• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2431-2440
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• 2015

Background: Registry data from four major public hospitals indicate trends in clinical care and survival from colorectal cancer over three decades, from 1980 to 2010. Materials and Methods: Kaplan-Meier productlimit estimates and Cox proportional hazards models were used to investigate disease-specific survival and multiple logistic regression analyses to explore first-round treatment trends. Results: Five-year survivals increased from 48% for 1980-1986 to 63% for 2005-2010 diagnoses. Survival increases applied to each ACPS stage (Australian Clinico-Pathological Stage), and particularly stage C (an increase from 38% to 68%). Risk of death from colorectal cancer halved (hazards ratio: 0.50 (0.45, 0.56)) over the study period after adjusting for age, sex, stage, differentiation, primary sub-site, health administrative region, and measures of socioeconomic status and geographic remoteness. Decreases in stage were not observed. Survivals did not vary by sex or place of residence, suggesting reasonable equity in service access and outcomes. Of staged cases, 91% were treated surgically with lower surgical rates for older ages and more advanced stage. Proportions of surgical cases having adjuvant therapy during primary courses of treatment increased for all stages and were highest for stage C (an increase from 5% in 1980-1986 to 63% for 2005-2010). Radiotherapy was more common for rectal than colonic cases. Proportions of rectal cases receiving radiotherapy increased, particularly for stage C where the increase was from 8% in 1980-1986 to 60% in 2005-2010. The percentage of stage C colorectal cases less than 70 years of age having systemic therapy as part of their first treatment round increased from 3% in 1980-1986 to 81% by 1995-2010. Based on survey data on uptake of adjuvant therapy among those offered this care, it is likely that all these younger patients were offered systemic treatment. Conclusions: We conclude that pronounced increases in survivals from colorectal cancer have occurred at major public hospitals in South Australia due to increases in stage-specific survivals. Use of adjuvant therapies has increased and the patterns of change accord with clinical guideline recommendations. Reasons for sub-optimal use of radiotherapy for rectal cases warrant further investigation, including the potential for limited rural access to impede uptake of treatments at metropolitan-based radiotherapy centres.

• Journal of Climate Change Research
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• v.1 no.2
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• pp.133-145
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• 2010

This study examined the characteristics of tropical cyclone(TC) activity over the western North Pacific(WNP) in 2009. Twenty-two TCs formed in 2009, which is slightly below normal(1979~2009 average: 25.8) and most of these occurred during the months of July to October. Most TCs in 2009 was formed over the northern Philippines and the eastern part of the WNP and they moved towards the South China Sea and the east of Japan, resulting in less TC affecting the East China Sea and Korea. The TC activity in 2009 is modulated by the large-scale circulations induced by the El $Ni{\tilde{n}}o$ and vigorous convection activity over the WNP. As the general characteristics of El $Ni{\tilde{n}}o$ year, the difference in sea surface temperature between the central Pacific and the eastern Pacific causes an anomalous westerly winds, expanding the WNP monsoon trough farther eastward. Accordingly, TC formation has relatively increased in the east part of the WNP. Active convection activities over the subtropical western Pacific excite a Rossby wave propagating from the South China Sea to mid-latitudes, resulting in an anomalous easterly steering flow in the South China, anomalous northwesterly over the East China Sea and Korea, and anomalous southwesterly over the east of Japan. Summing up, the TCs cannot enter the East China Sea and Korean region and instead they move towards the South China Sea or south-east of Japan. There were no effects of TCs in Korea in 2009. It is anticipated that this study which analyzed unusual TC activity and large-scale circulations in 2009 would help the predictability of TC effects to increase according to climate change in the East Asia.

