• Title/Summary/Keyword: Specialized Research Institute

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Development of a Cosmetic Ingredient Containing DHA Derivatives for Anti-inflammation, Anti-wrinkle, and Improvement of Skin Barrier Function (DHA 유도체를 이용한 항염, 항노화, 피부장벽 강화용 화장품 원료의 개발)

  • Lee, Miyoung;Lee, Gil-Yong;Suh, Jinyoung;Lee, Kyung min;Lee, Woojung;Cho, Hee Won;Yi, Jong-Jae;Seo, Jeong-Woo;Choi, Heonsik
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.1
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    • pp.65-73
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    • 2021
  • It is very important to control the inflammation of the skin because it can develop into diseases such as atopy as well as scarring and aging. In this work, we recently identified the in vitro synthesis of specialized pro-resolving mediators (SPMs) known to control inflammation in the human body and the applicability of cosmetics. Using recombinant protein of lipoxygenase from Glycine max, we succeeded to prepare mixtures of mono- or di-hydroxy DHA named as S-SPMs and used them for in vitro efficacy test. To investigate anti-inflammatory effect of S-SPMs, mRNA level of TNF-α and IL-6 were analyzed. Under UVB exposed condition, expression of both were decreased by S-SPMs treatment. And we observed reduced production of nitric oxide (NO) by S-SPMs application under the condition with diesel particulate matter (DPM). At the same experimental condition, malondialdehyde (MDA) production was decreased by S-SPMs, indicating the inhibitory effect of S-SPMs in lipid peroxidation. In addition, S-SPMs treatment resulted in reduction of matrix metalloproteinases-1 (MMP-1) expression and elevation of procollagen type I synthesis. Together with this, mRNA level of filaggrin and loricrin were increased by S-SPMs, indicating enhancement of skin barrier function. These results demonstrate that S-SPMs is a good candidate to develop as a cosmetic ingredient for anti-inflammation, anti-wrinkle, and improvement of skin barrier function.

Development of the implant surgical technique and assessment rating system

  • Park, Jung-Chul;Hwang, Ji-Wan;Lee, Jung-Seok;Jung, Ui-Won;Choi, Seong-Ho;Cho, Kyoo-Sung;Chai, Jung-Kiu;Kim, Chang-Sung
    • Journal of Periodontal and Implant Science
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    • v.42 no.1
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    • pp.25-29
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    • 2012
  • Purpose: There has been no attempt to establish an objective implant surgical evaluation protocol to assess residents' surgical competence and improve their surgical outcomes. The present study presents a newly developed assessment and rating system and simulation model that can assist the teaching staffs to evaluate the surgical events and surgical skills of residents objectively. Methods: Articles published in peer-reviewed English journals were selected using several scientific databases and subsequently reviewed regarding surgical competence and assessment tools. Particularly, medical journals reporting rating and evaluation protocols for various types of medical surgeries were thoroughly analyzed. Based on these studies, an implant surgical technique assessment and rating system (iSTAR) has been developed. Also, a specialized dental typodont was developed for the valid and reliable assessment of surgery. Results: The iSTAR consists of two parts including surgical information and task-specific checklists. Specialized simulation model was subsequently produced and can be used in combination with iSTAR. Conclusions: The assessment and rating system provided may serve as a reference guide for teaching staffs to evaluate the residents' implant surgical techniques.

Universal Personal Telecommunications using Specialized Resource Functions in the Intelligent Peripheral (Intelligent Peripheral의 특수 음성 자원을 이용한 Universal Personal Telecommunications 서비스)

  • Kim, Gi-Ryeong;Kim, Tae-Il;Choe, Go-Bong
    • The Transactions of the Korea Information Processing Society
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    • v.3 no.6
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    • pp.1506-1514
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    • 1996
  • This paper proposes enhanced features for the Universal Telecommunications (UPT), voice authentication and voice synthesis, using the specialized resources functions in the Intelligent peripheral(IP). The proposed voice authentication is able ti provide simple and user-friendly security mechanism and to prevent unauthorized users from fraudulently using the UPT number. Also, traditional UPT service deliveries only fixed message to the UPT user, but the proposed UPT service can support flexible message transfer by use of the voice synthesis.

