• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1667-1674
• /
• 2012

Objective: To explore the differential protein expression profile in EC304 gastric cancer cells induced by alphastatin. Methods: Cultured EC304 cells in the exponential phase of growth were randomly divided into alphastatin and control groups. Total proteins were extracted and the two dimensional electrophoresis (2-DE) technique was applied to analyze differences in expression with ImageMaster 2D Platinum 5.0 software. Proteins were identified using the MASCOT database and selected differently expressed proteins were characterised by western blotting and immunofluorescence. Results: $1350{\pm}90$ protein spots were detected by the ImageMaster software in the 2-DE gel images from the control and alphastatin groups. The match rate was about 72-80% for the spectrum profiles, with 29 significantly different protein spots being identified, 10 upregulated, 16 downregulated, two new and one lost. The MASCOT search scores were 64-666 and the peptide matching numbers were 3-27 with sequence coverage of 8-62%. Twenty-three proteins were checked by mass spectrometry, including decrease in Nm23 and profilin-2 isoform b associated with the regulation of actin multimerisation induced by extracellular signals. Conclusion: The proteome in EC304 cells is dramatically altered by alphastatin, which appears to play an important role in modulating cellular activity and anti-angiogenesis by regulating protein expression and signal transduction pathways through Nm23 and profilin-2 isoform b, providing new research directions for anti-angiogenic therapy of gastric cancer.

• 대한토목학회논문집
• /
• 제42권6호
• /
• pp.803-814
• /
• 2022

라오스 정부는 증가할 것으로 예상되는 전기 수요량을 충족하기 위해, 남능강 유역 내에 기존 8개소의 발전소 외에도 발전소 댐을 지속적으로 개발하고 있거나 기존 발전소의 발전 설비용량을 증설하고 있다. 이에 따라 라오스 정부는 발전소를 효율적으로 운영하기 위해 기존 저수지 운영규정 곡선(reservoir operation rule curve)을 갱신할 필요성을 제기하였다. 본 연구는 이를 위해 범용적인 동적 계획법(Dynamic Programming:DP) 프로그램인 CSUDP를 활용하여 발전소에서 생산되는 연간 발전량을 극대화하기 위해 현재의 단독 운영체계 외에 연계 운영체계도 검토하였다. 이의 결과로부터 적절한 운영규정 곡선 형태(URC/LRC, MRC)를 추출하였고, 이를 HEC-ResSim 프로그램의 저수지 운영 세트의 운영기초 자료로 입력하여 연간 발전량을 모의하였다. 모의된 연간 발전량과 기존의 운영규정 곡선, 운영실적, 그리고 현장 운영자의 의견 등을 종합하여, 대상 발전소의 연간 발전량을 최대화하는 최적의 저수지 운영규정 곡선(reservoir operation rule curve)을 개발하였다. 이 경우, 저수지를 연계하여 운영하는 체계가 저수지 단독의 운영체계보다 연계에 따른 시너지 효과로 약 2.5 %의 발전량을 더 생산하는 것으로 모의 되었다.

• 항공우주기술
• /
• 제4권1호
• /
• pp.1-8
• /
• 2005

미감항규정인 FAR과 이에 기반한 하중해석 절차를 설명하였다. 하중해석을 위해서는 규정과 하중조건을 준비하고, 공기력, 중량 및 구조 모델링을 수행해야 한다. 항공기 비행하중 해석시 공기력은 일반적으로 패널방법을 이용하여 산출하게 된다. 본 연구에서는 하중해석을 위해 In-house 프로그램인 ARGON을 사용하였다. ARGON은 KARI와 TsAGI가 공동 개발한 고정익 항공기 설계 프로그램으로서 비행하중, 지상하중, 플러터 및 응력해석을 지원한다. 본 논문에서는 ARGON을 이용하여 4인승 선미익 항공기 개발에 있어 필수적인 비행하중 해석을 수행하였고 그 결과를 제시하였다.

• 한국자동차공학회논문집
• /
• 제13권3호
• /
• pp.24-34
• /
• 2005

The automobile seat must satisfy various safety regulations for the passenger's safety. In many design practices, each component is independently designed by concentrating on a single related regulation. However, since multiple regulations can be involved in a seat component, there may be design confliction among the various safety regulations. Therefore, a new design methodology is required to effectively design an automobile seat. The axiomatic approach is employed for considering multiple regulations. The Independence Axiom is used to define the overall flow of the seat design. Functional requirements (FRs) are defined by safety regulations and components of the seat are classified into groups which yield design Parameters (DPs). The classification is carried out to have independence in the FR-DP relationship. Components in a DP group are determined by using orthogonal away of the design of experiments (DOE). Numerical analyses are utilized to evaluate the safety levels by using a commercial software system for nonlinear transient finite element analysis.

• 한국인터넷방송통신학회논문지
• /
• 제10권6호
• /
• pp.301-306
• /
• 2010

최근 유통물류를 비롯한 산업 전반에 걸쳐 RFID (Radio Frequency Identification) 기술이 새로운 성장 동력으로 각광을 받고 있다. RFID 시스템을 대부분 수입에 의존하고 있고, 기술 인력도 현재 부족하여 어려움을 겪고 있다. 이런 문제점을 보안하기 위하여 공부하는 학생들이 RFID 시스템을 쉽게 접근할 수 있도록 제작하였다. 여러 가지 규약에 의해 제안되었던 문제점을 해결하는데 의의가 있다. 별도의 RFID 전용칩을 사용하지 않고, 마이크로콘트롤러를 사용하여 저가격 RFID 학습 시스템을 구현하였다. 구현한 RFID 시스템을 활용하여, 학생증 발급 시스템을 구현하였다.