• Analyses & Alternatives
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• v.1 no.2
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• pp.31-43
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• 2017

The article is devoted to the theoretical and practical analysis of Chinese global leadership. The concept of leadership is applied as a methodology, which involves identifying the main factors, such as strategic power, the attractiveness of political institutions, the ability to provide acceptable ideas and the presence of allies that contribute to a comprehensive analysis of the country's leadership potential. The authors also describe the relevance of Chinese global leadership and analyze its domestic, economic and international causes. Moreover, the ''Belt and Road'' initiative is defined as the main mechanism for providing the influence of China on the global level which is now being changed its quantitative component, namely the increasing attention to the security aspects of this initiative. In addition to that, it is important to note that China maintains its economic and political positions in Africa, Central Asia and South-East Asia. Africa has a special role in the Chinese ''Belt and Road'' initiative as a recipient of Chinese investments and a site for the deployment of China's naval facilities to protect the trade routes. On the regional level, China will strive to become a leader of the trade and economic processes in the Asia-Pacific region, the South China Sea and the North Korea nuclear program issues. The American factor in modern international relations, namely so-called "Trump factor", which means the U.S. withdrawal from the Trans-Pacific Partnership and the Paris Agreement, will cause demand for Chinese leadership in the Asia-Pacific region and in the world as well. However, in this case a number of questions arise: is China prepared for this? Is Beijing able to bear greater responsibility? Does China have the potential for this? The article concludes that China will not become global leaders in the next 20-30 years, because of internal (political reforms) and foreign policy reasons (doctrinal formulation of foreign policy initiatives, military-political and economic power, international posture and relations with other states). The authors believe that the implementation of Chinese leadership is possible not on the condition of confrontation between China and the United States, but on the establishing of constructive relations between these countries. The last meeting between Trump and Xi Jinping showed a trend for creating channels for dialogue between Beijing and Washington, which can become the basis for interaction. An important place in the work is given to the analysis of development and forecasting the evolution of Russian-Chinese and U.S.-China relations. As for Russia, Moscow should conduct a policy that will not allow it to become a ''junior partner'' of China.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.38-38
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• 2012

The East Asia (EA) region including China, Taiwan, Japan, and Korea are especially vulnerable to hydrometerological extremes during the boreal summer (June-September). This study, therefore, pursued an exploratory analysis to improve better understanding of the potential impacts of the two types of PJ patterns on WNP Tropical cyclone (TC) activities and TC-induced extreme moisture fluxes over Korea's five major river basins. This study shows that during positive PJ years, the large-scale atmospheric environments are more favorable for the TC activities than those in negative PJ years. During positive PJ year, it is found that there are weaker wind shear, stronger rising motion, as well as large relative humidity over the Korean peninsula (KP) compared to negative PJ years. As a result, TCs making landfall are more exhibited over the southeastern portions of South Korea. Despite the relatively modest sample size, we expect that insights and results presented here will be useful for developing a critical support system for the effective reduction and mitigation of TC-caused disasters, as well as for water supply management in coupled human and natural systems.

• SUVANNABHUMI
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• v.9 no.2
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• pp.51-89
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• 2017

Strategically situated between the East-West maritime crossroads, the peoples of Southeast Asia over the centuries witnessed the comings and goings of traders from territories from East Asia, South Asia, West Asia and Europe. There were also those from North America that crossed the Pacific for commercial profits in this region. Foreign traders undoubtedly in the course of their visits and sojourns had liaisons with local women, some engaged in marriages. Offspring of these interracial miscegenation possessed rather unique characteristics. As a community, they were identified with the Malay term, peranakan, from the root word, "anak" meaning "child," hence "offspring" or "descendent". Specific terms - Baba Nyonya, Tionghoa-Selat, Chitty, Jawi Pekan, Pashu, Kristang - referred to particular groups. Although socially they appeared 'neither here nor there', members of mixed parentage were able to carve an especial niche in the local environment throughout Southeast Asia, conspicuously in urban, port-cities where trade and commerce predominated. Following in the footsteps of their progenitor, the Peranakan acted as intermediaries, comprador between foreign and indigenous enterprises, profiting financially and socially from trade and commerce. Tapping on the author's personal experiences and first-hand observations, complementing with oral sources, and support from secondary materials, this present essay explores, discusses, and analyzes the eclectic sociocultural practices and traditions of the Baba Nyonya of George Town, Penang. Purposeful intention is to further enlighten our understanding, and in turn, our appreciation, of these ever increasingly diminishing communities and their cultures across Southeast Asia.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.511-516
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• 2012

