• Bulletin of the Korean Chemical Society
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• v.35 no.11
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• pp.3267-3274
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• 2014

In order to investigate the effects of the double replacement of $\small{L}$-Pro, $\small{D}$-Pro, $\small{D}$-Leu or Nleu (the peptoid residue for Leu) in the hydrophobic face (positions 9 and 13) of amphipathic ${\alpha}$-helical non-cell-selective antimicrobial peptide $L_8K_9W_1$ on the structure, cell selectivity and mechanism of action, we synthesized a series of $L_8K_9W_1$ analogs with double replacement of $\small{L}$-Pro, $\small{D}$-Pro, $\small{D}$-Leu or Nleu in the hydrophobic face of $L_8K_9W_1$. In this study, we have confirmed that the double replacement of $\small{L}$-Pro, $\small{D}$-Pro, or Nleu in the hydrophobic face of $L_8K_9W_1$ let to a great increase in the selectivity toward bacterial cells and a complete destruction of ${\alpha}$-helical structure. Interestingly, $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu preferentially interacted with negatively charged phospholipids, but unlike $L_8K_9W_1$ and $L_8K_9W_1$-$\small{D}$-Leu, they did not disrupt the integrity of lipid bilayers and depolarize the bacterial cytoplasmic membrane. These results suggested that the mode of action of $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu involves the intracellular target other than the bacterial membrane. In particular, $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu had powerful antimicrobial activity (MIC range, 1 to $4{\mu}M$) against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Pseudomonas aeruginosa (MDRPA). Taken together, our results suggested that $L_8K_9W_1$-$\small{L}$-Pro, $L_8K_9W_1$-$\small{D}$-Pro and $L_8K_9W_1$-Nleu with great cell selectivity may be promising candidates for novel therapeutic agents, complementing conventional antibiotic therapies to combat pathogenic microorganisms.

• Journal of Periodontal and Implant Science
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• v.48 no.3
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• pp.152-163
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• 2018

Purpose: To determine whether the swelling and mechanical properties of osmotic self-inflating expanders allow or not the induction of intraoral soft tissue expansion in dogs. Methods: Three different volumes (0.15, 0.25, and 0.42 mL; referred to respectively as the S, M, and L groups) of soft tissue expanders (STEs) consisting of a hydrogel core coated with a silicone-perforated membrane were investigated in vitro to assess their swelling behavior (volume swelling ratio) and mechanical properties (tensile strength, tensile strain). For in vivo investigations, the STEs were subperiosteally inserted for 4 weeks in dogs (n=5). Soft tissue expansion was clinically monitored. Histological analyses included the examination of alveolar bone underneath the expanders and thickness measurements of the surrounding fibrous capsule. Results: The volume swelling ratio of all STEs did not exceed 5.2. In tensile mode, the highest mean strain was registered for the L group ($98.03{\pm}0.3g/cm$), whereas the lowest mean value was obtained in the S group ($81.3{\pm}0.1g/cm$), which was a statistically significant difference (P<0.05). In addition, the S and L groups were significantly different in terms of tensile strength ($1.5{\pm}0.1g/cm$ for the S group and $2.2{\pm}0.1g/cm$ for the L group, P<0.05). Clinical monitoring showed successful dilatation of the soft tissues without signs of inflammation up to 28 days. The STEs remained volumetrically stable, with a mean diameter in vivo of 6.98 mm, close to the in vitro post-expansion findings (6.69 mm). Significant histological effects included highly vascularized collagen-rich fibrous encapsulation of the STEs, with a mean thickness of $0.67{\pm}0.12mm$. The bone reaction consisted of resorption underneath the STEs, while apposition was observed at their edges. Conclusions: The swelling and mechanical properties of the STEs enabled clinically successful soft tissue expansion. A tissue reaction consisting of fibrous capsule formation and bone loss were the main histological events.

