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A Study of Lupus Anticoagulants and Anticardiolipin Antibodies in Patients with Infertility and Recurrent Spontaneous Abortion  

Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
Baek, Jin-Young (Department of Clinical Pathology, College of Medicine, Pocheon CHA University)
Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
Kang, Myung-Seo (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
Oh, Do-Yeon (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
Publication Information
Clinical and Experimental Reproductive Medicine / v.29, no.1, 2002 , pp. 29-35 More about this Journal
Abstract
Objective : To report the prevalence of lupus anticoagulants and anticardiolipin antibodies in patients with recurrent spontaneous abortion and infertility. Material and Method: Lupus anticoagulants and anticardiolipin antibodies were analyzed by Diluted Russell's Viper Venom Test (DRVVT) and solid phase enzyme immunoassay, respectively. Results : In 200 patients with infertility, there were 6 cases (3%) with positive lupus anticoagulants or anticardiolipin antibodies. Of these, 3 patients (1.5%) showed positive lupus anticoagulants and anticardiolipin antibodies, respectively. In 120 patients with recurrent spontaneous abortion, there were 13 cases (10.8%) of positive lupus anticoagulants or anticardiolipin antibodies. Of these, one patient (1%) showed lupus anticoagulants and 12 patients (10%) showed anticardiolipin antibodies. But in two groups, there was no cases with positive lupus anticoagulants and anticardiolipin antibodies. Conclusion: Lupus anticoagulants and anticardiolipin antibodies are definite cause of recurrent spontaneous abortion. There has been a speculation that they might be associated with infertility and repeated IVF failures. But it was found that the role of lupus anticoagulants and anticardiolipin antibodies in these cases are not clear.
Keywords
Lupus anticoagulants; Anticardiolipin antibodies; Recurrent spontaneous abortion; Infertility;
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1 Petri M, Rheinschmidt M, Whiting-Okeefe Q, Hellman D, Corash L. The frequency of lupus anticoagulant in systemic lupus erythematosus. Ann Intern Med 1987; 106: 524-31   DOI   PUBMED
2 Lubbe WF, Butler WS, Palmer SJ, Liggins GC. Lupus anticoagulant in pregnancy. Br J Obstet Gynecol 1984; 91: 357-63   DOI
3 Dudley DJ, Mitchell MD, Branch DW. Pathophysiology of antiphospholipid antibodies. Absence of prostaglandin-mediated effects on cultured endothelium Am J Obstet Gynecol 1990; 162: 953-9
4 Paeceman AM, Rehnberg KA. The immunoglobulin G fraction from plasma containing antiphopholipid antibodies causes increased placental thromboxane production. Am J Obstet Gynecol 1992; 167: 1543-7   DOI
5 Brenner B, Blumenfeld Z, Markiewicz W, Reisner SA. Cardiac involvement in patients with primary antiphospholipid syndrome. J Am Coll Cardiol 1991; 18: 931-6   DOI   PUBMED
6 Matthey F, Walshe K, Mackie JJ, Machin SJ. Familial occurrence of the antiphospholipid syndrome. J Clin Pathol 1989; 42: 495-7   DOI
7 Kalashnikova LA, Nasonov EL, Kushckhacua AE, Grachcua LA. Anticardiolipin antibodies in Sneddon's syndrome. Neurology 1990; 40: 464-7   DOI   PUBMED
8 Becker JC, Winkler B, Klingert S, Brocker EB. Antiphospholipid syndrome associated with immunotherapy for patients with melanoma. Cancer 1994; 73: 1621-4   DOI   ScienceOn
9 Jouhikainen T. Platelet autoantibodies detected by immunoblotting in systemic lupus erythematosus: association with the lupus anticoagulant and with history of thrombosis and thrombocytopenia. Eur J Hematol 1990; 44: 234-9   DOI   ScienceOn
10 Triplett DA. Antiphospholipid antibodies, lupus anticoagulants and thromboembolic disease. Haematologica 1995; 80: 122-6   PUBMED
11 Peaceman AM, Silver RK, MacGregor SN, Socol ML. Interlaboratory variation in antiphospholipid antibody testing. Am J Obstet Gynecol 1992; 166: 1780-4   DOI   PUBMED
12 Harris EN, Spinnato JA. Should anticardiolipin test be performed in otherwise healthy pregnant women? Am J Obstet Gynecol 1991; 165: 1272-7
13 Harris EN, Chan JK, Asherson RA. Thrombosis, recurrent fetal loss and thrombobytopenia Predictive value of the anticardiolipin antibody test. Arch Intern Med 1986; 146: 2153-6   DOI
14 Shapiro SS. The lupus anticoagulant / antiphospholipid syndrome. Ann Rev Med 1995; 47: 533-53   DOI   ScienceOn
15 Peaceman AM, Rehnberg KA. The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production. Am J Obstet Gynecol 1993; 169: 1403-6   DOI   PUBMED
