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Neuroprotective Effects of Korean Kiwifruit against t-BHP-induced Cell Damage in PC12 Cells (국내산 참다래 추출물의 신경독성 방어효과)

  • Kim, Jeong-Hee;Yang, Hee-Kyoung;Hong, Hyun-Ju;Kang, Won-Young;Kim, Dong-Geon;Kim, Seong-Cheol;Song, Kwan-Jeong;King, Dale;Han, Chang-Hoon;Lee, Young-Jae
    • Korean Journal of Plant Resources
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    • v.23 no.2
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    • pp.165-171
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    • 2010
  • Oxidative stress induced by reactive oxygen intermediates has been implicated in a variety of human diseases including neurodegenerative disorders, cancer, cardiovascular and respiratory diseases, and mode of action of environmental toxicants. Tert-butylhydroperoxide (t-BHP) is an organic lipid hydroperoxide analogue, which is commonly used as a pro-oxidant for evaluating mechanisms involving oxidative stress in cells and tissues. In this study, the underlying mechanisms involved in the protective effects of Hwabuk 94 kiwifruit (Actinidia deliciosa cv. 'Hwabuk 94'), which is cultivated in Jeju, on the t-BHP-induced cytotoxicity in PC12 cell. The pretreatment of rat pheochromocytoma cell line PC12 with Hwabuk 94 extract ($1-100\;{\mu}g/ml$) resulted in a significant recovery from t-BHP-induced cell death and increased Bcl-2 and procaspase-3 expression, whereas the expression of Bax and cleaved PARP were decreased in a dose-dependent manner compared to the control. Furthermore, Hwabuk 94 inhibited the t-BHP-induced p38 MAP kinase and extracellular signal-regulated kinase 1/2, but not c-Jun N-terminal kinase activations. Finally, these findings suggest that Hwabuk 94 kiwifruit might attenuate t-BHP-induced PC12 cell cytotoxicity, at least in part, through the inhibition of signaling pathways mediated by the ERK1/2 and p38 MAP kinase.

Determining Fare Discount Level for MaaS Implementation - Based on Time and Cost Changes - (MasS(Mobility as a Service)의 적정요금할인 수준 분석 - 통행시간 및 비용변화를 중심으로 -)

  • Lee, Ja Young;Im, I Jeong;song, Jae in;Hwang, Kee Yeon
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.18 no.1
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    • pp.1-13
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    • 2019
  • With commercial apps popular in EU, MaaS has been emerging around the globe as a new approach to worsening urban traffic problems. In contrast, it is still mainstay in Korea simply discussing the concept and necessities of MaaS, rather than seeking for real-world solutions for the commercialization. The purpose of this research is to analyze the demand-side i1mpacts of travel time and cost changes according to MaaS adoption, and to see its commercial feasibility in Korea. The 2010 KTDB traveler's nationwide OD data is used to estimate the level of fare discount for balancing the mode shift and fare revenue changes followed by MaaS implementation. The analysis results show that MaaS leads to the increase of public transport ridership as a result of the diminishing travel cost and time, and that the time saving works more positively for ridership increase. Also, the optimum level of fare discount is estimated 2.56% without damaging the revenue. This finding reveals that MaaS impact is superior to the other single-sided public transport inventive measures since it can affect both travel cost and time reduction at the same time.

Experimental Test Results of Nine Scheduling Operational Modes of PV and Battery Hybrid System for the Development of Automatic Control Algorithm for Continual Operation without being shut-downed (태양광 배터리 Hybrid 전력공급시스템 9가지 운전 모드 시험결과 및 무고장 연속 운전을 위한 자동제어 알고리즘 개발)

