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Efficacy of alpha-lipoic acid in patients with burning mouth syndrome compared to that of placebo or other interventions: a systematic review with meta-analyses

  • Christy, Jessica;Noorani, Salman;Sy, Frank;Al-Eryani, Kamal;Enciso, Reyes
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.22 no.5
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    • pp.323-338
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    • 2022
  • Burning mouth syndrome (BMS) is a chronic oral disorder of unknown etiology which presents therapeutic challenges. Alpha-lipoic acid (ALA) has been studied as a potential treatment for BMS. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of ALA compared to that of placebo or other interventions in individuals with BMS. Randomized controlled trials (RCT) using ALA to treat BMS were identified from MEDLINE, Cochrane Library, EMBASE, and Web of Science up to February 3, 2021. The assessment of the risk of bias in the included studies was based on the Cochrane guidelines. The primary outcome evaluated was the visual analog scale (VAS) pain intensity. ALA was compared with placebo, clonazepam, gabapentin, pregabalin, ALA plus gabapentin, capsaicin, Biotène®, and laser therapy. Altogether, 137 records were scanned for inclusion/exclusion, and nine RCTs (two unclear and seven at high risk of bias) were included in the qualitative and quantitative analyses, with a total of 594 patients with BMS included in this review. All studies reported an improvement in VAS pain scores ranging from -0.72 to -2.77. Meta-analysis results showed a non-significant reduction in pain intensity for ALA (P = 0.616) compared to that of placebo on a VAS of 0-10. Patients taking ALA were 1.923 times more likely to show an improvement in self-reported BMS symptoms (P = 0.031) than those in the placebo group. Clonazepam and pregabalin showed a significant VAS pain reduction of 4.08 and 4.68 (P < 0.001), respectively, compared to that with ALA. Although ALA intervention provided a non-significant improvement in the pain score and was more likely to produce a reduction in BMS symptoms, the evidence was of low quality. Further research is needed to establish clear guidelines for the use of ALA for BMS treatment.

Corneal Ulcer Region Detection With Semantic Segmentation Using Deep Learning

  • Im, Jinhyuk;Kim, Daewon
    • Journal of the Korea Society of Computer and Information
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    • v.27 no.9
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    • pp.1-12
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    • 2022
  • Traditional methods of measuring corneal ulcers were difficult to present objective basis for diagnosis because of the subjective judgment of the medical staff through photographs taken with special equipment. In this paper, we propose a method to detect the ulcer area on a pixel basis in corneal ulcer images using a semantic segmentation model. In order to solve this problem, we performed the experiment to detect the ulcer area based on the DeepLab model which has the highest performance in semantic segmentation model. For the experiment, the training and test data were selected and the backbone network of DeepLab model which set as Xception and ResNet, respectively were evaluated and compared the performances. We used Dice similarity coefficient and IoU value as an indicator to evaluate the performances. Experimental results show that when 'crop & resized' images are added to the dataset, it segment the ulcer area with an average accuracy about 93% of Dice similarity coefficient on the DeepLab model with ResNet101 as the backbone network. This study shows that the semantic segmentation model used for object detection also has an ability to make significant results when classifying objects with irregular shapes such as corneal ulcers. Ultimately, we will perform the extension of datasets and experiment with adaptive learning methods through future studies so that they can be implemented in real medical diagnosis environment.

