• 대한산업공학회지
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• 제18권1호
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• pp.47-62
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• 1992

This paper describes a procedure for optimizing the route selection and production conditions in alternate process plans under a cellular manufacturing environment. The type of production is mainly production-to-order which deals with unexpected products as the changes factor. The flexible cellular manufacturing can be viewed as a complete unification of both flexible manufacturing process and flexible production management. The integrated problem for designing flexible cellular manufacturing associated with determining the optimal values of the machining speeds, overtime, and intercell flow is formulated as Nonlinear Mixed Integer Programming(NMIP) in order to minimize total production change cost. This is achieved by introducing the marginal cost analysis into the NMIP, which will compute the optimal machining speed, overtime, intercell flow, and routing. The application of this procedure offers greater flexibility to take advantage of the cellular manufacturing due to the optimum use of resources. A solution procedure for this problem was developed and a numerical example is included.

• Current Applied Physics
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• 제18권11호
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• pp.1300-1305
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• 2018

The tunable electronic performance of the solution-processed semiconductor metal oxide is of great significance for the printing electronics. In current work, transparent thin-film transistors (TFTs) with indium-zinc oxide (IZO) were fabricated as active layer by a simple eco-friendly aqueous route. The aqueous precursor solution is composed of water without any other organic additives and the IZO films are amorphous revealed by the X-ray diffraction (XRD). With systematic studies of atomic force microscopy (AFM), X-ray photoemission spectroscopy (XPS) and the semiconductor property characterizations, it was revealed that the electrical performance of the IZO TFTs is dependent on the concentration of precursor solution. As well, the optimum preparation process was obtained. The concentrations induced the regulation of the electronic performance was clearly demonstrated with a proposed mechanism. The results are expected to be beneficial for development of solution-processed metal oxide TFTs.

• 공업화학
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• 제21권6호
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• pp.694-696
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• 2010

용액공정을 이용하여 표면에 알킬기를 도입하고, 붕소(boron) 또는 인(phosphorous)으로 도핑된 실리콘 나노 입자를 합성하였다. 나노 입자의 합성 여부 및 입자크기는 핵자기공명분광기(NMR), 적외선분광기(FT-IR), 자외선가시광선분광기(UV-Vis), 인광분광기(PL)를 이용하여 분석하였다. 마이크로웨이브 소결기를 이용하여 표면의 알킬기를 제거하고, 결정성을 갖는 필름을 제작하였다. 필름의 조각은 $200{\mu}m$ 정도의 크기를 가지며 큐빅구조를 가지고 있다는 것을 전자주사현미경(FE-SEM)과 투과전자현미경(FR-TEM)으로 확인할 수 있었다. 필름의 전도도는 도핑 타입을 통해 조절할 수 있었다.

• 대한약리학회지
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• 제17권1호
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• pp.27-32
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• 1981

It has been known that ethanol stimulates the secretion of gastric acid regardless of its route of administration. Recently, however, some studies have challenged this view and claimed that ethanol inhibits the gastric acid secretion. This study was undertaken to investigate the effects of ethanol on the gastric acid secretion in anesthetized rat in respect to the route of administration and the concentration of alcohol. Normal saline (pH adjusted to 6.0) was used as standard perfusion solution and ethanol was mixed as 0.8, 1.7, 5, 10 and 20%. Four ml of perfusion fluid was given into stomach via gastric tube and drained from duodenal tube every 5 min. Acid secretion was measured by back titration to pH 6.0 with N/20 NaOH and expressed as ${\mu}Eq/5$ min. Low concentration of ethanol up to 1.7% in perfusion solution caused little changes in acid secretion, but moderate concentration such as perfusion of 5% or 10% ethanol solution inhibited both the basal and histamine-induced gastric secretion. Moreover, loss of perfused acid was seen by 20% ethanol, which means back diffusion of hydrogen ions into the gastric mucosa. However, intravenous administration of ethanol, maintained at the level of 0.1% alcohol in blood, caused significant stimulation of gastric acid. We, therefore, conclude that in anesthetized rat ethanol has dual effects on acid secretion, i.e., inhibiting and enhancing by oral and intravenous administration, respectively, but further investigation is necessary to clarify these effects.

• 정보처리학회논문지B
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• 제17B권5호
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• pp.389-398
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• 2010

차량 경로 스케줄링 문제(VRSPTW, the Vehicle Routing and Scheduling Problem with Time Window)는 여러 고객의 시간 제약과 요구량을 만족시키면서 최소 이동 비용을 가지는 경로를 구성하는 문제이다. 이 문제는 NP-Hard 문제이기 때문에 해를 산출하는데 시간이 오래 걸린다. 본 연구는 VRSPTW를 빠른 시간 내에 최근사해를 구하기 위한 멀티 비용 함수(Multi Cost Function)를 갖는 개미 군집 최적화(Ant Colony Optimization)을 이용한 휴리스틱을 제안하였다. 멀티 비용 함수는 각 개미가 다음 고객 노드로 이동하기 위해 비용을 평가할 때 거리, 요구량, 각도, 시간제약에 대해 서로 다른 가중치를 반영하여 우수한 초기 경로를 구할 수 있도록 한다. 본 연구의 실험결과에서 제안된 휴리스틱이 Solomon I1 휴리스틱과 기회시간이 반영된 하이브리드 휴리스틱보다 효율적으로 최근사 해를 얻을 수 있음을 보였다.

