• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1667-1674
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• 2012

Objective: To explore the differential protein expression profile in EC304 gastric cancer cells induced by alphastatin. Methods: Cultured EC304 cells in the exponential phase of growth were randomly divided into alphastatin and control groups. Total proteins were extracted and the two dimensional electrophoresis (2-DE) technique was applied to analyze differences in expression with ImageMaster 2D Platinum 5.0 software. Proteins were identified using the MASCOT database and selected differently expressed proteins were characterised by western blotting and immunofluorescence. Results: $1350{\pm}90$ protein spots were detected by the ImageMaster software in the 2-DE gel images from the control and alphastatin groups. The match rate was about 72-80% for the spectrum profiles, with 29 significantly different protein spots being identified, 10 upregulated, 16 downregulated, two new and one lost. The MASCOT search scores were 64-666 and the peptide matching numbers were 3-27 with sequence coverage of 8-62%. Twenty-three proteins were checked by mass spectrometry, including decrease in Nm23 and profilin-2 isoform b associated with the regulation of actin multimerisation induced by extracellular signals. Conclusion: The proteome in EC304 cells is dramatically altered by alphastatin, which appears to play an important role in modulating cellular activity and anti-angiogenesis by regulating protein expression and signal transduction pathways through Nm23 and profilin-2 isoform b, providing new research directions for anti-angiogenic therapy of gastric cancer.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.6
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• pp.803-814
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• 2022

The Lao government is continuously developing hydro-power dams in addition to the existing eight power plants in the Nam Ngum River basin and is expanding the power capacity of the existing power plants to meet the expected increase in electricity demand. Accordingly, the Lao government has requested an update on the existing reservoir operating rule curve in order to run the power plants efficiently. To this end, this study reviewed the current independent operating system as well as the joint operating system in order to maximize the annual power generation produced by a power plant by using CSUDP, general-purpose dynamic programming (DP) software. The appropriate operating regulation curve forms (URC/LRC, MRC) were extracted from the DP results, and the annual power generations were simulated by inputting them as the basic operating data of the reservoir operation set of the HEC-ResSim program. By synthesizing the amount of the annual power generation simulated, the existing operation regulation curve, the operational performance, and the opinion of the field operator, the optimal reservoir operation regulation curves that maximize the annual power generation of the target power plant were developed. Results revealed that a system operating in conjunction with the reservoir produces about 2.5 % more power generation than an independent reservoir due to the synergistic effect of the connection.

• Aerospace Engineering and Technology
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• v.4 no.1
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• pp.1-8
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• 2005

Civil aviation regulation such as FAR and loads analysis procedure based on this was explained, and loads analysis procedure and results for Smart UAV was presented for application case. For loads analysis, applicable regulations and loads conditions should be prepared in advance, and modeling for aerodynamics, weight, and structure should be performed. Panel method is usually adopted for aircraft loads analysis to obtain aerodynamic loads. In this study, ARGON which is multidisciplinary fixed wing aircraft design software co-developed by KARI and TsAGI was used for loads analysis. ARGON can be utilized for flutter and stress analysis as well as for flight and ground loads analysis. In this paper, flight loads analysis of 4-seater canard airplane was performed with ARGON and that results were presented.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.3
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• pp.24-34
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• 2005

The automobile seat must satisfy various safety regulations for the passenger's safety. In many design practices, each component is independently designed by concentrating on a single related regulation. However, since multiple regulations can be involved in a seat component, there may be design confliction among the various safety regulations. Therefore, a new design methodology is required to effectively design an automobile seat. The axiomatic approach is employed for considering multiple regulations. The Independence Axiom is used to define the overall flow of the seat design. Functional requirements (FRs) are defined by safety regulations and components of the seat are classified into groups which yield design Parameters (DPs). The classification is carried out to have independence in the FR-DP relationship. Components in a DP group are determined by using orthogonal away of the design of experiments (DOE). Numerical analyses are utilized to evaluate the safety levels by using a commercial software system for nonlinear transient finite element analysis.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.10 no.6
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• pp.301-306
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• 2010

Thesis is about RFID(Radio Frequency Identification) technology which is recently in the spotlight of overall industry including physical distribution. Most RFID systems in Korea are imported, and there are also problems in manpower. In order to prevent these kinds of problems, students made to get and easy access to RFID system. The purpose of is to solve the regulation problems. We made an application software to practice RFID system implemented, which have several modules so that it can be easy for users to understand RFID system. We also invented a system which makes student ID to help users understand how RFID system is implemented in real life.