Classification of Diabetic Retinopathy using Mask R-CNN and Random Forest Method

  • Jung, Younghoon;Kim, Daewon
    • Journal of the Korea Society of Computer and Information
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    • v.27 no.12
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    • pp.29-40
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    • 2022
  • In this paper, we studied a system that detects and analyzes the pathological features of diabetic retinopathy using Mask R-CNN and a Random Forest classifier. Those are one of the deep learning techniques and automatically diagnoses diabetic retinopathy. Diabetic retinopathy can be diagnosed through fundus images taken with special equipment. Brightness, color tone, and contrast may vary depending on the device. Research and development of an automatic diagnosis system using artificial intelligence to help ophthalmologists make medical judgments possible. This system detects pathological features such as microvascular perfusion and retinal hemorrhage using the Mask R-CNN technique. It also diagnoses normal and abnormal conditions of the eye by using a Random Forest classifier after pre-processing. In order to improve the detection performance of the Mask R-CNN algorithm, image augmentation was performed and learning procedure was conducted. Dice similarity coefficients and mean accuracy were used as evaluation indicators to measure detection accuracy. The Faster R-CNN method was used as a control group, and the detection performance of the Mask R-CNN method through this study showed an average of 90% accuracy through Dice coefficients. In the case of mean accuracy it showed 91% accuracy. When diabetic retinopathy was diagnosed by learning a Random Forest classifier based on the detected pathological symptoms, the accuracy was 99%.

Analysis of the Causes for Continuous Employment of Employed Students after Graduation from Characterization High School -Focusing on the Commercial High Schools (특성화고등학교 졸업 후 취업자의 근속 원인 분석 연구 -상업계 고등학교를 중심으로)

  • Jeong, Kyu-Han;Lee, Jang-Hee
    • Journal of Practical Engineering Education
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    • v.14 no.1
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    • pp.165-177
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    • 2022
  • The purpose of this study is to present the direction of employment guidance for long-term service through the analysis of the cause of employment of employed students who graduated from specialized high school. In particular, the purpose is to present student guidance plans for long-term service by analyzing personal reasons for students graduating from commercial high schools and policy factors for individual, school, company, and government service after employment. To this end, a survey was conducted for graduates of commercial high schools nationwide, and the validity, reliability, and causality of the survey data were analyzed by applying Exploratory Factor Analysis, Cronbach's Alpha, and decision tree analysis techniques. We found that personal goal setting for employment is an important factor for working for more than 1 year, personal relationships at work and personal characteristics are important factors for working for more than 3 years. In addition, we found that the reason for getting a job is that personal reasons and school recommendations are great, special lectures on employment, camps, and 'advice from seniors and teachers' programs are helpful in finding a job, and accounting and computer related subjects are helpful for long-term employment. Accordingly, in specialized high schools, it is required to prepare specific instructional measures for education such as setting personal goals and the formation of human relationships that are the basis of social life, and to actively operate the above subjects and programs to help with employment and longevity.

Disaster Reduction Plan through Forklift Accident Case Analysis (지게차 재해사례 분석을 통한 재해감소방안)

  • Young Min Park
    • Journal of the Society of Disaster Information
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    • v.19 no.1
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    • pp.173-183
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    • 2023
  • Purpose: In order to reduce industrial accidents caused by forklift trucks, it is actually necessary to analyze the causes of accidents. This study aims to present disaster prevention measures by analyzing accident cases by forklift accident type. Method: For the analysis of industrial accidents, including serious industrial accidents caused by forklifts from 2021 to 2022, accident statistics from the Korea Occupational Safety and Health Agency were used to analyze accidents in four types. Result: In the last two years, the total number of victims, including deaths and other serious injuries, was 2,559, which was 1,396 in 2021 and 1,163 in 2022. Disaster prevention measures were presented for industrial accidents by size and occurrence type of equipment that cause serious industrial accidents in which more than 1,000 people are injured annually. Conclusion: It is necessary to expand the number of workers subject to the forklift financial support project to less than 100. It is necessary to amend the proviso on boarding restrictions in Article 86, Paragraph 7 of the 「Regulations on Industrial Safety and Health Standards」. It is mandatory to install front and rear cameras. It is necessary to install driving-linked safety belts. It is necessary to install line beams obligatory. It is necessary to expand the subject of forklift special safety and health education to workplaces that have more than one forklift truck, and it is necessary to redesignate the training hours to 16 hours every year.

