• International Journal of CAD/CAM
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• v.6 no.1
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• pp.9-17
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• 2006

Performing inspections for Hull Condition Monitoring and Assessment as stipulated in IACS unified requirements and IMO's Condition Assessment Scheme (CAS) IMO Resolution MEPC.94(46), 2001, Condition Assessment Scheme, IMO Resolution MEPC.111(50), 2003, Amendments to regulation 13G, addition of new regulation 13H involves a huge amount of measurement data to be collected, processed, analysed and maintained. Information to be recorded consists of thickness measurements and visual assessment of coating and cracks. The amount of data and increasing requirements with respect to condition assessment demand efficient computer support. Currently, due to the lack of standardization for this kind of data, the thickness measurements are recorded manually on ship drawings or tables. In this form, handling of the measurements is tedious and error-prone and assessment is difficult. Data reporting and analysis takes a long time, leading to some repairs being performed only at the next docking of the ship or making an additional docking necessary. The recently started ED funded project CAS addresses this topic and develops-as a first step-a data model for Hull Condition Monitoring and Assessment (HCMA) based on XML-technology. The model includes simple geometry representation to facilitate a graphically supported data collection as well as an easy visualisation of the measurement results. In order to ensure compatibility with the current way of working, the content of the data model is strictly confined to the requirements of the measurement process. Appropriate data interfaces to classification software will enable rapid assessment by the classification societies, thus improving the process in terms of time and cost savings. In particular, decision-making can be done while the ship is still in the dock for maintenance.

• Molecules and Cells
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• v.37 no.9
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• pp.664-671
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• 2014

MiR-217 can function as an oncogene or a tumour suppressor gene depending on cell type. However, the function of miR-217 in lung cancer remains unclear to date. This study aims to evaluate the function of miR-217 in lung cancer and investigate its effect on the sensitivity of lung cancer cells to cisplatin. The expression of miR-217 was detected in 100 patients by real-time PCR. The effects of miR-217 overexpression on the proliferation, apoptosis, migration and invasion of SPC-A-1 and A549 cells were investigated. The target gene of miR-217 was predicted by Targetscan online software, screened by dual luciferase reporter gene assay and demonstrated by Western blot. Finally, the effects of miR-217 up-regulation on the sensitivity of A549 cells to cisplatin were determined. The expression of miR-217 was significantly lower in lung cancer tissues than in noncancerous tissues (p < 0.001). The overexpression of miR-217 significantly inhibited the proliferation, migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS. The up-regulation of miR-217 enhanced the sensitivity of SPC-A-1 and A549 cells to cisplatin. In conclusion, miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. Our results encourage researchers to use cisplatin in combination with miR-217 to treat lung cancer. This regime might lead to low-dose cisplatin application and cisplatin side-effect reduction.

• Journal of the Korea Society for Simulation
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• v.24 no.4
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• pp.127-136
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• 2015

The e-government project management consignment system to allow the public PMO has been introduced to resolve the quality management issue and the business risk, pointed out by the reorganized Software Industry Promotion Act. The additional regulation improvements are demanded because the public PMO system cannot settle down due to the different opinions among related parties: owner, operator and PMO. Therefore, to make balanced regulation improvements, the in-depth studies are necessary to analyze the fundamental causes of the disagreement between the related parties. This study analyses the each related party's cognitive structure to perform public PMO successfully and the fundamental reasons that cause the different opinions by applying the cognitive psychological Means-end chain theory, the laddering technique and the HVM, Hierarchical Value Map. In addition, this study analyses the regulations required for the related parties to obtain the expected benefits.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.1
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• pp.37-45
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• 2022

The aim of the present study was to investigate the physiological role of nicotinamide phosphoribosyltransferase (NAMPT) associated with odontogenic differentiation during tooth development in mice. Mouse dental papilla cell-23 (MDPC-23) cells cultured in differentiation media were stimulated with the specific NAMPT inhibitor, FK866, and Visfatin (NAMPT) for up to 10 days. The cells were evaluated after 0, 4, 7, and 10 days. Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The mineralization assay was performed by staining MDPC-23 cells with Alizarin Red S solution. After cultivation, MDPC-23 cells were harvested for quantitative PCR or Western blotting. Analysis of variance was performed using StatView 5.0 software (SAS Institute Inc., Cary, NC, USA). Statistical significance was set at p < 0.05. The expression of NAMPT increased during the differentiation of murine odontoblast-like MDPC-23 cells. Furthermore, the up-regulation of NAMPT promoted odontogenic differentiation and accelerated mineralization through an increase in representative odontoblastic biomarkers, such as dentin sialophosphoprotein, dentin matrix protein-1, and alkaline phosphatase in MDPC-23 cells. However, treatment of the cells with the NAMPT inhibitor, FK866, attenuated odontogenic differentiation, as evidenced by the suppression of odontoblastic biomarkers. These data indicate that NAMPT regulated odontoblastic differentiation through the regulation of odontoblastic biomarkers. The increase in NAMPT expression in odontoblasts was closely related to the formation of the extracellular matrix and dentin via the Runx signaling pathway. Therefore, these data suggest that NAMPT is a critical regulator of odontoblast differentiation during tooth development.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.50 no.2
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• pp.103-110
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• 2022

Degradation of handling qualities(HQs) due to bad weather or mechanical failure can pose a fatal risk to pilots unfamiliar with such situation. In particular, icing is an important issue to consider as it is a frequent cause of accidents. Most of the previous research works focuses on aerodynamic performance changes due to icing and the corresponding icing modeling or methods to prevent icing, whereas the present work attempts to actively compensate for HQ degradation due to icing on a full-scale helicopter through flight control law design. To this end, the present work first demonstrates HQ degradation due to icing using CONDUIT software, and subsequently presents a robust control design via the RS-LQR(Robust Servomechanism Linear Quadratic Regulation) procedure to compensate for the HQ degradation. Simulation results show that the proposed robust control maintains Level 1 HQ in the presence of icing.