  • Song, Taek Ho;Yang, Seung Kwon;Kim, Minjeong
    • KEPCO Journal on Electric Power and Energy
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    • v.5 no.1
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    • pp.25-32
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    • 2019
  • K-BEMS System was introduced to reduce peak load and to save total energy of the 200 buildings that KEPCO headquarter and branch offices use. And K-BEMS system is composed of PV, battery, and hybrid PCS. KEPCO research institute has carried out this K-BEMS research project for 3 years since January 2016. In this paper, the results of the project are shown. 9 modes of test results of K-BEMS system and are operational problems were analyzed. And measures to cure the trouble are also suggested. Batteries are operated more than 20% of SOC, and less than 20% of SOC battery protection switches are automatically shutting down the system and the system no longer respond to EMS, ending the supply of PV, and so therefore to continue the PV power supply it was turn out to be necessary that the EMS should automatically change its policy to change PV only supply mode automatically when the Battery Switch automatically operated. To operate the system continuously and automatically, it is necessary to modify the minimum operational SOC value, and in addition to that the EMS computer must remember the last shut-down SOC and Voltage which interrupted the system and add some margin to reflect the measurement error in the system.

Imaging Diagnosis of Dilated Cardiomyopathy in a Maltese Dog

  • An, Soyon;Park, Junghyun;Mok, Jinsu;Kim, Areum;Han, Changhee;Song, Joong Hyun;Yu, Dohyeon;Hwang, Tae Sung;Lee, Hee-Chun
    • Journal of Veterinary Clinics
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    • v.38 no.3
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    • pp.163-168
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    • 2021
  • A 6-year-old, spayed female, Maltese dog with tachypnea and dry cough was presented to Gyeongsang National University Veterinary Medical Teaching hospital. On physical examination, its respiration rate was 132 per minute. Decreased partial pressure of oxygen, partial pressure of carbon dioxide, and hyperlactatemia were found on arterial blood gas analysis. Its diastolic blood pressure was 80 mmHg. Auscultation revealed arrhythmia. Electrocardiogram revealed P pulmonale, P mitrale, and ventricular premature complexes. Thoracic radiographs revealed mild enlargement of both atrium and moderate enlargement of the left ventricular. There was also a moderate alveolar pattern in the right and caudal part of the left cranial lung lobe. Two-dimensional echocardiography showed enlargement of generalized four chambers without remarkable findings of valvular degeneration. M-mode echocardiography showed decreased left ventricular fractional shortening and enlarged left ventricular internal diameter at both end-systolic and end-diastolic. Color-flow Doppler imaging revealed eccentric turbulent flow starting below the left ventricular outflow tract and extending into the left atrium during systole. Spectral Doppler recordings revealed a high velocity flow through the mitral, tricuspid, aorta, and pulmonic regurgitation. Restrictive transmitral flow revealed high E-wave velocity, short E-wave deceleration time, and reduced A-wave velocity. There was also low ejection velocity thorough left ventricular out tract flow. Based on echocardiographic examination, dilated cardiomyopathy was the tentative diagnosis. The dog was medicated with inotropes, angiotensin converting enzyme inhibitor, and diuretics. At the 10-day following-up, the dog died suddenly. This report describes echocardiographic diagnosis and prognosis of dilated cardiomyopathy rarely reported in small breed dogs.

The Effect of Socially Prescribed Perfectionism of University Student to Depression: Focusing on the Mediating Effects of Intolerance of Uncertainty and Rumination, Reflective Response Style (대학생의 사회부과적 완벽주의가 우울에 미치는 영향: 불확실성에 대한 인내력 부족과 반추적, 반성적 반응양식의 매개효과)

  • Choi, Jaegwang;Song, Wonyoung
    • Korean Journal of School Psychology
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    • v.17 no.2
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    • pp.199-222
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    • 2020
  • This study was conducted to verify the effects of socially prescribed perfectionism on depression as mediated by intolerance of uncertainty and either ruminating or reflective response styles, on as will as to find ways to effectively address depression as it presents in university students. For this purpose, 283 university students at the central region were assesed using data collected from the following surveys: the Center for Epidemiological Studies-Depression Scale(CES-D), the Multidimensional Perfectionism Scale(HMPS), the Intolerance of Uncertainty Scale(IUS), and the Response to Depressed Mood Questionnaire(RDQ) and that were used to collect data. The results of this study are as follows. First, there was a positive correlation between the Intolerance of uncertainty and the rumination response style to the uncertainty of socially prescribed perfectionism, but not correlation the reflective response mode. Second, with respect to the relationship between socially prescribed perfectionism and depression, intolerance of uncertainty was set as the primary mediator variable and the rumination response style were set as the secondary mediator variables. The results shown to have a significant mediating effects. However this mediating effect was not significant when, in order to verify the mediating effect, we set the secondary mediator variable as the reflective response style. These results suggest that to prevent depression that manifests as socially prescribed perfectionism, it may be effective to intervene with a focus on the intolerance of uncertainty and the rumination response style. Finally, the implications and limitations of the study are discussed based on the results.