Flexural Experiments on Reinforced Concrete Beams Strengthened with SHCC and Special Reinforcements (SHCC와 특수 보강근으로 보강된 철근콘크리트 보의 휨 성능 실험)

  • Chang-Jin Hyun;Ji-Seok Seo;Yun-Yong Kim
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.1
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    • pp.46-53
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    • 2023
  • In this paper, we evaluated the flexural performance of three types of reinforced concrete beams (SHCC-RB, SHCC-SB, SHCC-FRP) strengthened with ordinary steel rebar, very high strength (super strength) rebar, and FRP bars together with strain-hardening cement composite (SHCC). For this purpose, a series of beam specimens were manufactured and four-point load bending experiments were performed. As a result of the experiment, all specimens strengthened with SHCC exhibited tightly controlled flexural microcrakcs with the crack width of less than 100 ㎛. This is mostly due to the material properties of SHCC showing tensile strain hardening properties with multiple microcracks under uniaxial tension. The specimen SHCC-FRP showed lower initial cracking moment and yield flexural strength than SHCC-RB, whereas the maximum flexural strength of SHCC-FRP was superior to that of SHCC-RC. This is because the tensile strength of FRP bars is higher than that of ordinary steel reabr. The initial cracking moment of the beam specimen SHCC-SB was similar to that of SHCC-RB, but the yield flexural strength and maximum flexural strength of SHCC-SB were evaluated to be the highest.

Records on Ginseng and Medical Book during the Goryeo Dynasty (고려 시대 인삼과 의약서에 대한 기록)

  • Sungdong Lee
    • Journal of Ginseng Culture
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    • v.5
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    • pp.21-31
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    • 2023
  • Korean ginseng, a special product of Korea, has been one of the most important exports since the era of the Three Kingdoms. However, not many records were kept about ginseng in Korea until the Goryeo Dynasty. This paper summarizes the records relating to international diplomatic relations and trade of ginseng in the Goryeo Dynasty and the medicinal books known to have been published at the time. During the Goryeo Dynasty, ginseng was actively transported to the neighboring countries of Bohai, Song, Wa, Later Jin, and Yuan as a diplomatic gift or as a trade item. Ginseng was mainly exported from Goryeo to these countries, but it was also received as a diplomatic gift from Bohai and Khitan. Arabian merchants came to Byeokran Port, a representative international trading port of Goryeo, and traded ginseng. After the Mongol invasion, the demand for ginseng in the Yuan Dynasty was excessive, which became a big social problem. During the Goryeo Dynasty, several medicinal books were published, including Jejungiphyobang, Eouuichwalyobang, Hyangyakgobang, Samhwajahyangyakbang, Hyangyak Hyemin Gyeongheombang, Hyangyak Gugeupbang, and Biyebaekyobang. Hyangyak Gugeupbang, which was reprinted during the Joseon Dynasty, has been handed down to the present time, although this has not been the case for the originals of the remaining books. Recently, some of the latter books have been restored through the study of the references in various medicinal books of later generations. While the medicinal books used in the royal court showed that a high proportion of the prescriptions containing ginseng, not a single prescription for ginseng has been found in theHyangyak Gugeupbang, which was mainly used for commoners. This is thought to be because ginseng was very rare and expensive at the time, so it was difficult for commoners to access it.

A Study of Influences Transportation Welfare Facilities on the Mobility Handicapped: Focusing on the Factors of Characteristics Public Transit (교통복지시설이 교통약자에 미치는 영향: 대중교통특성 요소를 중심으로)

