• 생명과학회지
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• 제20권7호
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• pp.1005-1011
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• 2010

$\gamma$-aminobutyric acid (GABA)는 중추신경계에서 억제성으로 작용하는 주요한 신경전달물질이다. GABA 수송체(GAT)는 연접간격에 존재하는 GABA를 세포 내로 재 흡수하여 GABA의 농도를 조절한다. 그런데 GABA 수송체가 어떻게 조절되는지는 아직 밝혀지지 않았다. 본 연구에서는 효모 two-hybrid system을 사용하여 뇌의 주요 GABA 수송체인 GAT1의 C-말단과 특이적으로 결합하는 ubiquitin-specific protease 14 (Usp14)를 분리하였다. Usp14는 GABA 수송체 GAT1및 GAT2와는 결합하지만, 다른 GAT isoform과는 결합하지 않았다. GAT1과의 결합에는 Usp14의 C-말단부위가 필수적으로 관여함을 확인하였다. 또한 이 단백질간의 결합을 GST pull-down assay로 확인하였으며, 생쥐 뇌 균질액의 co-immunoprecipitation을 통하여 in vivo에서도 GAT1과 Usp14가 결합함을 확인하였다. 이러한 결과들은 Usp14가 GAT1과 결합하여 세포막에 존재하는 GAT1의 수를 조절하는 역할을 할 가능성을 시사한다.

• 대한조선학회논문집
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• 제57권2호
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• pp.61-69
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• 2020

Due to its flexibility of the composite propeller blade, it is necessary to design a shape capable of generating a desired load at a design point in consideration of the shape change of the propeller. In order to design it, we need to evaluate not only the hydrodynamic force around it, but also its structural response of flexible propeller according to its deformation. So, it is necessary to develop a design tool to predict the hydroelastic performance of a flexible propeller with deformation considering fluid-structure interaction and special operating conditions. Finally a design optimization tool for flexible propellermade of CFRP is required. In this study, a design methodology of the specific flexible composite propeller is suggested, considering fluid-structural interaction analysis of the specific flexible propeller.

• 로봇학회논문지
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• 제18권4호
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• pp.463-471
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• 2023

This paper proposes a method to estimate the level of interest shown by visitors towards a specific target, a guide robot, in spaces where a large number of visitors, such as exhibition halls and museums, can show interest in a specific subject. To accomplish this, we apply deep learning-based behavior recognition and object tracking techniques for multiple visitors, and based on this, we derive the behavior analysis and interest level of visitors. To implement this research, a personalized dataset tailored to the characteristics of exhibition hall and museum environments was created, and a deep learning model was constructed based on this. Four scenarios that visitors can exhibit were classified, and through this, prediction and experimental values were obtained, thus completing the validation for the interest estimation method proposed in this paper.

• 경영과학
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• 제20권2호
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• pp.81-93
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• 2003

These days we come across many wicked problems whose solutions are beyond individuals intellectual ability. These problems can be resolved through collaborative group interaction. We developed an internet-based asynchronous group interaction support system, after looking into the collaborative problem solving process and the IBIS (Issue-Based Information System) argumentation model. It has the following characteristics ; 1) it is developed based on the modified IBIS model which is a model for group interaction to resolve wicked problems ; 2) it supports both processes of seeking and comparing solutions, while most similar systems do not have a feature to support the latter process ; 3) different structures can be defined dynamically according to the purpose of group interaction, so that it could be used for collaborative problem solving in a specific domain. To show the usability of the system, we carried out an experiment, whose result is shown at the end.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1987년도 한국자동제어학술회의논문집; 한국과학기술대학, 충남; 16-17 Oct. 1987
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• pp.63-68
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• 1987

In this study, a pantograph leg of the four legged walking vehicle is analysed with regard to mechanical energy consumption. Energy efficiency of the vehicle is estimated in terms of specific resistance varying body height, stride length and walking speed. The interaction between specific resistance and the parameters is investigated.