Analysis of Built and Walking Environment for Coastal Ferry Terminal using IPA -Focusing on Yeosu Coastal Ferry Terminal- (IPA를 이용한 연안여객터미널의 시설 및 보행특성 분석 -여수연안여객터미널을 중심으로-)

  • Song, Tea-Han;Kim, Hwa-Young
    • Journal of Korea Port Economic Association
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    • v.37 no.3
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    • pp.93-104
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    • 2021
  • A coastal ferries, which serve as a mode between mainland and offshore islands, are frequently used by islanders and travelers visiting islands. Therefore, it is located in a place with good accessibility to the downtown so that users can use it conveniently. However, research on the built environment and walking environment of coastal ferry terminals has not been conducted to ensure that elderly islanders and general travelers can use comfortably the coastal ferry terminal. In this study, with a focus on the coastal ferry terminal space, the walking section was set as 1)the accessibility of the coastal ferry terminal, 2)the built environment for using the coastal ferry terminal, and 3)walking environment in the ferry boarding and disembarkation at the coastal ferry terminal, and 4, 5)walking environment in the ferry. An evaluation tool was developed to measure the walking environment for each walking section, and the importance and satisfaction of users were analyzed using the IPA for the Yeosu Coastal Ferry Terminal. As a result, in the process of approaching the ferry terminal, 'convenience of using public transportation by foot' and 'convenience of using signposts guiding the location and direction of the ferry terminal' were investigated as concentrated areas. On the other hand, the built environment inside the ferry terminal and the walking environment showed that the satisfaction of the users was high. Regarding the walking environment from the ferry terminal to the ferry, the 'surface walking environment of the walking path', 'convenience of walking with luggage', 'convenience of walking in the slope section', and 'convenience of walking in the ferry ramp section' showed low satisfaction. This study can be used as basic data for improving the facilities and walking environment of Yeosu Coastal Ferry Terminal and is expected to be used as data for comparative research with other coastal ferry terminals.

An Analysis of Temperature Change and TI MI using Tissue Mimicking Phantom in Ultrasonic Examination (초음파검사에서 인체모의 매질팬텀을 이용한 온도 변화와 TI MI 분석)

  • Cheol-Min, Jeon;Jae-Bok, Han;Jong-Gil ,Kwak;Jong-Nam, Song
    • Journal of the Korean Society of Radiology
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    • v.16 no.6
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    • pp.751-759
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    • 2022
  • Currently, ultrasound examination for diagnostic ultrasound and health examination purposes is widely used, and it is showing an increasing trend due to the application of health insurance. However, the risk of ultrasound has not been clearly identified so far, and in this study, surface and deep temperature changes according to frequency and mode were measured by using a tissue mimicking phantom and TI and MI values were compared. A simulated phantom was manufactured by adding a small amount of kappa-caraginan powder with acoustic characteristics similar to that of the human body and potassium chloride for solidification, and the change of surface and depth temperature was measured using a surface thermometer and a probe thermometer. As a result, the convex probe using low frequency showed a higher temperature increase than the linear probe using high frequency, so there was a significant difference, and the temperature increase was the highest on the surface, and the depth of 1cm showed a temporary temperature increase, but there was no significant temperature change. There was no change in the deep temperature of 5 cm to 15 cm, and the TI and MI values did not change during the test time. Since only the surface temperature rose during the 15-minute test and there was no temperature change in the core, so it is not expected to show a temperature change that is harmful to the human body. However, it is thought that prolonged examination of one area may cause temperature rise, so it should be avoided.