  • Eun-Yeol, Oh;Jun-Ok, Shin
    • Journal of Industrial Convergence
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    • v.20 no.11
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    • pp.85-93
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    • 2022
  • As of the end of 2019, the total population nationwide was 51,849,861, and over the past five years, the population per household has decreased by 1.52% annually from 2.45 in 2015 to 2.31 in 2019. Looking at the current status of population distribution by age group, Busan metropolitan city had the highest proportion of senior citizens aged 65 or older at 18.2%, and Sejong Special Self-Governing city had the lowest at 9.4%. In particular, as of 2019, the population of the mobility handicapped was 15,219,000 nationwide, showing a ratio of about 29.4% of the total population. Therefore, it is important to secure the right to move according to the mobile facilities so that the mobility handicapped can move safely and conveniently. Against this background, this study places value on transportation welfare facilities centered on the mobility handicapped for safe and convenient movement, and in particular, in proposing measures to cope with the entry of an aging society and the continuous increase of the mobility handicapped, the transportation facilities, The purpose of this study is to analyze the impact of welfare facilities on the mobility handicapped and suggest implications. As a research method, the results of statistical analysis methods were presented through major preceding studies and expert surveys.

A Study on Improvement of Air Quality Dispersion Model Application Method in Environmental Impact Assessment (II) - Focusing on AERMOD Model Application Method - (환경영향평가에서의 대기질 확산모델 적용방법 개선 연구(II) - AERMOD 모델 적용방법을 중심으로 -)

  • Suhyang Kim;Sunhwan Park;Hyunsoo Joo;Minseop So;Naehyun Lee
    • Journal of Environmental Impact Assessment
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    • v.32 no.4
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    • pp.203-213
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    • 2023
  • The AERMOD model was the most used, accounting for 89.0%, based on the analysis of the environmental impact assessment reports published in the Environmental Impact Assessment Information Support System (EIASS) between 2021 and 2022. The mismatch of versions between AERMET and AERMOD was found to be 25.3%. There was the operational time discrepancy of 50.6% from industrial complexes, urban development projects between used in the model and applied in estimating pollutant emissions. The results of applying various versions of the AERMET and AERMOD models to both area sources and point sources in both simple and complex terrain in the Gunsan area showed similar values after AERMOD version 12 (15181). Emissions are assessed as 24-hour operation, and the predicted concentration in both simple and complex terrain when using the variable emission coefficient option that applies an 8-hour daytime operation in the model is lowered by 37.42% ~ 74.27% for area sources and by 32.06% ~ 54.45% for point sources. Therefore, to prevent the error in using the variable emission coefficient, it is required to clearly present the emission calculation process and provide a detailed explanation of the composition of modeling input data in the environmental impact assessment reports. Also, thorough reviews by special institutions are essential.

A Study on the Satirical Content Plot of an Absurd Play - Focused on Lee Keun-sam's Play - (부조리극의 풍자적 콘텐츠 플롯 연구 - 이근삼 희곡 <원고지>를 중심으로 -)

  • Son, Dae-Hwan
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.5
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    • pp.73-82
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    • 2019
  • The satirical content of the absurd play, centered on Lee Keun-sam's play, represents the family image of a modern capitalist society where only duty is emphasized while the characters are lost in love with the family. They show humans becoming subordinate to economic logic as traditional relationships and family relationships change into material ones due to the rapid development of the economy. The narrator expresses the roles of the performer and the narrator together. It also presents the plot as a characteristic element of epic and absurd dramas, and directs actors as directors. It also foretells the events that will take place in the future, presents the inner consciousness of the characters in the play, and reduces and expands events and times. In terms of conflict, in order to fulfill the financial responsibility of their children, the professor translates them like a machine and the wife distributes the money they earn as they demand. The middle-aged professor and his wife are not willing to make a difference in the real world, so specific conflicts are not revealed. Therefore, no concrete conflict appears within this work. The plot of consisted of 22 epicentre compartments, consisting of a time frame from evening to the next morning. And no special events happen and show only one family's daily life. In addition, materials that show simple repetition of daily life such as newspapers, rice, birthdays, etc. are effectively showing the character of absurdity through repeated structure. The linguistic features of the absurd play focus on expressing anxiety, despair, fantasy and the sense of loss that the object's purpose has disappeared. The stage system avoids detailed portrayals of naturalist plays and creates a thoroughly simplified image that the theme of the play demands, which shows that the stage unit is also an important element that characterizes the absurdity of reflexes.