Background: We investigated the association between polymorphisms in the $p53$ tumor suppressor gene and breast cancer risk in women especially in the Southern part of India. Methods: Genotyping was performed for 50 breast cancer women and 50 controls to determine the status of $p53$ exon 4 codon 72 polymorphism and exon 7 codon 249 mutation and their possible role in breast cancer risk. Results: Frequency of Arg/Arg at codon 72 was 18% in controls and 28% in patients, Arg/Pro frequency was 56% and 66%, Pro/Pro genotype was 8% in controls and 8% in patients. No significance was observed for breast cancer risk with either Arg/Arg or Pro/Pro genotype in codon 72 polymorphism. Similarly, mutation analysis of exon 7 codon 249 revealed that 72% of breast cancer patients have mutation, which is not statistically significant. However, there is a strong association between increase in exon 7 codon 249 mutation and exposure to pollution. Conclusion: The results suggested that there is no risk for exon 4 with Arg/Arg or Pro/Pro polymorphisms in the $p53$ gene and there is no strong correlation between breast cancer patients and mutation in exon 7 codon 249 in South Indian women.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3677-3680
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• 2013

We aimed to assess the role of XPG, XPC and MMS19L polymorphisms on response to chemotherapy in osteosarcomas, and the clinical outcomes. One hundred and eighty five osteosarcoma patients who were histologically confirmed were enrolled in our study between January 2007 and December 2009. Genotyping of XPG, XPC and MMS19L was performed in a 384-well plate format on the MassARRAY$^{(R)}$ platform. Individuals with XPG TT genotype and T allele were more likely to be better response to chemotherapy than CC genotype, with the OR (95% CI) of 4.17 (1.64-11.54) and 2.66 (1.39-5.11), respectively. Those carrying MMS19L TT genotype and T allele showed better response to chemotherapy, with ORs (95% CI) of 4.8 (1.56-17.7) and 2.3 (1.22-4.36), respectively. Patients carrying TT genotype of XPG and MMS19L showed a significantly longer overall survival than CC genotype, with a 0.47 and 0.30-fold risk of death when compared with the wild-type of the gene. XPG and MMS19L are correlated with response to chemotherapy and prognosis of osteosarcoma, so that they could be used as predictive markers for prognosis.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5149-5153
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• 2012

Introduction: This study assessed the relationship of E-cadherin mRNA and protein expression with the diagnosis of lung cancer with the aim of providing an auxiliary diagnostic method. Methods: Semi-quantitative nested RT-PCR and western blotting were applied to detect E-cadherin mRNA transcripts and protein, respectively, in 30 cases of diagnostic lung cancer, 30 cases of clinically suspected patients with lung cancer and 30 cases of other disease. Immunohistochemical staining was also used to detect E-cadherin. Results: Remarkably decreased levels of relative E-cadherin mRNA value and increased E-cadherin protein negativity were observed in probable lung cancer, when compared with possible lung cancer and others. With a threshold of 1.45, relative E-cadherin mRNA value showed a sensitivity of 90% and a specifity of 83% for the diagnosis of lung cancer. The combination of decreased relative E-cadherin mRNA value and negative E-cadherin protein increased the specificity and sensitivity. Conclusion: These data suggest that Chinese patients with diagnostic lung cancer have similar decreased levels of relative E-cadherin mRNA and E-cadherin protein value in the lung cancer tissues as in lung cancer patients in other countries. Measurement of relative E-cadherin mRNA and protein values in lung cancer tissues has potential for lung cancer diagnosis.