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Evaluation on the Specialized Quality Programs of the Senior Welfare Centers in Gyeonggi-do: Focusing on the Perspectives of the Service Users (경기도 노인복지관 특화 프로그램 평가: 서비스 이용자 관점을 중심으로)

  • Ji, Eric Seung-Hoon
    • 한국노년학
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    • v.36 no.3
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    • pp.847-867
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    • 2016
  • The purpose of this study is to observe whether the specialized quality programs of senior welfare centers actually help service users and meet their needs. In order to find out, we have utilized three different research methods. First, an in-depth interview was generated among the service users of senior welfare centers. Second, the specialized quality program in senior welfare centers was analyzed. Third, a focused group interview among the senior welfare experts was conducted. Based on the results of this study, they suggest four practical proposals. First is to enhancing programs of senior welfare centers based on the service users' rights. Second is to providing high-class services by developing and transforming the 'elderly culture.' Third is to converting the existing programs to make associations with their local communities. Last is to building a network as a hub to communicate and sharing outstanding programs within senior welfare centers.

A Study on Research Trends and Development Process of Health Policy for the Elderly (노인보건정책의 발전과정 및 연구동향에 대한 일고찰)

  • Sunwoo, Duk
    • 한국노년학
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    • v.28 no.4
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    • pp.773-784
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    • 2008
  • This paper is to suggest policy issues to be done in the future health policy for the elderly, analyzing contents of results suggested in academic papers published in Journal of the Korean Gerontological Society. Number of Papers published in the Journal is 61, occupying most of papers related with chronic disease, medical expenditures and health delivery system except dental and psychiatric health. Method used to be analyzed is mostly random sampling among community inhabitants or hospital patients. Policy issues are as follows in case of being based in the above analysis results. Firstly, it is necessary that the development of health promotion specialized for the elderly be developed and activated. Secondly, it is necessary that the primary health care system specialized for the elderly be constructed. Thirdly, it is necessary that the subacute care system specialized for the elderly be constructed after acute care services. Finally, it is necessary that the health care system specialized for the elderly in need of long-term care be constructed also.

A Study on the Specialized Mix Design of Mine Sprayed Concrete Using Industrial Byproducts (산업부산물(産業副産物)을 이용(利用)한 광산(鑛山) 스프레이 콘크리트의 물성연구(物性硏究))

  • Ma, Sang-Joon
    • Resources Recycling
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    • v.22 no.3
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    • pp.18-27
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    • 2013
  • In this study, it was developed eco-friendly mix design of mine sprayed concrete, which satisfies both the stability and economics by mixing the industrial in cement, for development of the mine sprayed concrete and recycling of industrial. From this research, it is found that mixing of mineral admixture is effective on strength enhancement. Also, it is considered that designed mixing ratio of sprayed concrete using industrial byproducts should be applied to the field through field test.

Endogenous Proteinaceous Inhibitor for Protein Methylation Reactions

  • Paik, Woon-Ki;Lee, Hyang-Woo;Kim, Sangduk
    • Archives of Pharmacal Research
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    • v.10 no.3
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    • pp.193-196
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    • 1987
  • Protein methylation occurs ubiquitously in nature and involves N-methylation of lysine, arginine, histidine, alanine, proline and glutamine, O-methylesterfication o dicarboxylic acids, and S-methylation of cysteine and methionine. In nature, methylated amino acids accur in highly specialized proteins such as histones, flagella proteins, myosin, actin, ribosomal proteins. hn RNA-bound protein, HMG-1 and HMG-2 protein, opsin, EF-Tu, EF-$1\alpha$, porcine heart citrate synthase, calmodulin, ferredoxin, $1\alpha$-amylase, heat shock protein, scleroderma antigen, nucleolar protein C23 and IF-3l.