• 한국수산과학회지
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• 제53권5호
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• pp.681-687
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• 2020

Physicochemical properties of fucoidan and alginate extracted from Sargassium horneri were investigated. The alginates were extracted and purified via three different routes (CaCl₂, HCl and ethanol routes), and their rheological properties at various concentrations and temperatures were determined. The yield of fucoidan was 3.08%, and it was mainly composed of fucose and galactose. Fourier-transform infrared spectrum of fucoidan showed strong absorption band at 1,254 and 827 cm^-1 corresponding to the sulfate group. Flow behavior of the alginate solution was characterized using the power-law model. The consistency index increased with increasing concentrations. The sodium alginate solution (1.5%) exhibited Newtonian behavior when extracted via the CaCl₂ and HCl routes, while it exhibited pseudoplastic behavior when extracted via the ethanol route. The effect of temperature on the flow behavior was investigated in terms of the activation energy (E_a), which was obtained using the Arrhenius equation. The E_a value corresponding to the alginate solution decreased with increasing shear rates. The E_a values corresponding to the alginate solutions purified via the CaCl₂, HCl, and ethanol routes were 13.54-18.64 kJ/mol, 13.42-19.21 kJ/mol, and 9.51-10.67 kJ/mol, respectively. The low E_a values corresponding to the solutions extracted via the ethanol route suggest that the flow behavior does not depend significantly on temperature.

• Biomolecules & Therapeutics
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• 제3권1호
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• pp.63-71
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• 1995

The local irritation studies of DA-3002, an authentic recombinant human growth hormone (rhGH), were carried out in rabbits after the following treatment ; application into the conjunctival sac of the eye (single), single subcutaneous and intramuscular injection, 7-day repeated subcutaneous and intramuscular injection. The results obtained were as follows. In the result of ocular irritation test, 0.16% solution of DA-3002 could be considered as a non-irritating material. In single subcutaneous and intramuscular irritation test, the irritancy of 0.16% DA-3002 solution was not so much different from that of saline. The local irritation of DA-3002 by 7-day repeated injection was negligible and similar to that of saline by both subcutaneous and intramuscular routes. These results suggest that DA-3002 has no irritating activity when injected through subcutaneous or intramuscular route for clinical practice as 0.16% solution.

• 한국경영과학회지
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• 제34권1호
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• pp.153-165
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• 2009

This paper apollos an ant colony system (ACS) for the vehicle routing problem with time window (VRPTW). The VRPTW is a generalization of the VRP where the service of a customer can begin within the time windows defined by the earliest and latest times when the customer will permit the start of service. The ACS has been applied effectively in geographical environment such as TSP or VRP by meta-heuristic that imitate an ant's biologic special duality in route construction, 3 saving based ACS (SB-ACS) is introduced and its solution is improved by local search. Through iterative precesses, the SB-ACS is shown to drive the best solution. The algorithm has been tested on 56 Solomon benchmarking problems and compared to the best-known solutions on literature. Experimental results shows that SB-ACS algorithm could obtain food solution in total travel distance minimization.

• 대한교통학회지
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• 제18권3호
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• pp.55-76
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• 2000

실시간 통행시간관련자료의 집계시간간격은 보다 신뢰성있는 통행시간정보제공과 교통정보센터의 효율적인 운영을 위해 매우 중요한 요소이다. 그러나 대부분의 기존 VDS 및 TCS교통정보 데이터는 통계학적·공학적 차원에서의 합리적인 연구나 검증없이 경험적 간격으로 집계되고 있다. 본 연구의 목적은 링크 및 교통축(Corridor) 통행시간 산정 및 예측시의 최적 집계 시간간격을 결정할 수 있는 통계학적 모형을 개발하고 실제 도로망에서 수집되는 통행시간자료에 적용하는 것이다 첫째로, 본 연구는 링크 및 교통축 통행시간 산정 및 예측으로 인한 오차를 계량화하는 통계학적 모형을 제시하고, 제시된 모형의 의미를 교통류이론 측면과 통행시간정보 이용자측면에서 살펴보았다. 둘째로, 미국 Texas, Houston의 도시고속도로에서 AVI시스템을 통해 수집된 통행시간자료를 제시된 모형에 적용하였다. 적용결과 링크통행시간 산정을 위한 최적 집계시간간격보다 링크통행시간예측을 위한 최적 집계시간간격이 큰 것으로 나타났으며, 교통축 통행시간 산정 및 예측을 위한 최적 집계시간간격은 교통축을 구성하는 링크간의 상관관계 (Correlation)에 큰 영향을 받는 것으로 분석되었다.

• 약학회지
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• 제56권2호
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• pp.74-79
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• 2012

Citrate-capped silver nanoparticles (AgNPs) are widely used in industry, consumer products and medical appliances. However, information on the toxicity, environmental fate and toxicokinetics are not enough. In this study, stability of citrate-capped AgNPs was investigated using different types of isotonic solution, which is important in the toxicokinetic study by the exposure route of intravenous injection. Size, morphology, zeta potential and ion formation were investigated in isotonic solutions for the physico-chemical characterization of AgNPs. Aggregation and precipitation of AgNPs were observed in saline or phosphate-buffered saline while they were stable without precipitation in 2% glycerol of isotonic solution. The average size of AgNPs in 2% glycerol was 6~10 nm, which was almost same as that in water-based suspension of AgNPs. Zeta potential was ranged from -30 mV to -60 mV, which was in the range of original stock AgNPs. The stability was maintained during the whole experimental period of 48 hours. Furthermore, the stability was not changed in different temperature (10~36$^{\circ}C$) and at different concentrations (10~1,000 ppm). The osmolarity of the AgNPs suspension was $299{\pm}1$ mOsm/kg which was in isotonic range. These data suggest that AgNPs in 2% glycerol solution can be used for the preparations of intravenous injection for toxicokinetic study without undesired disturbance of blood isotonicity.