• Journal of Fisheries and Marine Sciences Education
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• v.3 no.2
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• pp.73-82
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• 1991

In recent years, the communication and the trade between the Republic of Korea(South Korea) and the Communist bloc has been activated. The simultaneous entrance of South Korea and North Korea to the United Nations will accelerate the political dialogue and also the trade which is indirectly carried out through a third country at present will be turned into direct way. Fisheries products are also treated as one of the important trade goods and there is a hopeful prospect that the amount of trade will be steeply increased in the near future. Furthermore, there is a great possibility of development up to the joint utilization of fishing grounds or the joint investment in fisheries projects. Concerning such points, since it is very much important to understand the present status of fisheries in North Korea, the author made a study on this field as requested by the Board of Unification, and report a part of the study here. The prominent character of North Korea's ruling sea area is that the sea is completely separated into two regions-the East Sea Region and the West Sea Region-and no continuity exists between them. The East Sea Region locates in the fringe of the biggest fishing ground of the world-the North Pacific Ocean-and very rich in resources not only warm water fishes but also cold water fishes. Especially alaska pollack, Theragra chalcogramma, is caught abundantly in this region. Contrary to that, fishing activity in the West Sea Region seems to be interrupted in winter. Even though some valuable warm water fishes-yellow corvenia, Pseudosciaena manchurica, and hair tail, Trichiurus lepturus, and so forth-come to this region from spring to summer along the coast line of this region for spawning, and vigorous fishing activity is carried out. But the most of them migrate southward to the neighboring waters of Cheju Island for wintering from autumn to winter, and so the fishing activity in this region seems to be interrupted greatly during winter. The total number of fishing boats in North Korea is estimated at 36 thousand and the rate of mechnization at about 70% compared with 99 thousand and 78% in South Korea. North Korea proclaimed an exclusive economic zone of 200 nautical miles in 1977. Specific character of this zone is setting of military boundary zone, up to 50 miles from the base line in the East Sea Region and also it covers whole region of the economic zone in the West Sea Region. Especially in the East Sea Region she set up a straight base line which can not be permissible by the international law. North Korea's statistics on fisheries product has not been announced officially on account of her unique isolationism, but it can be estimated through several data procured. At the first, the amount of fisheries products in the North Korea is reported as about 1.7 million ${\frac{M}{T}}$ by Fisheries Statistics which issued by the FAO in 1987, but a North Korea's trade organization announced the amount as 3.5 million ${\frac{M}{T}}$ in 1988. The former seems to be underestimated and the latter must be an exaggeration. According to Chikuni, who is a Japanese worker for FAO, prepared the unofficial statistics based on the evidence which he collected through the fineries development plan of the FAO/UNDP, and estimated the mean amount between 1982 and 1984 was 2.4 million ${\frac{M}{T}}$ or so. The Board of Unification estimated on the basis of various factors that the amount was 2.2 million ${\frac{M}{T}}$ or so in 1987 and in 1988. This seems to be the most reasonable. To solve the chronic lack of foreign currency, North Korea makes effort on the development of fisheries, and has even aimed fisheries product at 11 million ${\frac{M}{T}}$ by 1993, but this target looks unrealistic under the present circumstances. Somehow, we can exploit her extreme policy which has gone so far as to establish such an excessive and impractical target. Nevertheless this will be helpful to promote the joint development of the fishery activity between South Korea and North Korea.

• Asia Pacific Journal of Business Review
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• v.4 no.2
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• pp.35-46
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• 2020

In Hwaseong, South Korea, it is necessary to vitalize local festival by attracting local residents and tourists since 'Hwaseong Songsan Grape Festival' should be in the direction to help the influx of tourists and cultural development for the local residents. It has been known that the quality and readiness of festival affects visitor satisfaction and actual visit. However, there have been only a few studies to examine the effect of local festival on post-behavior. Hence, this study, focusing on 'Hwaseong Songsan Grape Festival'which is a representative cultural tourism festival in the region of Hwaseong, South Korea, aims to understand the visitor's post-behavior intention in terms of revisit intention and recommendation intention. The results suggest that the impact of experiential, purchase visit motivation on post-behavior were smaller than deviant, social, interest, and cultural visit motivation. It also showed that visitor satisfaction leads to revisit intention and at the same time recommendation intention. Based on the result, we suggest practical implication for the success of local festival including 'Hwaseong Songsan Grape Festival'.