• Title/Summary/Keyword: Spontaneous abortion

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The Oriental and Western Medical Study on Habitual Abortion (습관성유산(習慣性流産)에 대(對)한 동서의학적(東西醫學的) 고찰(考察))

  • Kim, Eun-Seop;Yoo, Dong-Youl
    • Journal of Haehwa Medicine
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    • v.18 no.2
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    • pp.95-104
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    • 2009
  • This study was carried out through the investigation of Oriental and Western medical literature and we was discovered these conclusions about the etiology, treatment, prescription of habitual abortion. The result of this study were as follows : 1. The habitual abortion does agree with 'Hwaltae(滑胎)' and means that spontaneous abortion repeats three times or more. 2. The etiology of habitual abortion is divided 'Deficiency of kidney'(腎虛), 'Deficiency of vital energy and blood'(氣血虛弱), 'Deficiency of yin'(陰虛), 'Clotted blood'(瘀血). 3. By means of cause, the treatment of habitual abortion was mainly made use of 'Tonifying kidney and promoting spleen'(補腎健脾), 'Invigorating vital energy and nourishing blood'(補氣補血), 'Supplementing yin fluid and alleviating fever'(滋陰淸熱), 'Resuscitating blood and removing clotted blood'(活血祛瘀). 4. By means of cause, the prescription of habitual abortion was frequent made use of Bosingochunghwan(補腎固沖丸), Bosingotae$\breve{u}$m(補腎固胎飮), Taesanbans$\breve{o}$ksan(泰山磐石散), $Ch\breve{o}ng\breve{u}mboinghwan$(千金保孕丸), Agyotang(阿膠湯), Gungguibojungtang(芎歸補中湯), Taewon$\breve{u}$m(胎元飮), Gotaej$\breve{o}$n(固胎煎), Baekchulj$\breve{o}$n(白朮煎), Sas$\breve{o}$ngsan(四聖散), Gyegibokryonghwan(桂枝茯苓丸), $Dangguich\breve{o}ng\breve{u}mtang$(當歸千金湯). 5. The Western medical etiology of habitual abortion(recurrent spontaneous early pregnancy loss) is divided Genetic factor(Chromosome aberration), Anatomical deformity, Endocrinologic disorder, Infection, Immunologic factor, Unknown factor(Others).

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The Effect of Exposure-Risk Behavior toward Endocrine-disrupting Chemicals, Occupational Environments and Daily Habits Related to Endocrine-disrupting Chemicals on Development of Spontaneous Abortion (환경호르몬 노출 위험행위, 직업환경 및 환경호르몬 관련 생활습관이 자연 유산 발생에 미치는 영향)

  • Choe, Myeong-Hui
    • Journal of the Korea Convergence Society
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    • v.11 no.7
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    • pp.377-387
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    • 2020
  • This study is a retrospective and descriptive research to identify the factors affecting development of spontaneous abortion in women of childbearing age. The subjects totaled 198 females aged 20~45 who had experienced childbirth or spontaneous abortion at least once, and data was collected for one month since July 2019 through self-reporting questionnaires. The results showed that the factors affecting development of spontaneous abortion were use of panty liners (daily: reference, 1~2 times a week: B=-1.74, no: B=-0.77) and antimicrobials (often or a lot: reference, small or normal: B=-0.71, no: B=0.79), occupational groups (inoccupation: reference, service industry employee: B=0.73, white collar: B=1.22, professional: B=0.63, manager: B=1.54), and exposure-risk behavior toward endocrine-disrupting chemicals (B=0.81) during pregnancy, and their explanatory power for development of spontaneous abortion was 24.4% (R2=.24). As a result, it is necessary to prevent endocrine-disrupting chemicals exposure and pay attention to the occupational environment during pregnancy in order to reduce the development of spontaneous abortion.

