• Title/Summary/Keyword: Sodium Bicarbonate

Search Result 241, Processing Time 0.026 seconds

A Clinical Study of Changes in Serum Electrolyte Concentration During and After Extracorporeal Circulation with Heart-Lung Machine (심폐기 체외순환에 의한 혈청 전해질 변동에 관한 연구)

  • 김근호
    • Journal of Chest Surgery
    • /
    • v.11 no.4
    • /
    • pp.404-415
    • /
    • 1978
  • The present study was carried out to develop the better measures for safety of open heart surgery under extracorporeal circulation (ECC) with Heart-Lung-Machine by preventing changes in the concentrations of serum electrolytes during and after ECC. For this purpose, the cocentrations of serum electrolytes were measured before, during, and after ECC in 21 patients with congenital and acquired heart diseases who received open heart surger, - under ECC using Heart-Lung-Machine. Also considered was the development of safety measured by which changes in serum electrolyte concentrations were prevented during and after open heart surgery under ECC. The mean values for serum sodium levels were observed to be ; $13.14{\pm}0.47$mEq./L. for the samples obtained before ECC. $139.59{\pm}0.68$mEq./L. for the samples obtained 10 minutes after ECC and $138.0{\pm}0.68$mEq./L. for the samples obt"ined 24 hours after ECC. These results indicate that serum sodium concentrations were \\'ithin normal range during and until 24 hours after ECC. 2) The concentrations of serum chloride were found to be $105.38{\pm}0.70$105.38$\pm$0. 70 mEq./L. for the samples collected before ECC, $105.07{\pm}1.01$mEq./L. for the Simples collected 24 minutes aiter ECC and $101.95{\pm}1.09$mEq./L. for the samples collectect 24 hours afte ECC. As was tile case with serum sodium levels, no significant changes were observed in serum chloride levels during and 24 hours after ECC. 3)With proper provisions of potassium chloride solution during ECC, the concentrations of serum potassium were found to be $4.22{\pm}0.06$mEq./L. for the samples removed before EeC, $4.06{\pm}0.14$mEq./L. for the samples removed 10 minutes after ECC and $4.39{\pm}0.07$ mEq./L. for the samples removed 24 hours after ECC. 4)The concentrations of serum calcium were also maintained within normal during and after ECC; $9.15{\pm}0.14$mg/dl for the serum collected before ECC, $8.36{\pm}0.21$mg/dI for the serum collected 10 minutes after ECC and $8.47{\pm}0.14$mg/dl 21 hours after ECC. The maintenance of serum calcium level within normal throughout ECC was achieved by parenteral administrations of calcium gluconate as frequent as required. 5) As were the cases with serum potassium and calcium, the concentrations of plasma bicarbonate was regulated within normal range during and after ECC, only when sodium bicarbonate solution was admini"tered parenterally as it was required; $23.7{\pm}0.50$mEq./L. for the serum collected before ECC. $22.33{\pm}1.09$mEq.lL. for the serum collected 10 minutes after ECC and $25.3{\pm}0.96$mEq./L. for the serum collected 24 hours after ECC. The above results indicate tha t during and after ECC serum sodium and chloride levels remined unchanged without any provision of normal saline, while serum potassium, calcium, and bicarbonate concentrations were kept within normal limits only when these ealectrolytes were administered through parenteral routes. With these results it can be concluded that serum potassium, calcium, and bicarbonate levels should be determined as often as possible during and after ECC and that in order to maintain serum electrolyte levels within normal these electrolytes in the forms of potassium chloride, calcium gluconate, and sodium bicarbonate shou'd be given parenterally as they were found to be required.

  • PDF

Electricity Production from Fe[III]-reducing Bacterium Geobacter sulfurreducens in Microbial Fuel Cell (미생물 연료전지에서 Fe[III] 환원 미생물 Geobacter sulfurreducens를 이용한 전기 생산)

  • Lee, Yu-Jin;Oh, You-Kwan;Kim, Mi-Sun
    • Journal of Hydrogen and New Energy
    • /
    • v.19 no.6
    • /
    • pp.498-504
    • /
    • 2008
  • Metal-reducing bacterium, Geobacter sulfurreducens is available for mediator-less microbial fuel cell (MFC) because it has biological nanowires(pili) which transfer electrons to outside the cell. In this study, in the anode chamber of the MFC system using G. sulfurreducens, the concentrations of NaCl, sodium phosphate and sodium bicarbonate as electrolytes were mainly optimized for the generation of electricity from acetate. 0.4%(w/v) NaClO and 0.5M $H_2SO_4$ could be utilized for the sterilization of acrylic plates and proton exchange membrane (major construction materials of the MFC reactor), respectively. When NaCl concentration in anode phosphate buffer increased from 5 to 50 mM, power density increased from 6 to $20\;mW/m^2$. However, with increasing sodium phosphate buffer concentration from 5 to 50 mM, power density significantly decreased from 18 to $1\;mW/m^2$. Twenty-four mM sodium bicarbonate did not affect electricity generation as well as pH under 50 mM phosphate buffer condition. Optimized anode chamber of MFC using G. sulfurreducens generated relatively high power density ($20\;mW/m^2$) with the maximum coulombic efficiency (41.3%).