• Journal of Environmental Impact Assessment
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• v.3 no.2
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• pp.57-67
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• 1994

The National Park should be preserved as described in the regulation. However, the development has resulted in degrading the environment in the park. Especially, the collective facility area has been developed for the commercial benefit rather than for the preservation. So, it is necessary to figure out the impact of the development plan proposed. Thus, the purpose of this study is to explore the hydrologic effects due to the collective facility area development in the National Park. The study site is the second collective facility area of Mt. Kyeryong National Park. The analysis of hydrologic effects due to the development has been carried out using the GIS in this study. The Rational Method and Soil Conservation Service(SCS) were used to estimate the runoff volume. During this procedure, GIS software, ARC/INFO was used to integrate, manipulate, and calculate the attribute value of a number of ploygons which represen each land use characteristic. A program was written to compute the attribute value of each polygon and to estimate the difference of peaktime runoff volume before and after development.

• Korean Journal of Computational Design and Engineering
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• v.21 no.4
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• pp.433-442
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• 2016

This paper aims to define the relational logic of in-between code articles as well as within atomic sentences in Korean Building Code, as an intermediate research and development process for the automated building permit system of Korea. The approach depicted in this paper enables the software developers to figure out the logical relations in order to compose KBimCode and its databases. KBimCode is a computer-readable form of Korean Building Code sentences based on a logic rule-based mechanism. Two types of relational logic definition are described in this paper. First type is a logic definition of relation between code sentences. Due to the complexity of Korean Building code structure that consists of decree, regulation or ordinance, an intensive analysis of sentence relations has been performed. Code sentences have a relation based on delegation or reference each other. Another type is a relational logic definition in a code sentence based on translated atomic sentence(TAS) which is an explicit form of atomic sentence(AS). The analysis has been performed because the natural language has intrinsic ambiguity which hinders interpreting embedded meaning of Building Code. Thus, both analyses have been conducted for capturing accurate meaning of building permit-related requirements as a part of the logic rule-based mechanism.

• Journal of Advanced Marine Engineering and Technology
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• v.35 no.3
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• pp.301-308
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• 2011

International Maritime Organization (IMO) proposed the Energy Efficiency Operation Indicator (EEOI) in 2005 and the Energy Efficiency Design Index (EEDI) in 2008 so as to address emission concern and regulation. Likewise, Ship Energy Efficiency Management Plan (SEEMP) and Greenhouse Gas (GHG) monitoring and management are also becoming an issue lately. This paper introduces the energy efficiency design index (operation indicator) monitoring system (EDiMS) software can continuously monitor $CO_2$, $NO_x$, $SO_x$, and PM values emitted from ship. The accurate inventory of ships GHG can be obtained from base of emission result during the engine shop test trial and the actual monitoring of shaft power and ship speed. In addition, the ability to store all exhaust emission and engine operation data can be applied as the useful tool of the inventory work of air pollution and ship energy management plan for the mitigation or reduction of ship emissions.

• Journal of Information Technology Services
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• v.10 no.3
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• pp.31-47
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• 2011

With the saturation of the local market, the domestic media industry is searching for new growth drivers by crossing over to other industries, but due to the limited size of the market, results fail to meet expectations. Despite its strengths in cultural contents, as verified by the Korean Wave Hallyu, and advanced platform services, the industry feels threatened by the entry of global foreign media businesses in the domestic arena. This and the stagnated growth in the local media market are challenges we are facing today. On the other hand, it could prove to be a timely opportunity to transform the existing media industry structure where exporting hardware and terminals is at the heart of a globalized business into a structure based on software and contents exports. Based on such critical thinking, this study examines the current status of media markets, home and abroad, and aims to come up with strategic measures through a discussion on the issues and methods proposed for the globalization of local media businesses from a holistic viewpoint based on ecosystem, M&A and contents.

• Journal of Distribution Science
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• v.18 no.6
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• pp.77-82
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• 2020

Purpose: In the period of international integration, how is the implementation of intellectual property regulation in developing countries? Do intellectual property rights help attract more Foreign direct investment (FDI)? This study aims to show the effect of intellectual property rights, reflect in the number of patent registered (Patent distribution into two components: Patent_residents and Patent_non-residents) on FDI attraction in Vietnam. Research design, data and methodology: Using Autoregressive distributed lag (ARDL) model for the data collected from 1990 to 2018 with EViews version 9 software. Conclusions: The results indicate that the number of patent protection has a positive effect on FDI in both short term and long term. In particular, only patent registration of foreign individuals and organizations has a significant positive effect on attracting FDI, while that of Vietnamese patents is not statistically significant. From the results of this study, we provide some recommendations to help attract FDI based on raising awareness of intellectual property rights: Increase international cooperation for innovation to learn and encourage patent; Improve the capac ity of inventing as well as the ability to register patents of Vietnamese people; Government agencies are tasked to support a nd review registration procedures; Encouraging patent registration based on the patent.