• 한국토양비료학회지
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• 제45권6호
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• pp.867-876
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• 2012

The concentration of veterinary antibiotics in aqueous and sediment matrices was measured in agricultural irrigation ditches bordering several animal-feeding operations (AFOs) and then compared to its concentration in the watershed. Analytical determination in aqueous samples was based on solid phase extraction (SPE) and appropriate buffer solutions were used to extract residuals in sediment samples. Separation and detection of extracted veterinary antibiotics were performed with high performance liquid chromatograph tandem mass spectrometry (HPLC/MS/MS). In general, higher concentrations of antibiotic were observed in the aqueous phase of irrigation ditches, with the highest concentration of erythromycin hydrochloride (ETM-$H_2O$) of $0.53{\mu}g\;L^{-1}$, than in aqueous watershed samples. In contrast, higher concentrations were measured in river sediment than in irrigation ditch sediment with the highest concentration of oxytetracycline of $110.9{\mu}g\;kg^{-1}$. There was a high calculated correlation ( > 0.95) between precipitation and measured concentration in aqueous samples from the irrigation ditches for five of the ten targeted veterinary antibiotics, indicating that surface runoff could be an important transport mechanism of veterinary antibiotics from field to environment. Further, environmental loading calculation based on measured concentrations in aqueous samples and flow information clearly showed that irrigation ditches were 18 times greater than river. This result suggests the likelihood that veterinary antibiotics can be transported via irrigation ditches to the watershed. The transport via surface runoff and likely environmental loading via irrigation ditches examined in this study helps identify the pathway of veterinary antibiotics residuals in the environment.

• 한국환경농학회지
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• 제25권4호
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• pp.359-364
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• 2006

Reversed-phase high-performance liquid chromatography (HPLC) techniques were developed to quantify abamectin (ABM) in paprika (Capsicum annum). Separation was achieved on a $C_{18}$ ODS column with a mobile phase of acetonitrile/water (96/4, v/v) mixture in an isocratic elution at the flow tate of 1.2 mL/min for avermectins (AVMs). The retention times were 8.0 and 9.7mins for AVM $B_{lb}$ and AVM $B_{1a}$, respectively. Residual AVMs (sum of AVM $B_{1a}$, AVM $B_{1b}$ and 8,9-Z-AVM $B_{1a}$) in the vegetable were extracted with acetonitrile, and the silica solid-phase extraction cartridges were used to purify the extract. AVMs were derivatized using trifluoroacetic acid and 1-methylimidazole, and the derivatives were determined with a fluorescence detector (excitation at 365 nm and emission at 470 nm). High and consistent recoveries, ranging from 93% to 115%, were obtained for AVM $B_{1a}$ and 8, 9-Z-AVM $B_{1a}$ at fortified levels of $20{\mu}g/kg\;and\;200{\mu}g/kg$ for paprika. The limit of quantitation (LOQ) was $2{\mu}g/kg$. The residual levels of AVMs in paprika in a field experiment from one day to seven days after the last application decreased from 18.40 to $7.59{\mu}g/kg$. The half-life $(T_{1/2})$ of AVMs in paprika was 1.47 days.

• Geomechanics and Engineering
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• 제7권3호
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• pp.233-246
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• 2014

Estimation of fracture initiation pressure is one of the most difficult technical challenges in hydraulic fracturing treatment of vertical or horizontal oil wells. In this study, the influence of in-situ stresses and pore pressure values on fracture initiation pressure and its profile in vertical and horizontal oil wells in a normal stress regime have been investigated. Cohesive elements with traction-separation law (XFEM-based cohesive law) are used for simulating the fracturing process in a fluid-solid coupling finite element model. The maximum nominal stress criterion is selected for initiation of damage in the cohesive elements. The stress intensity factors are verified for both XFEM-based cohesive law and analytical solution to show the validation of the cohesive law in fracture modeling where the compared results are in a very good agreement with less than 1% error. The results showed that, generally by increasing the difference between the maximum and minimum horizontal stress, the fracture pressure and its profile has been strongly changed in the vertical wells. Also, it's been clearly observed that in a horizontal well drilled in the direction of minimum horizontal stress, the values of fracture pressure have been significantly affected by the difference between overburden pressure and maximum horizontal stress. Additionally, increasing pore pressure from under-pressure regime to over-pressure state has made a considerable fall on fracture pressure in both vertical and horizontal oil wells.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.471-481
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• 2005

