• Parasites, Hosts and Diseases
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• v.58 no.3
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• pp.267-278
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• 2020

The heterogeneity and complexity of malaria involves political and natural environments, socioeconomic development, cross-border movement, and vector biology; factors that cannot be changed in a short time. This study aimed to assess the impact of economic growth and cross-border movement, toward elimination of malaria in Yunnan Province during its pre-elimination phase. Malaria data during 2011-2016 were extracted from 18 counties of Yunnan and from 7 villages, 11 displaced person camps of the Kachin Special Region II of Myanmar. Data of per-capita gross domestic product (GDP) were obtained from Yunnan Bureau of Statistics. Data were analyzed and mapped to determine spatiotemporal heterogeneity at county and village levels. There were a total 2,117 malaria cases with 85.2% imported cases; most imported cases came from Myanmar (78.5%). Along the demarcation line, malaria incidence rates in villages/camps in Myanmar were significantly higher than those of the neighboring villages in China. The spatial and temporal trends suggested that increasing per-capita GDP may have an indirect effect on the reduction of malaria cases when observed at macro level; however, malaria persists owing to complex, multi-faceted factors including poverty at individual level and cross-border movement of the workforce. In moving toward malaria elimination, despite economic growth, cooperative efforts with neighboring countries are critical to interrupt local transmission and prevent reintroduction of malaria via imported cases. Cross-border workers should be educated in preventive measures through effective behavior change communication, and investment is needed in active surveillance systems and novel diagnostic and treatment services during the elimination phase.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.607-615
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• 2020

The purpose of this study was to analyze the research status and trends related to the industrial mathematics based on text mining techniques with a sample of 4910 papers collected in the SIAM Journal on Applied Mathematics from 1970 to 2019. The R program was used to collect titles, abstracts, and key words from the papers and to analyze topic modeling techniques based on LDA algorithm. As a result of the coherence score on the collected papers, 20 topics were determined optimally using the Gibbs sampling methods. The main results were as follows. First, studies on industrial mathematics were conducted in a variety of mathematics fields, including computational mathematics, geometry, mathematical modeling, topology, discrete mathematics, probability and statistics, with a focus on analysis and algebra. Second, 5 hot topics (mathematical biology, nonlinear partial differential equation, discrete mathematics, statistics, topology) and 1 cold topic (probability theory) were found based on time series regression analysis. Third, among the fields that were not reflected in the 2015 revised mathematics curriculum, numeral system, matrix, vector in space, and complex numbers were extracted as the contents to be covered in the high school mathematical curriculum. Finally, this study suggested strategies to activate industrial mathematics in Korea, described the study limitations, and proposed directions for future research.

• The Korean Journal of Ecology
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• v.25 no.3 s.107
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• pp.145-152
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• 2002

Saussurea chabyoungsanica was recorded in new species by Lim Hyoung Tak in 1997. In order to understand the entity of new species, we investigated the new distribution sites, vegetation structure and soil environmental factors. Additionally discovered distribution sites of S. chabyoungsanica were Manduckbong, Mt. Sukbyoung, Mt. Duckhang, and Sukgaejae, which were located on ridge of the Taebaek Mountains. Those sites are typical limestone zones of Korea and among them Sukgaejae belongs to lower great limestone area and Manduckbong, Mt. Sukbyoung and Mt. Duckhang belong to upper great limestone area. According to the result of phytosociological study, plant communities of S. chabyoungsanica were classified by 1 Community group, 4 Communities and 2 Subcommunities; Carex humilis var. nana-Saussurea chabyoungsanica Community group in wide sense Quercus mongolica Community group, Lespedeza maximowiczii-Saussurea chabyounsanica Community, Galium kinuta-Saussurea chabyoungsanica Community, Salvia chanryonica-Saussurea chabyoungsanica Community, Zabelia coreana-Saussurea chabyoungsanica Community. Environmental factor analysis of habitat showed that the distribution site of S. chabyoungsanica was ridge of North aspect and displayed pH $7{\sim}8$ typical of limestone. Soil moisture content was high, whereas organic matter content was low. Considering its high occurrence in sites of $1{\sim}10cm$ in soil depth, and of $30{\sim}45%$ in relative light intensity, major distribution sites were outcrops and boundaries between shrubland and forest. After community division by vegetation structure in habitat of S. chabyoungsanica, we investigated characters of soil environment by community. As a result of PCA analysis of soil sample by community, it was possible to divide community by characters of soil environmental factor. The cumulative value of contribution rate represented in second dimension space was 73% and the major factors for that value were soil texture, organic matter content and field capacity.

