414-420
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• 2015

Flavonoids, such as fisetin (3,7,3',4'-tetrahydroxyflavone), are plant secondary metabolites. It has been reported that fisetin is able to perform numerous pharmacological roles including anti-inflammatory, anti-microbial, and anti-cancer activities; however, the exact anti-inflammatory mechanism of fisetin is not understood. In this study, the pharmacological action modes of fisetin in lipopolysaccharide (LPS)-stimulated macrophage-like cells were elucidated by using immunoblotting analysis, kinase assays, and an overexpression strategy. Fisetin diminished the release of nitric oxide (NO) and reduced the mRNA levels of inducible NO synthase (iNOS), tumor necrosis factor (TNF)-${\alpha}$, and cyclooxygenase (COX)-2 in LPS-stimulated RAW264.7 cells without displaying cytotoxicity. This compound also blocked the nuclear translocation of p65/nuclear factor (NF)-${\kappa}B$. In agreement, the upstream phosphorylation events for NF-${\kappa}B$ activation, composed of Src, Syk, and I${\kappa}B{\alpha}$, were also reduced by fisetin. The phospho-Src level, triggered by overexpression of wild-type Src, was also inhibited by fisetin. Therefore, these results strongly suggest that fisetin can be considered a bioactive immunomodulatory compound with anti-inflammatory properties through suppression of Src and Syk activities.

• The Transactions of the Korean Institute of Power Electronics
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• v.27 no.3
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• pp.256-264
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• 2022

The frequency power control method (FCM) which has a wide operating frequency range is adopted for induction heating (IH) cooktops. When FCM is applied to the full-bridge series resonant converter (FB-SRC) based IH system, high-frequency switching of the inverter is required compared to the half-bridge SRC (HB-SRC)-based IH system. Therefore, the switching loss of the inverter increases, and applying FCM under the condition that the inverter operating frequency range is limited is difficult. Therefore, this paper proposes a control strategy with the phase shift power control method considering that limited frequency conditions are presented. Loss analysis following the control method is performed through simulation and mathematical analysis. In addition, the validity of the proposed control strategy is verified by analyzing the heating performance following the control method through the test results of the 3,200[W] prototype.

• Journal of Korean Association for Spatial Structures
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• v.22 no.4
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• pp.59-70
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• 2022

In SRC column, the closed hoops are applied with the same detail of both 135° standard hooks to expect the same performance as hoops of RC columns. This standard detail is actually complicated to construct, thus, two separating rebars are connected in the form of a square shape and welded over the overlapping section. But this is also complicated in construction practice. Therefore, this study describes experimental results regarding cyclic behaviors shown with alternative hoops cramped by the steel clip type-binding device instead of welding and standard specimen. As a result of the experiment, the specimens with alternative hoops of the SRC column showed comparable performance to the specimens with closed hoops. Therefore, it can be evaluated that the alternative hoops applied with the rebar confinement clips in the SRC column can replace the closed hoop.

• Steel and Composite Structures
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• v.47 no.3
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• pp.423-436
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• 2023

In this research, we tested 10 simply supported concrete-encased composite columns under monotonic eccentric loads and investigated their shear behaviour. The specimens tested were two reinforced concrete specimens, three steel-reinforced concrete (SRC) specimens with an H-shaped steel section (also called a beam section), and five SRC specimens with a cruciform-shaped steel section (also called a column section). The experimental variables included the transverse steel shape's depth and the longitudinal steel flange's width. Experimental observations indicated the following. (1) The ultimate load-carrying capacity was controlled by web compression failure, defined as a situation where the concrete within the diagonal strut's upper end was crushed. (2) The composite effect was strong before the crushing of the concrete outside the steel shape. (3) We adjusted the softened strut-and-tie SRC (SST-SRC) model to yield more accurate strength predictions than those obtained using the strength superposition method. (4) The MSST-SRC model can more reasonably predict shear strength at an initial concrete softening load point. The rationality of the MSST-SRC model was inferred by experimentally observing shear behaviour, including concrete crushing and the point of sharp variation in the shear strain.