• Proceedings of the Korea Concrete Institute Conference
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• 2001.05a
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• pp.571-576
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• 2001

The objective of this study is to assess seismic damage potential and evaluate structural performance of columns in concrete moment frames. For this purpose the results of 3 former studies are compared. Experimental variables considered in these studies are lap-splice of longitudinal reinforcement, axial load level, longitudinal reinforcement ratio, etc. The columns in 1st story of the building are considered in these studies since the columns in 1st story shall resist largest axial force during an earthquake. Based on test results strength, ductility capacities as well as plastic hinge length are compared and discussed.

• Proceedings of the Korea Concrete Institute Conference
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• 2002.05a
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• pp.793-798
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• 2002

This paper presents the analytical results on the seismic retrofit of circular bridge columns with poor lap-splice details using FRP jacket. The as-built column suffered brittle failure due to the deterioration of lap-spliced longitudinal reinforcement without developing its flexural capacity or ductility. The retrofitted columns using FRP jacket showed significant improvement in seismic performance due to FRP's confinement effect. FRP's confinement effect is predicted by the classical elasticity solution for the laminated circular tube manufactural with several layers, and induces the flexural failure instead of bondslip failure.

• Proceedings of the Korea Concrete Institute Conference
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• 1997.10a
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• pp.737-742
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• 1997

In this paper the effect of tie wire in lap spliced bars is investigated by experiment. The variables considered in the beam behaviors are beam dimension, lapped splice length and numbers of tie wire. 3 test pieces having the same variables consist one series and a total of 6 series ar tested. The test results show the beam behavior is not affected by numbers of tie wire but by the manner of tie. It was revealed hat the load bearing capacity of the beam is increased when the tie wire is extended to top bar.

• Proceedings of the Korea Concrete Institute Conference
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• 2003.05a
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• pp.973-978
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• 2003

This paper describes the experimental study on seismic strengthening effect of circular bridge columns with poor lap-splice details using FRP(Fiber Reinforced Plastic) wrapping, The as-built column suffered brittle failure due to the deterioration of lap-spliced longitudinal reinforcement without developing its flexural capacity or any ductility, The strengthening columns using FRP wrapping showed significant improvement in seismic performance due to FRP's confinement effect.

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.188.1-188
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• 2000

No Abstract, See Full Text

• Proceedings of the Korea Concrete Institute Conference
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• 1996.10a
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• pp.447-452
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• 1996

An experimental study was conducted to evaluate the bond performance of reinforcing bars embedded in high-strength concrete. Ten beam spice Specimens using concrete with compressive strength of 240kg/$\textrm{cm}^2$ and 640kg/$\textrm{cm}^2$ were tested. The effect of several variables on basic development length is discussed. The test results showed that the current trend in concrete specification of making the splice length longer to compensate for having smaller cover and spacing may not be an effective approach.

• Tuberculosis and Respiratory Diseases
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• v.79 no.2
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• pp.85-90
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• 2016

Background: Lung cancer is the most common cause of cancer related death. Alterations in gene sequence, structure, and expression have an important role in the pathogenesis of lung cancer. Fusion genes and alternative splicing of cancer-related genes have the potential to be oncogenic. In the current study, we performed RNA-sequencing (RNA-seq) to investigate potential fusion genes and alternative splicing in non-small cell lung cancer. Methods: RNA was isolated from lung tissues obtained from 86 subjects with lung cancer. The RNA samples from lung cancer and normal tissues were processed with RNA-seq using the HiSeq 2000 system. Fusion genes were evaluated using Defuse and ChimeraScan. Candidate fusion transcripts were validated by Sanger sequencing. Alternative splicing was analyzed using multivariate analysis of transcript sequencing and validated using quantitative real time polymerase chain reaction. Results: RNA-seq data identified oncogenic fusion genes EML4-ALK and SLC34A2-ROS1 in three of 86 normal-cancer paired samples. Nine distinct fusion transcripts were selected using DeFuse and ChimeraScan; of which, four fusion transcripts were validated by Sanger sequencing. In 33 squamous cell carcinoma, 29 tumor specific skipped exon events and six mutually exclusive exon events were identified. ITGB4 and PYCR1 were top genes that showed significant tumor specific splice variants. Conclusion: In conclusion, RNA-seq data identified novel potential fusion transcripts and splice variants. Further evaluation of their functional significance in the pathogenesis of lung cancer is required.