• 한국비블리아학회지
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• 제30권2호
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• pp.145-166
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• 2019

정보행태 연구 커뮤니티에서 그간 다수의 이용자 관련 모형들이 제시되어온바, 본 연구의 출발점은 정보검색 상호작용 모형을 포함한 대부분의 모형들이 포괄적 영역을 제시하는 다(多)영역 모형이라는 점이다. 본 연구는 다 영역 모형의 제한점을 논의한 후, 새로운 모형 유형 제시의 필요성을 제기한다. 이와 관련, 연구 커뮤니티내의 핵심 모형 네 가지를 분석 고찰한 후, 특정영역 초점 모형화(Specific Domain Focus Modeling - SDFM)에 기반한 새로운 모형 유형을 제시한다. 이러한 모형화의 예로써, 본 연구는 필자의 시스템-자료 군 연계정도 기반 정보검색 상호작용 모형을 제시한다.

• The Plant Pathology Journal
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• 제24권3호
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• pp.337-351
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• 2008

Host-pathogen interaction in rice bacterial blight pathosystem was analyzed for a better understanding of their relationship and recognition of stable pathogenicity among the populations of Xanthomonas oryzae pv. oryzae. A total number of 52 bacterial strains isolated from diseased leaf samples collected from 12 rice growing states and one Union Territory of India, were inoculated on 16 rice varieties, each possessing known genes for resistance. Analysis of variance revealed that the host genotypes(G) accounted for largest(78.4%) proportion of the total sum of squares(SS), followed by 16.5% due to the pathogen isolates(I) and 5.1% due to the $I{\times}G$ interactions. Application of the Additive Main effects and Multiplicative Interaction(AMMI) model revealed that the first two interaction principal component axes(IPCA) accounted for 66.8% and 21.5% of the interaction SS, respectively. The biplot generated using the isolate and genotypic scores of the first two IPCAs revealed groups of host genotypes and pathogen isolates falling into four sectors. A group of five isolates with high virulence, high absolute IPCA-1 scores, moderate IPCA-2 scores, low AMMI stability index '$D_i$' values and minimal deviations from additive main effects displayed in AMMI biplot as well as response plot, were identified as possessing stable pathogenicity across 16 host genotypes. The largest group of 27 isolates with low virulence, small IPCA-1 as well as IPCA-2 scores, low $D_i$ values and minimal deviations from additive main effect predictions, possessed stable pathogenicity for low virulence. The AMMI analysis and biplot display facilitated in a better understanding of the host-pathogen interaction, adaptability of pathogen isolates to specific host genotypes, identification of isolates showing stable pathogenicity and most discriminating host genotypes, which could be useful in location specific breeding programs aiming at deployment of resistant host genotypes in bacterial blight disease control strategies.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2004년도 KSOT/KEMS fall annual meeting
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• pp.23-25
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• 2004

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2006년 창립20주년기념 정기학술대회 및 국제워크샵
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• pp.113-120
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• 2006

In this paper, generation mechanisms of ocean freak waves are briefly introduced in the context of wave-current interaction phenomena. As an accurate and efficient numerical tool, the spectral element method is presented with general features and specific treatment for the wave-current interaction problem. The present model of the fluid motion is based on the Navier-Stokes equations incorporating a velocity-pressure formulation. In order to deal with the free surface motion, an Arbitrary Lagrangian-Eulerian (ALE) description is adopted. As an intermediate stage of development, solution procedure and characteristic aspects of the present modeling and numerical method features are addressed in detail, and numerical results for wave-current interaction is left as further study.

• International Journal of CAD/CAM
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• 제9권1호
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• pp.93-102
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• 2010

Shaping realistic hairstyles for digital characters is a difficult, long and tedious task. The lack of appropriate interaction metaphors enabling efficient and simple, yet accurate hair modeling further aggravates the situation. This paper presents 3D interaction metaphors for modeling virtual hair using haptic interfaces. We discuss user tasks, ergonomic aspects, as well as haptics-based styling and fine-tuning tools on an experimental prototype. In order to achieve faster haptic rates with respect to the hair simulation and obtain a transparent rendering, we adapt our simulation models to comply with the specific requirements of haptic hairstyling actions and decouple the simulation of the hair strand dynamics from the haptic rendering while relying on the same physiochemical hair constants. Besides the direct use of the discussed interaction metaphors in the 3D modeling area, the presented results have further application potential in hair modeling facilities for the entertainment industry and the cosmetic sciences.