• The Korean Journal of Physiology and Pharmacology
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• v.10 no.6
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• pp.297-302
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• 2006

Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced by whole bee venom. Melittin-induced nociception has been known to be modulated by the changes in the activity of excitatory amino acid receptors, voltage-dependent calcium channels, cyclooxygenase and serotonin receptors. The present study was undertaken to investigate the role of calcium chelators (TMB-8 & Quin 2) in melittin-induced nociceptive responses. Changes of mechanical threshold and spontaneous flinching behaviors were measured at a given time point following intraplantar injection of melittin ($30{\mu}g/paw$). Intrathecal or intraplantar pre-administration and intrathecal posttreatment of TMB-8 and Quin 2 significantly prevented the melittin-induced reduction of mechanical threshold, and intraplantar or intrathecal pre-treatment of TMB-8 and Quin 2 suppressed melittininduced flinching behaviors. These results indicate that calcium ion in the spinal dorsal horn neurons and peripheral nerves plays an important role in the production and maintenance of mechanical allodynia and spontaneous pain by melittin.

• The Journal of Fisheries Business Administration
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• v.36 no.3 s.69
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• pp.1-24
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• 2005

Korean fishery wage system has been evolved with the different titles. However, Since the law of fishing crew was enacted in 1984, the fishery wage system has been established as a rate system, which is a legal term. The present rate system in practice shows various contents and modalities, depending on fisheries and regions, but the fisheries of large trawl cooperative employ a rate system of fixed plus rate wage. However, such change did not transform basically the properties of pure rate scheme. As well known, fishing vessel owners face an awful lot of difficulty in managing and controlling effectively the production process because fishing activities are carried out in the seas remote from the land. Thus, it tend to be inevitable for vessel owners to employ a rate system to induce fishermen's positive motivation for promoting productivity and saving operating costs. However, the rate system has worked out as a driving force, which induce an increase in production more strongly under the expansion of vessel numbers and power and the keener competition of fishing activities. Even though the control mechanism of fishing instruments are well established, fishermen become naturally to have an incentive to increase their fishing effort for maximizing production since they are able to raise their shares by maximizing the quantity harvested. Thus, as far as the rate system exists, fisheries administration may have much difficulty in realizing its fishery management goals only through vessel reduction and fishing gear regulations. Also, under the rate system fishery management authority may be in face of a serious dilemma between the spontaneous rate system and vessel reduction policy. If the realistic aspect of the rate system is recognized and resource restoration and profit promotion are main policy goals, it is necessary to develop effective ways to control vessel owners' and fishermen's production-maximizing motives at an appropriate level. From this point of view, it seems reasonable to introduce TAC system by species or by fisheries into the existing fishery system. The research results suggest that if the fisheries administration could understand clearly the spontaneous fisheries wage system, it would know the norm of TAC and the basic reasons for illegal fishing activities and thus it would be able to develop and implement more realistic resource management policies.

• Toxicological Research
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• v.11 no.2
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• pp.261-266
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• 1995

Age-related change in the frequency of spontaneous sister chromatid exchange (SCE) and chromosornal aberrations were investigated in bone marrow cells of accelerated senescence-resistant mice (SAM R1) and senescence accelerated ones (SAM P1). And the effect of chronic treatment of ginseng extract (Panax ginseng C.A. Meyer) on these chromosomal abnormalities was tested in SAM P1. SCE frequency in the cells was progressively increased with age in both mice, but it was consistently higher in SAM P1 than in SAM R1 at all corresponding age. Chromosomal aberrations were, however, not significantly changed with age except that it was slightly increased in only aged SAM P1. Interestingly, the rate of these genetic instabilities in SAM P1 was remarkably retarded by long-term administration of ginseng water extract (0.05% in drinking water). These results suggest that frequency of spontaneous SCE in bone marrow cells increase in parallel with senescence of the mice, and SAM P1 is in the condition of being more exposed than SAM R1 to DNA damaging factors. These also indicate that long-term treatment of ginseng may reduce the genetic damage.

• Tuberculosis and Respiratory Diseases
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• v.65 no.3
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• pp.222-224
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• 2008

Spontaneous pneumomediastinum is defined as a clinical syndrome that's characterized by the presence of air in the mediastinal space, which is not due to an old previous injury or surgery. The condition is caused by a sustained increase in the intraalveolar and intrabronchial pressure with extravasated air dissecting along the perivascular spaces of the mediastinum. This is an uncommon complication of sports activity. The most common symptom is chest pain. This diagnosis should be considered for younger people who present with pleuritic chest pain or dyspnea and a characteristic crackling feel (known as subcutaneous crepitation) when touching of the skin covering the chest wall or neck, and they look otherwise well with normal vital signs. Usually no treatment is required, but the mediastinal air will be absorbed faster if the patient inspires high concentrations of oxygen. We present here a case of spontaneous pneumomediastinum that occurred during a Taekwondo match, along with a review of the relevant literature.