• Korean Journal of Ecology and Environment
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• v.36 no.1 s.102
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• pp.57-65
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• 2003

The algal growth potential test (AGPT) bioassay were conducted to assess the water quality and fertility in the Chinyang Reservoir and the lower part of the Nam River from August 2000 to July 2001, The AGPT value of the Chinyang Reservoir ranged from 0 to 23.4 mg dw $1^{-1}$, while 79% of the algae cultivation have not grown. The AGPT value was in proportion to phosphorus concentration of the water, and it was less when chlorophyll-a was high. This value was higher in the middle and lower layers than in the upper layer, and in the inflow part where the water is shallower than in the lacustrine. The AGPT value has increased in the whole reservoir in August${\sim}$September when the water volume is high. In contrast, the AGPT value in the Nam River varied greatly compared to that of the reservoir, and ranged from 0 to 252.0 mg dw $1^{-1}$ and 65% of the algae cultivation have grown. The value was less than 10 mg dw $1^{-1}$ in the upstream, over the point where the treated wastewater discharged. It was 57 mg dw $1^{-1}$ on the average in the downstream, except in March and July when the discharged water influenced greatly, exceeding the hypertrophic condition. The result of AGPT shows the differences in the time and space on the reservoir and the streams. The AGPT value has increased in July${\sim}$September, and in December in the inflow part of the reservoir; in March and August${\sim}$December in the lower part; and in January, May, and November in the streams. AGPT is useful not only in defining the influence of the limiting nutrients on the algal growth, but also in evaluating the nutrients fertility in the inland water.

• The Korean Journal of Malacology
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• v.15 no.1
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• pp.21-30
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• 1999

This study was carried out to describe the growth of Ruditapes philippinarum on Chohwa and Toksan tidal flat in Kwangyang Bay, from June 1994 to July 1995. On the Chohwa tidal flat, the mean gran size, organic content and chlorophyll-a of the surface sediment were the range of 2.50-4.46 , 4.99-5.11%, 14.53-19.90 $\mu\textrm{g}$ cm$\^$-3/, and on the Toksan tidal flat, 0.83-1.66 , 2.22-2.34%, 6.20-6.90 $\mu\textrm{g}$ cm$\^$-3/, respectively. The shell length of R. philippinarum increased rapidly from spring to summer, and gently from summer to autumn, and ceased during winter. Fresh weight increased during spring and autumn, and decreased during summer and winter. condition factors also showed the same variations of weights. Synthesized annual growth pattern of 4 year classes in shell length fitted the von Bertalnffy growth model well. The annual growth of weight fitted the Gompertz model relatively well. The values of w, initial shell growth rate, and AGR$\sub$max/, maximum weight growth rate, on the Chohwa tidal flat were lower than those on the Toksan tidal flat. Comparing the growth patterns in the same tidal flat, growth rate was higher on the lover tidal flat than those on the higher tidal flat. In conclusion, the Chohwa tidal flat maintaining higher density showed lover growth rate, because of relatively insufficient food supply and inhabiting space.

• Korean Journal of Plant Taxonomy
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• v.43 no.4
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• pp.274-284
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• 2013

This study presents a survey on the bryophytes in Dongbaek-dongsan located at Seonheul Gotjawal on the north-eastern face of Mt. Halla in Jeju Island, Korea. A total of 85 taxa belonging to the Bryophyta (22 families 44 genera 62 species), Marchantiophyta (12 families 16 genera 23 species) were found. Among them, 3 moss species, Diphyscium perminutum Takaki, Racomitrium japonicum Dozy & Molk., and Isopterygium minutirameum (M$\ddot{u}$. Hal.) A. Jaeger. were new additions to the bryophyte flora of Korea. The liverwort index was 27.0%. Predominant life-form was weft. The rates for the bryophytes dominating in mesic to hygric sites were higher than for the bryophytes mainly observed in xeric habitats. We considered that the composition and distribution of species are affected by the different environmental factors according to the evergreen broad-leaved forests, wetlands and exposed spaces. Moreover, the rocks were the substrate type that play a major role in providing the micro-habitats for bryophytes in this area. Particularly, the bryophytes of swamps in this area were very unique and various for its limited space and showed plant communities with mosaic spatial pattern, along with vascular plants. We suggest more detailed and comprehensive studies on the swamps where endemic fern Mankyua chejuense B. -Y. Sun, M. H. Kim & C. H. Kim inhabits to provide valuable information for the conservation and restoration of the species and habitats.

• Journal of Korean Society of Forest Science
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• v.88 no.4
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• pp.523-532
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• 1999

The studies were carried out to develop an urban forest aromatic bath in the idle space within city area for handicapped persons, patients and city workers, who having less chance to visit the natural forest aromatic bath. The environmental conditions were checked in the experimental double vinyl house where native and exotic aromatic woody and herbaceous plants were growing with minimum energy input in the periods of mid-winter and mid-summer. The growth and photoperiodic responses of the plants to the low and high temperatures were observed during winter and summer respectively. The most of herbaceous plants in the double vinyl house with the controlled minimum night temperature of $-2^{\circ}C$ had no winter injury but did not grow and started the growth in April. The exotic herbs such as Catnip faassen's(Nepeta x faassenia) and Lemon bergamot(Monarda citriodora) grew better in the longer photoperiodic conditions. The growth rates of Abies koreana, Thuja koraiensis and Pinus sylvestriformis in the early spring were affected mainly by the night minimum temperature and less affected by the photoperiodic conditions during winter. The native aromatic herbs such as Robdosia japonica, Molsa punctulata, Agastache rugosa and Codonopsis lanceolata showed stimulatory growth at the 16 hours day-length in case of the high temperature vinyl hose. The height and root collar diameter growth of pine seedlings were inhibited in maxim temperatures over $40^{\circ}C$ during summer.