16 Vaarala O, Palusuo T, Kleemola M. Anticardiolipin response in acute infections. Clin Immunol Immunopathol 1986; 41: 8-15   DOI   ScienceOn
17 Branch DW, Dudley DJ, Mitchell MD. IgG fractions from patients with antiphospholipid antibodies cause fetal death in Balb/c mice: A model for autoimmune fetal loss. Am J Obstet Gynecol 1990; 163: 210-6   DOI   PUBMED
18 Silver RM, Draper ML, Byrne JLB, Ashwood EA, Lyon JL, Branch DW. Unexplained elevations of maternal serum alpha-fetoprotein in women with antiphospholipid antibodies: A harbinger of fetal death. Obstet Gynecol 1994; 83: 150-5   PUBMED
19 DeWolf F, Carreras LO, Moerman P, Vermylen P, Van Assche A, Renaer M. Decidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 1982; 142: 829-34   DOI
20 Galli M. Interaction between platelets and lupus anticoagulants. Eur J Haematol 1988; 41: 88-94   DOI   PUBMED   ScienceOn
21 Bevers EM. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only but to a complex of lipid bound prothrombin. Thromb Haemost 1991; 66: 629-32
22 Carreras LO, Machin SJ, Defreyn G. Arterial thrombosis, intrauterine fetal death and 'lupus' anticoagulant: Detection of immunoglobulin interfering with prostacyclin formation. Lancet 1981; 31: 244-6
23 Silver RK, Adler L, Hickman AR, Hageman JR. Anticardiolipin antibody poritive serum enhances endothelial cell platelet activating factor production. Am J Obstet Gynecol 1991; 165: 1748-52   DOI   PUBMED
24 Out HJ, Bruinse HW, Godlieve CML. A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies. Am J Obstet Gynecol 1992; 167: 26-32   DOI   PUBMED
25 Out HJ, Kooijman CD, Bruinse HW, Derksen RHWM. Histo-pathological findings from patients with intrauterine fetal death and antiphospholipid antibodies. Eur J Obstet Gtnecol 1991; 41: 179-86   DOI
26 Cariou R, Tobelem G, Soria C, Caen J. Inhibition of protein C activation by endothelial cells in the presence of lupus anticoagulant. N Engl J Med 1986; 314: 1193-4   DOI   PUBMED   ScienceOn
27 Amout J. The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin induced thrombocytopenia. Thromb Haemost 1996; 75: 536-41
28 Triplett DA. Antiphospholipid-protein antibodies: laboratory detection and clinical relevance. Thromb Res 1995; 78: 1-31   DOI   ScienceOn
29 Harris EN. The second international anticardiolipin standardization workshop / The Kingston antiphospholipid antibody study (KAPS) group. Am J Clin Pathol 1990; 94: 476-84   DOI   PUBMED
30 Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulant: an update. Thromb Haemost 1995; 74: 1185-90   PUBMED
31 Oosting JD. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C or protein S. An explanation for their pathogenic mechanism. Blood 1993; 81: 2618-25   PUBMED
32 Branch DW, Rodgers GM. Induction of endothelial cell tissue factor activity by sera from patients with antiphospholipid syndrome: A possible mechanism of thrombosis. Am J Obstet Gynecol 1993; 168: 206-10   DOI   PUBMED
33 Derksen RH, Hasselaar P, Blokzijl L. Coagulation screen is more specific than the anticardiolipin ELISA in defining a thrombotic subset of lupus patients. Ann Rheum Dis 1988; 47: 364-7   DOI
34 Lockwood CJ, Rand JR. The immunobiology and obstetrical consequences of antiphospholipid antibodies. Obstet Gynecol Surv 1994; 49: 432-41   DOI   ScienceOn
35 Hojnik M, George J, Ziporen L, Shoenfeld Y. Heart valve involvement (Libman-Sacks endocarditis) in the antiphospholipid syndrome. Circulation 1996; 93: 1579-87   DOI   PUBMED
36 Roldan CA. Systemic lupus erythematosus valve disease by transesophageal echocardiography and the role of antiphospholipid antibodies. J Am Coll Cardiol 1992; 20: 1127-34   DOI   PUBMED
37 Lockshin MD, Druzin ML, Qamar T. Prednisone does not prevent recurrent fetal death in women with antiphospholipid antibody. Am J Obstet Gynecol 1989; 160: 439-43   DOI   PUBMED
38 Carreras LO, Vermylen J, Spitz B, Van Asshe A. 'Lupus' anticoagulant and inhibition of prostacyclin formation in patients with repeated abortion, intrauterine growth retardation, and intrauterine fetal death. Br J Obstet Gynecol 1981; 88: 890-4   DOI
39 Lockwood CJ, Romero R, Feinberg RF, Clyne LP, Coster B, Hobbins JC. The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population. Am J Obstet Gynecol 1989; 161: 369-73   DOI   PUBMED
40 Walker TS, Triplett DA, Javed N, Musgrave K. Evaluation of lupus anticoagulants: Antiphospholipid antibodies, endothelial cell immunoglobulin, endothelial prostacyclin secretion, and antigenic protein S levels. Thromb Res 1988; 51: 267-81   DOI   ScienceOn