• Fire Science and Engineering
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• v.15 no.2
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• pp.1-5
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• 2001

We had investigated combustion properties of starch. Decomposition of starch scavenged by pre-cipitator of spinning factory with temperature were investigated using DSC and TGA. Combustion properties of starch according to amount were checked as temperature variation according to time using spontaneous ignition apparatus. Moreover, combustion properties with blowing or without blowing condition were checked in spontaneous ignition apparatus. As results of thermal analyses, increase in raising temperature causes initial smoldering temperature to move towards low temperature section. In addition, as amount of starch was increased, initial smoldering temperature was lowered. All of combustion forms were smoldering combustion. Initial smoldering temperature was low more slightly with blowing condition than without blowing condition in spontaneous ignition apparatus, which condition made heating value high.

• Journal of Korean Foot and Ankle Society
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• v.8 no.2
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• pp.218-220
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• 2004

It is known that steroids increase the risk for tendon ruptures. Despite this local steroids are still used in the treatment of achilles tendinitis. 46-year-old women had occurred achilles tendon rupture after repeated local steroid injection. Intraoperatively, necrotic change were seen at both side of ruptured end. Like this, tendon rupture after repeated steroid injection often result in a large defect, which needed surgical repair. After debridement of ruptured end, tenorrhaphy with single Krackow method and plantaris tendon augmentation was done. The patient showed favorable result with return to range in a degree of activity levels.

• Environmental Analysis Health and Toxicology
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• v.4 no.3_4
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• pp.15-28
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• 1989

The effects of ethanol on the toxicity of 2, 4-Dichlorophenoxyacetic acid in ICR mice were examined. The results were summerized as follows; 1. The LD$\sub$50/ of 2.4-dichlorphenoxyacetic acid sodium injected intraperitoneally in mice was approximately 367 mg/kg. When the animals were administered with ethanol, 2 ml/kg or 4 ml/kg the LD$\sub$50/ of 2.4-D sodium were decreased to 338 mg/kg or 32 mg/kg, respectively. 2. In the acute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent decrease in mice administered with 2.4-D sodium and ethanol. 3. However, in subacute experimental group, spontaneous motor activity in the ANIMEX system exhibited dose-dependent increase in mice treated with ethanol.

• Korean Journal of Child Studies
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• v.22 no.2
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• pp.291-300
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• 2001

This study investigated the effects of shared writing strategies within a whole language approach on children's writing behaviors and abilities. The subjects were thirty-six 5-to 6-year-old kindergarten children, 18 each in the experimental and control groups. The results indicated a significant increase in frequency of spontaneous writing, quantity of writing, and quality of writing in the experimental group compared with the control group. The educational implications for kindergarten teachers are that teachers need to integrate shared writing strategies into teacher-initiated activities and use various strategies of whole language to improve literacy learning for children.

• Speech Sciences
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• v.8 no.4
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• pp.157-168
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• 2001

The limited capacity model has been used to explain linguistic interactions and trade-offs that occur in children's speech. The purpose of the present investigation is to explore the interrelationship of MLU (as an index of syntactic development) and fluency in the spontaneous speech of normal children. Twenty normal children's (ten girls and ten boys, aged 36-48 months) spontaneous speech samples were obtained during free-play interactions with their mothers or other adults. The results indicated that the MLU of disfluent utterances were significantly longer than that of fluent utterances. Also, disfluencies occurred more frequently in longer utterances than in shorter utterances. In addition, the utterances where disfluencies occurred more than 2 times were longer than those where disfluencies occurred once. These results imply that the increase of MLU appear to affect not only the occurrence of disfluent utterances, but also the number of disfluencies within the utterances. In other' words, these findings show that there are trade-off effects between MLU and fluency. This is discussed within a limited capacity framework.

• Korean Journal of Veterinary Research
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• v.63 no.4
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• pp.36.1-36.4
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• 2023

We discuss the case of a 5-month-old male British Shorthair cat referred to our hospital following the detection of a heart murmur during a routine vaccination appointment. Two-dimensional echocardiography revealed a 1.18 mm ventricular septal defect (VSD) located immediately below the aortic valve, without signs of secondary cardiac remodeling. Given the absence of cardiac dysfunction, no treatment was administered, and the cat was periodically monitored over the next 2 years. Echocardiography at 29 months of age revealed no signs of the VSD. Future studies are needed to increase the evidence base for spontaneous VSD closure in small animals.