• Journal of KIISE:Databases
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• v.34 no.2
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• pp.119-132
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• 2007

In molecular biology, approximate subsequence search is one of the most important operations. In this paper, we propose an accurate and efficient method for approximate subsequence search in large DNA databases. The proposed method basically adopts a binary trie as its primary structure and stores all the window subsequences extracted from a DNA sequence. For approximate subsequence search, it traverses the binary trie in a breadth-first fashion and retrieves all the matched subsequences from the traversed path within the trie by a dynamic programming technique. However, the proposed method stores only window subsequences of the pre-determined length, and thus suffers from large post-processing time in case of long query sequences. To overcome this problem, we divide a query sequence into shorter pieces, perform searching for those subsequences, and then merge their results. To verify the superiority of the proposed method, we conducted performance evaluation via a series of experiments. The results reveal that the proposed method, which requires smaller storage space, achieves 4 to 17 times improvement in performance over the suffix tree based method. Even when the length of a query sequence is large, our method is more than an order of magnitude faster than the suffix tree based method and the Smith-Waterman algorithm.

• Development and Reproduction
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• v.13 no.4
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• pp.305-312
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• 2009

Multipotent spermatogonial stem cells (mSSCs), derived from uni-potent SSC, are a type of reprogrammed cells with similar characteristics to embryonic stem cells (ESCs). The aim of this study was to evaluate the potential for transgenesis of mSSC derived from outbred mice and the production of transgenic animal by the mSSC-insertion into embryo. mSSCs, established from outbred mice (ICR strain) in the previous study, were maintained and then transfected with a lenti-viral vector expressing green fluorescent protein (GFP), CS-CDF-CG-PRE. Embryonic stem cells (ESCs) were derived from inbred transgenic mice (C57BL/6-Tg (CAG-EGFP)) and were used as an experimental control. Transfected mSSCs were well proliferated in vitro and maintained their characteristics and normal karyotype. Ten to twelve mSSCs and ESCs were collected and inserted into perivitelline space of 8-cell mouse embryos, and then transferred them into uteri of poster mothers after an additional 2-days of culture. Percentage of mSSC-derived offsprings was 4.8% (47/980) and which was lower than those (11.7% (67/572)) of ESC-derived ones (P<0.05). However, even though different genetic background of mSSC and ESC origin, the production efficiency of coat-colored chimeric offspring in mSSC group was not different when compared it with ESC (6.4% (3/47) vs. 7.5% (5/67)). From these results, we confirmed that mSSC derived from outbred mice has a pluripotency and a potential to produce chimeric embryos or mice when reaggregatation with mSSC is performed.

• Reproductive and Developmental Biology
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• v.32 no.3
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• pp.175-181
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• 2008

This study was conducted to investigate an effective recipient oocyte and culture system for producing of Hanwoo (Korean native cattle) somatic cell nuclear transfer (SCNT) embryos. Hanwoo ear skin fibroblasts were used as donor cells. In vitro matured Hanwoo or Holstein oocytes were enucleated, and single donor cells were transferred into the perivitelline space of the enucleated oocytes. The couplets were subsequently fused and activated. The reconstructed embryos were cultured in a conventional or sequential culture system. In the former, embryos were cultured in CR2aa medium for eight days; in the latter, embryos were cultured in modified CR2aa-A (mCR2-A) for three days and then further cultured in modified CR2aa-B (mCR2-B) for five days. In the experiment with the recipient oocyte, the rate of embryo development to the blastocyst stage was significantly (p<0.05) higher in Hanwoo recipient oocytes than in Holstein ones (48.8% vs 38.9%). BIastocysts derived from Hanwoo recipient oocytes contained significantly (p<0.05) higher numbers of total cells than those derived from Holstein recipient oocytes ($156.0{\pm}68.2$ vs $134.7{\pm}54.8$). There was no difference in the mean proportion of apoptotic cells in blastocysts between the sources of recipient oocytes. In the experiment with the embryo culture system, the blastocyst rate was somewhat higher in sequential system than in conventional system (50.0% vs 43.5%), though there was no significant difference. The numbers of total ($160.0{\pm}69.0$ vs $156.7{\pm}68.4$) and apoptotic cells ($14.0{\pm}10.4$ vs $11.8{\pm}6.4$) were not different between the culture systems. In conclusion, the present study demonstrated that Hanwoo recipient oocytes and the sequential culture system were more effective in supporting the production of Hanwoo SCNT embryos.