• Journal of the Korea Convergence Society
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• v.6 no.6
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• pp.201-212
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• 2015

They insist that there is no more new stuff in modern art to change every circumstance rapidly. According to this situation, they recreate the works which are made with the existed idea or materials, and also transform creative concept which cites the existing functions with modern meaning. Furthermore they can look into any data everywhere from their daily routine using the internet. And this must become one of the general forms which they imitate others' works which are referred or chosen in modern art. These social complextion is called a parody and pastich is technique of the Post Modernism which is the existence of past. Using the new construction, the parody and pastich which can accomplish some better value and bring other meanings makes original recreation with the concept of copying and repeating. It keeps changing and is shaping up to be different aspect so far. Every field has a little different term using its own expression but it keeps empathizing each other a same essential meaning. Although it is like universal mode of expression, It is fact that the public cannot distinguish what is creation, imitation, or piracy. This thesis shows the concept of it and files for terms which is using like that. At last it selects some artist who worked with parody and pastich analyses and compares them and their works.

• Journal of the Korean earth science society
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• v.32 no.1
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• pp.21-32
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• 2011

Using six-year (2004-2009) SKYNET measurements, MODIS-derived AOTs were validated at five SKYNET sites (Seoul, Chiba, Etchujima, Fukuejima, and Hedomisaki), in addition to climatological analysis of MODIS-derived optical properties over the East Asian domain ($20-50^{\circ}N$, $90-150^{\circ}E$). In so doing MODIS-SKYNET collocated AOT data were constructed if two measurements are taken within 25 km distance and within 30 minute time difference. From the comparison of two measurements, it is demonstrated that aerosol type insignificantly affects the accuracy of MODIS AOT. It is because the aerosol model combining predefined fine aerosol model and coarse aerosol model is used for the retrieval. However, positive bias between MODIS and SKYNET increases as fraction of the coarse aerosol model increases. In addition, MODIS AOT appears to be overestimated in case of lower aerosol loading while the overestimation tends to decrease with increased aerosol loading. Regression analysis between MODIS AOT and SKYNET AOT for 550 nm band yields 0.86, 0.16, and 0.61 of regression slope, intercept, and coefficient of determination, respectively. Those statistical results may draw a conclusion that MODIS AOTs over East Asia carry a reasonable accuracy compared to ground-based SKYNET measurements.

• Transactions of the KSME C: Technology and Education
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• v.3 no.3
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• pp.165-173
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• 2015

This paper presents numerical results of static structural stability analysis in development of a vertical transfer device of a PRT(Personal Rapid Transit) vehicle. The vertical transfer of a fully occupied vehicle operating on a road network is the first attempt, which is expected to contribute to overcome the limitations of conventional 2-dimensional operation mode. In particular, the vertical transfer apparatus designed based on vertical circulating conveyors is capable of continuous transfer without time delay so that it enables to accommodate a high traffic density. This system has been frequently used in a logistics field; however, it is essential to assess a structural integrity because an external force by a vehicle weight is exerted on the conveyors in the form of a concentrated load unlike a conventional logistic transport. In this study, prior to the production process, the structural performance of the pilot design in an early stage is numerically evaluated using the commercial finite element method (FEM) solver (i.e., $Ansys^{(R)}$).

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.17 no.11
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• pp.1043-1049
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• 2007

Data transfer rate and storage capacity are main criteria of the performance of the optical disk drive. The highest data transfer rate and the largest storage capacity is most desirable. To increase these performances, the actuator of the optical disk drive should have a high servo bandwidth to compensate the vibration of an optical disk. The servo bandwidth is limited by some flexible modes of the actuator, thus it is essential to increase the natural frequencies of the flexible modes. In this paper, we suggested a moving magnet type actuator having high frequencies of the flexible modes. Generally, the moving magnet type actuator has an advantage to increase the natural frequencies of the flexible modes because the moving magnet type actuator has simple structure and the Young's modulus of magnet is high. However, large moving mass and inefficiency of EM(electromagnetic) circuit cut down driving sensitivities of the actuator. To improve driving sensitivities, we designed the model with the closed electromagnetic circuit for tracking direction. In addition, driving sensitivities and the natural frequencies of the flexible modes were improved by using DOE(design of experiments) for electromagnetic circuit and modifying the lens holder.