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Establishment of Condition Assessment Criteria in Agricultural Reservoirs by AHP (AHP 기법에 의한 농업용 저수지의 상태평가 기준 설정)

  • Shim, Jae-Woong;Lee, Young-Hak;Lee, Dal-Won
    • Journal of The Korean Society of Agricultural Engineers
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    • v.64 no.5
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    • pp.17-26
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    • 2022
  • In this study, in order to establish the criteria for evaluation of importance by the type of facility specialized for agricultural reservoirs, an expert group consisting of a total of 167 members who were in management, or specialized in the fields of design, research, and diagnosis were organized, and the importance for facilities was set with application of the AHP technique. The importance of dam body, spillway, and intake structure composing a reservoir were set at 59%, 24%, and 17%, and the importance of dam crest, upstream slope, and downstream slope constituting a dam body was set at 32%, 31%, and 37%, respectively. In addition, the importance of approach channel, regulated channel, chute channel, and stilling basin consisting a spillway was set at 15%, 44%, 26%, and 15%, and the importance of inclined conduit and outlet conduit consisting an intake structure was set at 35% and 65%, respectively. The safety grade of the reservoirs evaluated by applying the newly presented importance values in this study showed the rearrangement of the grades with a change of 11% compared to the previous grades. In this way, the newly established criteria are expected to be utilized as basic data with strategic importance in reservoir safety management and disaster prevention as well as the operation of systems in the future.

An Analysis of Health Promotion Programs Utilizing Forests based on Korea's Regional Healthcare Program Plans (지역보건의료계획에 근거한 보건소 숲 건강증진 프로그램 현황)

  • Lee, Insook;Kim, Sungjae;Bang, Kyung-Sook;Choi, Heeseung;Ko, Chinkang;Kim, Jieun;Kim, Sunyoung
    • Perspectives in Nursing Science
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    • v.11 no.1
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    • pp.10-17
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    • 2014
  • Purpose: The aim of this study was to analyze health promotion programs utilizing forests by reviewing regional healthcare program plans in Korea. Methods: We analyzed 227 regional healthcare program plans from 2011 to 2014; seven health promotion programs of the 16 major healthcare programs were prescribed by public health law. Results: Our analysis revealed that only 35 health promotion programs from 29 sites were utilizing forests. Furthermore, of 21 known categories of health promotion programs, only nine incorporated the use of forests. Atopy-asthma healthcare programs were the most common forest health promotion programs, which also included specialized disease management programs (e.g., for atopy prevention and healing, patients with metabolic syndrome or cancer) and specialized mental health management programs (e.g., for addiction or dementia prevention). Others included programs on the development of forest roads or industrial development using forest products. Conclusion: Health programs using forests in Korea are still very limited and primarily comprise atopy-asthma prevention/management, health behavioral change, and mental health programs. This study provided useful information for developing health policies and forest health promotion programs further in Korea.

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Analysis of Cytokine and Hormone on Sasang constitution (사상체질별 Cytokine 및 Hormone 분석)

  • Choi, Sun-Mi;Kim, Min-Hee;Chi, Sang-En;Kim, Hee-Soo;Sung, Hyun-Jea;Shin, Min-Kyu
    • Korean Journal of Oriental Medicine
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    • v.5 no.1
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    • pp.73-79
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    • 1999
  • In this research we proceeded experiments to find the basis which make it possible to explain the physical and pathological process of Sasang constitutional medicine, in the way substituting hematopoietic-immune system(essence of life, blood, Ki and mental faculties : 精血氣神) Under these suppositions, the essence of life(精) is the multipotent stem cell which has the possibility to be specialized to any cell, the Ki(氣), blood(血) and mental faculties(神) are inferred that they are formed from specialized the essence of life(精), the blood(血) is the red blood cells and etc. that appears as the result of the genesis of circulation system. The Ki(氣) is from specialized basic immunity, the mental faculties(神) means long-term memories or combined immunity. Cytokines can act as specilaizing, growing factors and particiate in extremly combined procedure being controlled by both positive and negative specializing signals. Blood gathering was carried out in the morning and on empty stomach. The plasma was seperated and Erythropoietin, Stem cell factor, Granulocyte-colony stimulaing factor, Tumor necrosis factor, interlukin-3, Interleukin-6 were measured with ELISA kit. According to the result of post analysis by Duncan, each constitution is different in SCF(stem cell factor), IL-6(interleukin-6), EPO(erythropoietin). The value of Stem cell factor is high in order of Soumin(少陰人), Soyangin(少陽人), and Taeumin(太陰人), The value of interleukin-6 is high in Taeumin, Soumin, and Soyangin. Erythropoietin is high in order of Soumin, Soyangin, and Taeumin.

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