The Study of Antithrombin III Deficiency in Patients with Recurrent Spontaneous Abortion (반복자연유산 환자에서 Antithrombin III 결핍증에 대한 연구)

  • Nam, Yoon-Sung;Cha, Kwang-Yul;Kim, Nam-Keun;Kang, Myung-Seo;Oh, Do-Yeon
    • Clinical and Experimental Reproductive Medicine
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    • v.28 no.4
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    • pp.301-305
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    • 2001
  • Objective : To analyze the antithrombin II deficiency in patients with recurrent spontaneous abortion. Material and Method: The blood samples were tested by chromogenic assay to evaluate the activity of antithrombin III. Results: There was only one case of antithrombin III deficiency. This patient experienced one neonatal death after delivery and one FDIU (fetal death in utero). And also this patient showed a lupus anticoagulant and the prolongation of PTT. Conclusions: Women with recurrent miscarriage who have no obvious identified cause should consider hematologic screening. Antithrombin III deficiency could be a cause of recurrent spontaneous abortion. But the incidence is very rare in Korean patients.

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A Case of Recurrent Spontaneous Abortion Successfully Delivered by Using Preimplantation Genetic Diagnosis (착상전 유전진단을 이용하여 성공적으로 분만한 반복자연유산 1례)

  • Nam, Yoon-Sung;Lee, Sook-Hwan;Oum, Ki-Bung;Lee, Eun-Jung;Chung, Hyung-Min;Cha, Kwang-Yul
    • Clinical and Experimental Reproductive Medicine
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    • v.27 no.3
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    • pp.307-311
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    • 2000
  • Objective: To report the successful delivery in a patient of recurrent spontaneous abortion caused by chromosomal abnormality. Material and Method: Case report. Results: Twelve oocytes were obtained by in vitro fertilization. Of eleven oocytes fertilized, two embryos turned out to be normal by using fluorescent in situ hybridization on blastomere biopsy. The patient succeeded in pregnancy and the result of amniocentesis was found to be normal. She delivered the healthy female baby by cesarean section. Conclusions: The successful delivery is possible in recurrent spontaneous abortion related with reciprocal translocation by using preimplantation genetic diagnosis.

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A Study of Lupus Anticoagulants and Anticardiolipin Antibodies in Patients with Infertility and Recurrent Spontaneous Abortion (불임환자와 반복자연유산 환자에서 루프스 항응고인자와 항카디오리핀 항체에 대한 연구)

  • Nam, Yoon-Sung;Cha, Kwang-Yul;Baek, Jin-Young;Kim, Nam-Keun;Kang, Myung-Seo;Oh, Do-Yeon
    • Clinical and Experimental Reproductive Medicine
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    • v.29 no.1
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    • pp.29-35
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    • 2002
  • Objective : To report the prevalence of lupus anticoagulants and anticardiolipin antibodies in patients with recurrent spontaneous abortion and infertility. Material and Method: Lupus anticoagulants and anticardiolipin antibodies were analyzed by Diluted Russell's Viper Venom Test (DRVVT) and solid phase enzyme immunoassay, respectively. Results : In 200 patients with infertility, there were 6 cases (3%) with positive lupus anticoagulants or anticardiolipin antibodies. Of these, 3 patients (1.5%) showed positive lupus anticoagulants and anticardiolipin antibodies, respectively. In 120 patients with recurrent spontaneous abortion, there were 13 cases (10.8%) of positive lupus anticoagulants or anticardiolipin antibodies. Of these, one patient (1%) showed lupus anticoagulants and 12 patients (10%) showed anticardiolipin antibodies. But in two groups, there was no cases with positive lupus anticoagulants and anticardiolipin antibodies. Conclusion: Lupus anticoagulants and anticardiolipin antibodies are definite cause of recurrent spontaneous abortion. There has been a speculation that they might be associated with infertility and repeated IVF failures. But it was found that the role of lupus anticoagulants and anticardiolipin antibodies in these cases are not clear.