In Korea, generic drug and bioequivalence test are the hot issues since a new medical system of separation of dispensary from medical practice was started in 2000. The KFDA(Korea FDA) had revised several times ${\ulcorner}Guidance\;for\;bioequivalence\;test{\lrcorner}$. In vitro dissolution test has been extensively used as a quality control tool for solid oral dosage forms. In an effort to minimize unnecessary human testing, in vitro/in vivo correlations (IVIVC) between in vitro dissolution and in vivo bioavailability are increasingly becoming an integral part on extended release drug product development. The recently published US guidance, ${\ulcorner}Extended\;release\;oral\;dosage\;forms\;:\;development,\;evaluation,\;and\;application\;of\;in\;vitro/in\;vivo\;correlations{\lrcorner}$ will be helpful for us to make our own guideline.

• Journal of Pharmaceutical Investigation
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• 제35권6호
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• pp.461-465
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• 2005

A simple HPLC method with ultraviolet detection of nicardipine in human plasma was developed and validated. After drug extraction with solid phase extraction (SPE) method, chromatographic separation of nicardipine in plasma was achieved at $30^{\circ}C$ with a $C_{18}$ column and acetonitrile-0.02% phosphate buffer mixture (with 0.02% triethylamine, final pH 7.0), as mobile phase. Quantitative determination was performed by ultraviolet detection at 254 nm. The method was specific and validated with a limit of quantification of 5 ng/mL. The intra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of the method was demonstrated by analysis of plasma after oral administration of a single 40 mg dose to 8 healthy subjects. From the plasma nicardipine concentration versus time curves, the mean $AUC_{t}$, was $134.04{\pm}59.72\;ng\;hr/mL$ and $C_{max}$ of $108.65{\pm}69.17\;ng/mL$ reached 1.5 hr after administration. The mean biological half-life of nicardipine was $3.93{\pm}0.82\;hr$. Based on the results, this simple and validated assay method could readily be used in any pharmacokinetic or bioequivalence studies using human.

• 한국추진공학회지
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• 제3권4호
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• pp.67-74
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• 1999

고체 물체 표면이나 지표면에 초음속 제트가 충돌할 때 발생되는 문제들은 다단 로켓의 분리, 우주공간에서의 도킹, 수직 이/착륙기, 제트 엔진의 배기가스, 가스터빈 블레이드, 지상 로켓 발사 등의 다양한 상황에서 일어나며 이러한 충돌제트의 유동은 아음속과 초음속 혼합영역, 충격파가 교차하는 영역, 팽창파, 난류 전단층 등의 매우 복잡한 구조를 이루고 있는 것으로 알려져 있다. 본 연구에서는 출구마하수 2, 축소-확대형 초음속 노즐을 통해 과소 팽창된 제트가 수직, 경사평판에 부딪힐 때 형성되는 표면압력분포 및 유동가시화 등을 초음속 유동시험장치를 이용하여 연구하였다. 평판에서의 최대압력은 수직일 경우보다 경사졌을 때 훨씬 더 컸으며, 이는 여러 충격파를 통한 압력 회복 때문이다. 또한, 평판이 자유제트의 첫 번째 충격파 셀 내에 위치할 때 과소 팽창비에 따른 표면압력분포는 서로 유사한 경향을 보여주었다.

• 대한환경공학회지
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• 제35권11호
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• pp.803-808
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• 2013

본 연구의 목적은 칼슘염을 함유한 레미콘 슬러지를 이용하여 불소함유폐수를 물에 난용성인 $CaF_2$ 화합물 형태로 침전시켜 처리하는데 있어 pH, 레미콘슬러지 주입량, Seed물질 주입량, 교반속도, 교반시간의 최적 조건을 도출하고자 하는데 있다. 실험결과 레미콘 슬러지를 이용한 대상폐수의 $CaF_2$ 침전 반응에서 함수율 및 불소의 제거효율 등을 고려할 경우 최적의 pH 6, 레미콘 슬러지 주입량은 10 g/L, Seed 물질 주입량은 2 g/L, 교반속도은 100 rpm, 교반시간은 60 min으로 관찰되었다. 이 때 Seed 물질의 주입은 불소제거효율에는 영향이 없는 것으로 나타났지만 침전물의 형성이 되는 반응을 촉진시키고 플럭형성을 원활하게 하여 고액 분리가 잘 되어 함수율이 낮아지는 결과가 나타났다.