• Geomechanics and Engineering
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• v.19 no.5
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• pp.421-434
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• 2019

It is of great significance to study the mechanical properties and failure mechanism of the defected rock for geological engineering. The defected sandstone modeling with power-law distribution of pre-cracks was built in this paper by Particle Flow Code software. Then the mechanical properties of sandstone and the corresponding failure process were meticulously analyzed by changing the power-law index (PLI) and the number of pre-cracks (NPC). The results show that (1) With the increase of the PLI, the proportion of prefabricated long cracks gradually decreases. (2) When the NPC is the same, the uniaxial compressive strength (UCS) of sandstone increases with the PLI; while when the PLI is the same, the UCS decreases with the NPC. (3) The damage model of rock strength is established based on the Mori-Tanaka method, which can be used to better describe the strength evolution of damaged rock. (4) The failure mode of the specimen is closely related to the total length of the pre-crack. As the total length of the pre-crack increases, the failure intensity of the specimen gradually becomes weaker. In addition, for the specimens with the total pre-crack length between 0.2-0.55 m, significant lateral expansion occurred during their failure process. (5) For the specimens with smaller PLI in the pre-peak loading process, the concentration of the force field inside is more serious than that of the specimens with larger PLI.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3687-3693
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• 2012

Objective: The current meta-analysis was performed to address a more accurate estimation of the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and risk of gastric cancer (GC), which has been widely reported with conflicting results. Methods: A comprehensive literature search was conducted to identify all the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 20 studies containing 2,821 GC cases and 6,240 controls were finally included in the analyses. Overall, no significant association between GSTP1 polymorphism and GC risk was observed in worldwide populations. However, subgroup analysis stratified by ethnicity showed that GSTP1 polymorphism was significantly associated with increased risk of GC in Asians (G vs. A, OR = 1.273, 95%CI=1.011-1.605; GG vs. AA, OR=2.103, 95%CI=1.197-3.387; GG vs. AA+AG, OR =2.103, 95%CI=1.186-3.414). In contrast, no significant association was found in Caucasians in any genetic models, except for with AG vs. AA (OR=0.791, 95%CI=0.669-0.936). Furthermore, the GSTP1 polymorphism was found to be significantly associated with GC in patients with H. pylori infection and in those with a cardiac GC. Subgroup analysis stratified by Lauren's classification and smoking status showed no significant association with any genetic model. No studies were found to significantly influence the pooled effects in each genetic mode, and no potential publication bias was detected. Conclusion: This meta-analysis suggested that the GSTP1 polymorphism might be associated with increased risk of GC in Asians, while GSTP1 heterozygote genotype seemed to be associated with reduced risk of GC. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.5
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• pp.397-403
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• 2016

During the rapid economic growth in Korea since the 1970s, many underground facilities were constructed such as under passes and railways. Seismic design has been mandated in 1988, but the structures built before 1988 were not reflected on the seismic design. Accordingly, these underground structures require effective seismic reinforcing methods to ensure safety when the earthquake happens. By these reasons, in this study, using the proposed pre-flexed members, RC box structure was analyzed for seismic reinforcement of the corner. This method is based on a principle that enlarging the resistance against the external force by installing the pre-flexed member to the box structure corner. To evaluate validity, a newly developed member with CornerSafe was compared with traditional type reinforcement using experiments and finite element analysis. In finite element mode, nonlinearity of steel was modeled based on J2 plasticity model and concrete was based on CEB FIP MODEL CODE 1990. Also, composite ratios of box and pre-flexed member were computed for design application. The reinforcement and box structure were analyzed under the bond condition completely attached by the tie, and the results of experiment and finite element analysis were same in the force-displacement curve.

• Korean Journal of Optics and Photonics
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• v.10 no.6
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• pp.500-506
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• 1999

We designed and fabricated a bidirectional optical transceiver module for low cost access network. An integrated chip forming a pin-PD on an 1.3 urn FP-LD was assembled by flip-chip bonding on a Si optical bench, a single mode fiber with an angled end facet was aligned passively with the integrated chip on V-groove of Si-optical bench. Gaussian beam theory was applied to evaluate the coupling coefficients as a function of some parameters such as alignment distance, angle of fiber end facet, vertical alignment error. The theory is also used to search the bottle-neck between transmittance and receiving coupling efficiency in the bi-directional optical system. Tn this paper, we confirmed that reduction of coupling efficiency by the vertical alignment error between laser beam and fiber core axis can be compensated by controlling the fiber facet angle. In the fabrication of sub-module, a'||'&'||' we made such that the fiber facet have a corn shape with an angled facet only core part, the reflection of transmitted laser beam from the fiber facet could be minimized below -35 dE in alignment distance of 2: 30 /J.m. In the same condition, transmitted output power of -12.1 dEm and responsivity of 0.2. AIW were obtained.