Techno-Economic Study on Non-Capture CO2 Utilization Technology

  • Lee, Ji Hyun;Lee, Dong Woog;Kwak, No-Sang;Lee, Jung Hyun;Shim, Jae-Goo
    • KEPCO Journal on Electric Power and Energy
    • /
    • v.2 no.1
    • /
    • pp.109-113
    • /
    • 2016
  • Techno-economic evaluation of Non-Capture $CO_2$ Utilization (NCCU) technology for the production of high-value-added products using greenhouse gas ($CO_2$) was performed. The general scheme of NCCU process is composed of $CO_2$ carbonation and brine electrolysis process. Through a carbonation reaction with sodium hydroxide that is generated from brine electrolysis and $CO_2$ of the flue gas, it is possible to get high-value-added products such as sodium bicarbonate, sodium hydroxide, hydrogen & chloride and also to reduce the $CO_2$ emission simultaneously. For the techno-economic study on NCCU technology, continuous operation of bench-scale facility which could treat $2kgCO_2/day$ was performed. and based on the key performance data evaluated, the economic evaluation analysis targeted on the commercial chemical plant, which could treat 6 tons $CO_2$ per day, was performed using the net present value (NPV) metrics. The results showed that the net profit obtained during the whole plant operation was about 7,890 mKRW (million Korean Won) on NPV metrics and annual $CO_2$ reduction was estimated as about $2,000tCO_2$. Also it was found that the energy consumption of brine electrolysis is one of the key factors which affect the plant operation cost (ex. electricity consumption) and the net profit of the plant. Based on these results, it could be deduced that NCCU technology of this study could be one of the cost-effective $CO_2$ utilization technology options.

Gas Production of Chemical Leavening Agents and Effects on Textures of Cookies (화학 팽창제의 가스 발생과 쿠키의 텍스쳐 비교)

  • Yang, Seong-Yeon;Kim, Sang-Yong;Jang, Kyu-Seob;Oh, Deok-Kun
    • Korean Journal of Food Science and Technology
    • /
    • v.29 no.6
    • /
    • pp.1131-1137
    • /
    • 1997
  • The production rates of leavening gases and textures of cookies were investigated with various chemical leavening agents(baking powders). The chemical leavening agents could be divided into three group of a fast-acting group such as potassium bicarbonate, tartaric acid, aluminium ammonium sulfate, and fumaric acid, a slow-acting group such as ammonium bicarbonate, sodium bicarbonate, $glucono-{\delta}-lactone$, and ammonium chloride. and a double-acting group such as anhydro monocalcium phosphate, disodium dihydrogenpyrophosphate, and aluminium potassium sulfate according to the different production rate of gases. The leavening rate of ammonium bicarbonate, which was the highest of all leavening agents used in this experiment, was 131.25%. But its after-taste in a cookie was not good due to the residual ammonia. $Glucono-{\delta}-lactone$ only had no after-taste. The higher leavening rate, the more peaks in texture profile graph. Ammonium bicarbonate showed the most peaks in this experiment. It was found that the number of peak had correlation with brittleness of cookies $(r^2=0.8176)$ and brittleness of cookies was different as to various chemical leavening agents.

  • PDF

Effects of Sodium Bicarbonate ($NaHCO_3$)) Addition on Performance in Broiler Chickens (Broiler사료에 있어서 중조($NaHCO_3$)첨가가 Broiler 성장에 미치는 영향)

  • 조성구
    • Korean Journal of Poultry Science
    • /
    • v.17 no.1
    • /
    • pp.27-31
    • /
    • 1990
  • An experiment was conducted to determine the influence of Sodium Bicarbonate($NaHCO_3$)on performance in the broilers. $NaHCO_3$, supplementation level(0, 1.5, 2.0, 2.5% ) was substituted for yellow corn in the broiler ration. 120 broilers(Cob strain) were fed for 4 weeks. The results of the experiment obtained were summerized as follows: Body weight gain showed better performance in $NaHCO_3$ 2.5% level group than other groups. but was no significant differences among treated groups, $NaHCO_3$ addition levels did not significant affect in feed intake and feed efficiency, but control group showed slightly higher feed intake amounts than other groups, lowest in feed efficiency, the other side $NaHCO_3$ 1.5% addition group was the lowest in feed intake and better feed efficiency than other treated groups.