A Case of Successful Pregnancy in Patient with Recurrent Spontaneous Abortion by Preimplantation Genetic Diagnosis Following IVF-ET (염색체 이상에 의한 반복 유산 환자에서 체외수정시술 및 착상전 유전진단을 통한 임신 성공 1례)

  • Jeong, Jin-Seok;Yeon, Gyu-Sun;Chae, Hee-Dong;Cheon, Yong-Pil;Kim, Chung-Hoon;Kang, Byung-Moon;Chang, Yoon-Seok;Mok, Jung-Eun
    • Clinical and Experimental Reproductive Medicine
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    • v.25 no.2
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    • pp.135-140
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    • 1998
  • It was reported that the etiologies of recurrent spontaneous abortion are immunologic factors, endocrinologic problems, anatomical abnormalities, genetic abnormalities, infection, and unexplained factors. Among those etiologic factors, genetic abnormalities occur in about 5% of the couples who experience recurrent spontaneous abortions, and most common parental chromosomal abnormality contributing to recurrent abortion is balanced translocation. The advent of in vitro fertilization (IVF), the development of skills associated with the handling of human embryo, and an explosion of knowledge in molecular biology have opened the possibility of early diagnosis of genetic disease in preimplantation embryos. Therefore preimplantation genetic diagnosis (PGD) is indicated for couples, infertile or not, at risk of transmitting a genetic disease. A case of successful pregnancy and term delivery by PGD using fluorescence in situ hybridization (FISH) technique in patient with recurrent spontaneous abortion due to balanced translocation is presented with brief review of literatures.

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Th 17 Cells and Nesfatin-1 are associated with Spontaneous Abortion in the CBA/j×DBA/2 Mouse Model

  • Chung, Yiwa;Kim, Heejeong;Im, Eunji;Kim, Philjae;Yang, Hyunwon
    • Development and Reproduction
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    • v.19 no.4
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    • pp.243-252
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    • 2015
  • The pregnancy and abortion process involves a complex mechanism with various immune cells present in the implantation sites and several hormones associated with pregnancy, such as leptin, ghrelin and nesfatin-1. However, the mechanism underlying spontaneous abortion by maternal T helper 17 (Th17) present in the implantation sites and nesfatin-1, which is of anorexigenic hormones, is not fully understood so far. Therefore, the purpose of this study was to examine the possible roles of Th17 cells present in the implantation sites and nesfatin-1 expressed in the uterus on spontaneous abortion using the $CBA/j{\times}DBA/2$ mouse model. Th17 transcription factor, ROR-${\gamma}t$ mRNA expression was significantly increased in the abortion sites compared with the implantation sites of abortion model mice on day 14.5 and 19.5 of pregnancy. In addition, the expression levels of IL-17A mRNA were significantly higher in abortion sites than in implantation sites on day 14.5 and 19.5. Moreover, the nesfatin-1/NUCB2 protein and mRNA levels were increased in abortion sites compared with levels in implantation sites of both normal pregnant and abortion model mice on day 14.5 of pregnancy. Interestingly, nesfatin-1/NUCB2 serum levels were not changed throughout the whole pregnancy in abortion model mice, but its serum level was dramatically increased on day 14.5, and then rapidly decreased on day 19.5 in normal pregnant mice. In this study, we showed for the first time the expression of nesfatin-1/NUCB2 mRNA and protein in implantation sites during pregnancy. The present results suggest that Th17 cells in the uterus may play an important role in the period of implantation and for maintenance of pregnancy. Furthermore, the present results suggest that Th17 cells in implantation sites may be a key regulator for maintenance of pregnancy and provides evidence that activation of these cells may be regulated by nesfatin-1/NUCB2. Further study is needed to elucidate the role of nesfatin-1 expressed in the uterus during pregnancy.

Etiologic Classification of Recurrent Spontaneous Abortion (습관성 유산의 원인적 분류)

  • Park, Moon-Il;Lee, Ki-Hun;Chung, Sung-Ro;Lee, Jai-Auk;Moon, Hyung;Kim, Doo-Sang
    • Clinical and Experimental Reproductive Medicine
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    • v.18 no.1
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    • pp.113-120
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    • 1991
  • Etiologic classification was performed in 155 patients with recurrent spontaneous abortion history. The incidence was 9.3% among 1658 pregnant women at Hanyang university hospital during the same period. In etiologic classification, 37 cases of on-going patients for diagnostic evaluation were excluded. Of the remained 118 patients, the patients with unknown etiology were 32 cases (27.1%), and 86 cases were classified into each etiologies using appropriate diagnostic modalities. Anatomic causes were the largest etiology, which revealed 46.6% (55 among 118 patients). The next etiology was immunologic cause, which revealed 24.6% (29 patients). Of the 86 patients who have at least one cause, 40.7% (35 among 86) have two or more etiologies. Furthermore, six cases (7%) have 3 combined etiologies. The uterine synechia and/or incompetent internal os of the cervix, namaly anatomic causes, revealed highest combination ratio than other etilogies. The popular abortion technique in Korea, D&C, seems to be main factors for these anatmic causes. The combined causes rather than single cause of recurrent spontaneous abortion were unique situation in Korea especially with anatomic etiologies. From this point of view, we think anatomic etiologies should be rule out first in the evaluation of the patients. For this purpose, we believe hysteroscopy would be helpful as a diagnostic work-up and treatment modality in the management of recurrent spontaneous abortion patients in Korea.

