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Disposition of sulfathiazole in plasma and tissue of broiler chicks following oral administration  

서형석 (전라북도축산진흥연구소)
임정철 (전라북도축산진흥연구소)
허부홍 (전라북도축산진흥연구소)
권정택 ((주)하림)
김성문 (전라북도축산진흥연구소)
천희웅 (전라북도축산진흥연구소)
최인방 (전라북도축산진흥연구소)
김진상 (전북대학교 생체안전성연구소)
Publication Information
Korean Journal of Veterinary Service / v.25, no.3, 2002 , pp. 299-308 More about this Journal
Abstract
The purposes of this study were to characterize the disposition of sulfathiazole(ST) and to investigate the effects of sodium bicarbonate on the disposition of ST in broiler chicks(2.5～3.0kg). Animals were given ST acutely(10～80mg/kg, PO), and plasma, kidney, muscle, heart, liver and spleen samples were collected and analyzed for ST by high performance liquid chromatography. The plasma and tissue data was consistent with a one-compartment pharmacokinetic model. The drug is rapidly but incompletely(2.5～3.87%) absorbed with peak plasma and tissue levels being achieved within one hour after dosing. The plasma and tissue levels depended on drug dosage, and the descending order in concentration of ST was kidney > plasma > heart > muscle $\geq$ spleen $\geq$ liver from animals sacrificed at one hour after dosing. Moreover, significant positive correlations(r>0.9) existed between plasma and tissue levels of ST. In addition, sodium bicarbonate pretreatment decreased plasma level, indicating that an alkalinization stimulate the excretion of ST. Results of this study suggest that oral application of ST was rapidly absorbed and eliminated, and confirmed that tissue residues of ST can be estimated from plasma drug concentration in broiler chicks.
Keywords
Sulfathiazole; Broiler chicks; HPLC; Plasma; Alkalinization;
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1 김윤지, 성기승, 윤칠석 등. 1996. 사료에 첨가된 sulfathiazole의 수준과 휴약기간에 따른 육계 가슴살에서의 잔류량. 한국축산식품학회 16(2) : 224-228
2 Jain SK, Hapke HJ. 1995. Deposition kinetics, metabolism and urinary excretion of sulfathiazole following oral administrator in sheep. Dtsch Tierarztl Wochenshr 102(10) : 394-395
3 Kawalek JC, Fetterer RH. 1990. Effect of Haemochus contortus infection on the clearance of antipyrine, sulfobromophthalein, chloramphenicol, and sulfathiazole in lambs. Am J Vet Res 51(2) : 2044-2049
4 Koritz GD, Bourne DW, Dittert LW, et al. 1977. Disposition of sulfonamides in food-producing animals: pharmacokinetics of sulfathiazole in sheep. Am J Vet Res 38(7) : 979- 982
5 Martlbaner E, Meier R, Usleber E, et al. 1992. Enzyme immunoassay for the detection of sulfamethazine, sulfadiazine, sulfarnethoxypyridiazine and trimetoprim on milk. Food Agr Immunol 4: 219-228   DOI   ScienceOn
6 Schenck FJ. 1992. Matrix solid-phase dispersion extraction and liquid chromatographic determination of nicarbazine in chicken tissue. JAOAC Int 75(4) : 659-662
7 Long AR. 1990. Multiresidue method for determination of sulfonamides in pork tissue. J Agric Food Chem 38: 423-426   DOI
8 Schenck FJ. 1992. Matrix solid-phase dispersion extraction and liquid chromatographic determination of nicarbazine in chicken tissue. JAOAC Int 75(4) : 659-662
9 정희영. 1985. 항생제의 길잡이. 수문사 : 315-318
10 Schwartz DP. 1985. Quantitative colorimetric method for sulfamethazine in swine feeds. JAOAC 68(2) : 214-217
11 Fleeker JR, Lovett LJ. 1985. Enzyme immunoassay for screening sulfamethazine residues in swine blood. JAOAC 68: 172-174
12 정경태, 조헌호, 이강록 등. 1998. 마우스 근육내 설파제 잔류량 조사 및 동시분석파장 연구. 한가위지 21(4) : 379-383
13 황래홍, 김영수, 윤은선 등. 1995. HPLC를 이용한 축산식품중 설폰아마이드제의 동시분석법 연구. 한가위지 19(1) : 13-28
14 백미순, 이영철, 이해영 등. 1998. 절박도축우의 항생제 및 설파제잔류조사. 한가위지 21(1) : 13-20
15 박준조, 이규춘, 고홍범. 1994. 고속액체크로마토그라피에 의한 식육중 설파제 잔류량 분석에 관한 연구. 한국수의공중보건학회지 18(4) : 317-326
16 Simpson RM, Suhre FB, Shafer JW. 1985. Quantitive gas chromatographicmass spectrometric assay of five sulfonamide residues in animal tissue. JAOAC 68(1) : 23-26
17 Daun RJ. 1971. Simultaneous gas liquid chromatographic determination of four sulfonamide in feeds. JAOAC 54(6): 1277-1282
18 한국계육협회홈페이지 (http://www.chicken.or.kr), 통계자료 도축현황
19 USDA-FSIS. 1987. Swine urine screen sulfa-on-site test kit. the scientific basis on SOS. Environmental Diagnostics. Inc 4
20 Phillips WF, Trafton JE. 1975. A screening method for sulfonamide extracted from animal tissue. JAOAC 58(1) : 44-47
21 Bevil RF, Swine KM, Luther HG, et al. 1978. Determination of sulfonamide in swine plasma. J Agr Food Chem 26: 1201-1203   DOI
22 Bevill RF, Koritz GD, Dittert LW, et al. 1977. Disposition of sulfonamides in food-producting animals V: Disposion of sulfathiazole in tissue, urine, and plasma of sheep following intravenous administration. J Pharm Sci 66(9): 1297-1300   DOI   PUBMED
23 Koritz GD, Bevill RF, Bourne DW, et al. 1978. Disposition of sulfonamides in food-producing animals: pharmacokinetics of sulfathiazole in swine. Am J Vet Res 39(3) : 481-484