• Journal of the Korea Society of Computer and Information
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• v.28 no.7
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• pp.179-187
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• 2023

Consumer trust plays a crucial role in the development of the sharing economy. This study primarily focuses on the factors influencing consumer trust and examines the case of ofo, a former leader in China's bike-sharing industry. This paper analyzes the decline in consumer trust in ofo, which can be attributed to internal management issues and the near-bankruptcy situation. The "difficulty in refunds" issue faced by ofo since December 2018 has been growing continuously, and this study explores the factors influencing trust and distrust in this context. By considering product factors (quality), platform factors (payment security, privacy protection, reputation), and social factors (social norms, government regulation) as independent variables, the study analyzes the factors affecting consumer trust. The analysis results revealed that as consumers' distrust towards shared bikes increases, their switching intention also increases. The company's reputation and social norms were found to influence both trust and distrust, while government regulation was found to influence trust. The research findings provide insights relevant to sharing economy platforms and offer guidance for future studies.

• Journal of Digital Convergence
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• v.11 no.2
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• pp.175-182
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• 2013

In this paper, the simulation model of house price is presented on the basis of pricing mechanism between the demand and the supply of apartments in seoul. The algorithm of house price simulation model for calculating the rate of price over time includes feedback control theory. The feedback control theory consists of stock variable, flow variable, auxiliary variable and constant variable. We suggest that the future price of apartment is simulated using mutual interaction variables which are demand, supply, price and parameters among them. In this paper we considers three items which include the behavior of apartment price index, the size of demand and supply, and the forecasting of the apartment price in the future economic scenarios. The proposed price simulation model could be used in public needs for developing a house price regulation policy using financial and non-financial aids. And the quantitative simulation model is to be applied in practice with more specific real data and Powersim Software modeling tool.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.132-137
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• 2004

On-Board Diagnostic(OBD) systems are in most cars and light trucks on the load today. During the 1970's and early 1980's manufacturers started using electronic means to control engine functions and diagnose engine problems. The CARB's diagnostic requirements to meet EPA emission standards have been designated as OBD with a goal of monitoring all of the emissions-related components, as well as the chassis, body, accessory devices and the diagnostic control network of the vehicle for proper operation. In this paper, we present a remote measurement system for the wireless monitoring of diagnosis signal and sensors output signals of ECU adopted KWP2000, united the OBD communication protocol, on OBD-compliant vehicle using the wirless communication technique of Bluetooth. In order to measure the ECU signals, the interface circuit is designed to communicate ECU and designed terminal wirelessly according to the ISO, SAE regulation of communication protocol standard. A microprocessor S3C3410X is used for communicating ECU signals. The embedded system's software is programmed to measure the ECU signals using the ARM compiler and ANCI C based on MicroC/OS kernel to communicate between bluetooth modules using bluetooth stack. The diagnostic system is developed using Visual C++ MFC and protocol stack of bluetooth for Windows environment. The self-diagnosis and sensor output signals of ECU is able to monitor using PC with bluetooth board connected in serial port of PC. The algorithms for measuring the ECU sensor output and self-diagnostic signals are verified to monitor ECU state. At the same time, the information to fix the vehicle's problem can be shown on the developed monitoring software. The possibility for remote measurement of self-diagnosis and sensor signals of ECU adopted KWP2000 in embedded system verified through the developed systems and algorithms.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.47 no.6
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• pp.19-26
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• 2010

Nowadays, the high technology weapons system has been developed and the importance of ATE which measures the test specification is growing bigger and bigger. So the ATE software reliability becomes critical but the regulation of ATE development/management is less inadequate than that of DoD. In this paper, the improvement way of the ATE software reliability verification and ATE development/management processes were proposed.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.2
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• pp.123-132
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• 2014

The maritime sector is advancing with dedicated endeavor to reduce greenhouse gas in addressing issues with regards to global warming. Since 01 January 2013, the International Maritime Organization (IMO) regulation mandatory requirement for Energy Efficiency Design Index (EEDI) has been in place and should be satisfied by newly-built ships of more than 400 gross tonnage and the Ship Energy Efficiency Management Plan (SEEMP) for all ships type. Therefore, compliance to this necessitates planning during the design stage whereas verification can be carried-out through an acceptable method during sea trial. The MEPC-approved 2013 guidance, ISO 15016 and ISO 19019 on EEDI serves the purpose for calculation and verification of attained EEDI value. Individual ships EEDI value should be lower than the required value set by these regulations. The key factors for EEDI verification are power and speed assessment and their synchronization. The shaft power can be measured by telemeter system using strain gage during sea trial. However, calibration of shaft power onboard condition is complicated. Hence, it relies only on proficient technology that operates within the permitted ISO allowance. On the other hand, the ship speed can be measured and calibrated by differential ground positioning system (DGPS). An actual test on a newly-built vessel was carried out to assess the correlation of power and speed. The Energy-efficiency Design Index or Operational Indicator Monitoring System (EDiMS) software developed by the Dynamics Laboratory-Mokpo Maritime University (DL-MMU) and Green Marine Equipment RIS Center (GMERC) of Mokpo Maritime University was utilized for this investigation. In addition, the software can continuously monitor air emission and is a useful tool for inventory and ship energy management plan. This paper introduces the synchronization and identification method between shaft power and ship speed for EEDI verification in accordance with the ISO guidance.