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The Analysis of Interrelationship between Homocysteine and Methylenetetrahydrofolate Reductase Mutation in Patients with Recurrent Spontaneous Abortion (반복자연유산 환자에서 Homocysteine과 Methylenetetrahydrofolate Reductase 돌연변이의 상관관계에 대한 분석)

  • Nam, Yoon-Sung;Cha, Kwang-Yul;Kim, Nam-Keun;Kang, Myung-Seo;Kim, Se-Hyun;Oh, Do-Yeon
    • Clinical and Experimental Reproductive Medicine
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    • v.29 no.3
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    • pp.187-193
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    • 2002
  • Objective : To analyze the interrelationship between homocysteine and methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. Material and Method: Homocysteine and MTHFR mutation were tested by fluorescent polarizing immunoassay and PCR-RFLP method, respectively. Results: In patients with homocysteine level less than 5 ?mol/L, there was no case of normal group but there were four cases of heterozygosity and one case of homozygosity. In patients with homocysteine level 5$\sim$10 ? mol/L, the number of normal, heterozygosity and homozygosity group were eleven, eighteen and eight, respectively. In patients with homocysteine level $10{\sim}15$ ? mol/L, the number of normal, heterozygosity and homozygosity group were four, one and one, respectively. In patients with homocysteine level more than 15 ? mol/L, there was no case of normal and heterozygosity group but there were two cases of homozygosity. Conclusions: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. And there was a significant relationship between homocysteine and MTHFR mutation.

A Cross-Sectional Study of Nutrient Intakes by Gestational Age and Pregnancy Outcome(I) (우리나라 임신부의 임신 시기별 영양 섭취상태 및 임신결과에 대한 횡적 조사 연구(I))

  • 유경희
    • Journal of Nutrition and Health
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    • v.32 no.8
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    • pp.877-886
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    • 1999
  • To assess the effect of an antenatal nutritional status on pregnancy outcome, especially neonatal birty weight, one-day 24hr-recall and two-day recording methods for dietary survey and interview for general and obstetric characteristics of each subject were completed and pregnancy outcome was recorded by phone after delivery. 147 pregnant women attending routinely public health centers in Ulsan were divided into 1st trimester(n=36), 2nd trimester(n=102), 3rd trimester(n=71) by LMP(Last Menstrual Period) because some subjects attended repeatedly in different trimester. The subjects were aged 27.9$\pm$2.9 as mean and the level of education was senior high school and more. 20.4% of subjects experienced spontaneous abortion and 30.0% experienced induced abortion in previous pregnancy. Mean intakes of all nutrients except ascorbic acid were significantly different but dietary composition of energy intakes was not different between trimester. Mineral of calcium, iron and zinc did not meet the RDA for pregnancy outcome was about 20%, which consists of spontaneous abortion (3.4%), caesarian section(15.6%), premature delivery(0.7%) and still births(0.7%). The mean birth weight of neonates is 3.31kg the rate of neonatal birth weight below 10th percentile was 8.4% and the rate of low birth weight(<2.5kg) was 3.1%. By analysis of nutrient factors that influence on the neonatal birth weight (NBW), iron intake correlated negatively and zinc intake correlated positively with NBW in 1st trimester but fat and iron intakes correlated with NBW positively in 3rd trimester. Prepregnancy weight, gestational age at delivery and No. of induced abortion had a positive effects on NBW and No. of spontaneous abortion and te severity of morning sickness had a negative effects on NBW.

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