Screening for Genotypes Lacking Lipoxygenase from Germplasm Collection of Korean Soybean Land Races (한국 재래종 콩집단에서 비린내 없는 콩품종 육성을 위한 Lipoxygenase 결실인자 변이 연구)

  • Kwon, Shin-Han;Park, Kyung-Sook;Kim, Mi-Young;Kim, Bong-Ryong;Song, Hi-Sup
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.37 no.6
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    • pp.528-533
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    • 1992
  • Soybean seeds contain lipoxygenase, which is responsible for the objectionable beany flavors in soybean seeds. The isozymes of lipoxygenase (1$\times$1, 1$\times$2, 1$\times$3) were discovered in United States of America, Japan, and Korea, and the mode of inheritance of the mutant genes was determined. This investigation was conducted to screen lipoxygenase-1, 2, and 3 lacking soybean lines from the Korean soybean land race population. Two lipoxygenase-1lacking lines, KAS 610-8 and KAS 621-8 were found in this investigation. In general, lipoxygenase acking varieties were small in seed size and low in oil content. A severe pod borer damage was observed in the two selected lipoxygenase-1 lacking lines. Lipoxygenase lacking line was not found in Korean wild soybean population used in this study and the lipoxygenase lacking lines were found only in Kyung-Nam province and the results imply that lipoxygenase lacking mutants were induced recently in cultivars.

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The Study on Control Algorithm of Elevator EDLC Emergency Power Converter (승강기 EDLC 비상전원 전력변환장치 제어 알고리즘 연구)

  • Lee, Sang-min;Kim, IL-Song;Kim, Nam
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.7 no.6
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    • pp.709-718
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    • 2017
  • The installation of the elevator ARD(Automatic Rescue Device) system has been forced into law in these days in order to safely rescue passengers during power failure. The configuration of the ARD system consists of energy storage device, power converter and control systems. The EDLC(Electric Double Layer Capacitor) are used as energy storage device for rapid charge/discharge purposes. The power conditioning system (PCS) consists of bi-directional converter, 3-phase converter and control system. The dead-beat control system is adopted for most systems however it requires complex mathematical calculations, the high performance microprocessors are mandatory and thus it can be a cause of high manufacturing cost. In this paper the new control method for average current mode control is presented for simple structure. The control algorithm is applied to the single phase system and then expands to three phase system to meet the sysem requirements. The mathematical modeling using average modeling method is presented and analysed by PSIM computer simulation to verifie the validity of the proposed control methods.

Spatial Similarity between the Changjiang Diluted Water and Marine Heatwaves in the East China Sea during Summer (여름철 양자강 희석수 공간 분포와 동중국해 해양열파의 공간적 유사성에 관한 연구)

  • YONG-JIN TAK;YANG-KI CHO;HAJOON SONG;SEUNG-HWA CHAE;YONG-YUB KIM
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.28 no.4
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    • pp.121-132
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    • 2023
  • Marine heatwaves (MHWs), referring to anomalously high sea surface temperatures, have drawn significant attention from marine scientists due to their broad impacts on the surface marine ecosystem, fisheries, weather patterns, and various human activities. In this study, we examined the impact of the distribution of Changjiang diluted water (CDW), a significant factor causing oceanic property changes in the East China Sea (ECS) during the summer, on MHWs. The surface salinity distribution in the ECS indicates that from June to August, the eastern extension of the CDW influences areas as far as Jeju Island and the Korea Strait. In September, however, the CDW tends to reside in the Changjiang estuary. Through the Empirical Orthogonal Function analysis of the cumulative intensity of MHWs during the summer, we extracted the loading vector of the first mode and its principal component time series to conduct a correlation analysis with the distribution of the CDW. The results revealed a strong negative spatial correlation between areas of the CDW and regions with high cumulative intensity of MHWs, indicating that the reinforcement of stratification due to low-salinity water can increase the intensity and duration of MHWs. This study suggests that the CDW may still influence the spatial distribution of MHWs in the region, highlighting the importance of oceanic environmental factors in the occurrence of MHWs in the waters surrounding the Korean Peninsula.