• 자원리싸이클링
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• 제22권2호
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• pp.37-43
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• 2013

다이아몬드 입자를 전착한 와이어를 사용하여 실리콘 잉곳을 슬라이싱 하는 방식은 기존의 슬러리를 사용하는 방식과 달리 절단매체인 실리콘카바이드를 사용하지 않기 때문에 웨이퍼링 후에 발생하는 슬러지에 함유되어 있는 고형분의 대부분은 잉곳으로부터 분리되어 나온 실리콘 성분으로 구성되어 있다. 따라서 슬러지에 함유되어 있는 액상성분만 제거하여도 어렵지 않게 90% 이상의 순도를 가지는 실리콘을 회수할 수 있는 이점이 있다. 본 연구에서 다이아몬드 와이어 쏘잉 방식에서 배출된 슬러지로부터 오일 성분을 제거하여 고품위 실리콘 분말을 회수하였으며, 성형 및 소결공정을 통하여 실리콘에 포함되어 있는 유기물을 포함한 금속불순물을 제거하고, 미분체 실리콘의 산화가 용이한 점을 활용하여 열산화 공정으로 3N급 순도의 실리카를 제조하였다.

• 한국물환경학회지
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• 제21권5호
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• pp.458-463
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• 2005

Considering the characteristics of a filtration bio-reactor equipped with a mesh filter module which can effectively maintain high concentration of biomass and enhanced solid-liquid separation performance, the hybrid process of filtration bio-reactor combined with coagulation was investigated to get improved filtration characteristics as well as water quality in this work. Two bio-reactors (Run-1 & Run-2) were operated under the following conditions: working volume of 25 L, continuous loading of a synthetic wastewater (BOD: 200 mg/L, T-N: 50 mg/L, T-P: 5 mg/L), where an appropriate amount of alum ($Al_2(SO_4)_3{\cdot}18H_2O$) was added once a day into the reactor (Run-2). In the system without using a alum (Run-1), the clogging of mesh filter module was observed two times through 85 days of whole operation. Meanwhile, the filter module did not clog even at higher MLSS concentration (6,000~12,000 mg/L) and the stable filtration (0.7 mid) was continued in the case of using a alum. Due to the stable formation of cake layers, BOD and SS were shown below 6 and 3 mg/L, respectively. T-P and pH of the effluent were changed because of the intermittent addition of the alum. In the case of Al/P=2.5, the average T-P removal efficiency per day was 85.2% and the average T-P concentration of the effluent was 0.3 mg/L. However, the removal efficiency of phosphate was influenced by pH in the reactor.

• 유기물자원화
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• 제20권2호
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• pp.76-88
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• 2012

본 연구는 생활계폐기물 중 별도로 분리 배출되어 재활용 선별장으로 반입된 재활용 폐기물에 대한 수집운반에서부터 최종처리까지의 흐름을 분석하였다. 연구는 실제 현장조사를 기본으로 실시하였으며, 조사 결과, 최종 재활용 측면에서는 대체적으로는 적정 처리가 이루어지는 것으로 파악 되었으나, 불필요한 이동 및 중간처리 경로를 통해 처리되는 품목이 상당수 있는 것으로 조사되었다. 지자체에서 선별된 폐자원을 처리 또는 수집운반 하는 업체들은 오로지 경제성 원리에 입각한 폐기물 처리비와 운반비 차익을 주요 수익원으로 하기 때문에 불필요한 중간단계 및 장거리 폐기물 이동현상이 나타나게 된다. 따라서 합리적인 자원순환망 구축을 위한 첫 번째 단계는 폐기물 발생원의 근거리에 있는 재활용업체에서의 우선처리원칙이 필요하며, 필요에 따라 인근 지역의 폐기물을 동시에 처리 할 수 있는 광역처리체계 도입이 타당하다.