Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The Study of Antithrombin III Deficiency in Patients with Recurrent Spontaneous Abortion

반복자연유산 환자에서 Antithrombin III 결핍증에 대한 연구

  • Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Kang, Myung-Seo (Institute for Clinical Research, College of Medicine, Pocheon CHA University) ;
  • Oh, Do-Yeon (Institute for Clinical Research, College of Medicine, Pocheon CHA University)
  • 남윤성 (포천중문의과대학 산부인과학교실) ;
  • 차광렬 (포천중문의과대학 산부인과학교실) ;
  • 김남근 (포천중문의과대학 임상의학연구소) ;
  • 강명서 (포천중문의과대학 임상의학연구소) ;
  • 오도연 (포천중문의과대학 임상의학연구소)
  • Published : 2001.12.30
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Abstract

Objective : To analyze the antithrombin II deficiency in patients with recurrent spontaneous abortion. Material and Method: The blood samples were tested by chromogenic assay to evaluate the activity of antithrombin III. Results: There was only one case of antithrombin III deficiency. This patient experienced one neonatal death after delivery and one FDIU (fetal death in utero). And also this patient showed a lupus anticoagulant and the prolongation of PTT. Conclusions: Women with recurrent miscarriage who have no obvious identified cause should consider hematologic screening. Antithrombin III deficiency could be a cause of recurrent spontaneous abortion. But the incidence is very rare in Korean patients.

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