• 환경영향평가
• /
• 제3권2호
• /
• pp.57-67
• /
• 1994

The National Park should be preserved as described in the regulation. However, the development has resulted in degrading the environment in the park. Especially, the collective facility area has been developed for the commercial benefit rather than for the preservation. So, it is necessary to figure out the impact of the development plan proposed. Thus, the purpose of this study is to explore the hydrologic effects due to the collective facility area development in the National Park. The study site is the second collective facility area of Mt. Kyeryong National Park. The analysis of hydrologic effects due to the development has been carried out using the GIS in this study. The Rational Method and Soil Conservation Service(SCS) were used to estimate the runoff volume. During this procedure, GIS software, ARC/INFO was used to integrate, manipulate, and calculate the attribute value of a number of ploygons which represen each land use characteristic. A program was written to compute the attribute value of each polygon and to estimate the difference of peaktime runoff volume before and after development.

• 한국CDE학회논문집
• /
• 제21권4호
• /
• pp.433-442
• /
• 2016

This paper aims to define the relational logic of in-between code articles as well as within atomic sentences in Korean Building Code, as an intermediate research and development process for the automated building permit system of Korea. The approach depicted in this paper enables the software developers to figure out the logical relations in order to compose KBimCode and its databases. KBimCode is a computer-readable form of Korean Building Code sentences based on a logic rule-based mechanism. Two types of relational logic definition are described in this paper. First type is a logic definition of relation between code sentences. Due to the complexity of Korean Building code structure that consists of decree, regulation or ordinance, an intensive analysis of sentence relations has been performed. Code sentences have a relation based on delegation or reference each other. Another type is a relational logic definition in a code sentence based on translated atomic sentence(TAS) which is an explicit form of atomic sentence(AS). The analysis has been performed because the natural language has intrinsic ambiguity which hinders interpreting embedded meaning of Building Code. Thus, both analyses have been conducted for capturing accurate meaning of building permit-related requirements as a part of the logic rule-based mechanism.

• Journal of Advanced Marine Engineering and Technology
• /
• 제35권3호
• /
• pp.301-308
• /
• 2011

International Maritime Organization (IMO) proposed the Energy Efficiency Operation Indicator (EEOI) in 2005 and the Energy Efficiency Design Index (EEDI) in 2008 so as to address emission concern and regulation. Likewise, Ship Energy Efficiency Management Plan (SEEMP) and Greenhouse Gas (GHG) monitoring and management are also becoming an issue lately. This paper introduces the energy efficiency design index (operation indicator) monitoring system (EDiMS) software can continuously monitor $CO_2$, $NO_x$, $SO_x$, and PM values emitted from ship. The accurate inventory of ships GHG can be obtained from base of emission result during the engine shop test trial and the actual monitoring of shaft power and ship speed. In addition, the ability to store all exhaust emission and engine operation data can be applied as the useful tool of the inventory work of air pollution and ship energy management plan for the mitigation or reduction of ship emissions.

• 한국IT서비스학회지
• /
• 제10권3호
• /
• pp.31-47
• /
• 2011

With the saturation of the local market, the domestic media industry is searching for new growth drivers by crossing over to other industries, but due to the limited size of the market, results fail to meet expectations. Despite its strengths in cultural contents, as verified by the Korean Wave Hallyu, and advanced platform services, the industry feels threatened by the entry of global foreign media businesses in the domestic arena. This and the stagnated growth in the local media market are challenges we are facing today. On the other hand, it could prove to be a timely opportunity to transform the existing media industry structure where exporting hardware and terminals is at the heart of a globalized business into a structure based on software and contents exports. Based on such critical thinking, this study examines the current status of media markets, home and abroad, and aims to come up with strategic measures through a discussion on the issues and methods proposed for the globalization of local media businesses from a holistic viewpoint based on ecosystem, M&A and contents.

• 유통과학연구
• /
• 제18권6호
• /
• pp.77-82
• /
• 2020

Purpose: In the period of international integration, how is the implementation of intellectual property regulation in developing countries? Do intellectual property rights help attract more Foreign direct investment (FDI)? This study aims to show the effect of intellectual property rights, reflect in the number of patent registered (Patent distribution into two components: Patent_residents and Patent_non-residents) on FDI attraction in Vietnam. Research design, data and methodology: Using Autoregressive distributed lag (ARDL) model for the data collected from 1990 to 2018 with EViews version 9 software. Conclusions: The results indicate that the number of patent protection has a positive effect on FDI in both short term and long term. In particular, only patent registration of foreign individuals and organizations has a significant positive effect on attracting FDI, while that of Vietnamese patents is not statistically significant. From the results of this study, we provide some recommendations to help attract FDI based on raising awareness of intellectual property rights: Increase international cooperation for innovation to learn and encourage patent; Improve the capac ity of inventing as well as the ability to register patents of Vietnamese people; Government agencies are tasked to support a nd review registration procedures; Encouraging patent registration based on the patent.