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http://dx.doi.org/10.5483/BMBRep.2010.43.2.091

Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells  

Park, Yun-Jung (Departments of Biochemistry, College of Natural Sciences, Kangwon National University)
Lee, Han-Soo (Departments of Biology, College of Natural Sciences, Kangwon National University)
Lee, Jeong-Hyung (Departments of Biochemistry, College of Natural Sciences, Kangwon National University)
Publication Information
BMB Reports / v.43, no.2, 2010 , pp. 91-96 More about this Journal
Abstract
The function of macrophage inhibitory cytokine-1 (MIC-1) in cancer remains controversial, and its signaling pathways remain poorly understood. In this study, we demonstrate that MIC-1 induces the transactivation of EGFR, ErbB2, and ErbB3 through the activation of c-Src in SK-BR-3 breast cells. MIC-1 induced significant phosphorylation of EGFR at Tyr845, ErbB2 at Tyr877, and ErbB3 at Tyr1289 as well as Akt and p38, Erk1/2, and JNK mitogen-activated protein kinases (MAPKs). Treatment of SK-BR-3 cells with MIC-1 increased the phosphorylation level of Src at Tyr416, and induced invasiveness of those cells. Inhibition of c-Src activity resulted in the complete abolition of MIC-1-induced phosphorylation of the EGFR, ErbB2, and ErbB3, as well as invasiveness and matrix metalloproteinase (MMP)-9 expression in SK-BR-3 cells. Collectively, these results show that MIC-1 may participate in the malignant progression of certain cancer cells through the activation of c-Src, which in turn may transactivate ErbB-family receptors.
Keywords
ErbB family receptors; Invasion; MIC-1/GDF-15; Transactivation; Src;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 6  (Related Records In Web of Science)
Times Cited By SCOPUS : 10
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