  • PDF

Preparation and Dissolution Characteristics of A Gastro-Retentive Tablet System Containing Gabapentin (가바펜틴을 함유한 위체류성 정제의 제조 및 용출 평가)

  • You, Kwang-Hee;Lee, Pung-Sok;Oh, Eui-Chaul
    • Journal of Pharmaceutical Investigation
    • /
    • v.39 no.4
    • /
    • pp.269-273
    • /
    • 2009
  • The objective of this investigation was to develop a gastro-retentive(GR) dosage form of gabapentin and was to evaluate of its dissolution characteristics. GR tablet consists of expandable core tablet matrix and semi-permeable membrane coating. Poloxamer 407 and sodium bicarbonate were used to prepare the core matrix. Polyvinly acetate dispersion (Kollicoat $SR30D^{(R)}$) and polyvinyl alcohol-polyethylene glycol copolymer ((Kollicoat $IR^{(R)}$)) were employed to form the semi-permeable membrane. The GR tablets significantly expanded up to fivefold in simulated gastrointestinal fluids with no apparent damage of the coating membrane over 12 hours. Also, the swelling rate was controllable with the amount of sodium bicarbonate. The drug release was observed to be substantially sustained based on coating level. The release rate of gabapentin from the GR tablet was gradually slowed down as the coasting amount was increased. The gabapentin GR tablet with 8% coating level showed a pseudo-zero order release kinetics over 12 hours. These results suggest that this swellable GR tablet system having semi-permeable membrane coating can be applicable for hydrophilic drug substances like gabapentin.

Preparation and Evaluation of Sustained Release Aspirin Microcapsules Using Eudragit $RS^{\circledR}$ Polymer (Eudragit $RS^{\circledR}$를 이용한 지속 방출형 아스피린 마이크로캅셀의 제조 및 평가)

  • Chun, In-Koo;Shin, Dong-Won
    • YAKHAK HOEJI
    • /
    • v.32 no.1
    • /
    • pp.26-39
    • /
    • 1988
  • Eudragit $RS^{\circledR}$ polymer was used as a wall material for the microencapsulation of aspirin by a phase separation method from chloroform-cyclohexane system with 5% polyisobutylene (PIB) in cyclohexane, and microcapsules obtained were evaluated by particle size analysis, scanning electron microscopy (SEM), drug release and drug stability test. With PIB as a coacervation inducing agent, smooth and tight microcapsules with less aggregation were obtained. Below 1 : 0.3 core-wall ratio, it was possible to coat individual particle. Variation of production conditions showed that increasing the proportion of wall material, particle size and wall thickness of microcapsules and the concentration of paraffin wax in cyclohexane as a sealant sustained drug release rates effectively. SEM confirmed that larger microcapsules after drug release did not rupture into smaller particles but contained a few small pores on the surface. Aspirin release from Eudragit $RS^{\circledR}$ coated microcapsules was independent of the pH of medium, and the mechanism of drug release from non-sealed and sealed microcapsules appeared to fit Higuchi matrix model kinetics. Aspirin in the mixture of aspirin microcapsules and sodium bicarbonate was by far more stable than that in the mixture of pure aspirin and sodium bicarbonate.

  • PDF

Disposition of sulfathiazole in plasma and tissue of broiler chicks following oral administration (육계에서 sulfathiazole 경구투여 후 혈장 및 조직내 잔류량)

  • 서형석;임정철;허부홍;권정택;김성문;천희웅;최인방;김진상
    • Korean Journal of Veterinary Service
    • /
    • v.25 no.3
    • /
    • pp.299-308
    • /
    • 2002
  • The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5~3.0kg). Animals were given ST acutely(10~80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5~3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney > plasma > heart > muscle $\geq$ spleen $\geq$ liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.

The Effects of Oral Care with Difflam Spray 0.3% and Sodium Bicarbonate-Normal Saline Solution on Postoperative Oral Comfort, Sore Throat, and Halitosis (디프람 스프레이(Difflam spray 0.3%)와 중조 생리식염수 분무요법이 전신마취 하 수술 환자의 구강 안위감, 인후통 및 구취에 미치는 효과)

  • Choi, Eun Hee;Lee, Hyun Su;Ko, Mi Suk
    • Journal of muscle and joint health
    • /
    • v.28 no.1
    • /
    • pp.41-49
    • /
    • 2021
  • Purpose: This study aimed to compare the effects of the Difflam spray 0.3% with the sodium bicarbonate-normal saline spray on oral care for postoperative patients. Methods: The participants were randomly allocated to either the Difflam (n=22) group or the saline solution (n=23) group. The data were collected at the 1-, 4-, 7-, and 10-hour marks after returning to the ward post operation using the Beck's subjective oral discomfort scale, Visual Analogue Scale for sore throat, and portable halitosis detector. Results: The sore throat (F=7.25, p=.001) score significantly decreased after oral care using the Difflam spray 0.3%. However, the difference in the scores of oral comfort (F=0.34, p=.797) and halitosis (F=0.91, p=.443) between the two groups was not statistically significant. Conclusion: These findings suggest that the Difflam spray 0.3% is effective in improving postoperative sore throat. A further study that explores the effect of various oral solutions for postoperative patients is needed to present systemic and effective evidence-based oral care guidelines.