• Journal of the Earthquake Engineering Society of Korea
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• v.11 no.4
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• pp.1-11
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• 2007

This paper verifies the difference of the seismic behavior and seismic damage of the neighboring two reinforced concrete piers damaged by the 1995 Hyogoken Nanbu earthquake. The two piers were almost the same size, carrying slightly different dead load, and were provided with the same reinforcement arrangement except the amount of longitudinal reinforcement at the bottom portion of the piers. The pier with more reinforcement was completely collapsed due to this near field earthquake by shear failure at the longitudinal reinforcement cut-off while the other was only damaged at the bottom by flexure even though the longitudinal reinforcement cut-off was also existed at the mid height of the pier. According to the results of the pseudo dynamic test, the seismic damage was recognized to be greatly dependent on the ground motion characteristics even though the employed ground motions had the same peak acceleration. The severe damage was observed when the test employed the seismic wave that had strong influence to the longer period range compared to the initial natural period of the pier. On the other hand, based on the similar model experiment, the defect of gas-pressure welded splice of longitudinal reinforcement was revealed to save the piers against collapse due to the so-called fail-safe mechanism contrary to the intuitive opinion of some researchers. It was concluded that the primary cause of the collapse of the pier was the extremely strong intensity and peculiar characteristics of the earthquake motion according to both the site-specific and the structure-specific effects.

• Advances in concrete construction
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• v.9 no.1
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• pp.83-92
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• 2020

The use of spliced reinforcing bars in sustainable concrete members to manage inadequate bars length is a common practical issue which is may be due to some limitations. The lap splicing means two bars overlapped in parallel with specified length called the splice length in order to provide the required bond between the two bars. The bond between sustainable concrete and spliced steel bars is another important issue. The normal strength sustainable concrete specimens of sizes 1700×150×150 mm with tension reinforcement lap spliced were selected according to testing device length limitations. These members were designed to fail in flexure in order to investigate the lap spliced tension bars effect. The selected lap spliced tension bars were of 10 mm size with smooth and deformed surfaces in order to investigate the surface nature accompanied with the splice nature. The sustainable concrete mechanical properties and mix workability were also studied. This study reveals that the effect of number of spliced bars on the response of beams reinforced with smooth bars is found to be more obvious than deformed one. Finite element modeling in three dimensions was carried out for the tested beams using ABAQUS software. A parametric study is carried out using finite elements on considering the following parameters, concrete compressive strength, load type and opening in cross section (hollow section) for weight reduction purposes.The laboratory and numerical results show good agreements in terms of ultimate load and deflection with an average difference of 10% and 15% in ultimate load and deflection respectively.

• Journal of Periodontal and Implant Science
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• v.45 no.2
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• pp.69-75
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• 2015

Purpose: Salivary fluid formation is primarily driven by Ca2+-activated, apical efflux of chloride into the lumen of the salivary acinus. The anoctamin1 protein is an anion channel with properties resembling the endogenous calcium-activated chloride channels. In order to better understand the role of anoctamin proteins in salivary exocrine secretion, the expression of the ten members of the anoctamin gene family in the mouse submandibular gland was studied. Methods: Total RNA extracted from mouse submandibular salivary glands was reverse transcribed using primer pairs to amplify the full-length coding regions of each anoctamin gene and was subcloned into plasmid vectors for DNA sequencing. Alternative splice variants were also screened by polymerase chain reaction using primer pairs that amplified six overlapping regions of the complementary DNA of each anoctamin gene, spanning multiple exons. Results: Multiple anoctamin transcripts were found in the mouse submandibular salivary gland, including full-length transcripts of anoctamin1, anoctamin3, anoctamin4, anoctamin5, anoctamin6, anoctamin9, and anoctamin10. Exon-skipping splicing in the N-terminal exons of the anoctamins1, anoctamin5, and anoctamin6 genes resulted in multiple alternative splice variants. No expression of anoctamin2, anoctamin7, or anoctamin8 was found. Conclusions: The predominant anoctamin transcript expressed in the mouse submandibular gland is anoctamin1ac. The chloride channel protein produced by anoctamin1ac is likely responsible for the $Ca^{2+}$-activated chloride efflux, which is the rate-limiting step in salivary exocrine secretion.